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  1. Article ; Online: Autoinflammatory Keratinization Diseases-The Concept, Pathophysiology, and Clinical Implications.

    Blicharz, Leszek / Czuwara, Joanna / Rudnicka, Lidia / Torrelo, Antonio

    Clinical reviews in allergy & immunology

    2023  Volume 65, Issue 3, Page(s) 377–402

    Abstract: Recent advances in medical genetics elucidated the background of diseases characterized by superficial dermal and epidermal inflammation with resultant aberrant keratosis. This led to introducing the term autoinflammatory keratinization diseases ... ...

    Abstract Recent advances in medical genetics elucidated the background of diseases characterized by superficial dermal and epidermal inflammation with resultant aberrant keratosis. This led to introducing the term autoinflammatory keratinization diseases encompassing entities in which monogenic mutations cause spontaneous activation of the innate immunity and subsequent disruption of the keratinization process. Originally, autoinflammatory keratinization diseases were attributed to pathogenic variants of CARD14 (generalized pustular psoriasis with concomitant psoriasis vulgaris, palmoplantar pustulosis, type V pityriasis rubra pilaris), IL36RN (generalized pustular psoriasis without concomitant psoriasis vulgaris, impetigo herpetiformis, acrodermatitis continua of Hallopeau), NLRP1 (familial forms of keratosis lichenoides chronica), and genes of the mevalonate pathway, i.e., MVK, PMVK, MVD, and FDPS (porokeratosis). Since then, endotypes underlying novel entities matching the concept of autoinflammatory keratinization diseases have been discovered (mutations of JAK1, POMP, and EGFR). This review describes the concept and pathophysiology of autoinflammatory keratinization diseases and outlines the characteristic clinical features of the associated entities. Furthermore, a novel term for NLRP1-associated autoinflammatory disease with epithelial dyskeratosis (NADED) describing the spectrum of autoinflammatory keratinization diseases secondary to NLRP1 mutations is proposed.
    MeSH term(s) Humans ; Psoriasis/genetics ; Psoriasis/pathology ; Inflammation/genetics ; Mutation ; Immunity, Innate ; Keratosis ; Guanylate Cyclase/genetics ; Membrane Proteins ; CARD Signaling Adaptor Proteins/genetics ; Interleukins/genetics
    Chemical Substances CARD14 protein, human (EC 4.6.1.-) ; Guanylate Cyclase (EC 4.6.1.2) ; Membrane Proteins ; CARD Signaling Adaptor Proteins ; IL36RN protein, human ; Interleukins
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1239045-8
    ISSN 1559-0267 ; 1080-0549
    ISSN (online) 1559-0267
    ISSN 1080-0549
    DOI 10.1007/s12016-023-08971-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1844: Show issues Location:
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  2. Article: Topical proactive therapy in dermatology. A scoping review.

    Makowska, Karolina / Nowaczyk, Joanna / Samochocki, Zbigniew / Blicharz, Leszek / Rudnicka, Lidia

    Postepy dermatologii i alergologii

    2023  Volume 40, Issue 4, Page(s) 510–517

    Abstract: The term 'proactive therapy' refers to a long-term management of clinically intact skin in previously disease-affected areas. This method was initially implemented in atopic dermatitis to maintain the remission and decrease the risk of exacerbations. ... ...

    Abstract The term 'proactive therapy' refers to a long-term management of clinically intact skin in previously disease-affected areas. This method was initially implemented in atopic dermatitis to maintain the remission and decrease the risk of exacerbations. Proactive therapy aims to limit the need for reactive treatment and improve the patients' quality of life. A proactive approach is likely to be adopted for other relapsing and inflammatory skin conditions in the future. This scoping review aims to identify dermatological conditions to be treated with the proactive approach, evaluate the available evidence for its efficacy and safety, as well as highlight the research gaps.
    Language English
    Publishing date 2023-09-01
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2596142-1
    ISSN 1642-395X
    ISSN 1642-395X
    DOI 10.5114/ada.2023.129454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A congenital folliculosebaceous cystic hamartoma on the nipple and areola.

    Blicharz, Leszek / Colmenero, Isabel / Hernández-Martín, Angela / Torrelo, Antonio

    International journal of dermatology

    2023  Volume 62, Issue 8, Page(s) e458–e460

    MeSH term(s) Humans ; Nipples ; Skin Neoplasms ; Follicular Cyst ; Neoplasms, Basal Cell ; Hamartoma/diagnosis
    Language English
    Publishing date 2023-04-23
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Clinical Significance of Salusins in Systemic Sclerosis-A Cross-Sectional Study.

    Nowaczyk, Joanna / Blicharz, Leszek / Zawistowski, Michał / Sikora, Mariusz / Zaremba, Michał / Czuwara, Joanna / Rudnicka, Lidia

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13050848
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  5. Article ; Online: Differential diagnosis of red scalp. The importance of trichoscopy.

    Waśkiel-Burnat, Anna / Czuwara, Joanna / Blicharz, Leszek / Olszewska, Małgorzata / Rudnicka, Lidia

    Clinical and experimental dermatology

    2023  

    Abstract: Red scalp is a common complaint which may constitute a diagnostic and therapeutic challenge in daily clinical practice. Among the numerous diseases which cause diffuse scalp erythema are psoriasis, seborrheic dermatitis, contact dermatitis, diffuse ... ...

    Abstract Red scalp is a common complaint which may constitute a diagnostic and therapeutic challenge in daily clinical practice. Among the numerous diseases which cause diffuse scalp erythema are psoriasis, seborrheic dermatitis, contact dermatitis, diffuse lichen planopilaris, dermatomyositis and scalp rosacea. Accurate diagnosis is crucial for optimal treatment outcomes. Histology most frequently discriminates the underlying condition, but it requires scalp biopsy. In many cases the combination of clinical examination and trichoscopy is sufficient for establishing the correct diagnosis. The main trichoscopic features of psoriasis are silver-white scaling, regular distributed dotted (glomerular) vessels or twisted red loops and punctate hemorrhages. Yellowish-white scaling and thin arborizing vessels are typical features of seborrheic dermatitis. Contact dermatitis is characterized by the presence of yellow exudate and polymorphic vessels, while perifollicular scaling and erythema with the lack of follicular openings are typical findings in lichen planopilaris. In scalp dermatomyositis, tortuous and arborizing vessels with interfollicular and perifollicular pigmentation may be detected. The most characteristic features of scalp rosacea are perifollicular scaling and arborizing vessels. This review also summarizes histologic features and therapeutic options for these conditions.
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llad366
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    Zs.A 1278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Multilocus-sequence typing reveals clonality of Staphylococcus aureus in atopic dermatitis.

    Blicharz, Leszek / Szymanek-Majchrzak, Ksenia / Młynarczyk, Grażyna / Czuwara, Joanna / Waśkiel-Burnat, Anna / Goldust, Mohamad / Samochocki, Zbigniew / Rudnicka, Lidia

    Clinical and experimental dermatology

    2023  Volume 48, Issue 12, Page(s) 1341–1346

    Abstract: Background: Atopic dermatitis (AD) is exacerbated by Staphylococcus aureus, which is capable of displacing not only the physiological microbiota, but also other strains of its own species. Analyses of the molecular characteristics and relationships of S. ...

    Abstract Background: Atopic dermatitis (AD) is exacerbated by Staphylococcus aureus, which is capable of displacing not only the physiological microbiota, but also other strains of its own species. Analyses of the molecular characteristics and relationships of S. aureus strains present in different microniches are lacking.
    Objectives: To determine, using multilocus sequence typing (MLST), the relationship of S. aureus isolates from the lesional and nonlesional skin and anterior nares of patients with AD, and to review the characteristics of the dominant clones.
    Methods: Sixty-three individuals with active AD were enrolled. Ten patients with moderate-to-severe AD (SCoring of Atopic Dermatitis score ≥ 25) colonized by S. aureus in all analysed locations were included in the MLST analysis.
    Results: The most prevalent sequence types were 7 (10/30 strains; 33.3%), 15 and 97 (both 5/30 strains; 16.7%) all of which were associated with the expression of adhesins and toxins promoting chronic microbial dysbiosis, skin barrier damage and inflammation. Six patients (60%) were carriers of clonal S. aureus strains at all analysed locations, three (30%) carriers in lesional and nonlesional skin, and one (10%) was a carrier in nonlesional skin and the anterior nares.
    Conclusions: The results imply that the identified S. aureus lineages are better adapted to dominate the microbiota in AD. Decontaminating the identified reservoirs of S. aureus (i.e. anterior nares and nonlesional skin) could reduce the severity of AD.
    MeSH term(s) Humans ; Dermatitis, Atopic ; Staphylococcus aureus/genetics ; Multilocus Sequence Typing ; Staphylococcal Skin Infections ; Skin ; Staphylococcal Infections
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llad262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1278: Show issues Location:
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  7. Article: Staphylococcus aureus

    Blicharz, Leszek / Rudnicka, Lidia / Samochocki, Zbigniew

    Postepy dermatologii i alergologii

    2019  Volume 36, Issue 1, Page(s) 11–17

    Abstract: Atopic dermatitis is a common, recurrent pruritic dermatosis with a complex pathogenesis. It has been associated with disordered patterns of immunological response and impaired epithelial barrier integrity. These features predispose the patients to ... ...

    Abstract Atopic dermatitis is a common, recurrent pruritic dermatosis with a complex pathogenesis. It has been associated with disordered patterns of immunological response and impaired epithelial barrier integrity. These features predispose the patients to robust colonization of skin lesions by
    Language English
    Publishing date 2019-02-22
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2596142-1
    ISSN 1642-395X
    ISSN 1642-395X
    DOI 10.5114/ada.2019.82821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Nonscarring Alopecia and Hypopigmented Lesions May Be Unusual Signs of Secondary Syphilis.

    Ciupińska, Magdalena / Skibińska, Justyna / Sikora, Mariusz / Blicharz, Leszek / Kotowska, Maja / Rudnicka, Lidia

    Skin appendage disorders

    2021  Volume 7, Issue 3, Page(s) 203–205

    Abstract: Noncicatricial patchy alopecia of the scalp and focal areas of skin hypopigmentation imply a diagnosis of alopecia areata and vitiligo. We present a case of a 22-year-old patient in whom these symptoms were associated with positive spirochete reactions, ... ...

    Abstract Noncicatricial patchy alopecia of the scalp and focal areas of skin hypopigmentation imply a diagnosis of alopecia areata and vitiligo. We present a case of a 22-year-old patient in whom these symptoms were associated with positive spirochete reactions, which allowed making a diagnosis of syphilitic alopecia coexisting with leukoderma syphiliticum. Skin lesions and hair loss resolved after the treatment with benzathine benzylpenicillin. Trichoscopy in syphilitic alopecia is nonspecific, but the absence of features typical for alopecia areata such as exclamation mark hairs may be important on an early stage of the clinical workup.
    Language English
    Publishing date 2021-02-17
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2806972-9
    ISSN 2296-9160 ; 2296-9195
    ISSN (online) 2296-9160
    ISSN 2296-9195
    DOI 10.1159/000511577
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  9. Article ; Online: The Role of the Cutaneous Mycobiome in Atopic Dermatitis.

    Szczepańska, Milena / Blicharz, Leszek / Nowaczyk, Joanna / Makowska, Karolina / Goldust, Mohamad / Waśkiel-Burnat, Anna / Czuwara, Joanna / Samochocki, Zbigniew / Rudnicka, Lidia

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 11

    Abstract: Atopic dermatitis is a chronic inflammatory skin disorder characterized by eczematous lesions, itch, and a significant deterioration in the quality of life. Recently, microbiome dysbiosis has been implicated in the pathogenesis of atopic dermatitis. ... ...

    Abstract Atopic dermatitis is a chronic inflammatory skin disorder characterized by eczematous lesions, itch, and a significant deterioration in the quality of life. Recently, microbiome dysbiosis has been implicated in the pathogenesis of atopic dermatitis. Changes in the fungal microbiome (also termed mycobiome) appear to be an important factor influencing the clinical picture of this entity. This review summarizes the available insights into the role of the cutaneous mycobiome in atopic dermatitis and the new research possibilities in this field. The prevalence and characteristics of key fungal species, the most important pathogenesis pathways, as well as classic and emerging therapies of fungal dysbiosis and infections complicating atopic dermatitis, are presented.
    Language English
    Publishing date 2022-10-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8111153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Medical therapies for melasma.

    Mahajan, Vikram K / Patil, Anant / Blicharz, Leszek / Kassir, Martin / Konnikov, Nellie / Gold, Michael H / Goldman, Mitchel P / Galadari, Hassan / Goldust, Mohamad

    Journal of cosmetic dermatology

    2022  Volume 21, Issue 9, Page(s) 3707–3728

    Abstract: Melasma is a common malady affecting all races with a higher incidence in Hispanics, Middle Eastern, Asians, and African origin females (Fitzpatrick skin phototypes III-V). Women are affected much more often than men. Melasma remains a significant cause ... ...

    Abstract Melasma is a common malady affecting all races with a higher incidence in Hispanics, Middle Eastern, Asians, and African origin females (Fitzpatrick skin phototypes III-V). Women are affected much more often than men. Melasma remains a significant cause of cosmetic morbidity and psychosocial embarrassment affecting quality of life necessitating effective and reliable treatment. Unfortunately, treatment remains unsatisfactory due to limited efficacy, adverse effects, and relapses after stopping treatment. Although chemical peels, laser and light therapies and dermabrasion may have utility, the evidence available for their efficacy is limited and they often cause post-inflammatory hyperpigmentation, particularly in individuals with darker skin types. Medical therapies remain mainstay in the management of melasma. The triple combination, hydroquinone 4%, tretinoin 0.05%, and fluocinolone acetonide 0.01% (Triluma, Galderma, Ft. Worth Texas, often modified incorporating different corticosteroids) remains the only US FDA-approved treatment for melasma and is the gold standard due its demonstrated efficacy across ethnicities. Oral tranexamic acid alone or in combination with other modalities has also shown significant efficacy. Several cosmeceuticals and botanical extracts used as skin lightening agents have been demonstrated to be useful. Physical sunscreens containing zinc oxide, iron oxide, titanium dioxide, and silicones provide photoprotective and camouflage effect. We propose that a multimodality approach to the treatment of melasma is the most effective treatment approach. This review is focused on the medical therapies for melasma.
    MeSH term(s) Adrenal Cortex Hormones ; Cosmeceuticals ; Female ; Fluocinolone Acetonide ; Humans ; Hydroquinones/therapeutic use ; Male ; Melanosis/etiology ; Melanosis/therapy ; Quality of Life ; Silicones ; Sunscreening Agents ; Tranexamic Acid ; Treatment Outcome ; Tretinoin/therapeutic use ; Zinc Oxide
    Chemical Substances Adrenal Cortex Hormones ; Cosmeceuticals ; Hydroquinones ; Silicones ; Sunscreening Agents ; Fluocinolone Acetonide (0CD5FD6S2M) ; Tretinoin (5688UTC01R) ; Tranexamic Acid (6T84R30KC1) ; Zinc Oxide (SOI2LOH54Z)
    Language English
    Publishing date 2022-07-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15242
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