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Article ; Online: ASO Author Reflections: Patterns of Metastatic Recurrence of Genetically Confirmed Myxoid Liposarcoma.

Homsy, Pauliina / Blomqvist, Carl

2023 Volume 30, Issue 7, Page(s) 4498

MeSH term(s)	Adult ; Humans ; Liposarcoma, Myxoid/genetics ; Liposarcoma, Myxoid/surgery ; Liposarcoma, Myxoid/pathology ; Liposarcoma/pathology ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13380-z
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Article ; Online: Validation of primary and outcome data quality in a Swedish population-based breast cancer quality registry.

Palmér, Sofia / Blomqvist, Carl / Holmqvist, Marit / Lindman, Henrik / Lambe, Mats / Ahlgren, Johan

BMC cancer

2024 Volume 24, Issue 1, Page(s) 329

Abstract: Background: Population-based cancer quality registries are of great importance for the improvement of cancer care. However, little is known about the quality of recurrence data in cancer quality registries. The aim of this study was to evaluate data ... ...

Abstract	Background: Population-based cancer quality registries are of great importance for the improvement of cancer care. However, little is known about the quality of recurrence data in cancer quality registries. The aim of this study was to evaluate data quality in the regional Breast Cancer Quality Registry of Central Sweden, with emphasis on the validity of recorded information on recurrence. Methods: Validation by re-abstraction was performed on a random sample of 800 women with primary invasive breast cancer stage I-III diagnosed between 1993 and 2010, of which 400 had at least one registered recurrence and 400 had no registered recurrence. Registry data were compared with data from medical records. Exact agreement, correlation and kappa values, sensitivity and specificity were calculated. Results: Seven hundred forty-seven women (93%) were available for analysis. Exact agreement was high for diagnostics, tumor characteristics, surgery, and adjuvant oncological treatment (90% or more for most variables). The registry's sensitivity was low for regional recurrence (47%), but higher for local and distant recurrence (80% and 75%), whereas specificity was overall high (≥ 95%). Combining all recurrence categories irrespective of localization improved sensitivity to 90% with a specificity of 91%. In 87% of women, the date of first recurrence according to medical records fell within ± 90 days of the date recorded in the registry. Conclusions: While the quality of data in the regional Breast Cancer Quality Registry was generally high, data accuracy on recurrences was lower. The overall precision of identifying any recurrence, irrespective of localization, was high. However, the accuracy of classification of recurrences (local, regional or distant) was lower, with evidence of underreporting for each of the recurrence categories. Given the importance of recurrence-related outcomes in the assessment of quality of care, efforts should be made to improve the reporting of recurrences.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; Data Accuracy ; Sweden/epidemiology ; Sensitivity and Specificity ; Registries ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-12073-4
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Article ; Online: Ultra-low-dose computed tomography and chest X-ray in follow-up of high-grade soft tissue sarcoma-a prospective comparative study.

Salminen, Samuli / Jäämaa, Sari / Nevala, Riikka / Sormaala, Markus J / Koivikko, Mika / Tukiainen, Erkki / Repo, Jussi / Blomqvist, Carl / Sampo, Mika

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7181

Abstract: Ultra-low-dose computed tomography (ULD-CT) may combine the high sensitivity of conventional computed tomography (CT) in detecting sarcoma pulmonary metastasis, with a radiation dose in the same magnitude as chest X-ray (CXR). Fifty patients with non- ... ...

Abstract	Ultra-low-dose computed tomography (ULD-CT) may combine the high sensitivity of conventional computed tomography (CT) in detecting sarcoma pulmonary metastasis, with a radiation dose in the same magnitude as chest X-ray (CXR). Fifty patients with non-metastatic high-grade soft tissue sarcoma treated with curative intention were recruited. Their follow-up involved both CXR and ULD-CT to evaluate their different sensitivity. Suspected findings were confirmed by conventional CT if necessary. Patients with isolated pulmonary metastases were treated with surgery or stereotactic body radiation therapy (SBRT) with curative intent if possible. The median effective dose from a single ULD-CT study was 0.27 mSv (range 0.12 to 0.89 mSv). Nine patients were diagnosed with asymptomatic lung metastases during the follow-up. Only three of them were visible in CXR and all nine in ULD-CT. CXR had therefore only a 33% sensitivity compared to ULD-CT. Four patients were operated, and one had SBRT to all pulmonary lesions. Eight of them, however, died of the disease. Two patients developed symptomatic metastatic recurrence involving extrapulmonary sites+/-the lungs between two imaging rounds. ULD-CT has higher sensitivity for the detection of sarcoma pulmonary metastasis than CXR, with a radiation dose considerably lower than conventional CT.Clinical trial registration: NCT05813808. 04-14-2023.
MeSH term(s)	Humans ; Follow-Up Studies ; Lung Neoplasms/secondary ; Prospective Studies ; Radiation Dosage ; Sarcoma/pathology ; Tomography, X-Ray Computed/methods ; X-Rays
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57770-z
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Article ; Online: Patterns of Metastatic Recurrence of Genetically Confirmed Myxoid Liposarcoma.

Homsy, Pauliina / Böhling, Tom / Seitsonen, Anne / Sampo, Mika / Tukiainen, Erkki / Blomqvist, Carl

Annals of surgical oncology

2023 Volume 30, Issue 7, Page(s) 4489–4497

Abstract: Background: Most sarcomas metastasize predominantly to the lungs, and chest x-ray, or computed tomography, is the most commonly used staging investigation. Myxoid liposarcomas (MLSs) are rare tumors with a tendency to metastasize to extrapulmonary loci. ...

Abstract	Background: Most sarcomas metastasize predominantly to the lungs, and chest x-ray, or computed tomography, is the most commonly used staging investigation. Myxoid liposarcomas (MLSs) are rare tumors with a tendency to metastasize to extrapulmonary loci. The aim of this study was to assess the locations of the first metastases in MLS patients, to guide the design of effective staging and follow-up imaging protocols. Methods: Patients treated for MLS between 1987 and 2017 were identified in a prospectively maintained register. Histology of the tumors was reassessed. In addition, the presence of one of the pathognomonic gene translocations was confirmed, uniquely for a retrospective series. The surgical and oncological outcomes were reviewed. A comprehensive review of the literature was performed on the metastatic pattern of MLS, including series with 10 or more MLS patients with metastatic disease. Results: A total of 32 patients with genetically confirmed MLS were identified, with a median follow-up of 7.6 years. Seven patients (22%) developed metastatic disease, five initially intra-abdominally and only one to the lungs. The comprehensive review included 14 series with 1853 patients, 348 (19%) of whom had metastases. The location of the first metastases was soft tissues in 32% of patients, intra-abdominal in 26%, pulmonary in 24%, and bone in 17%. Conclusions: MLSs metastasize often intra-abdominally and to extra-abdominal soft tissues. Thus, whole-body imaging may be indicated during the initial assessment and follow-up of these patients.
MeSH term(s)	Adult ; Humans ; Liposarcoma, Myxoid/genetics ; Liposarcoma, Myxoid/surgery ; Liposarcoma, Myxoid/pathology ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Liposarcoma ; Soft Tissue Neoplasms/pathology ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-03-12
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13312-x
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Article ; Online: ASO Author Reflections: Registry-Based Analysis of Radiation-Associated Angiosarcoma of the Breast Provides Unbiased Insights into this Disease.

Salminen, Samuli H / Blomqvist, Carl P

Annals of surgical oncology

2019 Volume 27, Issue 4, Page(s) 1011–1012

MeSH term(s)	Breast ; Breast Neoplasms ; Hemangiosarcoma ; Humans ; Registries
Language	English
Publishing date	2019-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-019-08132-x
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Book ; Thesis: Cancer and bone

Blomqvist, Carl P.

serum calcium levels in patients with cancer ; supportive therapy and response evaluation in patients with skeletal metastases

1988

Author's details	by Carl Peter Blomqvist
Size	Getr. Zählung : graph. Darst.
Publishing country	Finland
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Helsinki, Univ., Diss., 1988
HBZ-ID	HT003657000
ISBN	951-9046-10-0 ; 978-951-9046-10-5
Database	Catalogue ZB MED Medicine, Health

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90 E 1316	order for loan	Magazin

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Article ; Online: Serum Concentration of Thymidine Kinase 1 (TK1) as a Tumor Marker in Soft Tissue Sarcomas.

Jaamaa, Sari / Nevala, Riikka / Jagarlamudi, Kiran / Tukiainen, Erkki / Blomqvist, Carl / Sampo, Mika

Anticancer research

2022 Volume 42, Issue 3, Page(s) 1509–1515

Abstract: Background/aim: The aim of this prospective study was to determine whether serum Thymidine kinase -1 (TK1) could serve as a tumor marker in soft tissue sarcomas (STS).: Patients and methods: A total of 48 patients diagnosed with localized STS were ... ...

Abstract	Background/aim: The aim of this prospective study was to determine whether serum Thymidine kinase -1 (TK1) could serve as a tumor marker in soft tissue sarcomas (STS). Patients and methods: A total of 48 patients diagnosed with localized STS were included. None had received preoperative oncological treatment. Samples were collected before and after surgery and TK1 levels measured with the AroCell TK210 ELISA. Results: Mean preoperative TK1 was 0.32 μg/l, range=0.11-1.47, and 18 cases (38%) had values above the reference limit (0.41 μg/l). Mean postoperative TK1 was 0.35 μg/l (0.06-0.86). In patients with preoperative values above the reference limit, TK1 decreased significantly after surgery (n=13, p=0.001). We found no association between increased preoperative TK1 and age, sex, tumor size, grade, and the presence of vascular invasion or necrosis. Conclusion: TK1 has limited use as a tumor marker in localized STS.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/blood ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Sarcoma/blood ; Sarcoma/diagnosis ; Sarcoma/enzymology ; Sarcoma/surgery ; Soft Tissue Neoplasms/blood ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/enzymology ; Soft Tissue Neoplasms/surgery ; Thymidine Kinase/blood ; Treatment Outcome ; Young Adult
Chemical Substances	Biomarkers, Tumor ; Thymidine Kinase (EC 2.7.1.21) ; thymidine kinase 1 (EC 2.7.1.21)
Language	English
Publishing date	2022-02-22
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.15623
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Article: Pathogenic Variant Spectrum in Breast Cancer Risk Genes in Finnish Patients.

Nurmi, Anna K / Suvanto, Maija / Dennis, Joe / Aittomäki, Kristiina / Blomqvist, Carl / Nevanlinna, Heli

Cancers

2022 Volume 14, Issue 24

Abstract: Recurrent pathogenic variants have been detected in several breast and ovarian cancer (BC/OC) risk genes in the Finnish population. We conducted a gene-panel sequencing and copy number variant (CNV) analysis to define a more comprehensive spectrum of ... ...

Abstract	Recurrent pathogenic variants have been detected in several breast and ovarian cancer (BC/OC) risk genes in the Finnish population. We conducted a gene-panel sequencing and copy number variant (CNV) analysis to define a more comprehensive spectrum of pathogenic variants in
Language	English
Publishing date	2022-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14246158
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Article ; Online: Local relapse of soft tissue sarcoma of the extremities or trunk wall operated on with wide margins without radiation therapy.

Lemma, Jasmiini / Jäämaa, Sari / Repo, Jussi P / Santti, Kirsi / Salo, Juho / Blomqvist, Carl P / Sampo, Mika M

BJS open

2023 Volume 7, Issue 2

Abstract: Background: The quality of surgical margins is the most important factor affecting local control in soft tissue sarcoma (STS). Despite this, there is no universally accepted consensus on the definition of an adequate surgical margin or on which patients ...

Abstract	Background: The quality of surgical margins is the most important factor affecting local control in soft tissue sarcoma (STS). Despite this, there is no universally accepted consensus on the definition of an adequate surgical margin or on which patients should be offered radiation therapy. This study focuses on local control and its prognostic factors in patients with trunk wall and extremity STS. Methods: Adult patients with a final diagnosis of trunk wall or extremity STS referred to a single tertiary referral centre between August 1987 and December 2016 were identified from a prospective institutional database. Patients were treated according to a protocol instituted in 1987. The classification of surgical margins and indications for radiation therapy were based on anatomy and strict definition of surgical margins as metric distance to the resection border. Local treatment was defined as adequate if patients received either surgery with wide margins alone or marginal surgery combined with radiation therapy. Margins were considered wide if the tumour was excised with pathological margins greater than 2.5 cm or with an uninvolved natural anatomical barrier. After treatment, patients were followed up with local imaging and chest X-ray: 5 years for high-grade STS, 10 years for low-grade STS. Results: A total of 812 patients were included with a median follow-up of 5.8 (range 0.5-19.5) years. Forty-four patients had a grade 1 tumour: there were no instances of recurrence in this group thus they were excluded from further analysis. Five-year local control in the 768 patients with grade 2-3 STS was 90.1 per cent in patients receiving adequate local treatment according to the protocol. Altogether, 333 patients (43.4 per cent) were treated with wide surgery alone and their 5-year local control rate was 91.1 per cent. Among patients treated with wide surgery alone, deep location was the only factor adversely associated with local relapse risk in multivariable analysis; 5-year local control was 95.3 per cent in superficial and 88.3 per cent in deep-sited sarcomas (hazards ratio 3.154 (95% c.i. 1.265 to 7.860), P = 0.014). Conclusion: A high local control rate is achievable with surgery alone for a substantial proportion of patients with STS of the extremities or superficial trunk wall.
MeSH term(s)	Adult ; Humans ; Margins of Excision ; Prospective Studies ; Neoplasm Recurrence, Local/pathology ; Soft Tissue Neoplasms/diagnostic imaging ; Soft Tissue Neoplasms/radiotherapy ; Soft Tissue Neoplasms/surgery ; Extremities/surgery ; Extremities/pathology ; Sarcoma/diagnostic imaging ; Sarcoma/radiotherapy ; Sarcoma/surgery ; Recurrence
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2474-9842
ISSN (online)	2474-9842
DOI	10.1093/bjsopen/zrac172
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Article ; Online: Digital solution in the follow-up of early breast cancer a randomized study.

Mattson, Johanna / Peltola, Maria / Poikonen-Saksela, Paula / Hermanson, Terhi / Their, Jenny / Färkkilä, Niilo / Roine, Risto / Blomqvist, Carl

Acta oncologica (Stockholm, Sweden)

2023 Volume 62, Issue 5, Page(s) 513–521

Abstract: Background: After primary treatment, patients with early breast cancer (EBC) are followed-up for at least 5 years. At the Helsinki University Hospital (HUS) surveillance includes appointments at 1, 3 and 5 years, and between pre-planned visits a phone ... ...

Abstract	Background: After primary treatment, patients with early breast cancer (EBC) are followed-up for at least 5 years. At the Helsinki University Hospital (HUS) surveillance includes appointments at 1, 3 and 5 years, and between pre-planned visits a phone call service operated by a nurse practitioner for counseling about symptoms related to side-effects or potential recurrence. In 2015 HUS launched a digital solution for cancer patients. This study was designed to find out patient preference, Health related (HR) quality of life (QOL) and satisfaction with a digital solution compared to a phone call service during the first year of follow-up. Material and methods: Patients with EBC were randomized at the final visit of radiotherapy to surveillance by phone calls or by the digital Noona solution during the first year outside pre-planned visits. After six months the groups were crossed over to the other arm. Primary endpoint was patient preference for either follow-up method among those who had contacted the study nurse at least once by both phone service and digital solution. Results: Out of the 765 patients randomized, 142 had contacted the hospital with both methods and were eligible for inclusion in the analyses of the present study. Out of the 142 patients, 56 preferred phone calls, 43 the digital solution while 43 considered both modalities equal. Preference for the digital solution was higher among patients aged 65 or less. There were no differences in HR QoL or overall satisfaction between the modalities. However, the patients rated the timeliness of response better while using the digital solution. Conclusion: Of the patients 30% preferred the digital solution, 40% phone calls while 30% found them equal as the primary follow-up method for EBC during the first year outside pre-planned visits. There is a need to include also digital solutions in surveillance of EBC. Clinicaltrials.gov identifier: NCT04980989.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/surgery ; Quality of Life ; Follow-Up Studies
Language	English
Publishing date	2023-05-16
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2023.2212409
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