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  1. Article ; Online: Dual Cross-Linked Stimuli-Responsive Alginate-Based Hydrogels.

    Habib, Michel / Berthalon, Steve / Leclercq, Laurent / Tourrette, Audrey / Sharkawi, Tahmer / Blanquer, Sebastien

    Biomacromolecules

    2024  Volume 25, Issue 3, Page(s) 1660–1670

    Abstract: Sodium alginate with different molecular weights (55, 170, and 320 kg ... ...

    Abstract Sodium alginate with different molecular weights (55, 170, and 320 kg mol
    MeSH term(s) Hydrogels/chemistry ; Alginates/chemistry
    Chemical Substances Hydrogels ; Alginates
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c01201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Synthesis of Poly(Trimethylene Carbonate) from Amine Group Initiation: Role of Urethane Bonds in the Crystallinity.

    Brossier, Thomas / Volpi, Gael / Lapinte, Vincent / Blanquer, Sebastien

    Polymers

    2021  Volume 13, Issue 2

    Abstract: Semi-crystalline poly(trimethylene carbonate) (PTMC) can be efficiently prepared by ring-opening polymerization (ROP) initiated by amine using various catalysts. More promising results were reached with the one-step process of stannous octanoate unlike ... ...

    Abstract Semi-crystalline poly(trimethylene carbonate) (PTMC) can be efficiently prepared by ring-opening polymerization (ROP) initiated by amine using various catalysts. More promising results were reached with the one-step process of stannous octanoate unlike the two-step one-pot reaction using TBD and MSA catalysts. The ROP-amine of TMC consists in a simple isocyanate free process to produce polycarbonate-urethanes, compatible with the large availability of amines ranging from mono- to multifunctional until natural amino acids. ROP-amine of TMC leads to urethane bonds monitored by FTIR spectroscopy. The relationship between the nature of amines and the crystallinity of PTMC was discussed through X-ray diffraction and thermal studies by DSC and TGA. The impact of the crystallinity was also demonstrated on the mechanical properties of semi-crystalline PTMC in comparison to amorphous PTMC, synthesized by ROP initiated by alcohol. The semi-crystalline PTMC synthesized by ROP-amine opens many perspectives.
    Language English
    Publishing date 2021-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13020280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Triply Periodic Minimal Surfaces (TPMS) for the Generation of Porous Architectures Using Stereolithography.

    Blanquer, Sebastien B G / Grijpma, Dirk W

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2147, Page(s) 19–30

    Abstract: A new generation of sophisticated tissue engineering scaffolds are developed using the periodicity of trigonometric equations to generate triply periodic minimal surfaces (TPMS). TPMS architectures display minimal surface energy that induce typical pore ... ...

    Abstract A new generation of sophisticated tissue engineering scaffolds are developed using the periodicity of trigonometric equations to generate triply periodic minimal surfaces (TPMS). TPMS architectures display minimal surface energy that induce typical pore features and surface curvatures. Here we described a series of TPMS geometries and developed a procedure to build such scaffolds by stereolithography using biocompatible and biodegradable photosensitive resins.
    MeSH term(s) Absorbable Implants ; Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Bone and Bones/physiology ; Computer-Aided Design ; Cross-Linking Reagents/chemistry ; Humans ; Polyesters/chemical synthesis ; Polyesters/chemistry ; Porosity ; Stereolithography ; Surface Properties ; Tissue Engineering/instrumentation ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry
    Chemical Substances Biocompatible Materials ; Cross-Linking Reagents ; Polyesters ; poly(lactide-co-trimethylene carbonate) ; poly(tetramethylene carbonate)
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0611-7_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Photoprintable Gelatin-graft-Poly(trimethylene carbonate) by Stereolithography for Tissue Engineering Applications

    Brossier, Thomas / Volpi, Gael / Vasquez-Villegas, Jonaz / Petitjean, Noémie / Guillaume, Olivier / Lapinte, Vincent / Blanquer, Sébastien

    Biomacromolecules. 2021 Aug. 16, v. 22, no. 9

    2021  

    Abstract: The stereolithography process is a powerful additive manufacturing technology to fabricate scaffolds for regenerative medicine. Nevertheless, the quest for versatile inks allowing one to produce scaffolds with controlled properties is still unsatisfied. ... ...

    Abstract The stereolithography process is a powerful additive manufacturing technology to fabricate scaffolds for regenerative medicine. Nevertheless, the quest for versatile inks allowing one to produce scaffolds with controlled properties is still unsatisfied. In this original article, we tackle this bottleneck by synthesizing a panel of photoprocessable hybrid copolymers composed of gelatin-graft-poly(trimethylene carbonate)s (Gel-g-PTMCₙ). We demonstrated that by changing the length of PTMC blocks grafted from gelatin, it is possible to tailor the final properties of the photofabricated objects. We reported here on the synthesis of Gel-g-PTMCₙ with various lengths of PTMC blocks grafted from gelatin using hydroxy and amino side groups of the constitutive amino acids. Then, the characterization of the resulting hybrid copolymers was fully investigated by quantitative NMR spectroscopy before rendering them photosensitive by methacrylation of the PTMC terminal groups. Homogeneous composition of the photocrosslinked hybrid polymers was demonstrated by EDX spectroscopy and electronic microscopy. To unravel the individual contribution of the PTMC moiety on the hybrid copolymer behavior, water absorption, contact angle measurements, and degradation studies were undertaken. Interestingly, the photocrosslinked materials immersed in water were examined using tensile experiments and displayed a large panel of behavior from hydrogel to elastomer-like depending on the PTMC/gel ratio. Moreover, the absence of cytotoxicity was conducted following the ISO 10993 assay. As a proof of concept, 3D porous objects were successfully fabricated using stereolithography. Those results validate the great potential of this panel of inks for tissue engineering and regenerative medicine.
    Keywords carbonates ; composite polymers ; contact angle ; cytotoxicity ; electron microscopy ; energy-dispersive X-ray analysis ; gelatin ; hydrogels ; medicine ; moieties ; nuclear magnetic resonance spectroscopy ; photosensitivity ; water uptake
    Language English
    Dates of publication 2021-0816
    Size p. 3873-3883.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1526-4602
    DOI 10.1021/acs.biomac.1c00687
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Polyoxazoline hydrogels fabricated by stereolithography.

    Brossier, Thomas / Benkhaled, Belkacem Tarek / Colpaert, Maxime / Volpi, Gael / Guillaume, Olivier / Blanquer, Sébastien / Lapinte, Vincent

    Biomaterials science

    2022  Volume 10, Issue 10, Page(s) 2681–2691

    Abstract: The development of hydrogel materials in additive manufacturing displaying stiff and strong mechanical properties while maintaining high water uptake remains a great challenge. Taking advantage of the versatility of poly(oxazoline) (POx) chemistry and ... ...

    Abstract The development of hydrogel materials in additive manufacturing displaying stiff and strong mechanical properties while maintaining high water uptake remains a great challenge. Taking advantage of the versatility of poly(oxazoline) (POx) chemistry and properties, we investigated in this article a new generation of POx hydrogels fabricated by stereolithography (SLA). A large range of photosensitive poly(2-methyl-2-oxazoline) resins were synthesized as hydrogel precursors for SLA photofabrication. Functionalization has been performed by direct di-methacrylation of POx terminal groups (MA
    MeSH term(s) Hydrogels/chemistry ; Polymers ; Stereolithography ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry
    Chemical Substances Hydrogels ; Polymers
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm00138a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Photoprintable Gelatin-

    Brossier, Thomas / Volpi, Gael / Vasquez-Villegas, Jonaz / Petitjean, Noémie / Guillaume, Olivier / Lapinte, Vincent / Blanquer, Sébastien

    Biomacromolecules

    2021  Volume 22, Issue 9, Page(s) 3873–3883

    Abstract: The stereolithography process is a powerful additive manufacturing technology to fabricate scaffolds for regenerative medicine. Nevertheless, the quest for versatile inks allowing one to produce scaffolds with controlled properties is still unsatisfied. ... ...

    Abstract The stereolithography process is a powerful additive manufacturing technology to fabricate scaffolds for regenerative medicine. Nevertheless, the quest for versatile inks allowing one to produce scaffolds with controlled properties is still unsatisfied. In this original article, we tackle this bottleneck by synthesizing a panel of photoprocessable hybrid copolymers composed of gelatin-
    MeSH term(s) Dioxanes ; Gelatin ; Polymers ; Stereolithography ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Dioxanes ; Polymers ; polytrimethylene carbonate (31852-84-3) ; trimethylene carbonate (4316AQ174Q) ; Gelatin (9000-70-8)
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.1c00687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nanoparticles as contrast agents for brain nuclear magnetic resonance imaging in Alzheimer's disease diagnosis.

    Azria, David / Blanquer, Sébastien / Verdier, Jean-Michel / Belamie, Emmanuel

    Journal of materials chemistry. B

    2017  Volume 5, Issue 35, Page(s) 7216–7237

    Abstract: Nuclear Magnetic Resonance Imaging (MRI) of amyloid plaques is a powerful non-invasive approach for the early and accurate diagnosis of Alzheimer's disease (AD) along with clinical observations of behavioral changes and cognitive impairment. The present ... ...

    Abstract Nuclear Magnetic Resonance Imaging (MRI) of amyloid plaques is a powerful non-invasive approach for the early and accurate diagnosis of Alzheimer's disease (AD) along with clinical observations of behavioral changes and cognitive impairment. The present article aims at giving a critical and comprehensive review of recent advances in the development of nanoparticle-based contrast agents for brain MRI. Nanoparticles considered for the MRI of AD must comply with a highly stringent set of requirements including low toxicity and the ability to cross the blood-brain-barrier. In addition, to reach an optimal signal-to-noise ratio, they must exhibit a specific ability to target amyloid plaques, which can be achieved by grafting antibodies, peptides or small molecules. Finally, we propose to consider new directions for the future of MRI in the context of Alzheimer's disease, in particular by enhancing the performances of contrast agents and by including therapeutic functionalities following a theranostic strategy.
    Language English
    Publishing date 2017-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/c7tb01599b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Nanoparticles as contrast agents for brain nuclear magnetic resonance imaging in Alzheimer's disease diagnosis

    Azria, David / Blanquer, Sébastien / Verdier, Jean-Michel / Belamie, Emmanuel

    Journal of materials chemistry B. 2017 Sept. 13, v. 5, no. 35

    2017  

    Abstract: Nuclear Magnetic Resonance Imaging (MRI) of amyloid plaques is a powerful non-invasive approach for the early and accurate diagnosis of Alzheimer's disease (AD) along with clinical observations of behavioral changes and cognitive impairment. The present ... ...

    Abstract Nuclear Magnetic Resonance Imaging (MRI) of amyloid plaques is a powerful non-invasive approach for the early and accurate diagnosis of Alzheimer's disease (AD) along with clinical observations of behavioral changes and cognitive impairment. The present article aims at giving a critical and comprehensive review of recent advances in the development of nanoparticle-based contrast agents for brain MRI. Nanoparticles considered for the MRI of AD must comply with a highly stringent set of requirements including low toxicity and the ability to cross the blood–brain-barrier. In addition, to reach an optimal signal-to-noise ratio, they must exhibit a specific ability to target amyloid plaques, which can be achieved by grafting antibodies, peptides or small molecules. Finally, we propose to consider new directions for the future of MRI in the context of Alzheimer's disease, in particular by enhancing the performances of contrast agents and by including therapeutic functionalities following a theranostic strategy.
    Keywords Alzheimer disease ; amyloid ; antibodies ; behavior change ; blood-brain barrier ; brain ; cognitive disorders ; disease diagnosis ; magnetic resonance imaging ; nanoparticles ; nuclear magnetic resonance spectroscopy ; peptides ; signal-to-noise ratio ; therapeutics ; toxicity
    Language English
    Dates of publication 2017-0913
    Size p. 7216-7237.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/c7tb01599b
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Development of poly(trimethylene carbonate) network implants for annulus fibrosus tissue engineering.

    Blanquer, Sébastien B G / Sharifi, Shahriar / Grijpma, Dirk W

    Journal of applied biomaterials & functional materials

    2012  Volume 10, Issue 3, Page(s) 177–184

    Abstract: Purpose: Intervertebral disk degeneration is the main cause of chronic back pain. Disk degeneration often leads to tearing of the annulus fibrosus (AF) and extrusion of the nucleus pulposus (NP), which compresses the nerves. Current treatment involves ... ...

    Abstract Purpose: Intervertebral disk degeneration is the main cause of chronic back pain. Disk degeneration often leads to tearing of the annulus fibrosus (AF) and extrusion of the nucleus pulposus (NP), which compresses the nerves. Current treatment involves removing the herniated NP and suturing the damaged AF tissue. This surgical approach has several drawbacks. In this study, we designed a biodegradable AF closure system comprising a tissue engineering scaffold, a supporting membrane and an adhesive material, to not only restore the function of the herniated disc but also to promote tissue regeneration.
    Materials and methods: Porous scaffolds with precisely defined architectures were built by stereolithography using resins based on poly(trimethylene carbonate) (PTMC) macromers functionalized with methacrylate endgroups. In addition, a porous photo-cross-linked PTMC membrane was developed that can be used to keep the scaffold in place in the AF tissue.
    Results: After synthesis and characterization, the components of the implant are glued together and to the AF tissue using a diisocyanate glue based on polyethylene glycol-PTMC triblock copolymers. The adhesion strengths of the materials to each other and to AF tissue were determined in lap-shear tests.
    Conclusions: This study showed that a device for AF tissue engineering can be prepared from PTMC-based scaffolds, membranes and glues.
    MeSH term(s) Animals ; Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Biocompatible Materials/metabolism ; Cattle ; Dioxanes/chemistry ; Fibrocartilage/physiology ; Isocyanates/chemistry ; Polyethylene Glycols/chemistry ; Polymers/chemistry ; Porosity ; Prostheses and Implants ; Regeneration ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Biocompatible Materials ; Dioxanes ; Isocyanates ; Polymers ; Polyethylene Glycols (30IQX730WE) ; polytrimethylene carbonate (31852-84-3)
    Language English
    Publishing date 2012
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2673624-X
    ISSN 2280-8000 ; 1722-6899
    ISSN (online) 2280-8000
    ISSN 1722-6899
    DOI 10.5301/JABFM.2012.10354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Polymeric microstructures with shape-memory properties for biomedical use built by stereolithography.

    Sharifi, Shahriar / Blanquer, Sebastien / Grijpma, Dirk W

    Journal of applied biomaterials & functional materials

    2012  Volume 10, Issue 3, Page(s) 280–286

    Abstract: Purpose: The aim of this study was to design and build porous microstructures with shape memory behaviour using biodegradable poly(D,L-lactide-co-trimethylene carbonate) dimethacrylate macromers. These microstructures could be advantageous for tissue ... ...

    Abstract Purpose: The aim of this study was to design and build porous microstructures with shape memory behaviour using biodegradable poly(D,L-lactide-co-trimethylene carbonate) dimethacrylate macromers. These microstructures could be advantageous for tissue engineering and other advanced biomedical applications.
    Methods: Porous structures with a gyroid pore network architecture showing average pore sizes of 930 µm and complete pore interconnectivity were prepared by stereolithography. Built structures were characterized by Micro-computed tomography (µ-CT). Shape recovery and shape fixity of microstructures after 40% and 70% compression were evaluated.
    Results: At 37 °C the flexible structures showed compression modulus values of 60 KPa and could be fully compressed. Thermal analysis showed that the built networks were amorphous with Tg values of 23 °C. After compression to 40 and 70%, shape fixity and shape recovery of the structures at respectively 0 °C and 37 °C was almost quantitative.
    Conclusions: The well-defined pore network characteristics and the shape-memory properties of these structures allow their use as deployable tissue engineering scaffolds.
    MeSH term(s) Adipose Tissue/cytology ; Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Cell Culture Techniques ; Cells, Cultured ; Elastic Modulus ; Humans ; Polyesters/chemical synthesis ; Polyesters/chemistry ; Porosity ; Pressure ; Stem Cells/cytology ; Tissue Engineering ; Transition Temperature
    Chemical Substances Biocompatible Materials ; Polyesters ; poly(lactide-co-trimethylene carbonate)
    Language English
    Publishing date 2012
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2673624-X
    ISSN 2280-8000 ; 1722-6899
    ISSN (online) 2280-8000
    ISSN 1722-6899
    DOI 10.5301/JABFM.2012.10367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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