LIVIVO - Search results -

Search results

Result 1 - 10 of total 86

Search options

Article ; Online: Multicellular Tumor Spheroids in Nanomedicine Research: A Perspective.

Rossi, Martina / Blasi, Paolo

Frontiers in medical technology

2022 Volume 4, Page(s) 909943

Abstract: Multicellular tumor spheroids are largely exploited in cancer research since they are more predictive than bi-dimensional cell cultures. Nanomedicine would benefit from the integration of this three- ... ...

Abstract	Multicellular tumor spheroids are largely exploited in cancer research since they are more predictive than bi-dimensional cell cultures. Nanomedicine would benefit from the integration of this three-dimensional
Language	English
Publishing date	2022-06-15
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-3129
ISSN (online)	2673-3129
DOI	10.3389/fmedt.2022.909943
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article: Elastic Wave Propagation Control in Porous and Finitely Deformed Locally Resonant Nacre-like Metamaterials.

De Maio, Umberto / Greco, Fabrizio / Nevone Blasi, Paolo / Pranno, Andrea / Sgambitterra, Girolamo

Materials (Basel, Switzerland)

2024 Volume 17, Issue 3

Abstract: Recent studies have shown that the mechanical properties of bioinspired periodic composite materials can be strongly influenced by finite deformation effects, leading to highly nonlinear static and dynamic behaviors at multiple length scales. For ... ...

Abstract	Recent studies have shown that the mechanical properties of bioinspired periodic composite materials can be strongly influenced by finite deformation effects, leading to highly nonlinear static and dynamic behaviors at multiple length scales. For instance, in porous periodic nacre-like microstructures, microscopic and macroscopic instabilities may occur for a given uniaxial loading process and, as a consequence, wave attenuation properties may evolve as a function of the microstructural evolution, designating it as metamaterials. The numerical outcomes provide new opportunities to design bioinspired, soft composite metamaterials characterized by high deformability and enhanced elastic wave attenuation capabilities given by the insertion of voids and lead cores.
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17030705
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Nanospermidine in Combination with Nanofenretinide Induces Cell Death in Neuroblastoma Cell Lines.

Lodeserto, Pietro / Rossi, Martina / Blasi, Paolo / Farruggia, Giovanna / Orienti, Isabella

Pharmaceutics

2022 Volume 14, Issue 6

Abstract: A new strategy to cause cell death in tumors might be the increase of intracellular polyamines at concentrations above their physiological values to trigger the production of oxidation metabolites at levels exceeding cell tolerance. To test this ... ...

Abstract	A new strategy to cause cell death in tumors might be the increase of intracellular polyamines at concentrations above their physiological values to trigger the production of oxidation metabolites at levels exceeding cell tolerance. To test this hypothesis, we prepared nanospermidine as a carrier for spermidine penetration into the cells, able to escape the polyamine transport system that strictly regulates intracellular polyamine levels. Nanospermidine was prepared by spermidine encapsulation in nanomicelles and was characterized by size, zeta potential, loading, dimensional stability to dilution, and stability to spermidine leakage. Antitumor activity, ROS production, and cell penetration ability were evaluated in vitro in two neuroblastoma cell lines (NLF and BR6). Nanospermidine was tested as a single agent and in combination with nanofenretinide. Free spermidine was also tested as a comparison. The results indicated that the nanomicelles successfully transported spermidine into the cells inducing cell death in a concentration range (150-200 μM) tenfold lower than that required to provide similar cytotoxicity with free spermidine (1500-2000 μM). Nanofenretinide provided a cytostatic effect in combination with the lowest nanospermidine concentrations evaluated and slightly improved nanospermidine cytotoxicity at the highest concentrations. These data suggest that nanospermidine has the potential to become a new approach in cancer treatment. At the cellular level, in fact, it exploits polyamine catabolism by means of biocompatible doses of spermidine and, in vivo settings, it can exploit the selective accumulation of nanomedicines at the tumor site. Nanofenretinide combination further improves its efficacy. Furthermore, the proven ability of spermidine to activate macrophages and lymphocytes suggests that nanospermidine could inhibit immunosuppression in the tumor environment.
Language	English
Publishing date	2022-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14061215
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Small-angle X-ray scattering unveils the internal structure of lipid nanoparticles.

Spinozzi, Francesco / Moretti, Paolo / Perinelli, Diego Romano / Corucci, Giacomo / Piergiovanni, Paolo / Amenitsch, Heinz / Sancini, Giulio Alfredo / Franzese, Giancarlo / Blasi, Paolo

Journal of colloid and interface science

2024 Volume 662, Page(s) 446–459

Abstract: Lipid nanoparticles own a remarkable potential in nanomedicine, only partially disclosed. While the clinical use of liposomes and cationic lipid-nucleic acid complexes is well-established, liquid lipid nanoparticles (nanoemulsions), solid lipid ... ...

Abstract	Lipid nanoparticles own a remarkable potential in nanomedicine, only partially disclosed. While the clinical use of liposomes and cationic lipid-nucleic acid complexes is well-established, liquid lipid nanoparticles (nanoemulsions), solid lipid nanoparticles, and nanostructured lipid carriers have even greater possibilities. However, they face obstacles in being used in clinics due to a lack of understanding about the molecular mechanisms controlling their drug loading and release, interactions with the biological environment (such as the protein corona), and shelf-life stability. To create effective drug delivery carriers and successfully translate bench research to clinical settings, it is crucial to have a thorough understanding of the internal structure of lipid nanoparticles. Through synchrotron small-angle X-ray scattering experiments, we determined the spatial distribution and internal structure of the nanoparticles' lipid, surfactant, and the bound water in them. The nanoparticles themselves have a barrel-like shape that consists of coplanar lipid platelets (specifically cetyl palmitate) that are covered by loosely spaced polysorbate 80 surfactant molecules, whose polar heads retain a large amount of bound water. To reduce the interface cost of bound water with unbound water without stacking, the platelets collapse onto each other. This internal structure challenges the classical core-shell model typically used to describe solid lipid nanoparticles and could play a significant role in drug loading and release, biological fluid interaction, and nanoparticle stability, making our findings valuable for the rational design of lipid-based nanoparticles.
MeSH term(s)	Liposomes ; X-Rays ; Nanoparticles/chemistry ; Drug Carriers/chemistry ; Surface-Active Agents/chemistry ; Lipids/chemistry ; Water/chemistry ; Particle Size
Chemical Substances	Lipid Nanoparticles ; Liposomes ; Drug Carriers ; Surface-Active Agents ; Lipids ; Water (059QF0KO0R)
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.02.076
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 71/707: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Effect of Cocoa Roasting on Chocolate Polyphenols Evolution

La Mantia, Alessandro / Ianni, Federica / Schoubben, Aurélie / Cespi, Marco / Lisjak, Klemen / Guarnaccia, Davide / Sardella, Roccaldo / Blasi, Paolo

Antioxidants. 2023 Feb. 13, v. 12, no. 2

2023

Abstract: Cocoa and chocolate antioxidants might contribute to human health through, for instance, blood flow improvement or blood pressure and glycemia reduction, as well as cognitive function improvement. Unfortunately, polyphenol content is reduced during cocoa ...

Abstract	Cocoa and chocolate antioxidants might contribute to human health through, for instance, blood flow improvement or blood pressure and glycemia reduction, as well as cognitive function improvement. Unfortunately, polyphenol content is reduced during cocoa fermentation, drying, roasting and all the other phases involved in the chocolate production. Here, we investigated the evolution of the polyphenol content during all the different steps of chocolate production, with a special emphasis on roasting (3 different roasting cycles with 80, 100, and 130 °C as maximum temperature). Samples were followed throughout all processes by evaluating the total polyphenols content, the antioxidant power, the epicatechin content, and epicatechin mean degree of polymerization (phloroglucinol adducts method). Results showed a similar trend for total polyphenol content and antioxidant power with an unexpected bell-shaped curve: an increase followed by a decrease for the three different roasting temperatures. At the intermediate temperature (100 °C), the higher polyphenol content was found just after roasting. The epicatechin content had a trend similar to that of total polyphenol content but, interestingly, the mean degree of polymerization data had the opposite behavior with some deviation in the case of the highest temperature, probably due to epicatechin degradation. It seems likely that roasting can free epicatechin from oligomers, as a consequence of oligomers remodeling.
Keywords	antioxidant activity ; blood flow ; blood glucose ; blood pressure ; chocolate ; cognition ; epicatechin ; evolution ; fermentation ; human health ; polymerization ; polyphenols ; temperature
Language	English
Dates of publication	2023-0213
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12020469
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Effect of Cocoa Roasting on Chocolate Polyphenols Evolution.

La Mantia, Alessandro / Ianni, Federica / Schoubben, Aurélie / Cespi, Marco / Lisjak, Klemen / Guarnaccia, Davide / Sardella, Roccaldo / Blasi, Paolo

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract	Cocoa and chocolate antioxidants might contribute to human health through, for instance, blood flow improvement or blood pressure and glycemia reduction, as well as cognitive function improvement. Unfortunately, polyphenol content is reduced during cocoa fermentation, drying, roasting and all the other phases involved in the chocolate production. Here, we investigated the evolution of the polyphenol content during all the different steps of chocolate production, with a special emphasis on roasting (3 different roasting cycles with 80, 100, and 130 °C as maximum temperature). Samples were followed throughout all processes by evaluating the total polyphenols content, the antioxidant power, the epicatechin content, and epicatechin mean degree of polymerization (phloroglucinol adducts method). Results showed a similar trend for total polyphenol content and antioxidant power with an unexpected bell-shaped curve: an increase followed by a decrease for the three different roasting temperatures. At the intermediate temperature (100 °C), the higher polyphenol content was found just after roasting. The epicatechin content had a trend similar to that of total polyphenol content but, interestingly, the mean degree of polymerization data had the opposite behavior with some deviation in the case of the highest temperature, probably due to epicatechin degradation. It seems likely that roasting can free epicatechin from oligomers, as a consequence of oligomers remodeling.
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12020469
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Naxitamab Activity in Neuroblastoma Cells Is Enhanced by Nanofenretinide and Nanospermidine.

Galassi, Lucrezia / Rossi, Martina / Lodeserto, Pietro / Lenzi, Monia / Borsetti, Francesca / Voltattorni, Manuela / Farruggia, Giovanna / Blasi, Paolo / Orienti, Isabella

Pharmaceutics

2023 Volume 15, Issue 2

Abstract: Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is also expressed in neurons, skin melanocytes, and peripheral nerve fibers. Immunotherapy with monoclonal anti-GD2 antibodies has a proven ... ...

Abstract	Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is also expressed in neurons, skin melanocytes, and peripheral nerve fibers. Immunotherapy with monoclonal anti-GD2 antibodies has a proven efficacy in clinical trials and is included in the standard treatment for children with high-risk neuroblastoma. However, the strong neuro-toxicity associated with anti-GD2 antibodies administration has hindered, until now, the possibility for dose-escalation and protracted use, thus restraining their therapeutic potential. Strategies to increase the efficacy of anti-GD2 antibodies are actively sought, with the aim to enable chronic treatments that could eradicate minimal residual disease and subsequent relapses, often occurring after treatment. Here, we report that Nanofenretinide and Nanospermidine improved the expression of GD2 in neuroblastoma cells (CHP-134) and provided different effects in combination with the anti-GD2 antibody naxitamab. In particular, Nanofenretinide significantly increased the cytotoxic effect of naxitamab while Nanospermidine inhibited cell motility at extents proportional to naxitamab concentration. In neuroblastoma cells characterized by a low and heterogeneous basal expression of GD2, such as SH-SY5Y, which may represent the cell heterogeneity in tumors after chemotherapy, both Nanofenretinide and Nanospermidine increased GD2 expression in approximately 50% of cells, thus shifting the tumor population towards improved sensitivity to anti-GD2 antibodies.
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15020648
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Natural-like Chalcones with Antitumor Activity on Human MG63 Osteosarcoma Cells.

Rossi, Martina / Cappadone, Concettina / Picone, Giovanna / Bisi, Alessandra / Farruggia, Giovanna / Belluti, Federica / Blasi, Paolo / Gobbi, Silvia / Malucelli, Emil

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 12

Abstract: Osteosarcoma (OS) is a malignant disease characterized by poor prognosis due to a high incidence of metastasis and chemoresistance. Recently, Licochalcone A (Lic-A) has been reported as a promising agent against OS. Starting from chalcones selected from ... ...

Abstract	Osteosarcoma (OS) is a malignant disease characterized by poor prognosis due to a high incidence of metastasis and chemoresistance. Recently, Licochalcone A (Lic-A) has been reported as a promising agent against OS. Starting from chalcones selected from a wide in-house library, a new series was designed and synthetized. The antitumor activity of the compounds was tested on the MG63 OS cell line through the innovative Quantitative Phase Imaging technique and MTT assay. To further investigate the biological profile of active derivatives, cell cycle progression and apoptosis induction were evaluated. An earlier and more consistent arrest in the G2-M phase with respect to Lic-A was observed. Moreover, apoptosis was assessed by Annexin V staining as well as by the detection of typical morphological features of apoptotic cells. Among the selected compounds,
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Bone Neoplasms/drug therapy ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation ; Chalcone/pharmacology ; Chalcones/pharmacology ; Chalcones/therapeutic use ; Humans ; Osteosarcoma/pathology
Chemical Substances	Antineoplastic Agents ; Chalcones ; Chalcone (5S5A2Q39HX)
Language	English
Publishing date	2022-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27123751
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dynamics of Clay-Intercalated Ibuprofen Studied by Solid State Nuclear Magnetic Resonance.

Carignani, Elisa / Borsacchi, Silvia / Blasi, Paolo / Schoubben, Aurélie / Geppi, Marco

Molecular pharmaceutics

2019 Volume 16, Issue 6, Page(s) 2569–2578

Abstract: In designing drug delivery systems with improved release properties and bioavailability, the dynamic features of the active pharmaceutical ingredient can be crucial for the final product properties. In this work, we aimed at obtaining the first ... ...

Abstract	In designing drug delivery systems with improved release properties and bioavailability, the dynamic features of the active pharmaceutical ingredient can be crucial for the final product properties. In this work, we aimed at obtaining the first characterization of the molecular dynamic properties of one of the most common nonsteroidal anti-inflammatory drug, ibuprofen, intercalated in hydrotalcite, an interesting inorganic carrier. By exploiting a variety of solid state NMR techniques, including
MeSH term(s)	Aluminum Hydroxide/chemistry ; Ibuprofen/chemistry ; Magnesium Hydroxide/chemistry ; Magnetic Resonance Spectroscopy/methods ; Molecular Dynamics Simulation
Chemical Substances	hydrotalcite (17432CG1KU) ; Aluminum Hydroxide (5QB0T2IUN0) ; Magnesium Hydroxide (NBZ3QY004S) ; Ibuprofen (WK2XYI10QM)
Language	English
Publishing date	2019-05-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.9b00160
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6250: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Ketoprofen poly(lactide-co-glycolide) physical interaction studied by Brillouin spectroscopy and molecular dynamics simulations.

Blasi, Paolo / Casagrande, Serena / Pedretti, Alessandro / Fioretto, Daniele / Vistoli, Giulio / Corezzi, Silvia

International journal of pharmaceutics

2020 Volume 580, Page(s) 119235

Abstract: The performances of poly(lactic-co-glycolic acid) drug delivery systems are affected by the molecular interactions established between the drug and the polymer matrix as well as by the physical state of the drug embedded. Indeed, the drug may induce ... ...

Abstract	The performances of poly(lactic-co-glycolic acid) drug delivery systems are affected by the molecular interactions established between the drug and the polymer matrix as well as by the physical state of the drug embedded. Indeed, the drug may induce polymer plasticization with a drastic change in the release kinetics and medicinal product performances. The aim of this study was to better understand the interactions between poly(lactic-co-glycolic acid) and ketoprofen, the latter known to plasticize hydrophilic and hydrophobic polymers. Ketoprofen interacts with poly(lactic-co-glycolic acid) exerting a maximum plasticizing effect at weight fractions around 0.25. Higher ketoprofen amounts form heterogeneous mixtures with the non-soluble molecules dispersed in the matrix as crystals or amorphous domains, depending on the preparation method. Unexpectedly, the amorphous ketoprofen dispersed in the poly(lactic-co-glycolic acid) matrix is remarkably stable. H-bonding seems responsible for the glass transition temperature reduction and the limited solubility. Brillouin spectroscopy and molecular dynamics simulation data suggest that ketoprofen solubility increases with temperature and non-polar interactions are responsible for this phenomenon.
MeSH term(s)	Biocompatible Materials/chemistry ; Chemistry, Pharmaceutical/methods ; Drug Delivery Systems/methods ; Ketoprofen/chemistry ; Kinetics ; Molecular Dynamics Simulation ; Polyglactin 910/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Solubility/drug effects ; Spectrum Analysis/methods ; Temperature
Chemical Substances	Biocompatible Materials ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglactin 910 (34346-01-5) ; Ketoprofen (90Y4QC304K)
Language	English
Publishing date	2020-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2020.119235
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1409: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito