LIVIVO - Search results -

Search results

Result 1 - 8 of total 8

Search options

Article ; Online: Psychological interventions for interoception in mental health disorders: A systematic review of randomized-controlled trials.

Heim, Nikolas / Bobou, Marina / Tanzer, Michal / Jenkinson, Paul M / Steinert, Christiane / Fotopoulou, Aikaterini

2023 Volume 77, Issue 10, Page(s) 530–540

Abstract: Disturbed interoception (i.e., the sensing, awareness, and regulation of internal body signals) has been found across several mental disorders, leading to the development of interoception-based interventions (IBIs). Searching PubMed and PsycINFO, we ... ...

Abstract	Disturbed interoception (i.e., the sensing, awareness, and regulation of internal body signals) has been found across several mental disorders, leading to the development of interoception-based interventions (IBIs). Searching PubMed and PsycINFO, we conducted the first systematic review of randomized-controlled trials (RCTs) investigating the efficacy of behavioral IBIs at improving interoception and target symptoms of mental disorders in comparison to a non-interoception-based control condition [CRD42021297993]. Thirty-one RCTs fulfilled inclusion criteria. Across all studies, a pattern emerged with 20 (64.5%) RCTs demonstrating IBIs to be more efficacious at improving interoception compared to control conditions. The most promising results were found for post-traumatic stress disorder, irritable bowel syndrome, fibromyalgia and substance use disorders. Regarding symptom improvement, the evidence was inconclusive. The IBIs were heterogenous in their approach to improving interoception. The quality of RCTs was moderate to good. In conclusion, IBIs are potentially efficacious at improving interoception for some mental disorders. In terms of symptom reduction, the evidence is less promising. Future research on the efficacy of IBIs is needed.
MeSH term(s)	Humans ; Mental Health ; Psychosocial Intervention ; Interoception ; Stress Disorders, Post-Traumatic/psychology ; Substance-Related Disorders ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-08-09
Publishing country	Australia
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/pcn.13576
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui I Zs.238: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article: Psychological interventions for interoception in mental health disorders

Heim, Nikolas / Bobou, Marina / Tanzer, Michal / Jenkinson, Paul M. / Steinert, Christiane / Fotopoulou, Aikaterini

Psychiatry and Clinical Neurosciences

A systematic review of randomized-controlled trials

2023 Volume 77, Issue 10, Page(s) 530–540

Title translation	Psychologische Interventionen zur Interozeption bei psychischen Störungen: Eine systematische Übersicht über randomisiert-kontrollierte Studien
Abstract	Disturbed interoception (i.e., the sensing, awareness, and regulation of internal body signals) has been found across several mental disorders, leading to the development of interoception-based interventions (IBIs). Searching PubMed and PsycINFO, we conducted the first systematic review of randomized-controlled trials (RCTs) investigating the efficacy of behavioral IBIs at improving interoception and target symptoms of mental disorders in comparison to a non-interoception-based control condition [CRD42021297993]. Thirty-one RCTs fulfilled inclusion criteria. Across all studies, a pattern emerged with 20 (64.5%) RCTs demonstrating IBIs to be more efficacious at improving interoception compared to control conditions. The most promising results were found for posttraumatic stress disorder, irritable bowel syndrome, fibromyalgia and substance use disorders. Regarding symptom improvement, the evidence was inconclusive. The IBIs were heterogenous in their approach to improving interoception. The quality of RCTs was moderate to good. In conclusion, IBIs are potentially efficacious at improving interoception for some mental disorders. In terms of symptom reduction, the evidence is less promising. Future research on the efficacy of IBIs is needed.
Keywords	Body Awareness ; Cognitive Therapy ; Interoception ; Interozeption ; Intervention ; Kognitive Therapie ; Körperbewusstsein ; Mental Disorders ; Psychische Störungen ; Randomisierte kontrollierte Studien ; Randomized Controlled Trials ; Therapieergebnisse ; Treatment Outcomes
Language	English
Document type	Article
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/pcn.13576
Database	PSYNDEX

In stock of ZB MED Cologne/Königswinter

Ui I Zs.238: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Differing impact of the COVID-19 pandemic on youth mental health: combined population and clinical study.

Qi, Lu / Zhang, Zuo / Robinson, Lauren / Bobou, Marina / Gourlan, Chantal / Winterer, Jeanne / Adams, Rebecca / Agunbiade, Kofoworola / Zhang, Yuning / King, Sinead / Vaidya, Nilakshi / Artiges, Eric / Banaschewski, Tobias / Bokde, Arun L W / Broulidakis, M John / Brühl, Rüdiger / Flor, Herta / Fröhner, Juliane H / Garavan, Hugh /

Grigis, Antoine / Heinz, Andreas / Hohmann, Sarah / Martinot, Marie-Laure Paillère / Millenet, Sabina / Nees, Frauke / van Noort, Betteke Maria / Orfanos, Dimitri Papadopoulos / Poustka, Luise / Sinclair, Julia / Smolka, Michael N / Whelan, Robert / Stringaris, Argyris / Walter, Henrik / Martinot, Jean-Luc / Schumann, Gunter / Schmidt, Ulrike / Desrivières, Sylvane

BJPsych open

2023 Volume 9, Issue 6, Page(s) e217

Abstract: Background: Identifying youths most at risk to COVID-19-related mental illness is essential for the development of effective targeted interventions.: Aims: To compare trajectories of mental health throughout the pandemic in youth with and without ... ...

Abstract	Background: Identifying youths most at risk to COVID-19-related mental illness is essential for the development of effective targeted interventions. Aims: To compare trajectories of mental health throughout the pandemic in youth with and without prior mental illness and identify those most at risk of COVID-19-related mental illness. Method: Data were collected from individuals aged 18-26 years ( Results: Mental health trajectories differed significantly between cohorts. In the population cohort, depression and eating disorder symptoms increased by 33.9% (95% CI 31.78-36.57) and 15.6% (95% CI 15.39-15.68) during the pandemic, respectively. By contrast, these remained high over time in the clinical cohort. Conversely, trajectories of alcohol misuse were similar in both cohorts, decreasing continuously (a 15.2% decrease) during the pandemic. Pre-pandemic symptom severity predicted the observed mental health trajectories in the population cohort. Surprisingly, being relatively healthy predicted increases in depression and eating disorder symptoms and in body mass index. By contrast, those initially at higher risk for depression or eating disorders reported a lasting decrease. Conclusions: Healthier young people may be at greater risk of developing depressive or eating disorder symptoms during the COVID-19 pandemic. Targeted mental health interventions considering prior diagnostic risk may be warranted to help young people cope with the challenges of psychosocial stress and reduce the associated healthcare burden.
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2829557-2
ISSN	2056-4724
ISSN	2056-4724
DOI	10.1192/bjo.2023.601
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Machine learning models for diagnosis and risk prediction in eating disorders, depression, and alcohol use disorder.

Desrivières, Sylvane / Zhang, Zuo / Robinson, Lauren / Whelan, Robert / Jollans, Lee / Wang, Zijian / Nees, Frauke / Chu, Congying / Bobou, Marina / Du, Dongping / Cristea, Ilinca / Banaschewski, Tobias / Barker, Gareth / Bokde, Arun / Grigis, Antoine / Garavan, Hugh / Heinz, Andreas / Bruhl, Rudiger / Martinot, Jean-Luc /

Research square

2024

Abstract: This study uses machine learning models to uncover diagnostic and risk prediction markers for eating disorders (EDs), major depressive disorder (MDD), and alcohol use disorder (AUD). Utilizing case-control samples (ages 18-25 years) and a longitudinal ... ...

Abstract	This study uses machine learning models to uncover diagnostic and risk prediction markers for eating disorders (EDs), major depressive disorder (MDD), and alcohol use disorder (AUD). Utilizing case-control samples (ages 18-25 years) and a longitudinal population-based sample (n=1,851), the models, incorporating diverse data domains, achieved high accuracy in classifying EDs, MDD, and AUD from healthy controls. The area under the receiver operating characteristic curves (AUC-ROC [95% CI]) reached 0.92 [0.86-0.97] for AN and 0.91 [0.85-0.96] for BN, without relying on body mass index as a predictor. The classification accuracies for MDD (0.91 [0.88-0.94]) and AUD (0.80 [0.74-0.85]) were also high. Each data domain emerged as accurate classifiers individually, with personality distinguishing AN, BN, and their controls with AUC-ROCs ranging from 0.77 to 0.89. The models demonstrated high transdiagnostic potential, as those trained for EDs were also accurate in classifying AUD and MDD from healthy controls, and vice versa (AUC-ROCs, 0.75-0.93). Shared predictors, such as neuroticism, hopelessness, and symptoms of attention-deficit/hyperactivity disorder, were identified as reliable classifiers. For risk prediction in the longitudinal population sample, the models exhibited moderate performance (AUC-ROCs, 0.64-0.71), highlighting the potential of combining multi-domain data for precise diagnostic and risk prediction applications in psychiatry.
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3777784/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Author Correction: A shared neural basis underlying psychiatric comorbidity.

Xie, Chao / Xiang, Shitong / Shen, Chun / Peng, Xuerui / Kang, Jujiao / Li, Yuzhu / Cheng, Wei / He, Shiqi / Bobou, Marina / Broulidakis, M John / van Noort, Betteke Maria / Zhang, Zuo / Robinson, Lauren / Vaidya, Nilakshi / Winterer, Jeanne / Zhang, Yuning / King, Sinead / Banaschewski, Tobias / Barker, Gareth J /

Bokde, Arun L W / Bromberg, Uli / Büchel, Christian / Flor, Herta / Grigis, Antoine / Garavan, Hugh / Gowland, Penny / Heinz, Andreas / Ittermann, Bernd / Lemaître, Hervé / Martinot, Jean-Luc / Martinot, Marie-Laure Paillère / Nees, Frauke / Orfanos, Dimitri Papadopoulos / Paus, Tomáš / Poustka, Luise / Fröhner, Juliane H / Schmidt, Ulrike / Sinclair, Julia / Smolka, Michael N / Stringaris, Argyris / Walter, Henrik / Whelan, Robert / Desrivières, Sylvane / Sahakian, Barbara J / Robbins, Trevor W / Schumann, Gunter / Jia, Tianye / Feng, Jianfeng

Nature medicine

2023 Volume 29, Issue 9, Page(s) 2375

Language	English
Publishing date	2023-08-10
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-023-02512-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 39: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A shared neural basis underlying psychiatric comorbidity.

Nature medicine

2023 Volume 29, Issue 5, Page(s) 1232–1242

Abstract: Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging ... ...

Abstract	Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the Stratify Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.
MeSH term(s)	Adolescent ; Humans ; Young Adult ; Comorbidity ; Mental Disorders/diagnostic imaging ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Neuroimaging ; Psychopathology
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-023-02317-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 39: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Association of Genetic and Phenotypic Assessments With Onset of Disordered Eating Behaviors and Comorbid Mental Health Problems Among Adolescents.

Robinson, Lauren / Zhang, Zuo / Jia, Tianye / Bobou, Marina / Roach, Anna / Campbell, Iain / Irish, Madeleine / Quinlan, Erin Burke / Tay, Nicole / Barker, Edward D / Banaschewski, Tobias / Bokde, Arun L W / Grigis, Antoine / Garavan, Hugh / Heinz, Andreas / Ittermann, Bernd / Martinot, Jean-Luc / Stringaris, Argyris / Penttilä, Jani /

van Noort, Betteke / Grimmer, Yvonne / Martinot, Marie-Laure Paillère / Insensee, Corinna / Becker, Andreas / Nees, Frauke / Orfanos, Dimitri Papadopoulos / Paus, Tomáš / Poustka, Luise / Hohmann, Sarah / Fröhner, Juliane H / Smolka, Michael N / Walter, Henrik / Whelan, Robert / Schumann, Gunter / Schmidt, Ulrike / Desrivières, Sylvane

JAMA network open

2020 Volume 3, Issue 12, Page(s) e2026874

Abstract: Importance: Eating disorders are serious mental disorders with increasing prevalence. Without early identification and treatment, eating disorders may run a long-term course.: Objective: To characterize any associations among disordered eating ... ...

Abstract	Importance: Eating disorders are serious mental disorders with increasing prevalence. Without early identification and treatment, eating disorders may run a long-term course. Objective: To characterize any associations among disordered eating behaviors (DEBs) and other mental health disorders and to identify early associations with the development of symptoms over time. Design, setting, and participants: This multicenter, population-based, longitudinal cohort study used data from baseline (collected in 2010), follow-up 1 (collected in 2012), and follow-up 2 (collected in 2015) of the IMAGEN Study, which included adolescents recruited from 8 European sites. The present study assessed data from 1623 healthy adolescents, aged 14 years at baseline, recruited from high schools. Data analyses were performed from January 2018 to September 2019. Main outcomes and measures: Body mass index (BMI), mental health symptoms, substance use behaviors, and personality variables were investigated as time-varying associations of DEBs (dieting, binge eating, and purging) or change in BMI over time. Polygenic risk scores were calculated to investigate genetic contributions associated with BMI, attention-deficit/hyperactivity disorder (ADHD) and neuroticism to DEBs. Results: In this cohort study of 1623 adolescents (829 girls [51.1%]) recruited at a mean (SD) age of 14.5 (0.4) years and followed up at ages 16 and 19 years, 278 adolescents (17.1%) reported binge eating, 334 adolescents (20.6%) reported purging, and 356 adolescents (21.9%) reported dieting at 14, 16, or 19 years. Among the precursors of DEBs, high BMI was associated with future dieting (OR, 3.44; 95% CI, 2.09-5.65). High levels of neuroticism (OR, 1.04; 95% CI, 1.01-1.06), conduct problems (OR, 1.41; 95% CI, 1.17-1.69), and deliberate self-harm (OR, 2.18; 95% CI, 1.37-3.45) were associated with future binge eating. Low agreeableness (OR, 0.95; 95% CI, 0.92-0.97), deliberate self-harm (OR, 2.59; 95% CI, 1.69-3.95), conduct problems (OR, 1.42; 95% CI, 1.20-1.68), alcohol misuse (OR, 1.31; 95% CI, 1.10-1.54), and drug abuse (OR, 2.91; 95% CI, 1.78-4.74) were associated with future purging. Polygenetic risk scores for BMI were associated with dieting (at 14 years: OR, 1.27; lower bound 95% CI, 1.08; at 16 years: OR, 1.38; lower bound 95% CI, 1.17); ADHD, with purging (at 16 years: OR, 1.25; lower bound 95% CI, 1.08; at 19 years, OR, 1.23; lower bound 95% CI, 1.06); and neuroticism, with binge eating (at 14 years: OR, 1.32; lower bound 95% CI, 1.11; at 16 years: OR, 1.24; lower bound 95% CI, 1.06), highlighting distinct etiologic overlaps between these traits. The DEBs predated other mental health problems, with dieting at 14 years associated with future symptoms of depression (OR, 2.53; 95% CI, 1.56-4.10), generalized anxiety (OR, 2.27; 95% CI, 1.14-4.51), deliberate self-harm (OR, 2.10; 95% CI, 1.51-4.24), emotional problems (OR, 1.24; 95% CI, 1.08-1.43), and smoking (OR, 2.16; 95% CI, 1.36-3.48). Purging at 14 years was also associated with future depression (OR, 2.87; 95% CI, 1.69-5.01) and anxiety (OR, 2.48; 95% CI, 1.49-4.12) symptoms. Conclusions and relevance: The findings of this study delineate temporal associations and shared etiologies among DEBs and other mental health disorders and emphasize the potential of genetic and phenotypical assessments of obesity, behavioral disorders, and neuroticism to improve early and differential diagnosis of eating disorders.
MeSH term(s)	Adolescent ; Adolescent Behavior ; Adolescent Psychiatry ; Anxiety ; Comorbidity ; Depression ; Europe/epidemiology ; Feeding and Eating Disorders/epidemiology ; Feeding and Eating Disorders/genetics ; Feeding and Eating Disorders/psychology ; Female ; Genetics ; Humans ; Longitudinal Studies ; Male ; Mental Disorders/epidemiology ; Mental Disorders/genetics ; Mental Disorders/psychology ; Multifactorial Inheritance ; Phenotype ; Psychiatric Status Rating Scales ; Risk Factors
Language	English
Publishing date	2020-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2020.26874
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Association of genetic and phenotypic assessments with onset of disordered eating behaviors and comorbid mental health problems among adolescents

IMAGEN Consortium / Robinson, Lauren / Zhang, Zuo / Jia, Tianye / Bobou, Marina / Roach, Anna / Campbell, Iain / Irish, Madeleine / Quinlan, Erin Burke / Tay, Nicole / Barker, Edward D. / Banaschewski, Tobias / Bokde, Arun L. W. / Grigis, Antoine / Garavan, Hugh / Heinz, Andreas / Ittermann, Bernd / Martinot, Jean-Luc / Stringaris, Argyris /

Penttilä, Jani / van Noort, Betteke / Grimmer, Yvonne / Paillere Martinot, Marie-Laure / Insensee, Corinna / Becker, Andreas / Nees, Frauke / Dimitri Papadopoulos Orfanos, Dimitri / Paus, Tomas / Poustka, Luise / Hohmann, Sarah / Fröhner, Juliane H. / Smolka, Michael N. / Walter, Henrik / Whelan, Robert / Schumann, Gunter / Schmidt, Ulrike / Desrivieres, Sylvane

JAMA Network Open

2020 Volume 3, Issue 12, Page(s) No

Abstract: Importance: Eating disorders are serious mental disorders with increasing prevalence. Without early identification and treatment, eating disorders may run a long-term course. Objective: To characterize any associations among disordered eating behaviors ( ... ...

Title translation	Assoziation von genetischen und phänotypischen Merkmalen mit dem Auftreten von gestörtem Essverhalten und komorbiden psychischen Problemen bei Heranwachsenden (DeepL)
Abstract	Importance: Eating disorders are serious mental disorders with increasing prevalence. Without early identification and treatment, eating disorders may run a long-term course. Objective: To characterize any associations among disordered eating behaviors (DEBs) and other mental health disorders and to identify early associations with the development of symptoms over time. Design, Setting, and Participants: This multicenter, population-based, longitudinal cohort study used data from baseline (collected in 2010), follow-up 1 (collected in 2012), and follow-up 2 (collected in 2015) of the IMAGEN Study, which included adolescents recruited from 8 European sites. The present study assessed data from 1623 healthy adolescents, aged 14 years at baseline, recruited from high schools. Data analyses were performed from January 2018 to September 2019. Main Outcomes and Measures: Body mass index (BMI), mental health symptoms, substance use behaviors, and personality variables were investigated as time-varying associations of DEBs (dieting, binge eating, and purging) or change in BMI over time. Polygenic risk scores were calculated to investigate genetic contributions associated with BMI, attention-deficit/hyperactivity disorder (ADHD) and neuroticism to DEBs. Results: In this cohort study of 1623 adolescents (829 girls [51.1%]) recruited at a mean (SD) age of 14.5 (0.4) years and followed up at ages 16 and 19 years, 278 adolescents (17.1%) reported binge eating, 334 adolescents (20.6%) reported purging, and 356 adolescents (21.9%) reported dieting at 14, 16, or 19 years. Among the precursors of DEBs, high BMI was associated with future dieting (OR, 3.44; 95% CI, 2.09-5.65). High levels of neuroticism (OR, 1.04; 95% CI, 1.01-1.06), conduct problems (OR, 1.41; 95% CI, 1.17-1.69), and deliberate self-harm (OR, 2.18; 95% CI, 1.37-3.45) were associated with future binge eating. Low agreeableness (OR, 0.95; 95% CI, 0.92-0.97), deliberate self-harm (OR, 2.59; 95% CI, 1.69-3.95), conduct problems (OR, 1.42; 95% CI, 1.20-1.68), alcohol misuse (OR, 1.31; 95% CI, 1.10-1.54), and drug abuse (OR, 2.91; 95% CI, 1.78-4.74) were associated with future purging. Polygenetic risk scores for BMI were associated with dieting (at 14 years: OR, 1.27; lower bound 95% CI, 1.08; at 16 years: OR, 1.38; lower bound 95% CI, 1.17); ADHD, with purging (at 16 years: OR, 1.25; lower bound 95% CI, 1.08; at 19 years, OR, 1.23; lower bound 95% CI, 1.06); and neuroticism, with binge eating (at 14 years: OR, 1.32; lower bound 95% CI, 1.11; at 16 years: OR, 1.24; lower bound 95% CI, 1.06), highlighting distinct etiologic overlaps between these traits. The DEBs predated other mental health problems, with dieting at 14 years associated with future symptoms of depression (OR, 2.53; 95% CI, 1.56-4.10), generalized anxiety (OR, 2.27; 95% CI, 1.14-4.51), deliberate self-harm (OR, 2.10; 95% CI, 1.51-4.24), emotional problems (OR, 1.24; 95% CI, 1.08-1.43), and smoking (OR, 2.16; 95% CI, 1.36-3.48). Purging at 14 years was also associated with future depression (OR, 2.87; 95% CI, 1.69-5.01) and anxiety (OR, 2.48; 95% CI, 1.49-4.12) symptoms. Conclusions and Relevance: The findings of this study delineate temporal associations and shared etiologies among DEBs and other mental health disorders and emphasize the potential of genetic and phenotypical assessments of obesity, behavioral disorders, and neuroticism to improve early and differential diagnosis of eating disorders.
Keywords	At Risk Populations ; Comorbidity ; Eating Disorders ; Epidemiologie ; Epidemiology ; Essstörungen ; Etiology ; Genetics ; Genetik ; Ko-Morbidität ; Mental Disorders ; Psychische Störungen ; Risikofaktoren ; Risikogruppen ; Risk Factors ; Symptome ; Symptoms ; Ätiologie
Language	English
Document type	Article
ISSN	2574-3805
ISSN	2574-3805
DOI	10.1001/jamanetworkopen.2020.26874
Database	PSYNDEX

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED