Article ; Online: A Preliminary Study on the Morphological Changes of an NiTi-Shaped Memory Alloy Stent in the Vertebral Body.
2023 Volume 15, Issue 4, Page(s) 1028–1036
Abstract: Objective: At present, the most commonly used filler polymethyl methacrylate (PMMA) has the disadvantages of monomer toxicity, heat and leakage, and cannot be applied in young people. Therefore, finding a minimally invasive and good tissue-compatible ... ...
| Abstract | Objective: At present, the most commonly used filler polymethyl methacrylate (PMMA) has the disadvantages of monomer toxicity, heat and leakage, and cannot be applied in young people. Therefore, finding a minimally invasive and good tissue-compatible alternative material has been a research hotspot in spine surgery in recent years. The aim of this study is to explore whether the memory alloy stent can avoid the complications of bone cement or not. Methods: Four non-adjacent vertebral bodies of the thoracic and lumbar spine in the 18 10-month-old pigs were selected as the surgical site and were randomly divided into the scaffold group and the bone cement group. The memory alloy scaffold and PMMA (polymethyl methacrylate) bone cement were placed via percutaneous puncture, and intraoperative fluoroscopy and micro-CT were used to observe the changes in the height of scaffolds and bone cement in the vertebral body immediately, 6 weeks, and 12 weeks after operation, the microstructural parameters of the bone trabeculae (bone volume fraction, bone surface volume ratio, bone trabeculae number) were also measured. Results: The memory alloy stent could expand in the vertebral body, and its height gradually increased with time; additionally, the height of the bone cement mass did not change with time (p = 0.00). New bone trabeculae could grow into the scaffold along the gap, and the volume fraction of bone, the volume ratio of bone surface area, and the number of bone trabeculae increased gradually (p = 0.00). However, the volume fraction of bone, the volume ratio of bone surface area, and the number of trabeculae in the cement block decreased gradually (p = 0.00). Conclusions: Memory alloy scaffolds have dynamic expansion characteristics in vivo, which can effectively avoid the complications of bone cement. Thus, it is beneficial to explore this minimally invasive treatment for vertebral compression fractures. |
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| MeSH term(s) | Animals ; Bone Cements ; Fractures, Compression/surgery ; Kyphoplasty ; Lumbar Vertebrae/surgery ; Lumbar Vertebrae/injuries ; Osteoporotic Fractures/surgery ; Polymethyl Methacrylate/chemistry ; Retrospective Studies ; Shape Memory Alloys ; Spinal Fractures/surgery ; Spinal Fractures/etiology ; Swine ; Treatment Outcome ; Vertebral Body ; Vertebroplasty |
| Chemical Substances | Bone Cements ; Polymethyl Methacrylate (9011-14-7) ; Shape Memory Alloys |
| Language | English |
| Publishing date | 2023-02-16 |
| Publishing country | Australia |
| Document type | Journal Article ; Randomized Controlled Trial, Veterinary |
| ZDB-ID | 2503162-4 |
| ISSN | 1757-7861 ; 1757-7853 ; 1757-7861 |
| ISSN (online) | 1757-7861 ; 1757-7853 |
| ISSN | 1757-7861 |
| DOI | 10.1111/os.13680 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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