LIVIVO - Search results -

Search results

Result 1 - 10 of total 564

Search options

Article ; Online: An algorithm for the analysis of temporally structured multidimensional measurements.

Blumenfeld, Barak

2010 Volume 3, Page(s) 28

Abstract: Analysis of multichannel recordings acquired with contemporary imaging or electrophysiological methods in neuroscience is often difficult due to the high dimensionality of the data and the low signal-to-noise ratio. We developed a method that addresses ... ...

Abstract	Analysis of multichannel recordings acquired with contemporary imaging or electrophysiological methods in neuroscience is often difficult due to the high dimensionality of the data and the low signal-to-noise ratio. We developed a method that addresses both problems by utilizing prior information about the temporal structure of the signal and the noise. This information is expressed mathematically in terms of sets of correlation matrices, a versatile approach that allows the treatment of a large class of signal and noise sources, including non-stationary sources or correlated signal and noise sources. We present a mathematical analysis of the algorithm, as well as application to an artificial dataset, and show that the algorithm is tolerant to inaccurate assumptions about the temporal structure of the data. We suggest that the algorithm, which we name temporally structured component analysis, can be highly beneficial to various multichannel measurement techniques, such as fMRI or optical imaging.
Language	English
Publishing date	2010-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452964-3
ISSN	1662-5188 ; 1662-5188
ISSN (online)	1662-5188
ISSN	1662-5188
DOI	10.3389/neuro.10.028.2009
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Use of Health Information Technology among Patient Navigators in Community Health Interventions.

Haque, Saira / Ebron, Shellery / Bailey, Bob / Blumenfeld, Barry

Perspectives in health information management

2019 Volume 16, Issue Spring, Page(s) 1a

Abstract: Overview: As chronic disease and comorbidities increase, so does the complexity of patient care.This complexity requires interdisciplinary care teams and multifactor interventions to ensure that patients get the most efficient care. Patient navigators- ... ...

Abstract	Overview: As chronic disease and comorbidities increase, so does the complexity of patient care.This complexity requires interdisciplinary care teams and multifactor interventions to ensure that patients get the most efficient care. Patient navigators-defined as individuals who help patients move through the complex care continuum-can improve access to care and patient engagement, which can translate into better outcomes. Health information technology (health IT) can support timely communication and information sharing for patient navigators and the providers with whom they interact to better coordinate care. We explored the health IT that patient navigators used, how they used it, and their health IT needs in community-based interventions. Methods: We analyzed three years of qualitative program evaluation data captured though progress reports, site visits, and telephone interviews as part of a larger evaluation of community-based demonstration projects. We used inductive analysis to identify preliminary themes to develop a codebook. Using QSR International's NVivo qualitative analysis software (version 11.0), we then used the preliminary themes in a second round of independent coding. We identified themes relevant to navigators and to barriers and facilitators for health IT. Coders achieved a final kappa of 0.8, suggesting excellent interrater reliability. Results: Navigators used various types of health IT (e.g., health information exchanges, electronic health records, short message service) to capture and share information with the rest of the care team. Navigators used technology to document patient information, track services, and schedule appointments for patients; however, some respondents reported challenges with systems that were not integrated. Navigators must learn to use health IT systems of varying complexity to complete their job duties. Discussion: Health IT can improve workflow by facilitating task organization and communication with the care team. Ultimately, integrating the health IT systems used by navigators with those used by other care team members was most beneficial. Because of the various types of health IT used, patient navigators should receive training to ensure that they have the technical skills to use these systems efficiently and reduce duplication of effort. Conclusion: Managing the care of patients with chronic disease requires comprehensive care teams, which can include patient navigators. Integrating navigators' documentation into other health IT systems can keep providers updated on information while patients are outside of the providers' care. With the growth of health IT use in recent years, technical skills are becoming increasingly important. These findings can help leaders who are planning complex health interventions involving navigators to ensure that technology is used efficiently to support coordination and allow navigators to reach more patients.
MeSH term(s)	Communication ; Continuity of Patient Care/organization & administration ; Health Services Accessibility/organization & administration ; Humans ; Medical Informatics/organization & administration ; Patient Navigation/organization & administration ; Qualitative Research ; Reproducibility of Results ; Systems Integration ; Workflow
Language	English
Publishing date	2019-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2422433-9
ISSN	1559-4122 ; 1559-4122
ISSN (online)	1559-4122
ISSN	1559-4122
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Integrating knowledge bases at the point of care.

Blumenfeld, B

Health management technology

1997 Volume 18, Issue 7, Page(s) 44–46

MeSH term(s)	Abstracting and Indexing as Topic/standards ; Artificial Intelligence ; Medical Informatics ; Medical Records Systems, Computerized/standards ; Point-of-Care Systems/organization & administration ; Systems Integration ; United States ; Vocabulary, Controlled
Language	English
Publishing date	1997-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1204815-x
ISSN	1074-4770
ISSN	1074-4770
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2577: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Perturbations in the Replication Program Contribute to Genomic Instability in Cancer.

Blumenfeld, Britny / Ben-Zimra, Micha / Simon, Itamar

International journal of molecular sciences

2017 Volume 18, Issue 6

Abstract: Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss ... ...

Abstract	Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.
MeSH term(s)	Animals ; Carcinogens ; Cell Transformation, Neoplastic/genetics ; DNA Damage ; DNA Replication ; Disease Progression ; Genomic Instability ; Humans ; Mutation ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Stress, Physiological/genetics ; Time Factors
Chemical Substances	Carcinogens
Language	English
Publishing date	2017-05-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms18061138
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement.

Yehuda, Yishai / Blumenfeld, Britny / Lehmann, Dan / Simon, Itamar

Journal of visualized experiments : JoVE

2017 , Issue 119

Abstract: Replication of the genome occurs during S phase of the cell cycle in a highly regulated process that ensures the fidelity of DNA duplication. Each genomic region is replicated at a distinct time during S phase through the simultaneous activation of ... ...

Abstract	Replication of the genome occurs during S phase of the cell cycle in a highly regulated process that ensures the fidelity of DNA duplication. Each genomic region is replicated at a distinct time during S phase through the simultaneous activation of multiple origins of replication. Time of replication (ToR) correlates with many genomic and epigenetic features and is linked to mutation rates and cancer. Comprehending the full genomic view of the replication program, in health and disease is a major future goal and challenge. This article describes in detail the "Copy Number Ratio of S/G1 for mapping genomic Time of Replication" method (herein called: CNR-ToR), a simple approach to map the genome wide ToR of mammalian cells. The method is based on the copy number differences between S phase cells and G1 phase cells. The CNR-ToR method is performed in 6 steps: 1. Preparation of cells and staining with propidium iodide (PI); 2. Sorting G1 and S phase cells using fluorescence-activated cell sorting (FACS); 3. DNA purification; 4. Sonication; 5. Library preparation and sequencing; and 6. Bioinformatic analysis. The CNR-ToR method is a fast and easy approach that results in detailed replication maps.
MeSH term(s)	Animals ; Computational Biology ; DNA/genetics ; DNA Replication Timing ; Flow Cytometry ; G1 Phase ; Genomics ; Humans ; Mice ; Ploidies ; S Phase
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2017-01-19
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/55157
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cancer Mutational Processes Vary in Their Association with Replication Timing and Chromatin Accessibility.

Yaacov, Adar / Vardi, Oriya / Blumenfeld, Britny / Greenberg, Avraham / Massey, Dashiell J / Koren, Amnon / Adar, Sheera / Simon, Itamar / Rosenberg, Shai

Cancer research

2021 Volume 81, Issue 24, Page(s) 6106–6116

Abstract: Cancer somatic mutations are the product of multiple mutational and repair processes, both of which are tightly associated with DNA replication. Distinctive patterns of somatic mutation accumulation, termed mutational signatures, are indicative of ... ...

Abstract	Cancer somatic mutations are the product of multiple mutational and repair processes, both of which are tightly associated with DNA replication. Distinctive patterns of somatic mutation accumulation, termed mutational signatures, are indicative of processes sustained within tumors. However, the association of various mutational processes with replication timing (RT) remains an open question. In this study, we systematically analyzed the mutational landscape of 2,787 tumors from 32 tumor types separately for early and late replicating regions using sequence context normalization and chromatin data to account for sequence and chromatin accessibility differences. To account for sequence differences between various genomic regions, an artificial genome-based approach was developed to expand the signature analyses to doublet base substitutions and small insertions and deletions. The association of mutational processes and RT was signature specific: Some signatures were associated with early or late replication (such as SBS7b and SBS7a, respectively), and others had no association. Most associations existed even after normalizing for genome accessibility. A focused mutational signature identification approach was also developed that uses RT information to improve signature identification; this approach found that SBS16, which is biased toward early replication, is strongly associated with better survival rates in liver cancer. Overall, this novel and comprehensive approach provides a better understanding of the etiology of mutational signatures, which may lead to improved cancer prevention, diagnosis, and treatment. SIGNIFICANCE: Many mutational processes associate with early or late replication timing regions independently of chromatin accessibility, enabling development of a focused identification approach to improve mutational signature detection.
MeSH term(s)	Biomarkers, Tumor/genetics ; Chromatin Assembly and Disassembly ; DNA Replication ; Genome, Human ; Humans ; Mutation ; Mutation Accumulation ; Neoplasms/genetics ; Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-21-2039
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.135/5: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A connectionist approach to the recognition of trends in time-ordered medical parameters.

Blumenfeld, B

Computer methods and programs in biomedicine

1990 Volume 32, Issue 1, Page(s) 53–62

Abstract: Recognition of trends that emerge over time is a capability that successful medical systems must possess. In this paper the network architecture introduced by Elman (CRL, Technical Report 9901, Center for Research in Language, University of California, ... ...

Abstract	Recognition of trends that emerge over time is a capability that successful medical systems must possess. In this paper the network architecture introduced by Elman (CRL, Technical Report 9901, Center for Research in Language, University of California, San Diego, CA, 1988) for predicting successive elements of a sequence is reviewed. It is proposed that a similar architecture can be utilized in a medical domain. The simple example of a diabetic patient receiving a continuous insulin infusion, for whom only the current serum glucose and infusion status is known, is suggested as a test problem. Two networks are described, that when presented with the serum glucose and pump settings at time steps t and t + 1, are capable of predicting the serum glucose, and suggesting a pump setting at time t + 2. Possible applications, and the limitations of this model are then discussed.
MeSH term(s)	Artificial Intelligence ; Blood Glucose ; Drug Therapy, Computer-Assisted ; Humans ; Insulin Infusion Systems ; Software ; Therapy, Computer-Assisted ; Time Factors
Chemical Substances	Blood Glucose
Language	English
Publishing date	1990-05
Publishing country	Ireland
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/0169-2607(90)90085-n
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 521: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.

Feng, Sumin / Ma, Sai / Li, Kejiao / Gao, Shengxian / Ning, Shaokai / Shang, Jinfeng / Guo, Ruiyuan / Chen, Yingying / Blumenfeld, Britny / Simon, Itamar / Li, Qing / Guo, Rong / Xu, Dongyi

Nature communications

2022 Volume 13, Issue 1, Page(s) 957

Abstract: The 53BP1-RIF1 pathway antagonizes resection of DNA broken ends and confers PARP inhibitor sensitivity on BRCA1-mutated tumors. However, it is unclear how this pathway suppresses initiation of resection. Here, we identify ASF1 as a partner of RIF1 via an ...

Abstract	The 53BP1-RIF1 pathway antagonizes resection of DNA broken ends and confers PARP inhibitor sensitivity on BRCA1-mutated tumors. However, it is unclear how this pathway suppresses initiation of resection. Here, we identify ASF1 as a partner of RIF1 via an interacting manner similar to its interactions with histone chaperones CAF-1 and HIRA. ASF1 is recruited to distal chromatin flanking DNA breaks by 53BP1-RIF1 and promotes non-homologous end joining (NHEJ) using its histone chaperone activity. Epistasis analysis shows that ASF1 acts in the same NHEJ pathway as RIF1, but via a parallel pathway with the shieldin complex, which suppresses resection after initiation. Moreover, defects in end resection and homologous recombination (HR) in BRCA1-deficient cells are largely suppressed by ASF1 deficiency. Mechanistically, ASF1 compacts adjacent chromatin by heterochromatinization to protect broken DNA ends from BRCA1-mediated resection. Taken together, our findings identify a RIF1-ASF1 histone chaperone complex that promotes changes in high-order chromatin structure to stimulate the NHEJ pathway for DSB repair.
MeSH term(s)	Animals ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Chickens ; Chromatin/genetics ; Chromatin/metabolism ; DNA End-Joining Repair ; Epistasis, Genetic ; Gene Knockdown Techniques ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Telomere-Binding Proteins/genetics ; Telomere-Binding Proteins/metabolism
Chemical Substances	ASF1A protein, human ; ASF1B protein, human ; BRCA1 Protein ; BRCA1 protein, human ; Cell Cycle Proteins ; Chromatin ; Molecular Chaperones ; Rif1 protein, human ; Telomere-Binding Proteins
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-28588-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A qualitative framework-based evaluation of radiology clinical decision support initiatives: eliciting key factors to physician adoption in implementation.

Marcial, Laura Haak / Johnston, Douglas S / Shapiro, Michael R / Jacobs, Sara R / Blumenfeld, Barry / Rojas Smith, Lucia

JAMIA open

2019 Volume 2, Issue 1, Page(s) 187–196

Abstract: Objectives: To illustrate key contextual factors that may have effects on clinical decision support (CDS) adoption and, ultimately, success.: Materials and methods: We conducted a qualitative evaluation of 2 similar radiology CDS innovations for near- ...

Abstract	Objectives: To illustrate key contextual factors that may have effects on clinical decision support (CDS) adoption and, ultimately, success. Materials and methods: We conducted a qualitative evaluation of 2 similar radiology CDS innovations for near-term endpoints affecting adoption and present the findings using an evaluation framework. We identified key contextual factors between these 2 innovations and determined important adoption differences between them. Results: Degree of electronic health record integration, approach to education and training, key drivers of adoption, and tailoring of the CDS to the clinical context were handled differently between the 2 innovations, contributing to variation in their relative degrees of adoption and use. Attention to these factors had impacts on both near and later-term measures of success (eg, patient outcomes). Discussion: CDS adoption is a well-studied early-term measure of CDS success that directly impacts outcomes. Adoption requires attention throughout the design phases of an intervention especially to key factors directly affecting it, including how implementation across multiple sites and systems complicates adoption, which prior experience with CDS matters, and that practice guidelines invariably require tailoring to the clinical context. Conclusion: With better planning for the capture of early-term measures of successful CDS implementation, especially adoption, critical adjustments may be made to ensure that the CDS is effectively implemented to be successful.
Language	English
Publishing date	2019-02-22
Publishing country	United States
Document type	Journal Article
ISSN	2574-2531
ISSN (online)	2574-2531
DOI	10.1093/jamiaopen/ooz002
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Chromosomal coordination and differential structure of asynchronous replicating regions.

Blumenfeld, Britny / Masika, Hagit / Farago, Marganit / Yehuda, Yishai / Halaseh, Lamia / Vardi, Oriya / Rapoport, Rachel / Levin-Klein, Rena / Cedar, Howard / Bergman, Yehudit / Simon, Itamar

Nature communications

2021 Volume 12, Issue 1, Page(s) 1035

Abstract: Stochastic asynchronous replication timing (AS-RT) is a phenomenon in which the time of replication of each allele is different, and the identity of the early allele varies between cells. By taking advantage of stable clonal pre-B cell populations ... ...

Abstract	Stochastic asynchronous replication timing (AS-RT) is a phenomenon in which the time of replication of each allele is different, and the identity of the early allele varies between cells. By taking advantage of stable clonal pre-B cell populations derived from C57BL6/Castaneous mice, we have mapped the genome-wide AS-RT loci, independently of genetic differences. These regions are characterized by differential chromatin accessibility, mono-allelic expression and include new gene families involved in specifying cell identity. By combining population level mapping with single cell FISH, our data reveal the existence of a novel regulatory program that coordinates a fixed relationship between AS-RT regions on any given chromosome, with some loci set to replicate in a parallel and others set in the anti-parallel orientation. Our results show that AS-RT is a highly regulated epigenetic mark established during early embryogenesis that may be used for facilitating the programming of mono-allelic choice throughout development.
MeSH term(s)	Alleles ; Animals ; Bone Marrow Cells/cytology ; Bone Marrow Cells/metabolism ; Chromatin/chemistry ; Chromatin/metabolism ; Chromatin/ultrastructure ; Clone Cells ; Crosses, Genetic ; DNA Replication Timing ; Embryo, Mammalian ; Embryonic Development/genetics ; Epigenesis, Genetic ; Female ; Genetic Loci ; Genome ; In Situ Hybridization, Fluorescence ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Precursor Cells, B-Lymphoid/cytology ; Precursor Cells, B-Lymphoid/metabolism
Chemical Substances	Chromatin
Language	English
Publishing date	2021-02-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-21348-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito