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Article ; Online: Double Reverse Overlapping Scleral Trapdoor (DROST) Technique for the Removal of Juxtalenticular Intraocular Foreign Body.

Blatsios, Georgios / Bechrakis, Nikolaos E

Ophthalmic surgery, lasers & imaging retina

2023 Volume 54, Issue 10, Page(s) 600–602

Abstract: We describe the double reverse overlapping scleral trapdoor (DROST) technique, a novel minimally invasive technique for the removal of very anterior intraocular foreign bodies without the need of pars plana vitrectomy. ...

Abstract	We describe the double reverse overlapping scleral trapdoor (DROST) technique, a novel minimally invasive technique for the removal of very anterior intraocular foreign bodies without the need of pars plana vitrectomy.
MeSH term(s)	Humans ; Visual Acuity ; Sclera/surgery ; Vitrectomy/methods ; Eye Foreign Bodies/diagnosis ; Eye Foreign Bodies/surgery
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701167-7
ISSN	2325-8179 ; 2325-8160
ISSN (online)	2325-8179
ISSN	2325-8160
DOI	10.3928/23258160-20230827-02
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Article ; Online: Two Cases of Acute Macular Neuroretinopathy Associated with the Adenovirus-based COVID-19 Vaccine Vaxzevria (Astrazeneca).

Franchi, Alexander / Rauchegger, Teresa / Palme, Christoph / Frede, Katharina / Haas, Gertrud / Blatsios, Georgios / Kralinger, Martina / Zehetner, Claus

Ocular immunology and inflammation

2022 Volume 30, Issue 5, Page(s) 1234–1239

Abstract: Purpose: To report two cases of acute macular neuroretinopathy (AMN) in young female patients following the administration of the adenovirus-based coronavirus disease 2019 (COVID-19) vaccine Vaxzevria (AstraZeneca).: Methods: Spectral-domain optical ... ...

Abstract	Purpose: To report two cases of acute macular neuroretinopathy (AMN) in young female patients following the administration of the adenovirus-based coronavirus disease 2019 (COVID-19) vaccine Vaxzevria (AstraZeneca). Methods: Spectral-domain optical coherence tomography and infrared imaging were used to confirm the diagnosis of AMN. Results: Both patients showed a parafoveal hyperreflective band in the outer nuclear layer, disruption of the ellipsoid and interdigitation zones of the photoreceptor layers, and correlating hyporeflective areas on the near-infrared images. Both patients presented with flu-like fever and sudden onset of fortifications within 48 hours of vaccination. One patient showed altered flow in the deep capillary plexus and highly elevated thrombotic parameters. Conclusion: We report a possible association between immune-mediated AMN and the administration of adenovirus-based COVID-19 vaccine Vaxzevria.
MeSH term(s)	Female ; Humans ; Acute Disease ; Adenoviridae ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Fluorescein Angiography/methods ; Macula Lutea ; Retinal Diseases/diagnosis ; Tomography, Optical Coherence/methods ; White Dot Syndromes/chemically induced
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2022.2027463
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Article: C-Shaped Scotoma after Complicated Cesarean Section: A Case of Acute Macular Neuroretinopathy.

Rauchegger, Teresa / Blatsios, Georgios / Haas, Gertrud / Putz, Günther / Zehetner, Claus

Case reports in ophthalmology

2019 Volume 10, Issue 3, Page(s) 391–396

Abstract: Acute macular neuroretinopathy (AMN) is a rare retinal disease that produces transient or permanent visual impairment and occurs predominantly in young, Caucasian women of childbearing age. It is often characterized by wedge-like macular lesions. ... ...

Abstract	Acute macular neuroretinopathy (AMN) is a rare retinal disease that produces transient or permanent visual impairment and occurs predominantly in young, Caucasian women of childbearing age. It is often characterized by wedge-like macular lesions. Although the cause of AMN is unknown, recent research suggests a microvascular etiology. Various vascular pathologies, including post-viral illness, oral contraceptives, and use of vasoconstrictive agents, have been associated with AMN. We present a case of a woman with C-shaped visual field defects in both eyes after inadvertent exposure to intravenous high-dose epinephrine during onset of spinal anesthesia. At present, only 8 cases of AMN after exposure to epinephrine have been described in literature. To our knowledge, this is the first case of AMN that presented following epinephrine injection during childbirth.
Language	English
Publishing date	2019-11-26
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000504289
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Article ; Online: Characteristic facial features and cortical blindness distinguish the DOCK7-related epileptic encephalopathy.

Haberlandt, Edda / Valovka, Taras / Janjic, Tanja / Müller, Thomas / Blatsios, Georgios / Karall, Daniela / Janecke, Andreas R

Molecular genetics & genomic medicine

2021 Volume 9, Issue 3, Page(s) e1607

Abstract: Background: The epileptic encephalopathies display extensive locus and allelic heterogeneity. Biallelic truncating DOCK7 variants were recently reported in five children with early-onset epilepsy, intellectual disability, and cortical blindness, ... ...

Abstract	Background: The epileptic encephalopathies display extensive locus and allelic heterogeneity. Biallelic truncating DOCK7 variants were recently reported in five children with early-onset epilepsy, intellectual disability, and cortical blindness, indicating that DOCK7 deficiency causes a specific type of epileptic encephalopathy. Methods: We identified 23- and 27-year-old siblings with the clinical pattern reported for DOCK7 deficiency, and conducted genome-wide linkage analysis and WES. The consequences of a DOCK7 variant were analyzed on the transcript and protein level in patients' fibroblasts. Results: We identified a novel homozygous DOCK7 frameshift variant, an intragenic tandem duplication of 124-kb, previously missed by CGH array, in adult patients. Patients display atrophy in the occipital lobe and pontine hypoplasia with marked pontobulbar sulcus, and focal atrophy of occasional cerebellar folia is a novel finding. Recognizable dysmorphic features include normo-brachycephaly, narrow forehead, low anterior and posterior hairlines, prominent ears, full cheeks, and long eyelashes. Our patients function on the level of 4-year-old children, never showed signs of regression, and seizures are largely controlled with multi-pharmacotherapy. Studies of patients' fibroblasts showed nonsense-mediated RNA decay and lack of DOCK7 protein. Conclusion: DOCK7 deficiency causes a definable clinical entity, a recognizable type of epileptic encephalopathy.
MeSH term(s)	Adult ; Blindness, Cortical/genetics ; Blindness, Cortical/pathology ; Cells, Cultured ; Craniofacial Abnormalities/genetics ; Craniofacial Abnormalities/pathology ; Epilepsy/genetics ; Epilepsy/pathology ; Female ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/metabolism ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; Homozygote ; Humans ; Mutation ; Syndrome
Chemical Substances	DOCK7 protein, human ; GTPase-Activating Proteins ; Guanine Nucleotide Exchange Factors
Language	English
Publishing date	2021-01-20
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2734884-2
ISSN	2324-9269 ; 2324-9269
ISSN (online)	2324-9269
ISSN	2324-9269
DOI	10.1002/mgg3.1607
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Article ; Online: Ultra-wide-field imaging of choroidal melanoma before and after proton beam radiation therapy.

Psomiadi, Angeliki / Haas, Gertrud / Edlinger, Michael / Bechrakis, Nikolaos E / Blatsios, Georgios

European journal of ophthalmology

2019 Volume 30, Issue 6, Page(s) 1397–1402

Abstract: Objective: To evaluate the imaging characteristics of choroidal melanoma before and after proton beam radiotherapy via Optos: Methods: Retrospective, descriptive study of choroidal melanoma patients treated with proton beam radiotherapy. All patients ...

Abstract	Objective: To evaluate the imaging characteristics of choroidal melanoma before and after proton beam radiotherapy via Optos Methods: Retrospective, descriptive study of choroidal melanoma patients treated with proton beam radiotherapy. All patients underwent full clinical evaluation, including best-corrected visual acuity, ultrasound examination and ultra-wide-field scanning laser ophthalmoscopy imaging in the pseudo-colour (red and green channel) as well as auto-fluorescence mode. Tumours were classified and evaluated according to their location, size, presence of subretinal fluid, drusen, orange pigment and reflectance intensity in ultra-wide-field scanning laser ophthalmoscopy. Tumour sonographic (basal diameter, height) and ultra-wide-field scanning laser ophthalmoscopy imaging dimensions (maximal diameter) were documented. Results: A total of 39 eyes (38 patients) were followed for 24 months (range 6-48 months). Mean best-corrected visual acuity dropped from 20/40 to 20/63 after proton beam radiotherapy. There was no change in the imaging tumour characteristics during follow-up. Subretinal fluid changes were better detected in the autofluorescence compared to pseudo-colour mode. Mean tumour diameter did not significantly change in the ultra-wide-field scanning laser ophthalmoscopy although it did so in the ultrasound. No patient showed local tumour recurrence. Conclusion: The ultra-wide-field scanning laser ophthalmoscopy imaging characteristics of choroidal melanoma in the Optos
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Choroid Neoplasms/diagnosis ; Choroid Neoplasms/radiotherapy ; Diagnostic Imaging/methods ; Female ; Humans ; Male ; Melanoma/diagnosis ; Melanoma/radiotherapy ; Middle Aged ; Ophthalmoscopy/methods ; Proton Therapy/methods ; Retina/pathology ; Retrospective Studies
Language	English
Publishing date	2019-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/1120672119873210
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Article ; Online: Chirurgische Methoden in der Behandlung des Aderhautmelanoms.

Blatsios, Georgios / Haas, Gertrud / Zehetner, Claus / Bechrakis, Nikolaos E

Klinische Monatsblatter fur Augenheilkunde

2017 Volume 234, Issue 7, Page(s) 874–885

Abstract: Significant advancements have been made in the last decades in the treatment of uveal melanoma. Radiation therapy can achieve, depending on the method, local tumour control in up to 98% of cases. Surgical modalities have been implemented in the ocular ... ...

Title translation	Surgical Methods in the Treatment of Uveal Melanoma.
Abstract	Significant advancements have been made in the last decades in the treatment of uveal melanoma. Radiation therapy can achieve, depending on the method, local tumour control in up to 98% of cases. Surgical modalities have been implemented in the ocular therapy for uveal melanoma either to treat/prevent radiation complications, such as so-called toxic tumour syndrome, or to primarily treat the tumour with or without adjunctive radiotherapy. These include endoresection and transscleral resection for melanomas of the choroid/ciliary body or irido-trabeculo-cyclectomy for melanomas of the iris-ciliary body. Furthermore, tumour biopsy is playing a progressively more important role in the diagnosis, treatment and follow-up planning of melanoma cases. This paper focuses on the background, the surgical technique as well as the results and complications of tumour excisional and biopsy surgery.
MeSH term(s)	Biopsy ; Choroid Neoplasms/pathology ; Choroid Neoplasms/surgery ; Ciliary Body/pathology ; Ciliary Body/surgery ; Follow-Up Studies ; Humans ; Iris Neoplasms/pathology ; Iris Neoplasms/surgery ; Ophthalmoscopy ; Postoperative Complications/etiology ; Sclera/surgery ; Uveal Neoplasms/pathology ; Uveal Neoplasms/surgery
Language	German
Publishing date	2017-07-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	80175-6
ISSN	1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
ISSN (online)	1439-3999
ISSN	0344-6360 ; 0344-6387 ; 0023-2165
DOI	10.1055/s-0043-114421
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Article: C-Shaped Scotoma after Complicated Cesarean Section: A Case of Acute Macular Neuroretinopathy

Rauchegger , Teresa / Blatsios, Georgios / Haas, Gertrud / Putz, Günther / Zehetner, Claus

Case Reports in Ophthalmology

2019 Volume 10, Issue 3, Page(s) 391–396

Institution	Department of Ophthalmology and Optometry, Medical University Innsbruck, Innsbruck, Austria Department of Anesthesiology and Intensive Care, Medical University Innsbruck, Innsbruck, Austria
Abstract	Acute macular neuroretinopathy (AMN) is a rare retinal disease that produces transient or permanent visual impairment and occurs predominantly in young, Caucasian women of childbearing age. It is often characterized by wedge-like macular lesions. Although the cause of AMN is unknown, recent research suggests a microvascular etiology. Various vascular pathologies, including post-viral illness, oral contraceptives, and use of vasoconstrictive agents, have been associated with AMN. We present a case of a woman with C-shaped visual field defects in both eyes after inadvertent exposure to intravenous high-dose epinephrine during onset of spinal anesthesia. At present, only 8 cases of AMN after exposure to epinephrine have been described in literature. To our knowledge, this is the first case of AMN that presented following epinephrine injection during childbirth.
Keywords	Acute macular neuroretinopathy ; Epinephrine ; Cesarean section ; Retinal microvasculature ; Spectral-domain optical coherence tomography
Language	English
Publishing date	2019-11-26
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Case Report ; This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).
ZDB-ID	2577666-6
ISSN	1663-2699 ; 1663-2699
ISSN (online)	1663-2699
ISSN	1663-2699
DOI	10.1159/000504289
Database	Karger publisher's database

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Article: Serpinin in the Skin.

Fraquelli, Cristina / Hauzinger, Jasmine / Humpel, Christian / Nolano, Maria / Provitera, Vincenzo / Sharma, Vinay Kumar / Loh, Peng / Pidsudko, Zenon / Blatsios, Georgios / Troger, Josef

Biomedicines

2022 Volume 10, Issue 1

Abstract: The serpinins are relatively novel peptides generated by proteolytic processing of chromogranin A and they are comprised of free serpinin, serpinin-RRG and pGlu-serpinin. In this study, the presence and source of these peptides were studied in the skin. ... ...

Abstract	The serpinins are relatively novel peptides generated by proteolytic processing of chromogranin A and they are comprised of free serpinin, serpinin-RRG and pGlu-serpinin. In this study, the presence and source of these peptides were studied in the skin. By Western blot analysis, a 40 kDa and a 50 kDa protein containing the sequence of serpinin were detected in the trigeminal ganglion and dorsal root ganglia in rats but none in the skin. RP-HPLC followed by EIA revealed that the three serpinins are present in similar, moderate amounts in rat dorsal root ganglia, whereas in the rat skin, free serpinin represents the predominant molecular form. There were abundant serpinin-positive cells in rat dorsal root ganglia and colocalization with substance P was evident. However, much more widespread distribution of the serpinins was found in dorsal root ganglia when compared with substance P. In the skin, serpinin immunoreactivity was found in sensory nerves and showed colocalization with substance P; as well, some was present in autonomic nerves. Thus, although not exclusively, there is evidence that serpinin is a constituent of the sensory innervation of the skin. The serpinins are biologically highly active and might therefore be of functional significance in the skin.
Language	English
Publishing date	2022-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10010183
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Article ; Online: Proton beam radiation for iris melanoma: case series and review of literature.

Hauzinger, Jasmine Alexandra / Blatsios, Georgios / Haas, Gertrud / Zehetner, Claus / Velez-Escola, Luisa / Nowosielski, Yvonne / Seifarth, Christof / Rauchegger, Teresa / Haider, Bernhard / Bechrakis, Nikolaos E

BMJ open ophthalmology

2021 Volume 6, Issue 1, Page(s) e000683

Abstract: Objective: Purpose of this study is to analyse the visual outcomes, the complication and eye retention rate as well as tumour control data of patients treated with proton beam radiation therapy (PBRT) for iris melanoma.: Methods: Retrospective case ... ...

Abstract	Objective: Purpose of this study is to analyse the visual outcomes, the complication and eye retention rate as well as tumour control data of patients treated with proton beam radiation therapy (PBRT) for iris melanoma. Methods: Retrospective case series and review based on patients' records. All tumours were categorised according to the American Joint Committee of Cancer staging criteria for primary iris melanoma und underwent either sectorial or whole anterior segment PBRT. Results: Thirteen cases were identified of which five received PBRT of the whole anterior segment and eight received sectorial PBRT. Local tumour control after a mean follow-up of 25 months was 92%. Complications after PBRT included cataract (46%), secondary glaucoma (31%), superficial keratitis (15%) and madarosis (8%). Complications were more common in patients necessitating irradiation of the entire anterior segment than in patients which received sectorial irradiation. Eye retention was achieved in all cases. No statistically significant difference in the mean best corrected visual acuity (BCVA) and intraocular pressure (IOP) was found before and after treatment. Comparison of mean BCVA and IOP between different treatment groups (complete anterior segment vs sectorial irradiation) at the last follow-up visit were also not significantly different. No patient developed metastatic disease during follow-up. Conclusion: PBRT is a safe and vision preserving therapeutic modality for iris melanoma. Complete irradiation of the anterior segment is associated with higher complication rates.
Language	English
Publishing date	2021-12-23
Publishing country	England
Document type	Journal Article
ISSN	2397-3269
ISSN (online)	2397-3269
DOI	10.1136/bmjophth-2020-000683
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Article: Chirurgische Methoden in der Behandlung des Aderhautmelanoms

Blatsios, Georgios / Haas, Gertrud / Zehetner, Claus / Bechrakis, Nikolaos E.

Klinische Monatsblätter für Augenheilkunde

2017 Volume 234, Issue 07, Page(s) 874–885

Abstract: In der Behandlung von Aderhautmelanomen wurden in den letzten Jahrzehnten signifikante Fortschritte erzielt. Die lokale Tumorkontrolle kann mit Strahlentherapie je nach Methodik in bis zu 98% der Fälle erreicht werden. Chirurgische Techniken werden zur ... ...

Abstract	In der Behandlung von Aderhautmelanomen wurden in den letzten Jahrzehnten signifikante Fortschritte erzielt. Die lokale Tumorkontrolle kann mit Strahlentherapie je nach Methodik in bis zu 98% der Fälle erreicht werden. Chirurgische Techniken werden zur Behandlung von Strahlenkomplikationen, wie dem sogenannten toxischen Tumorsyndrom, oder zur primären Therapie des Tumors in Kombination mit oder ohne Strahlentherapie angewendet. Hierzu werden endo- und transsklerale Resektionstechniken für Melanome der Aderhaut und des Ziliarkörpers oder Iridotrabekulozyklektomie für Melanome der Iris und des Ziliarkörpers verwendet. Darüber hinaus spielt die Tumorbiopsie eine zunehmend wichtigere Rolle bei der Diagnose, Behandlung und Nachbehandlung von choroidalen Melanomen. Diese Übersichtsarbeit erläutert die therapeutischen Indikationen und chirurgischen Techniken sowie die Ergebnisse und Komplikationen im Rahmen der Exzision und Biopsie von Aderhautmelanomen.
Keywords	transsklerale Resektion ; Iridotrabekulozyklektomie ; Biopsie ; Endoresektion ; Melanom ; melanoma ; endoresection ; transscleral resection ; biopsy ; irido-trabeculo-cyclectomy
Language	German
Publishing date	2017-07-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80175-6
ISSN	1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
ISSN (online)	1439-3999
ISSN	0023-2165 ; 0344-6360 ; 0344-6387
DOI	10.1055/s-0043-114421
Database	Thieme publisher's database

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