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  1. Article: Co nového v Ewing-like family aneb malobuněčné/kulatobuněčné sarkomy měkkých tkání a kostí s rearanží genů CIC a BCOR. Přehled problematiky a naše prvotní zkušenosti.

    Kinkor, Zdeněk / Grossmann, Petr / Dubová, Magdaléna / Bludovský, David / Černá, Andrea / Krsková, Lenka / Lhoták, Petr

    Ceskoslovenska patologie

    2017  Volume 53, Issue 4, Page(s) 175–180

    Abstract: The literature is reviewed regarding of a rare molecularly defined group of sarcomas with rearrangement of both CIC and BCOR genes, which were originally placed into the EWSR1wt Ewing-like category. Personal experience with three cases demonstrating ... ...

    Title translation What´s new in Ewing-like sarcoma family? Soft tissue and bone sarcomas with CIC/BCOR rearrangement. Review of the literature and first personal experience.
    Abstract The literature is reviewed regarding of a rare molecularly defined group of sarcomas with rearrangement of both CIC and BCOR genes, which were originally placed into the EWSR1wt Ewing-like category. Personal experience with three cases demonstrating difficulties of this issue is added. Both groups of lesions differ not only by age and topography, but also vary in both the prognostic and the predictive parameters. CIC-rearranged tumors are very aggressive and almost never occur in the skeleton; in contrary, the BCOR-rearranged ones are predominantly bone tumors in young males behaving even better than classical Ewing sarcoma. From the morphologic point of view, it turned out to be a salient finding that these types of neoplasm might leave canonical morphotype of small blue round cell sarcoma. Instead of it, they are not uncommonly characterized as a relatively uniform spindle cell proliferation with prevailing myxoid transformation deserving much broader differential diagnosis. Our three cases reports display difficulties in reaching the correct diagnosis even by implementing sophisticated molecular techniques in routine practice. Notwithstanding of exhaustive molecular assays used, one may still encounter a lesion where original descriptive term Ewing-lie sarcoma remains uncorrected.
    MeSH term(s) Biomarkers, Tumor ; Gene Rearrangement ; Humans ; Male ; Oncogene Proteins, Fusion/genetics ; Proto-Oncogene Proteins/genetics ; Repressor Proteins/genetics ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/genetics ; Sarcoma, Small Cell/diagnosis ; Sarcoma, Small Cell/genetics ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/genetics
    Chemical Substances BCOR protein, human ; Biomarkers, Tumor ; Oncogene Proteins, Fusion ; Proto-Oncogene Proteins ; Repressor Proteins
    Language Czech
    Publishing date 2017-12-11
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 138273-1
    ISSN 1210-7875 ; 0009-0611 ; 0371-1854
    ISSN 1210-7875 ; 0009-0611 ; 0371-1854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Difúzní obrovskobuněčný tumor šlachových pochev krční páteře s destrukcí obratle C6 - kazuistika.

    Kinkor, Zdeněk / Svoboda, Tomáš / Grossman, Petr / Bludovský, David / Heidenreich, Filip / Švec, Andrej / Mečiarová, Iveta

    Ceskoslovenska patologie

    2016  Volume 52, Issue 4, Page(s) 218–221

    Abstract: Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left- ... ...

    Title translation Diffuse tenosynovial giant cell tumor of the cervical spine destroying vertebra C6 - a case report.
    Abstract Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left-sided intervertebral joint and destroying neighboring both vertebral arch and processus spinosus. Submitted specimen was interpreted as a possible metastatic skeletal process by clinicians and referring pathologist favored diagnosis of giant cell tumor/osteoclastoma of the bone. Microscopic features were consistent with giant cell lesion where uniform mononuclear mosaic stromal component dominated the unevenly distributed loose clusters of osteoclast-like giant cells frequently imparting appearance of peculiar pseudoalveolar spaces. Additionally, alternating geographic xanthomatous and densely hyalinized/ osteoid-like zones with speckled, coarsely granular haemosiderin pigment completed the variegated structural composition. The tumor infiltrated adjacent striated muscles; either original bone structures and/or extracellular matrix deposits were not identified. Immunohistochemical stains with p63, SATB2, desmin, EMA, clusterin and S100protein turned out to be completely negative. FISH analysis revealed no rearrangement of CSF1 gene. The diagnosis of the diffuse tenosynovial giant cell tumor was rendered.
    Language Czech
    Publishing date 2016
    Publishing country Czech Republic
    Document type Journal Article ; English Abstract
    ZDB-ID 138273-1
    ISSN 1210-7875 ; 0009-0611 ; 0371-1854
    ISSN 1210-7875 ; 0009-0611 ; 0371-1854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cognitive impairment measured by event-related potentials during early and late postoperative period following intravenous or inhalation anaesthesia.

    Holečková, Irena / Kletečka, Jakub / Štěpánek, David / Žídek, Slavomír / Bludovský, David / Pouska, Jiří / Mautner, Pavel / Přibáň, Vladimír

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2017  Volume 129, Issue 1, Page(s) 246–253

    Abstract: Objective: This study investigated modification in cognitive function following inhalation (IA) and total intravenous (TIVA) anaesthesia measured using auditory ERPs (Event Related Potentials).: Methods: Auditory ERPs examination with N1, P3a and P3b ...

    Abstract Objective: This study investigated modification in cognitive function following inhalation (IA) and total intravenous (TIVA) anaesthesia measured using auditory ERPs (Event Related Potentials).
    Methods: Auditory ERPs examination with N1, P3a and P3b component registration was carried out one day before surgery (D-1) and on the first (D+1), sixth (D+6) and 42nd (D+42) days after surgery. Results were compared between two anaesthetic groups.
    Results: On D+1, N1 latency was increased in the IA group. A significant reduction was observed in amplitude of the P3a component on D+6, which persisted up to D+42 for both IA and TIVA groups. A reduction in the amplitude of P3b on D+1 with normalization by D+6 was found in both groups as well.
    Conclusions: Intravenous and inhalation anaesthesia lead to similar changes in cognitive function as determined by ERPs, both during the early and late postoperative periods. It cannot be clearly confirmed whether the observed effects are due to anaesthesia or other unmonitored perioperative factors.
    Significance: Post anaesthetic changes represent a subclinical impairment; nevertheless, they represent a potential risk for subsequent development of cognitive difficulties.
    MeSH term(s) Adult ; Aged ; Anesthesia, Inhalation/adverse effects ; Anesthesia, Inhalation/methods ; Anesthesia, Intravenous/adverse effects ; Anesthesia, Intravenous/methods ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/physiopathology ; Evoked Potentials ; Female ; Humans ; Intraoperative Neurophysiological Monitoring ; Male ; Middle Aged ; Postoperative Period
    Language English
    Publishing date 2017-11-16
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2017.10.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Conference proceedings: Surgical Treatment of Temporobasal Injury

    Choc, Milan / Mork, Jan / Runt, Václav / Bludovský, David

    Skull Base

    2007  

    Abstract: Purpose: Temporobasal injury (TBI) is a term used for a hidden penetrating injury into an intracranial cavity involving fracture of the skull base of the middle cranial fossa and petrous bone, rupture of the dura mater with pneumocephalus, cerebrospinal ... ...

    Event/congress 8TH EUROPEAN SKULL BASE SOCIETY CONGRESS AND 15TH GERMAN SKULL BASE SOCIETY CONGRESS, Diplomat Hotel, Prague, Czech Republic,, 2007
    Abstract Purpose: Temporobasal injury (TBI) is a term used for a hidden penetrating injury into an intracranial cavity involving fracture of the skull base of the middle cranial fossa and petrous bone, rupture of the dura mater with pneumocephalus, cerebrospinal fluid (CSF) otorrhea, or nasal CSF leakage. Authors refer to their own experience with 93 patients with TBI treated at the Department of Neurosurgery in Pilsen in the period 1996 to 2005. Surgical treatment was indicated only in 12 of them (13%). Approaches and strategy of surgical treatment are described. Method: Diagnosis of TBI is based on the clinical findings, detection of CSF leakage, and high-resolution computed tomography (HRCT) or magnetic resonance imaging (HRMRI) of the skull base. Nasal CSF leakage through the eustachian tube should be considered to be a sign of TBI. The detection of a communication from the middle or posterior fossa is based on HRCT or HRMRI studies (type of fractures, location of pneumocephalus, etc.). The goal of surgical treatment is the closure of the dural defect upon the skull base fracture in the middle or posterior fossa by gluing a fascial graft. Nine patients were operated via a subtemporal extradural approach; in the other 3 patients we used a combined subtemporal-presigmoidal extradural approach. Early operation was indicated in cases of profuse CSF leakage, otocerebrorrhea, tension pneumocephalus, or simultaneous other post-traumatic expansion. Delayed operation (several days after trauma) was indicated for persistent CSF leakage or its progression. Eighty-seven percent of patients had a spontaneous cessation of CSF leakage within a few days after the trauma and were not operated on. Results: All surgically treated patients healed without any complications. Seven patients died because of severe brain trauma. Seventy-four patients treated conservatively had no intracranial inflammatory complications. Conclusions: Most patients with TBI (87% of our group) are successfully treated conservatively. An urgent surgical solution should be chosen in cases of profuse CSF leakage, otocerebrorrhea, or simultaneous intracranial expansive lesion. An indication for surgical treatment in other uncomplicated cases is the persistence of extra-intracranial communication (CSF leakage, repeated pneumocephalus) for several days. In our opinion, surgical closure of a dural defect using a subtemporal or presigmoidal extradural approach is an effective prevention of intracranial inflammatory complications.
    Language English
    Publishing date 2007-06-13
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2043690-7
    ISSN 1532-0065 ; 1531-5010
    ISSN (online) 1532-0065
    ISSN 1531-5010
    DOI 10.1055/s-2007-984188
    Database Thieme publisher's database

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