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  1. Article ; Online: Survie en vie réelle des patients ayant une fibrose pulmonaire idiopathique sous traitement anti-fibrosant.

    Bleinc, Alexandre / Blin, Timothée / Legue, Sylvie / Mankikian, Julie / Plantier, Laurent / Marchand-Adam, Sylvain

    Revue des maladies respiratoires

    2023  Volume 40, Issue 5, Page(s) 371–381

    Abstract: Introduction: Idiopathic pulmonary fibrosis (IPF) is an irreversible fibrosing disease with median survival at diagnosis of 2-5 years. That said, pirfenidone and nintedanib slow down the gradual decline in respiratory function. Clinical trials have ... ...

    Title translation Real-life survival of idiopathic pulmonary fibrosis with anti-fibrotic medication.
    Abstract Introduction: Idiopathic pulmonary fibrosis (IPF) is an irreversible fibrosing disease with median survival at diagnosis of 2-5 years. That said, pirfenidone and nintedanib slow down the gradual decline in respiratory function. Clinical trials have shown that while they are not curative, these drugs reduce mortality and increase survival time compared to placebo. This objective of this work was to compare the real-life survival of patients with IPF diagnosed at the Tours University Hospital depending on whether or not they took anti-fibrotic medication.
    Methods: This is a monocentric retrospective study involving 176 patients diagnosed with IPF starting from 1997. Out of these 176 patients, 100 were treated with anti-fibrotic agents and 76 did not receive any anti-fibrotic treatment.
    Results: Survival significantly increased in the group with anti-fibrotic medication, with median survival of 59 months [46-87] versus 39 months [29-65] (P=0.022). Predictive factors for death were neoplasia, IPF exacerbation and decreased DLCO.
    Conclusion: Our study corroborates the beneficial result observed in clinical trials by showing longer survival in patients using anti-fibrotic agents.
    MeSH term(s) Humans ; Retrospective Studies ; Antifibrotic Agents ; Idiopathic Pulmonary Fibrosis/drug therapy ; Pyridones/therapeutic use ; Treatment Outcome
    Chemical Substances Antifibrotic Agents ; Pyridones
    Language French
    Publishing date 2023-04-26
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 605743-3
    ISSN 1776-2588 ; 0301-0279 ; 0761-8425
    ISSN (online) 1776-2588
    ISSN 0301-0279 ; 0761-8425
    DOI 10.1016/j.rmr.2023.03.004
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  2. Article ; Online: Palliative care in cystic fibrosis.

    Blin, Timothée / Flament, Thomas / Mankikian, Julie / Vibet, Sophie / Chaumier, François

    BMJ supportive & palliative care

    2020  Volume 10, Issue 3, Page(s) 341–342

    Language English
    Publishing date 2020-06-09
    Publishing country England
    Document type Letter
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/bmjspcare-2019-002068
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  3. Article ; Online: Impulse oscillometry and spirometry measurements relative to personal best values at the time of acute exacerbations of cystic fibrosis in adults.

    Blin, Timothée / Flament, Thomas / Mankikian, Julie / Chambellan, Arnaud / Marchand-Adam, Sylvain / Plantier, Laurent

    Clinical physiology and functional imaging

    2020  Volume 41, Issue 1, Page(s) 76–84

    Abstract: Background: Diagnosis of acute exacerbation (AE) of cystic fibrosis (CF) must be precise because both under- and over-prescription of antibiotics may be detrimental. How lung function tests contribute to diagnose AE is unclear. We aimed to describe ... ...

    Abstract Background: Diagnosis of acute exacerbation (AE) of cystic fibrosis (CF) must be precise because both under- and over-prescription of antibiotics may be detrimental. How lung function tests contribute to diagnose AE is unclear. We aimed to describe variation of spirometry and oscillometry measurements, at Stable state and at AE in adults with CF.
    Methods: Patients were included in a retrospective single-centre study when both spirometry (FEV1, FVC) and oscillometry (X5, R5, R5-R20 and AX) data were available for at least one Stable and one AE visit between December 2016 and July 2019. For each visit, we calculated variation (Δ) in spirometry and oscillometry indices in comparison with personal best values. Measurements were expressed as % of predicted values and Z-scores when applicable. Areas under ROC curves (AUC) were computed.
    Results: Forty-two patients (28 ± 9 years, FEV1 64 ± 21%) were included; 80 AE and 104 Stable visits were analysed. FEV1 (L, %pred and Z-score) and FVC (%pred and Z-score) varied significantly between AE and Stable visits (p < .05), although differences were small (80 ml/2.7%pred for FEV1). Among oscillometry indices, X5 (kPa.s.L
    Conclusions: Performance of both spirometry and oscillometry to discriminate AE from Stable state was poor. Variation of oscillometry indices (X5, R5-R20, AX) may be helpful when spirometry is unreliable or uncomfortable.
    MeSH term(s) Adult ; Cystic Fibrosis/physiopathology ; Female ; France ; Humans ; Lung/physiopathology ; Male ; Oscillometry/methods ; Retrospective Studies ; Spirometry/methods
    Language English
    Publishing date 2020-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2071203-0
    ISSN 1475-097X ; 1475-0961
    ISSN (online) 1475-097X
    ISSN 1475-0961
    DOI 10.1111/cpf.12668
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  4. Article ; Online: The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies.

    Blin, Timothée / Parent, Christelle / Pichon, Gabrielle / Guillon, Antoine / Jouan, Youenn / Allouchi, Hassan / Aubrey, Nicolas / Boursin, Fanny / Domain, Roxane / Korkmaz, Baris / Sécher, Thomas / Heuzé-Vourc'h, Nathalie

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2023  Volume 195, Page(s) 114163

    Abstract: Like pneumonia, coronavirus disease 2019 (COVID-19) is characterized by a massive infiltration of innate immune cells (such as polymorphonuclear leukocytes) into the airways and alveolar spaces. These cells release proteases that may degrade therapeutic ... ...

    Abstract Like pneumonia, coronavirus disease 2019 (COVID-19) is characterized by a massive infiltration of innate immune cells (such as polymorphonuclear leukocytes) into the airways and alveolar spaces. These cells release proteases that may degrade therapeutic antibodies and thus limit their effectiveness. Here, we investigated the in vitro and ex vivo impact on anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) IgG1s and other IgG subclasses (IgG2 and IgG4) of the neutrophil elastase, proteinase 3 and cathepsin G (the three main neutrophil serine proteases) found in endotracheal aspirates from patients with severe COVID-19. Although the IgGs were sensitive to neutrophil serine proteases, IgG2 was most resistant to proteolytic degradation. The two anti-SARS CoV2 antibodies (casirivimab and imdevimab) were sensitive to the lung's proteolytic environment, although neutrophil serine protease inhibitors only partly limited the degradation. Overall, our results show that the pneumonia-associated imbalance between proteases and their inhibitors in the airways contributes to degradation of antiviral antibodies.
    MeSH term(s) Humans ; RNA, Viral ; Serine Proteases/metabolism ; Neutrophils/metabolism ; Pneumonia/metabolism ; COVID-19/metabolism ; Immunoglobulin G/metabolism
    Chemical Substances RNA, Viral ; Serine Proteases (EC 3.4.-) ; Immunoglobulin G
    Language English
    Publishing date 2023-12-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2023.12.003
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  5. Article: Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA.

    Ferreira, Marion / Blin, Timothee / Collercandy, Nived / Szychowiak, Piotr / Dequin, Pierre-François / Jouan, Youenn / Guillon, Antoine

    Annals of intensive care

    2020  Volume 10, Issue 1, Page(s) 43

    Keywords covid19
    Language English
    Publishing date 2020-04-19
    Publishing country Germany
    Document type Letter
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-020-00664-w
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  6. Article ; Online: Desquamative interstitial pneumonia induced by metal exposure. A case report and literature review.

    Blin, Timothée / De Muret, Anne / Teulier, Marion / Ferreira, Marion / Vincent, Michel / Catinon, Mickaël / Legras, Antoine / Diot, Patrice / Marchand-Adam, Sylvain

    Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

    2020  Volume 37, Issue 1, Page(s) 79–84

    Abstract: Background: Forms of interstitial pneumonia secondary to exposure to an air-contaminant are varied and so far, insufficiently described.: Objectives/methods: We report here a case of a 57-year-old patient managed in our department for the exploration ...

    Abstract Background: Forms of interstitial pneumonia secondary to exposure to an air-contaminant are varied and so far, insufficiently described.
    Objectives/methods: We report here a case of a 57-year-old patient managed in our department for the exploration of MRC grade 2 dyspnoea and interstitial pneumonia. He mentioned multiple occupational and domestic exposures such as hens' excrements, asbestos and metal particles; he also had a previous history of smoking.
    Results: High-resolution computed tomography showed ground glass opacities predominating in posterior territories and surrounding cystic lesions or emphysematous destruction. The entire etiological assessment revealed only macrophagic alveolitis with giant multinucleated cells on the bronchoalveolar lavage. A surgical lung biopsy allowed us to refine the diagnosis with evidence of desquamative interstitial pneumonia and pulmonary granulomatosis. Finally, the analysis of the mineral particles in the biopsy revealed abnormally high rates of Zirconium and Aluminium. We were therefore able to conclude to a desquamative interstitial pneumonia associated with pulmonary granulomatosis linked to metal exposure (Aluminium and Zirconium). The clinical, functional and radiological evolution was favorable after a systemic corticosteroid treatment with progressive decay over one year.
    Conclusion: This presentation reports the first case to our knowledge of desquamative interstitial pneumonitis related to exposure to Zirconium and the third one in the context of Aluminium exposure. The detailed analysis of the mineral particles present on the surgical lung biopsy allows for the identification of the relevant particle to refine the etiological diagnosis, to guide the therapeutic management and to give access to recognition as an occupational disease.
    MeSH term(s) Adrenal Cortex Hormones/administration & dosage ; Aluminum/adverse effects ; Aluminum/analysis ; Biopsy ; Granuloma, Respiratory Tract/chemically induced ; Granuloma, Respiratory Tract/diagnosis ; Granuloma, Respiratory Tract/drug therapy ; Granuloma, Respiratory Tract/metabolism ; Humans ; Inhalation Exposure/adverse effects ; Lung/chemistry ; Lung/diagnostic imaging ; Lung/drug effects ; Lung/pathology ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/metabolism ; Male ; Middle Aged ; Treatment Outcome ; Zirconium/adverse effects ; Zirconium/analysis
    Chemical Substances Adrenal Cortex Hormones ; Zirconium (C6V6S92N3C) ; Aluminum (CPD4NFA903)
    Language English
    Publishing date 2020-03-15
    Publishing country Italy
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1339192-6
    ISSN 2532-179X ; 1124-0490
    ISSN (online) 2532-179X
    ISSN 1124-0490
    DOI 10.36141/svdld.v37i1.9103
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  7. Article ; Online: Therapeutic antibodies - natural and pathological barriers and strategies to overcome them.

    Al Ojaimi, Yara / Blin, Timothée / Lamamy, Juliette / Gracia, Matthieu / Pitiot, Aubin / Denevault-Sabourin, Caroline / Joubert, Nicolas / Pouget, Jean-Pierre / Gouilleux-Gruart, Valérie / Heuzé-Vourc'h, Nathalie / Lanznaster, Débora / Poty, Sophie / Sécher, Thomas

    Pharmacology & therapeutics

    2021  Volume 233, Page(s) 108022

    Abstract: Antibody-based therapeutics have become a major class of therapeutics with over 120 recombinant antibodies approved or under review in the EU or US. This therapeutic class has experienced a remarkable expansion with an expected acceleration in 2021-2022 ... ...

    Abstract Antibody-based therapeutics have become a major class of therapeutics with over 120 recombinant antibodies approved or under review in the EU or US. This therapeutic class has experienced a remarkable expansion with an expected acceleration in 2021-2022 due to the extraordinary global response to SARS-CoV2 pandemic and the public disclosure of over a hundred anti-SARS-CoV2 antibodies. Mainly delivered intravenously, alternative delivery routes have emerged to improve antibody therapeutic index and patient comfort. A major hurdle for antibody delivery and efficacy as well as the development of alternative administration routes, is to understand the different natural and pathological barriers that antibodies face as soon as they enter the body up to the moment they bind to their target antigen. In this review, we discuss the well-known and more under-investigated extracellular and cellular barriers faced by antibodies. We also discuss some of the strategies developed in the recent years to overcome these barriers and increase antibody delivery to its site of action. A better understanding of the biological barriers that antibodies have to face will allow the optimization of antibody delivery near its target. This opens the way to the development of improved therapy with less systemic side effects and increased patients' adherence to the treatment.
    MeSH term(s) Antibodies/therapeutic use ; Humans ; Immunologic Factors ; Pandemics ; RNA, Viral ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antibodies ; Immunologic Factors ; RNA, Viral
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2021.108022
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  8. Article ; Online: Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA

    Ferreira, Marion / Blin, Timothee / Collercandy, Nived / Szychowiak, Piotr / Dequin, Pierre-François / Jouan, Youenn / Guillon, Antoine

    Annals of Intensive Care

    2020  Volume 10, Issue 1

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-020-00664-w
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  9. Article: Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA

    Ferreira, Marion / Blin, Timothee / Collercandy, Nived / Szychowiak, Piotr / Dequin, Pierre-François / Jouan, Youenn / Guillon, Antoine

    Ann. Intensive Care

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #72472
    Database COVID19

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  10. Article ; Online: Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA

    Ferreira, Marion / Blin, Timothee / Collercandy, Nived / Szychowiak, Piotr / Dequin, Pierre-François / Jouan, Youenn / Guillon, Antoine

    ISSN: 2110-5820 ; Annals of Intensive Care ; https://www.hal.inserm.fr/inserm-02567010 ; Annals of Intensive Care, SpringerOpen, 2020, 10 (1), pp.43. ⟨10.1186/s13613-020-00664-w⟩

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ; covid19
    Language English
    Publishing date 2020-04-19
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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