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  1. Book ; Thesis: Möglichkeiten der frühzeitigen Intervention in der Versorgung von Patienten mit schwerer Sepsis oder septischem Schock

    Bloos, Frank

    2014  

    Author's details von Dr. med. Frank Bloos, Ph.D. Univ. of West Ontario aus Berlin
    Language German ; English
    Size 134 Blätter in verschiedenen Zählungen, Illustrationen
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Friedrich-Schiller-Universität Jena, 2015
    HBZ-ID HT018904118
    Database Catalogue ZB MED Medicine, Health

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    2016 E 289 order for loan Magazin

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  2. Article: Therapie der Sepsis

    Bloos, Frank

    AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie

    2023  Volume 58, Issue 01, Page(s) 40–50

    Keywords Sepsis ; Volumentherapie ; Antibiotikatherapie ; Hydrokortison ; sepsis ; fluid therapy ; antibiotic therapy ; hydrocortisone
    Language German
    Publishing date 2023-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1065682-0
    ISSN 1439-1074 ; 0939-2661
    ISSN (online) 1439-1074
    ISSN 0939-2661
    DOI 10.1055/a-1813-2319
    Database Thieme publisher's database

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  3. Article: Therapie der Sepsis

    Bloos, Frank

    Intensivmedizin up2date

    2023  Volume 19, Issue 02, Page(s) 161–173

    Keywords Sepsis ; Volumentherapie ; Antibiotikatherapie ; Hydrokortison
    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2180698-6
    ISSN 1614-6697 ; 1614-4856
    ISSN (online) 1614-6697
    ISSN 1614-4856
    DOI 10.1055/a-2068-7305
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  4. Article ; Online: The importance of a hospital-dedicated sepsis response team.

    Bloos, Frank

    Expert review of anti-infective therapy

    2020  Volume 18, Issue 12, Page(s) 1235–1243

    Abstract: Introduction: As sepsis is a life-threatening disease, appropriate measures should be started as soon as possible after diagnosis. Duration until first therapy affects survival. However, guideline adherence of primary sepsis care is often low. Dedicated ...

    Abstract Introduction: As sepsis is a life-threatening disease, appropriate measures should be started as soon as possible after diagnosis. Duration until first therapy affects survival. However, guideline adherence of primary sepsis care is often low. Dedicated sepsis response teams (SRT) may improve primary sepsis care.
    Areas covered: PubMed was searched for studies investigating the effect of an implementation of SRTs. This review discusses the results of five studies presenting results before and after implementation of SRTs. The importance of choosing the alert and the right team composition of the SRT is also discussed.
    Expert opinion: Implementing SRTs is associated with a better compliance with guidelines regarding primary sepsis care and with a reduction in hospital mortality. However, scientific evidence of the studies is limited due to chosen study design. SRTs can be a strong method to improve primary sepsis care in specific hospital settings if the pros and cons against the other measures of quality improvement are considered and the technical details such as alerts and team members are customized to the individual hospital setting.
    MeSH term(s) Guideline Adherence ; Hospital Mortality ; Hospital Rapid Response Team/organization & administration ; Hospitals/standards ; Humans ; Practice Guidelines as Topic ; Quality Improvement ; Sepsis/diagnosis ; Sepsis/therapy
    Language English
    Publishing date 2020-07-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2020.1794813
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  5. Book: Hämodynamisches Monitoring

    Boldt, Joachim / Bloos, Frank

    (UNI-MED science)

    2007  

    Author's details [Joachim Boldt. Unter Mitarb. von Frank Bloos ...]
    Series title UNI-MED science
    Keywords Hemodynamics ; Monitoring, Physiologic ; Intensivtherapie ; Hämodynamik ; Monitoring
    Subject Intensivbehandlung
    Subject code 616.10754
    Language German
    Size 154 S. : Ill., graph. Darst., 25 cm
    Edition 1. Aufl.
    Publisher UNI-MED
    Publishing place Bremen u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT014973439
    ISBN 978-3-89599-216-2 ; 3-89599-216-X
    Database Catalogue ZB MED Medicine, Health

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  6. Article: Perceptions of Quality of Interprofessional Collaboration, Staff Well-Being and Nonbeneficial Treatment: A Comparison between Nurses and Physicians in Intensive and Palliative Care.

    Schwarzkopf, Daniel / Bloos, Frank / Meißner, Winfried / Rüddel, Hendrik / Thomas-Rüddel, Daniel O / Wedding, Ulrich

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 6

    Abstract: This study assessed differences in interprofessional collaboration, perception of nonbeneficial care, and staff well-being between critical care and palliative care teams. In six German hospitals, a staff survey was conducted between December 2013 and ... ...

    Abstract This study assessed differences in interprofessional collaboration, perception of nonbeneficial care, and staff well-being between critical care and palliative care teams. In six German hospitals, a staff survey was conducted between December 2013 and March 2015 among nurses and physicians in intensive and palliative care units. To allow comparability between unit types, a matching was performed for demographic characteristics of staff. N = 313 critical care and 79 palliative care staff participated, of which 72 each were successfully matched. Critical care nurses perceived the poorest overall quality of collaboration compared with critical care physicians and palliative care physicians and nurses. They also reported less inclusive leadership from attendings and head nurses, and the least collaboration on care decisions with physicians. They were most likely to perceive nonbeneficial care, and they reported the lowest levels of job satisfaction and the highest intention to leave the job. In partial correlations, aspects of high-quality collaboration were associated with less perceived nonbeneficial care and higher staff well-being for both critical care and palliative care staff. Our findings indicate that critical care teams could improve collaboration and enhance well-being, particularly among nurses, by adopting principles of collaborative work culture as established in palliative care.
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12060602
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  7. Article ; Online: Clinical diagnosis of sepsis and the combined use of biomarkers and culture- and non-culture-based assays.

    Bloos, Frank

    Methods in molecular biology (Clifton, N.J.)

    2015  Volume 1237, Page(s) 247–260

    Abstract: Sepsis is among the most common causes of death in hospitalized patients, and early recognition followed by immediate initiation of therapy is an important concept to improve survival in these patients. According to the definition of sepsis, diagnosis of ...

    Abstract Sepsis is among the most common causes of death in hospitalized patients, and early recognition followed by immediate initiation of therapy is an important concept to improve survival in these patients. According to the definition of sepsis, diagnosis of sepsis requires the recognition of the systemic inflammatory response syndrome (SIRS) caused by infection as well as recognition of possible infection-related organ dysfunctions for diagnosis of severe sepsis or septic shock. Both SIRS and organ dysfunctions may occur frequently in hospitalized patients for various reasons. However, the fast recognition of acute infection as a cause of SIRS and newly developed organ dysfunction may be a demanding task since culture-based results of microbiological samples will be available only days after onset of symptoms. Biomarkers and PCR-based pathogen detection may help the physician in differentiating SIRS from sepsis. Procalcitonin (PCT) is the best investigated biomarker for this purpose. Furthermore, the current data support the usage of PCT for guidance of antimicrobial therapy. C-reactive protein (CRP) may be used to monitor the course of infection but has only limited discriminative capabilities. Interleukin-6 is widely used for its fast response to the infectious stimulus, but conclusive data for the application of this biomarker are missing. None of the available biomarkers can by itself reliably differentiate SIRS from sepsis but can aid and shorten the decision process. PCR-based pathogen detection can theoretically shorten the recognition of the underlying pathogen to about 8 h. However, this technique is expensive and requires additional staff in the laboratory; controlled prospective studies are missing. Although current studies suggest that PCR-based pathogen detection may be useful to shorten time to adequate antimicrobial therapy and diagnose invasive Candida infections, no general recommendations about the application of PCR for the diagnosis of sepsis can be given.
    MeSH term(s) Biomarkers/blood ; C-Reactive Protein/immunology ; C-Reactive Protein/metabolism ; Calcitonin/blood ; Calcitonin/immunology ; Calcitonin Gene-Related Peptide ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/immunology ; Gram-Positive Bacterial Infections/microbiology ; Gram-Positive Bacterial Infections/pathology ; Humans ; Immunoassay ; Interleukin-6/blood ; Interleukin-6/immunology ; Male ; Middle Aged ; Molecular Diagnostic Techniques ; Polymerase Chain Reaction ; Protein Precursors/blood ; Protein Precursors/immunology ; Severity of Illness Index ; Shock, Septic/diagnosis ; Shock, Septic/immunology ; Shock, Septic/microbiology ; Shock, Septic/pathology
    Chemical Substances Biomarkers ; CALCA protein, human ; IL6 protein, human ; Interleukin-6 ; Protein Precursors ; Calcitonin Gene-Related Peptide (83652-28-2) ; Calcitonin (9007-12-9) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-1776-1_19
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  8. Article ; Online: Sepsis and underlying comorbidities in intensive care unit patients : Analysis of the cause of death by different clinicians-a pilot study.

    Thomas-Rüddel, Daniel O / Fröhlich, Holger / Schwarzkopf, Daniel / Bloos, Frank / Riessen, Reimer

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2023  Volume 119, Issue 2, Page(s) 123–128

    Abstract: Background: There is an ongoing debate as to whether death with sepsis is primarily caused by sepsis or, more often, by the underlying disease. There are no data on the influence of a researcher's background on such an assessment. Therefore, the aim of ... ...

    Title translation Sepsis und bestehende Komorbiditäten bei internistischen Intensivpatienten : Analyse der Todesursache durch unterschiedliche Kliniker – eine Pilotstudie.
    Abstract Background: There is an ongoing debate as to whether death with sepsis is primarily caused by sepsis or, more often, by the underlying disease. There are no data on the influence of a researcher's background on such an assessment. Therefore, the aim of this analysis was to assess the cause of death in sepsis and the influence of an investigator's professional background on such an assessment.
    Materials and methods: We performed a retrospective observational cohort study of sepsis patients treated in the medical intensive care unit (ICU) of a tertiary care center. For deceased patients, comorbidities and severity of illness were documented. The cause of death (sepsis or comorbidities or both combined) was independently assessed by four assessors with different professional backgrounds (medical student, senior physician in the medical ICU, anesthesiological intensivist, and senior physician specialized in the predominant comorbidity).
    Results: In all, 78 of 235 patients died in hospital. Agreement between assessors about cause of death was low (κ 0.37, 95% confidence interval 0.29-0.44). Depending on the assessor, sepsis was the sole cause of death in 6-12% of cases, sepsis and comorbidities in 54-76%, and comorbidities alone in 18-40%.
    Conclusions: In a relevant proportion of patients with sepsis treated in the medical ICU, comorbidities contribute significantly to mortality, and death from sepsis without relevant comorbidities is a rare event. Designation of the cause of death in sepsis patients is highly subjective and may be influenced by the professional background of the assessor.
    MeSH term(s) Humans ; Pilot Projects ; Retrospective Studies ; Cause of Death ; Sepsis/therapy ; Intensive Care Units ; Comorbidity ; Hospital Mortality ; Shock, Septic/therapy
    Language English
    Publishing date 2023-06-28
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-023-01037-4
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  9. Book ; Thesis: Zum Einfluß von Hyperoxie auf Hämodynamik, O2-Aufnahme und Muskeloxygenierung

    Bloos, Frank

    1990  

    Author's details vorgelegt von Frank Bloos
    Size 54 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 1990
    HBZ-ID HT003800298
    Database Catalogue ZB MED Medicine, Health

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  10. Article ; Online: Bloodstream infection due to Enterobacter ludwigii, correlating with massive aggregation on the surface of a central venous catheter.

    Wagner, Lysett / Bloos, Frank / Vylkova, Slavena

    Infection

    2020  Volume 48, Issue 6, Page(s) 955–958

    Abstract: We report a case of catheter associated bloodstream infection due to Enterobacter ludwigii with a massive aggregation on the outside surface of a central venous catheter (CVC). The 57 years old patient with a history of spondylodiscitis and ... ...

    Abstract We report a case of catheter associated bloodstream infection due to Enterobacter ludwigii with a massive aggregation on the outside surface of a central venous catheter (CVC). The 57 years old patient with a history of spondylodiscitis and Staphylococcus aureus-associated endocarditis was admitted to the intensive care unit for acute cerebral infarction. The patient developed signs of infections and the CVC was removed 11 days after placement. The infectious agent was identified by standard diagnostics to the genus level as belonging to the Enterobacter cloacae complex, and additional molecular testing determined the species as E. ludwigii. The catheter was selected for a study aiming to identify the influence of blood components on the formation of central venous catheter-associated biofilms. In this course a massive biofilm was recognized and is presented here.
    MeSH term(s) Biofilms ; Catheter-Related Infections/blood ; Catheter-Related Infections/diagnosis ; Catheter-Related Infections/microbiology ; Central Venous Catheters/microbiology ; Enterobacter/isolation & purification ; Enterobacter/physiology ; Enterobacteriaceae Infections/blood ; Enterobacteriaceae Infections/diagnosis ; Enterobacteriaceae Infections/microbiology ; Germany ; Humans ; Male ; Middle Aged ; Sepsis/blood ; Sepsis/diagnosis ; Sepsis/microbiology
    Language English
    Publishing date 2020-09-03
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-020-01482-9
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