Article ; Online: tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum.
Nature microbiology
2024
Abstract: Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like protein 13 (PfK13). Quiescence, a key aspect of resistance, may also be regulated by a yet unidentified epigenetic pathway. Transfer RNA modification reprogramming ... ...
| Abstract | Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like protein 13 (PfK13). Quiescence, a key aspect of resistance, may also be regulated by a yet unidentified epigenetic pathway. Transfer RNA modification reprogramming and codon bias translation is a conserved epitranscriptomic translational control mechanism that allows cells to rapidly respond to stress. We report a role for this mechanism in ART-resistant parasites by combining tRNA modification, proteomic and codon usage analyses in ring-stage ART-sensitive and ART-resistant parasites in response to drug. Post-drug, ART-resistant parasites differentially hypomodify mcm |
|---|---|
| Language | English |
| Publishing date | 2024-04-17 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2058-5276 |
| ISSN (online) | 2058-5276 |
| DOI | 10.1038/s41564-024-01664-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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