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  1. Book ; Online: Lung Diseases: Chronic Respiratory Infections

    Blasi, Francesco B.

    2018  

    Abstract: Both chronic and acute infections play a significant role in the pathogenesis and clinical course of chronic obstructive pulmonary disease (COPD) and both cystic fibrosis (CF) and non-CF bronchiectasis. There is also specific evidence that chronic ... ...

    Abstract Both chronic and acute infections play a significant role in the pathogenesis and clinical course of chronic obstructive pulmonary disease (COPD) and both cystic fibrosis (CF) and non-CF bronchiectasis. There is also specific evidence that chronic infection, even in the absence of acute infection, has an influence on the manifestations and disease course. The infections found in COPD, CF, and bronchiectasis share a number of clinical similarities, the most striking of which are bacterial persistence despite the use of antibiotics and antibiotic resistance.In the last two decades, the rate of antibiotic resistance has increased dramatically and poses serious threats for patients and public health. There are different reasons for this increase in resistance, but the overuse of antibiotics in the community is certainly the most prominent. On the other hand, the chronic use of antibiotics in chronic diseases like COPD, CF, and bronchiectasis is also potentially associated with an increase in MDR pathogens. During the last decade, a growing interest has been raised in evaluating nontuberculous mycobacteria's role in chronic respiratory diseases like bronchiectasis
    Keywords Medicine (General) ; Immunologic diseases. Allergy ; Therapeutics. Pharmacology
    Size 1 electronic resource (216 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020099446
    ISBN 9783038973386 ; 9783038973393 ; 3038973386 ; 3038973394
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Role of the oral beta-lactams in the treatment of exacerbations of chronic bronchitis

    Blasi, Francesco

    critical analysis and therapeutic recommendations

    (Journal of chemotherapy ; 22, Suppl. 1)

    2010  

    Author's details F. Blasi
    Series title Journal of chemotherapy ; 22, Suppl. 1
    Collection
    Language English
    Size 28 S.
    Publisher E.S.I.F.T. srl
    Publishing place Firenze
    Publishing country Italy
    Document type Book
    HBZ-ID HT016645674
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2701 -22,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: There is still no established and accepted definition of COPD.

    Cazzola, Mario / Blasi, Francesco

    Respiratory medicine

    2023  Volume 214, Page(s) 107262

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.19: Show issues Location:
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  4. Article ; Online: Lung Diseases: Chronic Respiratory Infections.

    Blasi, Francesco

    International journal of molecular sciences

    2018  Volume 19, Issue 10

    MeSH term(s) Animals ; Humans ; Pneumonia/drug therapy ; Pneumonia/immunology ; Pneumonia/microbiology
    Language English
    Publishing date 2018-10-07
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19103051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Long-Term Outcomes in Severe Community-Acquired Pneumonia.

    Carella, Francesco / Aliberti, Stefano / Stainer, Anna / Voza, Antonio / Blasi, Francesco

    Seminars in respiratory and critical care medicine

    2024  Volume 45, Issue 2, Page(s) 266–273

    Abstract: Community-acquired pneumonia (CAP) is globally one of the major causes of hospitalization and mortality. Severe CAP (sCAP) presents great challenges and need a comprehensive understanding of its long-term outcomes. Cardiovascular events and neurological ... ...

    Abstract Community-acquired pneumonia (CAP) is globally one of the major causes of hospitalization and mortality. Severe CAP (sCAP) presents great challenges and need a comprehensive understanding of its long-term outcomes. Cardiovascular events and neurological impairment, due to persistent inflammation and hypoxemia, contribute to long-term outcomes in CAP, including mortality. Very few data are available in the specific population of sCAP. Multiple studies have reported variable 1-year mortality rates for patients with CAP up to 40.7%, with a clear influence by age, comorbidities, and disease severity. In terms of treatment, the potential protective role of macrolides in reducing mortality emphasizes the importance of appropriate empiric antibiotic therapy. This narrative review explores the growing interest in the literature focusing on the long-term implications of sCAP. Improved understanding of long-term outcomes in sCAP can facilitate targeted interventions and enhance posthospitalization care protocols.
    MeSH term(s) Humans ; Pneumonia/drug therapy ; Community-Acquired Infections/drug therapy ; Hospitalization
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0044-1781426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1555: Show issues Location:
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  6. Article ; Online: Can Treatable Traits Be the Approach to Addressing the Complexity and Heterogeneity of COPD?

    Cazzola, Mario / Rogliani, Paola / Blasi, Francesco

    International journal of chronic obstructive pulmonary disease

    2023  Volume 18, Page(s) 1959–1964

    Abstract: The complexity of COPD implies the need to identify groups of patients with similar clinical characteristics and prognosis or treatment requirements. This is why much attention has been paid to identifying the different clinical phenotypes by ... ...

    Abstract The complexity of COPD implies the need to identify groups of patients with similar clinical characteristics and prognosis or treatment requirements. This is why much attention has been paid to identifying the different clinical phenotypes by investigating the clinical expression of the disease, and endotypes by studying the biological networks that enable and limit reactions. However, this approach is complicated because one endotype gives rise to one or more clinical characteristics, and clinical phenotypes can be derived from several endotypes. To simplify the approach, a new taxonomic classification of COPD based on the different causes (or etiotypes) has been proposed, but these etiotypes have not yet been validated. A simpler method is the so-called tractable traits approach, which is free from any designation of the disorder to be treated and does not present the criticality of using etiotypes. A large randomised controlled trial on using the treatable traits approach in COPD is still lacking. Nevertheless, this approach is already applied by following the GOLD strategy. However, its application is complicated because several potentially treatable traits have been identified within the pulmonary domain, the extrapulmonary domain, and the behavioural/risk factor domain. In addition, the hierarchy of the dominant treatable traits has not yet been established, and they change over time both spontaneously and because of treatment. This means that the patients being treated according to the tractable traits approach must be constantly followed over time so that the therapy is focused on their temporal needs.
    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/therapy ; Phenotype ; Risk Factors
    Language English
    Publishing date 2023-09-08
    Publishing country New Zealand
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S428391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prognostic scores of CPAP failure in COVID-19 patients: beware of biases to avoid pitfalls.

    Accordino, Silvia / Canetta, Ciro / Sozzi, Fabiola / Blasi, Francesco

    Internal and emergency medicine

    2023  Volume 18, Issue 6, Page(s) 1871–1873

    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/therapy ; Prognosis ; Respiratory Insufficiency ; Continuous Positive Airway Pressure ; Bias
    Language English
    Publishing date 2023-08-04
    Publishing country Italy
    Document type Letter
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03384-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6673: Show issues Location:
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  8. Article ; Online: Characteristics and outcomes of unvaccinated and vaccinated COVID-19 patients with acute respiratory failure treated with CPAP in a medical intermediate care unit.

    Accordino, Silvia / Canetta, Ciro / Blasi, Francesco

    European journal of internal medicine

    2023  Volume 111, Page(s) 124–126

    MeSH term(s) Humans ; COVID-19 ; Respiratory Insufficiency/therapy
    Language English
    Publishing date 2023-01-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2608: Show issues Location:
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  9. Article ; Online: MEIS1 in Hematopoiesis and Cancer. How MEIS1-PBX Interaction Can Be Used in Therapy.

    Blasi, Francesco / Bruckmann, Chiara

    Journal of developmental biology

    2021  Volume 9, Issue 4

    Abstract: Recently MEIS1 emerged as a major determinant of the MLL-r leukemic phenotype. The latest and most efficient drugs effectively decrease the levels of MEIS1 in cancer cells. Together with an overview of the latest drugs developed to target MEIS1 in MLL-r ... ...

    Abstract Recently MEIS1 emerged as a major determinant of the MLL-r leukemic phenotype. The latest and most efficient drugs effectively decrease the levels of MEIS1 in cancer cells. Together with an overview of the latest drugs developed to target MEIS1 in MLL-r leukemia, we review, in detail, the role of MEIS1 in embryonic and adult hematopoiesis and suggest how a more profound knowledge of MEIS1 biochemistry can be used to design potent and effective drugs against MLL-r leukemia. In addition, we present data showing that the interaction between MEIS1 and PBX1 can be blocked efficiently and might represent a new avenue in anti-MLL-r and anti-leukemic therapy.
    Language English
    Publishing date 2021-10-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720870-9
    ISSN 2221-3759 ; 2221-3759
    ISSN (online) 2221-3759
    ISSN 2221-3759
    DOI 10.3390/jdb9040044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Viral Respiratory Infections: From Bench to Bedside.

    Blasi, Francesco / Ramirez, Julio

    Seminars in respiratory and critical care medicine

    2021  Volume 42, Issue 6, Page(s) 735–736

    MeSH term(s) Humans ; Pneumonia ; Virus Diseases/epidemiology ; Virus Diseases/therapy
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0041-1740169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1555: Show issues Location:
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