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  1. Book: Ozone

    Bocci, Velio

    a new medical drug

    2011  

    Author's details Velio Bocci
    Language English
    Size XXI, 315 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016988871
    ISBN 978-90-481-9233-5 ; 9789048192342 ; 90-481-9233-1 ; 904819234X
    Database Catalogue ZB MED Medicine, Health

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  2. Article: A reasonable Approach for the Treatment of HIV Infection in the Early Phase with Ozonetherapy (Autohaemotherapy). How 'Inflammatory' Cytokines may have A therapeutic Role.

    Bocci, V

    Mediators of inflammation

    2008  Volume 3, Issue 5, Page(s) 315–321

    Abstract: Immunoregulatory cytokines produced by the TH1 subset and by CD8(+) T lymphocytes appear to brake naturally and sometimes arrest the progress of HIV infection in the early phase. It appears reasonable to assume that a mild and equilibrated stimulation of ...

    Abstract Immunoregulatory cytokines produced by the TH1 subset and by CD8(+) T lymphocytes appear to brake naturally and sometimes arrest the progress of HIV infection in the early phase. It appears reasonable to assume that a mild and equilibrated stimulation of the immune system may prevent or delay the fatal transition towards the prevalent production of TH2-type cytokines. The problem is how to stimulate the immune system in a physiological fashion. In the last 7 years we have clarified the main mechanisms of action of an unorthodox immunotherapeutic method first used 40 years ago. Optimized autohaemotherapy after a brief exposure ofblood to ozone may today afford the trick of reprogramming the immune system to keep HIV at bay. The autohaemotherapeutic procedure is simple, safe, inexpensive and most likely is more effective than conventional approaches.
    Language English
    Publishing date 2008-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 0962-9351
    ISSN 0962-9351
    DOI 10.1155/S0962935194000438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The case for oxygen-ozonetherapy.

    Bocci, V

    British journal of biomedical science

    2007  Volume 64, Issue 1, Page(s) 44–49

    Abstract: Ozone is a very reactive gas that is toxic to the respiratory system. However, under controlled conditions, it can be therapeutically useful in several human diseases. An unfavourable combination of factors (ozone is one of the worst troposphere ... ...

    Abstract Ozone is a very reactive gas that is toxic to the respiratory system. However, under controlled conditions, it can be therapeutically useful in several human diseases. An unfavourable combination of factors (ozone is one of the worst troposphere pollutants) and past misuse have led to misgivings about ozonetherapy. However, basic and clinical work developed over the past 10 years has clarified the fundamental mechanisms of action of ozone in biology and medicine. Interestingly, judicious doses of ozone dissolved in blood trigger a cascade of well-defined chemical compounds acting on multiple cellular targets according to well-known molecular, biochemical and pharmacological pathways. Ozonetherapy is proving to be very useful in age-related macular degeneration, ischaemic and infectious diseases, and in wound healing disorders, where conventional medicine has failed. Critical evaluation of the potential therapeutic utility of this simple, inexpensive medical application by national and international health authorities is warranted and may lead to clinical benefit for a large proportion of the world's population.
    MeSH term(s) Humans ; Ozone/therapeutic use ; Therapeutics/methods
    Chemical Substances Ozone (66H7ZZK23N)
    Language English
    Publishing date 2007-03-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1152119-3
    ISSN 0967-4845
    ISSN 0967-4845
    DOI 10.1080/09674845.2007.11732755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Freshwater plastisphere: a review on biodiversity, risks, and biodegradation potential with implications for the aquatic ecosystem health.

    Bocci, Valerio / Galafassi, Silvia / Levantesi, Caterina / Crognale, Simona / Amalfitano, Stefano / Congestri, Roberta / Matturro, Bruna / Rossetti, Simona / Di Pippo, Francesca

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1395401

    Abstract: The plastisphere, a unique microbial biofilm community colonizing plastic debris and microplastics (MPs) in aquatic environments, has attracted increasing attention owing to its ecological and public health implications. This review consolidates current ... ...

    Abstract The plastisphere, a unique microbial biofilm community colonizing plastic debris and microplastics (MPs) in aquatic environments, has attracted increasing attention owing to its ecological and public health implications. This review consolidates current state of knowledge on freshwater plastisphere, focussing on its biodiversity, community assembly, and interactions with environmental factors. Current biomolecular approaches revealed a variety of prokaryotic and eukaryotic taxa associated with plastic surfaces. Despite their ecological importance, the presence of potentially pathogenic bacteria and mobile genetic elements (i.e., antibiotic resistance genes) raises concerns for ecosystem and human health. However, the extent of these risks and their implications remain unclear. Advanced sequencing technologies are promising for elucidating the functions of plastisphere, particularly in plastic biodegradation processes. Overall, this review emphasizes the need for comprehensive studies to understand plastisphere dynamics in freshwater and to support effective management strategies to mitigate the impact of plastic pollution on freshwater resources.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1395401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Super-Stable Metal-Organic Framework (MOF)/Luciferase Paper-Sensing Platform for Rapid ATP Detection.

    Martínez-Pérez-Cejuela, Héctor / Calabretta, Maria Maddalena / Bocci, Valerio / D'Elia, Marcello / Michelini, Elisa

    Biosensors

    2023  Volume 13, Issue 4

    Abstract: Adenosine triphosphate (ATP) determination has been used for many decades to assess microbial contamination for hygiene monitoring in different locations and workplace environments. Highly sophisticated methods have been reported, yet commercially ... ...

    Abstract Adenosine triphosphate (ATP) determination has been used for many decades to assess microbial contamination for hygiene monitoring in different locations and workplace environments. Highly sophisticated methods have been reported, yet commercially available kits rely on a luciferase-luciferin system and require storage and shipping at controlled temperatures (+4 or -20 °C). The applicability of these systems is limited by the need for a secure cold chain, which is not always applicable, especially in remote areas or low-resource settings. In this scenario, easy-to-handle and portable sensors would be highly valuable. Prompted by this need, we developed a bioluminescence paper biosensor for ATP monitoring in which a new luciferase mutant was combined with a metal-organic framework (MOF); i.e., zeolitic imidazolate framework-8 (ZIF-8). A paper biosensor was developed, ZIF-8@Luc paper sensor, and interfaced with different portable light detectors, including a silicon photomultiplier (SiPM) and smartphones. The use of ZIF-8 not only provided a five-fold increase in the bioluminescence signal, but also significantly improved the stability of the sensor, both at +4 and +28 °C. The ATP content in complex biological matrices was analyzed with the ZIF-8@Luc paper sensor, enabling detection down to 7 × 10
    MeSH term(s) Animals ; Metal-Organic Frameworks ; Adenosine Triphosphate ; Moles ; Luciferases ; Biosensing Techniques/methods ; Zeolites
    Chemical Substances Metal-Organic Frameworks ; Adenosine Triphosphate (8L70Q75FXE) ; Luciferases (EC 1.13.12.-) ; Zeolites (1318-02-1)
    Language English
    Publishing date 2023-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13040451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: How a calculated oxidative stress can yield multiple therapeutic effects.

    Bocci, Velio

    Free radical research

    2012  Volume 46, Issue 9, Page(s) 1068–1075

    Abstract: It is proposed to discuss how ozonetherapy acts on patients affected by vascular and degenerative diseases. Ozone is a strong oxidant but, if used in small dosages on human blood ex vivo, acts as an acceptable stressor. By instantly reacting with PUFA ... ...

    Abstract It is proposed to discuss how ozonetherapy acts on patients affected by vascular and degenerative diseases. Ozone is a strong oxidant but, if used in small dosages on human blood ex vivo, acts as an acceptable stressor. By instantly reacting with PUFA bound to albumin, ozone is entirely consumed but generates two messengers acting in an early and in a late phase: the former is due to hydrogen peroxide, which triggers biochemical pathways on blood cells and the latter is due to alkenals which are infused into the donor patient. After undergoing a partial catabolism, alkenals enter into a great number of body's cells, where they react with Nrf2-Keap1 protein: the transfer of activated Nrf2 into the nucleus and its binding to antioxidant response element (ARE) is the crucial event able to upregulate the synthesis of antioxidant proteins, phase II enzymes and HO-1. With the progress of ozonetherapy, these protective enzymes are able to reverse the oxidative stress induced by chronic inflammation. Consequently, the repetition of graduated stresses induces a multiform adaptive response able to block the progress of the disease and to improve the quality of life.
    MeSH term(s) Animals ; Humans ; Oxidative Stress/drug effects ; Ozone/blood ; Ozone/metabolism ; Ozone/pharmacology ; Ozone/therapeutic use
    Chemical Substances Ozone (66H7ZZK23N)
    Language English
    Publishing date 2012-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1194130-3
    ISSN 1029-2470 ; 1071-5762
    ISSN (online) 1029-2470
    ISSN 1071-5762
    DOI 10.3109/10715762.2012.693609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases?

    Bocci, V / Valacchi, G

    Current medicinal chemistry

    2013  Volume 20, Issue 27, Page(s) 3397–3415

    Abstract: This review examines the biological role of oxidants and antioxidants continuously produced by all living cells. Physiologically, human beings, who have inherited good genes, used to eat moderately a healthy diet and exercised daily, both systems are ... ...

    Abstract This review examines the biological role of oxidants and antioxidants continuously produced by all living cells. Physiologically, human beings, who have inherited good genes, used to eat moderately a healthy diet and exercised daily, both systems are equally important and essential in maintaining a normal long life. However, the aging process slowly leads to a disequilibrium that is accentuated in pathologies such as diabetes, cardiovascular, degenerative, pulmonary, infective diseases, and cancer. All of these diseases shorten the life span in about 80% of individuals and represent a huge social-economic problem for health authorities. Several factors such as excessive feeding, smoking, alcoholism, and a poor life-style conjure up to their realization. Their progress, initially promoted by some pathogens and a wrong life-style, is deeply accentuated by an excessive and deranged production of deadly oxidants no longer tameable by an inhibited control of the antioxidant defences. Effective orthodox drugs are able to slow down these ailments but they impoverish the quality of life because they cannot reactivate the innate ability to restore the complexity of the antioxidant system. Several potential approaches to renew this system have been discussed and their possible roles to reactivate a valid protection in at least some of the outlined pathologies. It is hoped to evaluate this integrated medical approach because it represents a sheet anchor for many patients.
    MeSH term(s) Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Caloric Restriction ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Chronic Disease ; Free Radicals/metabolism ; Glutathione/metabolism ; Humans ; NF-E2-Related Factor 2/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Oxidative Stress/drug effects ; Oxidoreductases/metabolism
    Chemical Substances Antioxidants ; Free Radicals ; NF-E2-Related Factor 2 ; Oxidoreductases (EC 1.-) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2013-03-07
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867311320270005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: EFFICIENT LABELLING OF SERUM PROTEINS WITH I-131 USING CHLORAMINE T.

    BOCCI, V

    The International journal of applied radiation and isotopes

    2003  Volume 15, Page(s) 449–456

    MeSH term(s) Animals ; Autoradiography ; Biomedical Research ; Blood Protein Electrophoresis ; Blood Proteins ; Chloramines ; Guinea Pigs ; Iodine ; Iodine Isotopes ; Rabbits ; Radiometry ; Rats ; Research ; Serum Albumin ; Serum Albumin, Radio-Iodinated ; Serum Globulins ; Tosyl Compounds
    Chemical Substances Blood Proteins ; Chloramines ; Iodine Isotopes ; Serum Albumin ; Serum Albumin, Radio-Iodinated ; Serum Globulins ; Tosyl Compounds ; chloramine-T ; Iodine (9679TC07X4)
    Language English
    Publishing date 2003-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80265-7
    ISSN 0020-708X
    ISSN 0020-708X
    DOI 10.1016/0020-708x(64)90071-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: How a physiologist viewed and lived with the interferon problem.

    Bocci, V

    Journal of biological regulators and homeostatic agents

    2003  Volume 17, Issue 4, Page(s) 289–294

    MeSH term(s) Animals ; History, 20th Century ; Humans ; Immune System/physiology ; Interferons/administration & dosage ; Interferons/physiology ; Interferons/therapeutic use ; Models, Biological
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2003-10
    Publishing country Italy
    Document type Historical Article ; Journal Article
    ZDB-ID 639196-5
    ISSN 1724-6083 ; 0393-974X
    ISSN (online) 1724-6083
    ISSN 0393-974X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Separation of rabbit plasma proteins by zone electrophoresis on "pevikon C. 870".

    BOCCI, V

    Journal of chromatography

    2003  Volume 8, Page(s) 218–226

    MeSH term(s) Animals ; Blood Proteins/chemistry ; Electrophoresis ; Polyvinyls ; Proteins ; Rabbits
    Chemical Substances Blood Proteins ; Polyvinyls ; Proteins ; poly(vinyl chloride)-poly(vinyl acetate) copolymer (9003-22-9)
    Language English
    Publishing date 2003-04-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218139-3
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    ISSN 0021-9673 ; 0378-4355 ; 0376-737X
    DOI 10.1016/s0021-9673(01)99252-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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