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  1. AU="Blight, Colin R"
  2. AU="Tang, Jack"
  3. AU="Michael E. Dorcas"
  4. AU="Oliveira, Fernando Rocha de"
  5. AU="Rossmanith, R."
  6. AU="Xi He"
  7. AU="Somenath Mitra"
  8. AU=Zhao Limei AU=Zhao Limei
  9. AU="Feng, Sheau-Line"
  10. AU="Goldman, Nick"
  11. AU="Oumezzine, Ma"
  12. AU="Elena D. Nosyreva"
  13. AU="Birara, Sunita"
  14. AU=Banegas Matthew P. AU=Banegas Matthew P.
  15. AU="Mendelow, Alexander David"
  16. AU="Pereira, Taci"
  17. AU="Natalie Taylor"
  18. AU="Moradi, Tayebeh"
  19. AU="Ramesh C. Santra"
  20. AU="Selvarajah, Aravinda"
  21. AU="Vaisman, Adva"
  22. AU="Rádiková, Žofia"
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  1. Artikel ; Online: Sex differences in neuronal oscillatory activity and memory in the methylazoxymethanol acetate model of schizophrenia.

    Albeely, Abdalla M / Williams, Olivia O F / Blight, Colin R / Thériault, Rachel-Karson / Perreault, Melissa L

    Schizophrenia research

    2024  Band 267, Seite(n) 451–461

    Abstract: The methylazoxymethanol acetate (MAM) rodent model is used to study aspects of schizophrenia. However, numerous studies that have employed this model have used only males, resulting in a dearth of knowledge on sex differences in brain function and ... ...

    Abstract The methylazoxymethanol acetate (MAM) rodent model is used to study aspects of schizophrenia. However, numerous studies that have employed this model have used only males, resulting in a dearth of knowledge on sex differences in brain function and behaviour. The purpose of this study was to determine whether differences exist between male and female MAM rats in neuronal oscillatory function within and between the prefrontal cortex (PFC), ventral hippocampus (vHIP) and thalamus, behaviour, and in proteins linked to schizophrenia neuropathology. We showed that female MAM animals exhibited region-specific alterations in theta power, elevated low and high gamma power in all regions, and elevated PFC-thalamus high gamma coherence. Male MAM rats had elevated beta and low gamma power in PFC, and elevated vHIP-thalamus coherence. MAM females displayed impaired reversal learning whereas MAM males showed impairments in spatial memory. Glycogen synthase kinase-3 (GSK-3) was altered in the thalamus, with female MAM rats displaying elevated GSK-3α phosphorylation. Male MAM rats showed higher expression and phosphorylation GSK-3α, and higher expression of GSK-β. Sex-specific changes in phosphorylated Tau levels were observed in a region-specific manner. These findings demonstrate there are notable sex differences in behaviour, oscillatory network function, and GSK-3 signaling in MAM rats, thus highlighting the importance of inclusion of both sexes when using this model to study schizophrenia.
    Mesh-Begriff(e) Animals ; Methylazoxymethanol Acetate/pharmacology ; Schizophrenia/physiopathology ; Schizophrenia/chemically induced ; Schizophrenia/metabolism ; Female ; Male ; Disease Models, Animal ; Sex Characteristics ; Rats ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiopathology ; Prefrontal Cortex/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/physiopathology ; Thalamus/drug effects ; Thalamus/physiopathology ; Thalamus/metabolism ; Phosphorylation/drug effects ; tau Proteins/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Neurons/physiology ; Neurons/pathology ; Rats, Sprague-Dawley
    Sprache Englisch
    Erscheinungsdatum 2024-04-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2024.04.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Acute mitragynine administration suppresses cortical oscillatory power and systems theta coherence in rats.

    Thériault, Rachel-Karson / Manduca, Joshua D / Blight, Colin R / Khokhar, Jibran Y / Akhtar, Tariq A / Perreault, Melissa L

    Journal of psychopharmacology (Oxford, England)

    2020  Band 34, Heft 7, Seite(n) 759–770

    Abstract: Background: Mitragynine is the major alkaloid of : Aims: To evaluate the effects of mitragynine on neurophysiological systems function in the prefrontal cortex (PFC), cingulate cortex (Cg), orbitofrontal cortex, nucleus accumbens (NAc), hippocampus ( ... ...

    Abstract Background: Mitragynine is the major alkaloid of
    Aims: To evaluate the effects of mitragynine on neurophysiological systems function in the prefrontal cortex (PFC), cingulate cortex (Cg), orbitofrontal cortex, nucleus accumbens (NAc), hippocampus (HIP), thalamus (THAL), basolateral amygdala (BLA) and ventral tegmental area of rats.
    Methods: Local field potential recordings were taken from animals at baseline and for 45 min following mitragynine administration (10 mg/kg, intraperitoneally). Drug-induced changes in spectral power and coherence between regions at specific frequencies were evaluated. Mitragynine-induced changes in c-fos expression were also analyzed.
    Results: Mitragynine increased delta power and reduced theta power in all three cortical regions that were accompanied by increased c-fos expression. A transient suppression of gamma power in PFC and Cg was also evident. There were no effects of mitragynine on spectral power in any of the other regions. Mitragynine induced a widespread reduction in theta coherence (7-9 Hz) that involved disruptions in cortical and NAc connectivity with the BLA, HIP and THAL.
    Conclusions: These findings show that mitragynine induces frequency-specific changes in cortical neural oscillatory activity that could potentially impact cognitive functioning. However, the absence of drug effects within regions of the mesolimbic pathway may suggest either a lack of addiction potential, or an underlying mechanism of addiction that is distinct from other opioid analgesic agents.
    Mesh-Begriff(e) Animals ; Brain/drug effects ; Brain/metabolism ; Electrophysiological Phenomena ; Male ; Mitragyna/chemistry ; Proto-Oncogene Proteins c-fos/genetics ; Rats ; Rats, Wistar ; Secologanin Tryptamine Alkaloids/isolation & purification ; Secologanin Tryptamine Alkaloids/pharmacology
    Chemische Substanzen Proto-Oncogene Proteins c-fos ; Secologanin Tryptamine Alkaloids ; mitragynine (EP479K822J)
    Sprache Englisch
    Erscheinungsdatum 2020-04-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639313-5
    ISSN 1461-7285 ; 0269-8811
    ISSN (online) 1461-7285
    ISSN 0269-8811
    DOI 10.1177/0269881120914223
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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