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  1. Article: Dural Metastases of Advanced Prostate Cancer Detected by

    Morassi, Mauro / Bonacina, Mattia / Bnà, Claudio / Zaniboni, Alberto / Savelli, Giordano

    Diagnostics (Basel, Switzerland)

    2020  Volume 10, Issue 6

    Abstract: Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned ... ...

    Abstract Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned with complaints of headache and diplopia. Fluorocholine (
    Language English
    Publishing date 2020-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics10060385
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  2. Article ; Online: Contribution of Interventional Radiology to the Management of COVID-19 patient.

    Monfardini, Lorenzo / Sallemi, Claudio / Gennaro, Nicolò / Pedicini, Vittorio / Bnà, Claudio

    Cardiovascular and interventional radiology

    2020  Volume 43, Issue 6, Page(s) 837–839

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Radiology, Interventional ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome ; Singapore
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-020-02470-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1378: Show issues Location:
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  3. Article ; Online: Stroke in patients with COVID-19: Clinical and neuroimaging characteristics.

    Vogrig, Alberto / Gigli, Gian Luigi / Bnà, Claudio / Morassi, Mauro

    Neuroscience letters

    2020  Volume 743, Page(s) 135564

    Abstract: Acute cerebrovascular disease, particularly ischemic stroke, has emerged as a serious complication of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of the Coronavirus disease-2019 (COVID-19). ... ...

    Abstract Acute cerebrovascular disease, particularly ischemic stroke, has emerged as a serious complication of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of the Coronavirus disease-2019 (COVID-19). Accumulating data on patients with COVID-19-associated stroke have shed light on specificities concerning clinical presentation, neuroimaging findings, and outcome. Such specificities include a propensity towards large vessel occlusion, multi-territory stroke, and involvement of otherwise uncommonly affected vessels. Conversely, small-vessel brain disease, cerebral venous thrombosis, and intracerebral hemorrhage appear to be less frequent. Atypical neurovascular presentations were also described, ranging from bilateral carotid artery dissection to posterior reversible encephalopathy syndrome (PRES), and vasculitis. Cases presenting with encephalopathy or encephalitis with seizures heralding stroke were particularly challenging. The pathogenesis and optimal management of ischemic stroke associated with COVID-19 still remain uncertain, but emerging evidence suggest that cytokine storm-triggered coagulopathy and endotheliopathy represent possible targetable mechanisms. Some specific management issues in this population include the difficulty in identifying clinical signs of stroke in critically ill patients in the intensive care unit, as well as the need for a protected pathway for brain imaging, intravenous thrombolysis, and mechanical thrombectomy, keeping in mind that "time is brain" also for COVID-19 patients. In this review, we discuss the novel developments and challenges for the diagnosis and treatment of stroke in patients with COVID-19, and delineate the principles for a rational approach toward precision medicine in this emerging field.
    MeSH term(s) COVID-19/complications ; Humans ; SARS-CoV-2 ; Stroke/diagnostic imaging ; Stroke/pathology ; Stroke/virology
    Language English
    Publishing date 2020-12-19
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2020.135564
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  4. Article ; Online: A hybrid machine learning/deep learning COVID-19 severity predictive model from CT images and clinical data.

    Chieregato, Matteo / Frangiamore, Fabio / Morassi, Mauro / Baresi, Claudia / Nici, Stefania / Bassetti, Chiara / Bnà, Claudio / Galelli, Marco

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 4329

    Abstract: COVID-19 clinical presentation and prognosis are highly variable, ranging from asymptomatic and paucisymptomatic cases to acute respiratory distress syndrome and multi-organ involvement. We developed a hybrid machine learning/deep learning model to ... ...

    Abstract COVID-19 clinical presentation and prognosis are highly variable, ranging from asymptomatic and paucisymptomatic cases to acute respiratory distress syndrome and multi-organ involvement. We developed a hybrid machine learning/deep learning model to classify patients in two outcome categories, non-ICU and ICU (intensive care admission or death), using 558 patients admitted in a northern Italy hospital in February/May of 2020. A fully 3D patient-level CNN classifier on baseline CT images is used as feature extractor. Features extracted, alongside with laboratory and clinical data, are fed for selection in a Boruta algorithm with SHAP game theoretical values. A classifier is built on the reduced feature space using CatBoost gradient boosting algorithm and reaching a probabilistic AUC of 0.949 on holdout test set. The model aims to provide clinical decision support to medical doctors, with the probability score of belonging to an outcome class and with case-based SHAP interpretation of features importance.
    MeSH term(s) Algorithms ; COVID-19/diagnostic imaging ; Deep Learning ; Humans ; Machine Learning ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07890-1
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  5. Article ; Online: Bilateral carotid artery dissection in a SARS-CoV-2 infected patient: causality or coincidence?

    Morassi, Mauro / Bigni, Barbara / Cobelli, Milena / Giudice, Lodoviga / Bnà, Claudio / Vogrig, Alberto

    Journal of neurology

    2020  Volume 267, Issue 10, Page(s) 2812–2814

    MeSH term(s) Betacoronavirus ; Brain Neoplasms/complications ; COVID-19 ; Carotid Artery, Internal, Dissection/complications ; Coronavirus Infections/complications ; Humans ; Male ; Middle Aged ; Oligodendroglioma/complications ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-09984-0
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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.40: Show issues Location:
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  6. Article: Drug-Related Pneumonitis in Cancer Treatment during the COVID-19 Era.

    Cherri, Sara / Noventa, Silvia / Fanelli, Martina / Calandra, Giulio / Prochilo, Tiziana / Bnà, Claudio / Savelli, Giordano / Zaniboni, Alberto

    Cancers

    2021  Volume 13, Issue 5

    Abstract: Interstitial lung disease is recognized as a group of diseases with a different etiopathogenesis characterized by chronic lung inflammation with the accumulation of inflammatory cells, lymphocytes and macrophages, and the consequent release of ... ...

    Abstract Interstitial lung disease is recognized as a group of diseases with a different etiopathogenesis characterized by chronic lung inflammation with the accumulation of inflammatory cells, lymphocytes and macrophages, and the consequent release of proinflammatory cytokines. Various degrees of pulmonary fibrosis can be associated with this inflammatory condition. Interstitial lung disease related to oncological drugs is a relevant problem in clinical practice. The etiopathogenetic mechanisms underlying this adverse event are not completely known but can be partly explained by the mechanism of action of the drug involved. Therefore, knowledge of the relevance of this potentially fatal adverse event supported by the reported safety data of pivotal studies becomes fundamental in the management of patients. The prompt diagnosis of drug-related pneumonia and the consequent differential diagnosis with other forms of pneumonia allow a rapid suspension of treatment and the establishment of an immunosuppressive treatment if necessary. In the context of the health emergency related to SARS CoV2 infection and COVID-19-related interstitial lung disease, such knowledge holds decisive relevance in the conscious choice of cancer treatments. Our intent was to describe the oncological drugs most correlated with this adverse event by reporting, where possible, the percentages of insurgency in pivotal studies to provide an overview and therefore promote greater awareness of this important toxicity related to oncological treatment.
    Language English
    Publishing date 2021-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13051052
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  7. Article: Contribution of Interventional Radiology to the Management of COVID-19 patient

    Monfardini, Lorenzo / Sallemi, Claudio / Gennaro, Nicolò / Pedicini, Vittorio / Bnà, Claudio

    Cardiovasc Intervent Radiol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #102244
    Database COVID19

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  8. Article ; Online: Contribution of Interventional Radiology to the Management of COVID-19 patient

    Monfardini, Lorenzo / Sallemi, Claudio / Gennaro, Nicolò / Pedicini, Vittorio / Bnà, Claudio

    CardioVascular and Interventional Radiology

    2020  Volume 43, Issue 6, Page(s) 837–839

    Keywords Radiology Nuclear Medicine and imaging ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-020-02470-0
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    Zs.A 1378: Show issues Location:
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  9. Article ; Online: Diffuse white matter alteration in CLIPPERS: Advanced MRI findings from two cases.

    Morassi, Mauro / Cobelli, Milena / Ghiselli, Elena / Costa, Paolo / Bagatto, Daniele / Pievani, Michela / Bnà, Claudio

    Journal of the neurological sciences

    2019  Volume 402, Page(s) 40–47

    Abstract: Advanced MRI findings in two patients with probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) are presented. Diffusion tensor imaging indices (fractional anisotropy and mean diffusivity), ... ...

    Abstract Advanced MRI findings in two patients with probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) are presented. Diffusion tensor imaging indices (fractional anisotropy and mean diffusivity), evaluated in both patients at baseline MRI examination before treatment and during follow-up, indicated white matter structural changes not only affecting the brainstem, which represents the primary site of inflammatory damage, but also projection (corona radiata) and associative tracts in both patients, while alterations within the corpus callosum were detected in patient 1# at follow-up. Susceptibility weighted imaging (SWI) revealed hypointense lesions in both patients, MRI spectroscopy (MRS) indicated a mildly increased Cho/NAA ratio with no evidence of lipids/lactate peaks, indicating that it may be used as a non-invasive marker to identify CLIPPERS cases suspected for progression to lymphoma.
    MeSH term(s) Aged ; Brain Stem/diagnostic imaging ; Corpus Callosum/diagnostic imaging ; Diffusion Tensor Imaging ; Female ; Humans ; Inflammation/diagnostic imaging ; Magnetic Resonance Imaging ; Male ; White Matter/diagnostic imaging
    Language English
    Publishing date 2019-05-02
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2019.04.041
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    Zs.A 308: Show issues Location:
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  10. Article ; Online: Early-Stage Supraglottic "In Situ" Squamous Cell Carcinoma of the Larynx Incidentally Detected by 18F-Fluorocholine PET/CT.

    Mangili, Stefano Attilio / Rizzardi, Nicola / Illuminati, Sonia / Bnà, Claudio / Savelli, Giordano

    Clinical nuclear medicine

    2019  Volume 44, Issue 7, Page(s) e435–e438

    Abstract: F-fluorocholine (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. Despite its specificity, however, F-FCH may be taken up by other neoplasms such as multiple myeloma, lymphomas, lung, bladder, and colon cancer; brain tumors; ... ...

    Abstract F-fluorocholine (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. Despite its specificity, however, F-FCH may be taken up by other neoplasms such as multiple myeloma, lymphomas, lung, bladder, and colon cancer; brain tumors; and renal and hepatocellular carcinoma. This is due to its ability to evaluate the cell proliferation, which is typical of neoplastic cells. While this behavior may be an opportunity to image more neoplasms, on the other hand it could represent a source of error in the evaluation of the images. Here we present the case of a laryngeal squamous cell carcinoma detected by F-FCH.
    MeSH term(s) Carcinoma, Squamous Cell/diagnostic imaging ; Choline/analogs & derivatives ; Humans ; Laryngeal Neoplasms/diagnostic imaging ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals ; fluorocholine (6029HGL0QP) ; Choline (N91BDP6H0X)
    Language English
    Publishing date 2019-05-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000002596
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