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  1. AU="Boccara, Albert-Claude"
  2. AU="Tang, E Jessica"
  3. AU="Vasireddy, Ravikiran"
  4. AU="Nikula-Ijäs, Pirjo"
  5. AU="Germain, Elsa"
  6. AU="Veltink, Peter"
  7. AU=Subbarayan Karthikeyan
  8. AU="Bellomo, Chiara"
  9. AU="Jeon, Soo Min"
  10. AU="Rotaru, Mihaela"
  11. AU="Hakami, Mohammed Ageeli"
  12. AU="Garduño, Eugenio"
  13. AU="Kumar Vijay, Ajay"
  14. AU="Concheiro, Marta"
  15. AU="Kang, Ji-Hoon"
  16. AU="González-Gómez, Julio César"
  17. AU="Eisinger, Felix"
  18. AU="van Arkel, Gijs H J"
  19. AU="Dukkipati, Haripriya"
  20. AU="Mansoor, Farheen"
  21. AU="Stanton, Clive"
  22. AU=Herholz K AU=Herholz K
  23. AU="Marichal, Axel"
  24. AU="Camon, Ana M"
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  1. Book: Hybrid and novel imaging and new optical instrumentation for biomedical applications

    Boccara, Albert-Claude

    18, 20 - 21 June 2001, Munich, Germany

    (Proceedings of SPIE ; 4434 ; Progress in biomedical optics and imaging ; 2,34)

    2001  

    Author's details Albert-Claude Boccara ... chair/ed
    Series title Proceedings of SPIE ; 4434
    Progress in biomedical optics and imaging ; 2,34
    Proceedings / SPIE, The International Society for Optical Engineering
    Collection Proceedings / SPIE, The International Society for Optical Engineering
    Language English
    Size VII, 270 S. : Ill., graph. Darst.
    Publisher OSA, Optical Soc. of America u.a.
    Publishing place Washington, DC u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013392583
    ISBN 0-8194-4148-1 ; 978-0-8194-4148-5
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Time-domain full-field optical coherence tomography (TD-FF-OCT) in ophthalmic imaging.

    Zhang, Jinze / Mazlin, Viacheslav / Fei, Keyi / Boccara, Albert Claude / Yuan, Jin / Xiao, Peng

    Therapeutic advances in chronic disease

    2023  Volume 14, Page(s) 20406223231170146

    Abstract: Ocular imaging plays an irreplaceable role in the evaluation of eye diseases. Developing cellular-resolution ophthalmic imaging technique for more accurate and effective diagnosis and pathogenesis analysis of ocular diseases is a hot topic in the cross- ... ...

    Abstract Ocular imaging plays an irreplaceable role in the evaluation of eye diseases. Developing cellular-resolution ophthalmic imaging technique for more accurate and effective diagnosis and pathogenesis analysis of ocular diseases is a hot topic in the cross-cutting areas of ophthalmology and imaging. Currently, ocular imaging with traditional optical coherence tomography (OCT) is limited in lateral resolution and thus can hardly resolve cellular structures. Conventional OCT technology obtains ultra-high resolution at the expense of a certain imaging range and cannot achieve full field of view imaging. In the early years, Time-domain full-field OCT (TD-FF-OCT) has been mainly used for
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/20406223231170146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adaptive optics full-field optical coherence tomography.

    Xiao, Peng / Fink, Mathias / Boccara, Albert Claude

    Journal of biomedical optics

    2016  Volume 21, Issue 12, Page(s) 121505

    Abstract: We describe a simple and compact full-field optical coherence tomography (FFOCT) setup coupled to a transmissive liquid crystal spatial light modulator (LCSLM) to induce or correct aberrations. To reduce the system complexity, strict pupil conjugation ... ...

    Abstract We describe a simple and compact full-field optical coherence tomography (FFOCT) setup coupled to a transmissive liquid crystal spatial light modulator (LCSLM) to induce or correct aberrations. To reduce the system complexity, strict pupil conjugation was abandoned because low-order aberrations are often dominant. We experimentally confirmed a recent theoretical and experimental demonstration that the image resolution was almost insensitive to aberrations that mostly induce a reduction of the signal level. As a consequence, an image-based algorithm was applied for the optimization process by using the FFOCT image intensity as the metric. Aberration corrections were demonstrated with both an USAF resolution target and biological samples for LCSLM-induced and sample-induced wavefront distortions.
    Language English
    Publishing date 2016-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1309154-2
    ISSN 1560-2281 ; 1083-3668
    ISSN (online) 1560-2281
    ISSN 1083-3668
    DOI 10.1117/1.JBO.21.12.121505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Curved-field optical coherence tomography

    Mazlin, Viacheslav / Irsch, Kristina / Paques, Michel / Fink, Mathias / Boccara, Albert Claude

    large-field imaging of human corneal cells and nerves

    2020  

    Abstract: High-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers and the view ... ...

    Abstract High-resolution optical imaging methods, such as confocal microscopy and full-field optical coherence tomography, capture flat optical sections of the sample. If the sample is curved, the optical field sections through several sample layers and the view of each layer is reduced. Here we present curved-field optical coherence tomography, capable of capturing optical sections of arbitrary curvature. We test the device on a challenging task of imaging the human cornea in vivo and achieve 10x larger viewing area comparing to the clinical state-of-the-art. This enables more precise cell and nerve counts, opening a path to improved diagnosis of corneal and general health conditions (e.g. diabetes). The method is non-contact, compact and works in a single-shot, making it readily available for use in optical research and clinical practice.
    Keywords Physics - Medical Physics ; Electrical Engineering and Systems Science - Image and Video Processing ; Physics - Optics
    Subject code 535
    Publishing date 2020-04-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Intracellular dynamics measurements with full field optical coherence tomography suggest hindering effect of actomyosin contractility on organelle transport.

    Leroux, Charles-Edouard / Bertillot, Fabien / Thouvenin, Olivier / Boccara, Albert-Claude

    Biomedical optics express

    2016  Volume 7, Issue 11, Page(s) 4501–4513

    Abstract: Intracellular motion can be quantitatively monitored in tissues using coherence-gated microscopic techniques. With full-field optical coherence tomography (FFOCT), the use of high numerical aperture microscope objectives provides a high resolution ... ...

    Abstract Intracellular motion can be quantitatively monitored in tissues using coherence-gated microscopic techniques. With full-field optical coherence tomography (FFOCT), the use of high numerical aperture microscope objectives provides a high resolution mapping of intracellular dynamics that are probed with subwavelength sensitivity. In the upper temporal bandwidth that we have used (1-6 Hz) the main contribution to the dynamic signal arises from the overall dynamical, optically heterogeneous cytoplasm. We propose a method to specifically study the impact of actomyosin contractility on the intracellular dynamic signal by performing high throughput, comparative measurements of multicellular aggregates with and without blebbistatin action, a selective inhibitor of class-II myosins that disrupts actomyosin contractile activity. Our results indicate a significant increase in the fraction of the signal that decorrelates within 1 second after inhibition of contractility. This observation mitigates the anticipated importance of actomyosin contractile forces to directly move organelles, but highlights their role in hindering organelle transport via their stiffening effect of the viscoelastic cytoplasm.
    Language English
    Publishing date 2016-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.7.004501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Optical phase modulation by natural eye movements

    Mazlin, Viacheslav / Xiao, Peng / Irsch, Kristina / Scholler, Jules / Groux, Kassandra / Grieve, Kate / Fink, Mathias / Boccara, Albert Claude

    application to time-domain FF-OCT image retrieval

    2021  

    Abstract: Eye movements are commonly seen as an obstacle to high-resolution ophthalmic imaging. In this context we study the natural axial movements of the in vivo human eye and show that they can be used to modulate the optical phase and retrieve tomographic ... ...

    Abstract Eye movements are commonly seen as an obstacle to high-resolution ophthalmic imaging. In this context we study the natural axial movements of the in vivo human eye and show that they can be used to modulate the optical phase and retrieve tomographic images via time-domain full-field optical coherence tomography (TD-FF-OCT). This approach opens a path to a simplified ophthalmic TD-FF-OCT device, operating without the usual piezo motor-camera synchronization. The device demonstrates in vivo human corneal images under the different image retrieval schemes (2-phase and 4-phase) and different exposure times (3.5 ms, 10 ms, 20 ms). Data on eye movements, acquired with a 100 kHz spectral-domain OCT with axial eye tracking, are used to study the influence of ocular motion on the probability of capturing high-signal tomographic images without phase washout. The optimal combinations of camera acquisition speed and amplitude of piezo modulation are proposed and discussed.
    Keywords Physics - Medical Physics
    Subject code 629
    Publishing date 2021-10-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Conference proceedings: Novel optical instrumentation for biomedical applications

    Boccara, Albert-Claude

    24 - 25 June 2003, Munich, Germany ; [Conference on Novel Optical Instrumentation for Biomedical Applications, part of the SPIE/OSA Biomedical Optics Europe Meeting]

    (Proceedings of SPIE ; 5143 ; Progress in biomedical optics and imaging ; Vol. 4, No. 32)

    2003  

    Institution Conference on Novel Optical Instrumentation for Biomedical Applications
    European Conference on Biomedical Optics
    Optical Society of America
    Event/congress Conference on Novel Optical Instrumentation for Biomedical Applications (2003.06.224-25, Munich) ; SPIE/OSA Biomedical Optics Europe Meeting (2003.06.224-25, Munich)
    Author's details sponsored and publ. by SPIE, the International Society for Optical Engineering ... Albert-Claude Boccara, chair/ed
    Series title Proceedings of SPIE ; 5143
    Progress in biomedical optics and imaging ; Vol. 4, No. 32
    Keywords Biomedical engineering ; Diagnostic imaging ; Imaging systems in medicine ; Optical instruments/Design and construction
    Language English
    Size XIII, 334 S, Ill., graph. Darst.
    Publisher SPIE
    Publishing place Bellingham, Wash
    Document type Book ; Conference proceedings
    ISBN 0819450138 ; 9780819450135
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Conference proceedings: Hybrid and novel imaging and new optical instrumentation for biomedical applications

    Boccara, Albert-Claude

    18, 20 - 21 June 2001, Munich, Germany

    (Proceedings of SPIE ; 4434 ; Progress in biomedical optics and imaging ; Vol.2, No.34)

    2001  

    Institution Optical Society of America
    Event/congress Hybrid and novel imaging and new optical instrumentation for biomedical applications (2001.06.18, Munich) ; Hybrid and novel imaging and new optical instrumentation for biomedical applications (2001.06.20-21, Munich)
    Author's details sponsored and publ. by OSA, Optical Society of America .̤ Albert-Claude Boccara .̤, chairs/ed
    Series title Proceedings of SPIE ; 4434
    Progress in biomedical optics and imaging ; Vol.2, No.34
    Language English
    Size VII, 270 S
    Publisher SPIE, the International Society for Optical Engineering
    Publishing place Bellingham, Wash
    Document type Book ; Conference proceedings
    ISBN 0819441481 ; 9780819441485
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article: Full-field interferometry for counting and differentiating aquatic biotic nanoparticles: from laboratory to

    Boccara, Martine / Fedala, Yasmina / Bryan, Catherine Venien / Bailly-Bechet, Marc / Bowler, Chris / Boccara, Albert Claude

    Biomedical optics express

    2016  Volume 7, Issue 9, Page(s) 3736–3746

    Abstract: There is a huge abundance of viruses and membrane vesicles in seawater. We describe a new full-field, incoherently illuminated, shot-noise limited, common-path interferometric detection method that we couple with the analysis of Brownian motion to detect, ...

    Abstract There is a huge abundance of viruses and membrane vesicles in seawater. We describe a new full-field, incoherently illuminated, shot-noise limited, common-path interferometric detection method that we couple with the analysis of Brownian motion to detect, quantify, and differentiate biotic nanoparticles. We validated the method with calibrated nanoparticles and homogeneous DNA or RNA viruses. The smallest virus size that we characterized with a suitable signal-to-noise ratio was around 30 nm in diameter. Analysis of Brownian motions revealed anisotropic trajectories for myoviruses.We further applied the method for vesicles detection and for analysis of coastal and oligotrophic samples from
    Language English
    Publishing date 2016-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.7.003736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Utilization of interferometric light microscopy for the rapid analysis of virus abundance in a river.

    Roose-Amsaleg, Céline / Fedala, Yasmina / Vénien-Bryan, Catherine / Garnier, Josette / Boccara, Albert-Claude / Boccara, Martine

    Research in microbiology

    2017  Volume 168, Issue 5, Page(s) 413–418

    Abstract: There is a constant need for direct counting of biotic nanoparticles such as viruses to unravel river functioning. We used, for the first time in freshwater, a new method based on interferometry differentiating viruses from other particles such as ... ...

    Abstract There is a constant need for direct counting of biotic nanoparticles such as viruses to unravel river functioning. We used, for the first time in freshwater, a new method based on interferometry differentiating viruses from other particles such as membrane vesicles. In the French Marne River, viruses represented between 42 and 72% of the particles. A spring monitoring in 2014 revealed their increase (2.1 × 10
    Language English
    Publishing date 2017-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 1004220-9
    ISSN 1769-7123 ; 0923-2508
    ISSN (online) 1769-7123
    ISSN 0923-2508
    DOI 10.1016/j.resmic.2017.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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