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Article ; Online: A dominant

Bobinski, Montana / Pilgrim, David

microPublication biology

2023 Volume 2023

Abstract: ... ...

Abstract	Caenorhabditis
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article
ISSN	2578-9430
ISSN (online)	2578-9430
DOI	10.17912/micropub.biology.000900
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Article ; Online: Added value in stroke imaging: accuracy and utility of additional coronal diffusion-weighted imaging.

Baggett, M / Helmy, D / Chang, J / Bobinski, M / Assadsangabi, R

Clinical radiology

2021 Volume 76, Issue 10, Page(s) 785.e1–785.e7

Abstract: Aim: To evaluate the value of adding additional coronal diffusion-weighted imaging with the same section thickness as standard axial images to improve detection of small infarcts.: Materials and methods: Axial and coronal diffusion-weighted images (4 ...

Abstract	Aim: To evaluate the value of adding additional coronal diffusion-weighted imaging with the same section thickness as standard axial images to improve detection of small infarcts. Materials and methods: Axial and coronal diffusion-weighted images (4 or 5 mm section thickness, 1 mm gap) were studied retrospectively in two rounds of data collection. During the first round, two radiologists identified sub-centimetre infarcts on only axial images during one sitting, and only coronal images during a second sitting. During the second round, the two radiologists were asked to identify infarcts on only axial images during one sitting, and on both axial and coronal images simultaneously during the second sitting. An expert reviewer determined true infarcts and artefacts. Relative contrast-to-noise ratios (rCNR) and relative mean region of interest (rROI) within each lesion were calculated. Results: During the first round, sensitivity for infarct detection for the two radiologists was 92.7% and 100% on axial and 95.1% and 92.7% on coronal, respectively. During the second round, sensitivity improved from 88.9% to 98.1% for both radiologists (p=0.03). Specificity improved but did not reach statistical significance (p=0.06 and 0.12). False-negative and false-positive lesions had lower rCNR and rROI values. Conclusion: Including both axial and coronal DWI images with the same section thickness in the stroke protocol improves detection of small infarcts, which can be misdiagnosed on a single imaging plane. A second imaging plane is particularly useful for subtle infarcts, even without acquiring thin-section images.
MeSH term(s)	Aged ; Brain/diagnostic imaging ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Male ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Stroke/diagnostic imaging
Language	English
Publishing date	2021-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2021.07.006
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Article: The Potential Influence of Residual or Recurrent Disease on Bevacizumab Treatment Efficacy in Ovarian Cancer: Current Evidence and Future Perspectives.

Żak, Klaudia / Satora, Małgorzata / Skrabalak, Ilona / Tarkowski, Rafał / Ostrowska-Leśko, Marta / Bobiński, Marcin

Cancers

2024 Volume 16, Issue 5

Abstract: There were high hopes for the new antiangiogenic medicament, bevacizumab, which could inhibit the creation of new blood vessels through binding to isoform A of vascular endothelial growth factor (VEGF). However, it is not only blood vessels that are ... ...

Abstract	There were high hopes for the new antiangiogenic medicament, bevacizumab, which could inhibit the creation of new blood vessels through binding to isoform A of vascular endothelial growth factor (VEGF). However, it is not only blood vessels that are responsible for tumor cell spread. During the process of tumor growth, lymphangiogenesis is mediated by other members of the VEGF family, specifically VEGF-C and VEGF-D, which act independent to bevacizumab. Therefore, based on the mechanism of bevacizumab action and the processes of angio- and lymphangiogenesis, we formed three hypotheses: (1) if the lymph nodes in primary ovarian cancers are metastatic, the outcome of bevacizumab treatment is worsened; (2) concerning the second-line treatment, bevacizumab will act in a weakened manner if recurrence occurs in lymph nodes as opposed to a local recurrence; (3) patients treated by bevacizumab are more likely to have recurrences in lymph nodes. These hypotheses raise the issue of the existing knowledge gap, which concerns the effect of bevacizumab on metastatic lymph nodes.
Language	English
Publishing date	2024-03-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16051063
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Article ; Online: Scientific and clinical relevance of non-cellular tumor microenvironment components in ovarian cancer chemotherapy resistance.

Ostrowska-Lesko, Marta / Rajtak, Alicja / Moreno-Bueno, Gema / Bobinski, Marcin

Biochimica et biophysica acta. Reviews on cancer

2023 Volume 1879, Issue 1, Page(s) 189036

Abstract: The tumor microenvironment (TME) components play a crucial role in cancer cells' resistance to chemotherapeutic agents. This phenomenon is exceptionally fundamental in patients with ovarian cancer (OvCa), whose outcome depends mainly on their response to ...

Abstract	The tumor microenvironment (TME) components play a crucial role in cancer cells' resistance to chemotherapeutic agents. This phenomenon is exceptionally fundamental in patients with ovarian cancer (OvCa), whose outcome depends mainly on their response to chemotherapy. Until now, most reports have focused on the role of cellular components of the TME, while less attention has been paid to the stroma and other non-cellular elements of the TME, which may play an essential role in the therapy resistance. Inhibiting these components could help define new therapeutic targets and potentially restore chemosensitivity. The aim of the present article is both to summarize the knowledge about non-cellular components of the TME in the development of OvCa chemoresistance and to suggest targeting of non-cellular elements of the TME as a valuable strategy to overcome chemoresistance and to develop new therapeutic strategies in OvCA patients.
MeSH term(s)	Humans ; Female ; Tumor Microenvironment/physiology ; Clinical Relevance ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology
Language	English
Publishing date	2023-12-01
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2023.189036
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Article ; Online: Gadolinium Deposition within the Pediatric Brain: No Increased Intrinsic T1-Weighted Signal Intensity within the Dentate Nucleus following the Administration of a Minimum of 4 Doses of the Macrocyclic Agent Gadoteridol.

Young, J R / Pope, W B / Bobinski, M

AJNR. American journal of neuroradiology

2018 Volume 39, Issue 9, Page(s) 1604–1608

Abstract: Background and purpose: Our aim was to evaluate whether serial administration of the macrocyclic gadolinium-based contrast agent gadoteridol in children is associated with T1-weighted hyperintensity within the dentate nucleus, an imaging surrogate for ... ...

Abstract	Background and purpose: Our aim was to evaluate whether serial administration of the macrocyclic gadolinium-based contrast agent gadoteridol in children is associated with T1-weighted hyperintensity within the dentate nucleus, an imaging surrogate for gadolinium deposition. Materials and methods: We identified a retrospective cohort of 10 patients younger than 18 years of age who underwent between 4 and 8 gadoteridol-enhanced MR imaging examinations of the brain from 2016 to 2017. For comparison, we identified a retrospective cohort of 9 pediatric patients who each underwent 6 gadodiamide-enhanced MR imaging examinations. For each examination, both dentate nuclei were contoured on unenhanced images and the mean dentate-to-pons signal intensity ratio was calculated. Dentate-to-pons signal intensity ratios from the first and last scans were compared using paired Results: In the gadoteridol group, there was no significant change in the mean dentate-to-pons signal intensity ratio from the first to the last scan (0.99 versus 0.99, Conclusions: Repeat administration of the macrocyclic gadolinium-based contrast agent gadoteridol in children was not associated with T1-weighted dentate hyperintensity, while the repeat administration of the linear gadolinium-based contrast agent gadodiamide was associated with T1-weighted dentate hyperintensity, presumably due to gadolinium deposition.
MeSH term(s)	Adolescent ; Cerebellar Nuclei/diagnostic imaging ; Child ; Contrast Media/adverse effects ; Contrast Media/pharmacokinetics ; Female ; Gadolinium/adverse effects ; Gadolinium/pharmacokinetics ; Heterocyclic Compounds/adverse effects ; Heterocyclic Compounds/pharmacokinetics ; Humans ; Magnetic Resonance Imaging/adverse effects ; Magnetic Resonance Imaging/methods ; Male ; Neuroimaging/adverse effects ; Neuroimaging/methods ; Organometallic Compounds/adverse effects ; Organometallic Compounds/pharmacokinetics ; Retrospective Studies
Chemical Substances	Contrast Media ; Heterocyclic Compounds ; Organometallic Compounds ; gadoteridol (0199MV609F) ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2018-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A5748
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Article ; Online: Neuroradiology diagnostic errors at a tertiary academic centre: effect of participation in tumour boards and physician experience.

Ivanovic, V / Assadsangabi, R / Hacein-Bey, L / Raslan, O / Bobinski, M / Latchaw, R / Qi, L

Clinical radiology

2022 Volume 77, Issue 8, Page(s) 607–612

Abstract: Aim: To quantify and correlate the diagnostic error rates in radiological interpretation with the experience of the attending neuroradiologist at a tertiary academic medical centre.: Materials and methods: The institution's Neuroradiology Quality ... ...

Abstract	Aim: To quantify and correlate the diagnostic error rates in radiological interpretation with the experience of the attending neuroradiologist at a tertiary academic medical centre. Materials and methods: The institution's Neuroradiology Quality Assurance Database of diagnostic errors was searched for misses from 2014-2020. Attendance at Head and Neck (H&N), Brain, and Paediatric Neuroradiology (PN) tumour boards (TB) as the presenting radiologist was recorded. Number of post-fellowship years of clinical practice (CPY) and frequency of TB attendance were considered separate metrics of a radiologist's experience. Radiological errors were categorised as Total, H&N, Skull Base (SKB), Brain, or PN diagnostic errors. Diagnostic error rates per attending neuroradiologist within each category were correlated with the frequency of TB participation and CPY using Spearman's rank correlation coefficients. Results: A total 607 examinations contained a diagnostic error. Spearman's rank correlation coefficients between Total TB participation and Total, H&N, SKB, Brain error rates were: -0.89 (p=0.0002); -0.81 (p=0.002); -0.66 (p=0.03); -0.82 (p=0.002); respectively. Spearman's rank correlation coefficients between CPY and Total, H&N, SKB, Brain and PN error rates were: 0.05 (p=0.88); 0.08 (p=0.82); 0.28 (p=0.41); -0.10 (p=0.77); -0.16 (p=0.63), respectively. Spearman's rank correlation coefficients between H&N TB and H&N, SKB error rates; and between Brain TB attendance and Brain error rates were statistically significant (p<0.05). Conclusion: The present study shows a strong correlation between high TB participation rates and low diagnostic error rates. The number of years in practice did not appear to influence error rate.
MeSH term(s)	Child ; Diagnostic Errors ; Fellowships and Scholarships ; Humans ; Physicians ; Radiologists ; Radiology
Language	English
Publishing date	2022-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2022.04.006
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Article: Perioperative Factors Affecting the Healing of Rectovaginal Fistula.

Satora, Małgorzata / Żak, Klaudia / Frankowska, Karolina / Misiek, Marcin / Tarkowski, Rafał / Bobiński, Marcin

Journal of clinical medicine

2023 Volume 12, Issue 19

Abstract: Rectovaginal fistula is rare, but a severe complication in gynecology, which despite the effort of clinicians is still not treated successfully in many cases. According to statistics, the healing rates of surgery in patients with RVF range from 20 to 100% ...

Abstract	Rectovaginal fistula is rare, but a severe complication in gynecology, which despite the effort of clinicians is still not treated successfully in many cases. According to statistics, the healing rates of surgery in patients with RVF range from 20 to 100%. The treatment effectiveness depends on the etiology of fistula, the age of the patients, the presence of comorbidities, the type of surgery and many other factors. Considering the low efficiency of treatment and the high risk of recurrence, the question of possible methods to improve the results occurs. In our review, we analyzed both modifiable and non-modifiable factors which may influence the treatment, healing rate and future fate of the patients. Taking into account all analyzed risk factors, including age, comorbidities, smoking status, microbiology, medications, stoma and stool features, we are aware that rectovaginal fistula's treatment must be individualized and holistic. In cases of poorly healing RVF, the drainage of feces, the use of antibiotic prophylaxis or the implementation of estrogen therapy may be useful. Moreover, microbiome research in women with RVF and towards estrogen therapy should be performed in order to create treatment algorithms in women with fistulae. Those interventions, in our opinion, may significantly improve the outcome of the patients.
Language	English
Publishing date	2023-10-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12196421
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Article ; Online: Analysis of misses in imaging of head and neck pathology by attending neuroradiologists at a single tertiary academic medical centre.

Ferguson, A / Assadsangabi, R / Chang, J / Raslan, O / Bobinski, M / Bewley, A / Dublin, A / Latchaw, R / Ivanovic, V

Clinical radiology

2021 Volume 76, Issue 10, Page(s) 786.e9–786.e13

Abstract: Aim: To analyse errors in head and neck (H&N) pathology made by attending neuroradiologists at a single tertiary-care centre.: Materials and methods: A neuroradiology quality assurance (QA) database of radiological errors was searched for attending ... ...

Abstract	Aim: To analyse errors in head and neck (H&N) pathology made by attending neuroradiologists at a single tertiary-care centre. Materials and methods: A neuroradiology quality assurance (QA) database of radiological errors was searched for attending physician errors in H&N pathology from 2014-2020. Data were limited to computed tomography (CT) and magnetic resonance imaging (MRI) reports. Data were collected on missed pathologies and study types. Misses were grouped into three categories: central neck (thyroid gland, aerodigestive tract), lateral neck (salivary glands, lymph nodes, soft tissues), and face/orbits (orbits, sinuses, masticator space). Results: During the study period, a total of 283,248 CT and MRI neuroradiology examinations were interpreted (all indications). Seventy-four H&N misses were identified comprising 85.1% perceptual and 14.9% interpretive errors. The distribution of errors was face/orbits (37.8%), central neck (36.5%), and lateral neck (25.7%). Clinically significant errors were found most commonly in the aerodigestive tract (21%), orbits (17.7%), masticator space, and parotid glands (14.5% each). The majority (67.6%) of the misses were detected on examinations that were not performed for a primary H&N indication; MRI brain was the most common examination (27%). Clearly malignant or potentially malignant masses accounted for 48.6% of all misses. Conclusion: The majority of H&N misses were perceptual and were detected on examinations not performed for a H&N indication. Clearly malignant or potentially malignant masses represented half of all misses.
MeSH term(s)	Academic Medical Centers ; Diagnostic Errors/statistics & numerical data ; Head and Neck Neoplasms/diagnostic imaging ; Humans ; Magnetic Resonance Imaging/methods ; Radiologists ; Reproducibility of Results ; Retrospective Studies ; Tertiary Care Centers ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2021-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2021.06.011
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Article: Preoperative Differentiation of Uterine Leiomyomas and Leiomyosarcomas: Current Possibilities and Future Directions.

Żak, Klaudia / Zaremba, Bartłomiej / Rajtak, Alicja / Kotarski, Jan / Amant, Frédéric / Bobiński, Marcin

Cancers

2022 Volume 14, Issue 8

Abstract: The distinguishing of uterine leiomyosarcomas (ULMS) and uterine leiomyomas (ULM) before the operation and histopathological evaluation of tissue is one of the current challenges for clinicians and researchers. Recently, a few new and innovative methods ... ...

Abstract	The distinguishing of uterine leiomyosarcomas (ULMS) and uterine leiomyomas (ULM) before the operation and histopathological evaluation of tissue is one of the current challenges for clinicians and researchers. Recently, a few new and innovative methods have been developed. However, researchers are trying to create different scales analyzing available parameters and to combine them with imaging methods with the aim of ULMs and ULM preoperative differentiation ULMs and ULM. Moreover, it has been observed that the technology, meaning machine learning models and artificial intelligence (AI), is entering the world of medicine, including gynecology. Therefore, we can predict the diagnosis not only through symptoms, laboratory tests or imaging methods, but also, we can base it on AI. What is the best option to differentiate ULM and ULMS preoperatively? In our review, we focus on the possible methods to diagnose uterine lesions effectively, including clinical signs and symptoms, laboratory tests, imaging methods, molecular aspects, available scales, and AI. In addition, considering costs and availability, we list the most promising methods to be implemented and investigated on a larger scale.
Language	English
Publishing date	2022-04-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14081966
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Article ; Online: War in Ukraine: the opportunities for oncogynecologic patients in Poland.

Bobiński, Marcin / Hoptyana, Olha / Rasoul-Pelińska, Karolina / Lyzogub, Margaryta / Rychlik, Agnieszka / Pletnev, Andrei

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2022 Volume 32, Issue 6, Page(s) 809–810

MeSH term(s)	Armed Conflicts ; Health Services Accessibility ; Humans ; Poland ; Ukraine
Language	English
Publishing date	2022-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2022-003604
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