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Article ; Online: Author Correction: The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.

Schnell, Alexandra / Bod, Lloyd / Madi, Asaf / Kuchroo, Vijay K

2020 Volume 30, Issue 4, Page(s) 366

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Language	English
Publishing date	2020-02-21
Publishing country	England
Document type	Published Erratum
ZDB-ID	1319303-x
ISSN	1748-7838 ; 1001-0602
ISSN (online)	1748-7838
ISSN	1001-0602
DOI	10.1038/s41422-020-0285-x
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Article ; Online: The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity.

Schnell, Alexandra / Bod, Lloyd / Madi, Asaf / Kuchroo, Vijay K

Cell research

2020 Volume 30, Issue 4, Page(s) 285–299

Abstract: Co-inhibitory receptors are important regulators of T-cell function that define the balance between tolerance and autoimmunity. The immune regulatory function of co-inhibitory receptors, including CTLA-4, PD-1, TIM-3, TIGIT, and LAG-3, was first ... ...

Abstract	Co-inhibitory receptors are important regulators of T-cell function that define the balance between tolerance and autoimmunity. The immune regulatory function of co-inhibitory receptors, including CTLA-4, PD-1, TIM-3, TIGIT, and LAG-3, was first discovered in the setting of autoimmune disease models, in which their blockade or deficiency resulted in induction or exacerbation of the disease. Later on, co-inhibitory receptors on lymphocytes have also been found to influence outcomes in tumor and chronic viral infection settings. These receptors suppress T-cell function in the tumor microenvironment (TME), thereby making the T cells dysfunctional. Based on this observation, blockade of co-inhibitory receptors (also known as checkpoint molecules) has emerged as a successful treatment option for a number of human cancers. However, severe autoimmune-like side effects limit the use of therapeutics that block individual or combinations of co-inhibitory receptors for cancer treatment. In this review we provide an overview of the role of co-inhibitory receptors in autoimmunity and anti-tumor immunity. We then discuss current approaches and future directions to leverage our knowledge of co-inhibitory receptors to target them in tumor immunity without inducing autoimmunity.
MeSH term(s)	Animals ; Autoimmunity ; Humans ; Immune Checkpoint Proteins/physiology ; Immunotherapy ; Neoplasms/metabolism ; Neoplasms/therapy ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/pathology ; Tumor Microenvironment
Chemical Substances	Immune Checkpoint Proteins
Language	English
Publishing date	2020-01-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1319303-x
ISSN	1748-7838 ; 1001-0602
ISSN (online)	1748-7838
ISSN	1001-0602
DOI	10.1038/s41422-020-0277-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.

Cell

2024 Volume 187, Issue 8, Page(s) 2010–2028.e30

Abstract: Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cells is an ... ...

Abstract	Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cells is an important axis in this process, but our understanding has been challenged by incomplete cell-type definition and biogeography. To address this challenge, we used multiplexed error-robust fluorescence in situ hybridization (MERFISH) to profile the expression of 940 genes in 1.35 million cells imaged across the onset and recovery from a mouse colitis model. We identified diverse cell populations, charted their spatial organization, and revealed their polarization or recruitment in inflammation. We found a staged progression of inflammation-associated tissue neighborhoods defined, in part, by multiple inflammation-associated fibroblasts, with unique expression profiles, spatial localization, cell-cell interactions, and healthy fibroblast origins. Similar signatures in ulcerative colitis suggest conserved human processes. Broadly, we provide a framework for understanding inflammation-induced remodeling in the gut and other tissues.
MeSH term(s)	Animals ; Humans ; Mice ; Colitis/metabolism ; Colitis/pathology ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/pathology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; In Situ Hybridization, Fluorescence/methods ; Inflammation/metabolism ; Inflammation/pathology ; Cell Communication ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/pathology
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2024.03.013
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation.

Schnell, Alexandra / Huang, Linglin / Regan, Brianna M L / Singh, Vasundhara / Vonficht, Dominik / Bollhagen, Alina / Wang, Mona / Hou, Yu / Bod, Lloyd / Sobel, Raymond A / Chihara, Norio / Madi, Asaf / Anderson, Ana C / Regev, Aviv / Kuchroo, Vijay K

Nature immunology

2023 Volume 24, Issue 11, Page(s) 1908–1920

Abstract: Co-inhibitory and checkpoint molecules suppress T cell function in the tumor microenvironment, thereby rendering T cells dysfunctional. Although immune checkpoint blockade is a successful treatment option for multiple human cancers, severe autoimmune- ... ...

Abstract	Co-inhibitory and checkpoint molecules suppress T cell function in the tumor microenvironment, thereby rendering T cells dysfunctional. Although immune checkpoint blockade is a successful treatment option for multiple human cancers, severe autoimmune-like adverse effects can limit its application. Here, we show that the gene encoding peptidoglycan recognition protein 1 (PGLYRP1) is highly coexpressed with genes encoding co-inhibitory molecules, indicating that it might be a promising target for cancer immunotherapy. Genetic deletion of Pglyrp1 in mice led to decreased tumor growth and an increased activation/effector phenotype in CD8
MeSH term(s)	Animals ; Humans ; Mice ; CD8-Positive T-Lymphocytes/metabolism ; Cytokines/metabolism ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Immunotherapy ; Inflammation ; Neoplasms ; Neuroinflammatory Diseases ; Tumor Microenvironment
Chemical Substances	Cytokines ; PGLYRP1 protein, human ; Pglyrp1 protein, mouse
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01645-4
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

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Article: Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling.

bioRxiv : the preprint server for biology

2023

Abstract	Gut inflammation involves contributions from immune and non-immune cells, whose interactions are shaped by the spatial organization of the healthy gut and its remodeling during inflammation. The crosstalk between fibroblasts and immune cells is an important axis in this process, but our understanding has been challenged by incomplete cell-type definition and biogeography. To address this challenge, we used MERFISH to profile the expression of 940 genes in 1.35 million cells imaged across the onset and recovery from a mouse colitis model. We identified diverse cell populations; charted their spatial organization; and revealed their polarization or recruitment in inflammation. We found a staged progression of inflammation-associated tissue neighborhoods defined, in part, by multiple inflammation-associated fibroblasts, with unique expression profiles, spatial localization, cell-cell interactions, and healthy fibroblast origins. Similar signatures in ulcerative colitis suggest conserved human processes. Broadly, we provide a framework for understanding inflammation-induced remodeling in the gut and other tissues.
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.08.539701
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nitric Oxide Synthase 2 Improves Proliferation and Glycolysis of Peripheral γδ T Cells.

Douguet, Laetitia / Cherfils-Vicini, Julien / Bod, Lloyd / Lengagne, Renée / Gilson, Eric / Prévost-Blondel, Armelle

PloS one

2016 Volume 11, Issue 11, Page(s) e0165639

Abstract: γδ T cells play critical roles in host defense against infections and cancer. Although advances have been made in identifying γδ TCR ligands, it remains essential to understand molecular mechanisms responsible for in vivo expansion of γδ T cells in ... ...

Abstract	γδ T cells play critical roles in host defense against infections and cancer. Although advances have been made in identifying γδ TCR ligands, it remains essential to understand molecular mechanisms responsible for in vivo expansion of γδ T cells in periphery. Recent findings identified the expression of the inducible NO synthase (NOS2) in lymphoid cells and highlighted novel immunoregulatory functions of NOS2 in αβ T cell differentiation and B cell survival. In this context, we wondered whether NOS2 exerts an impact on γδ T cell properties. Here, we show that γδ T cells express NOS2 not only in vitro after TCR triggering, but also directly ex vivo. Nos2 deficient mice have fewer γδ T cells in peripheral lymph nodes (pLNs) than their wild-type counterparts, and these cells exhibit a reduced ability to produce IL-2. Using chemical NOS inhibitors and Nos2 deficient γδ T cells, we further evidence that the inactivation of endogenous NOS2 significantly reduced γδ T cell proliferation and glycolysis metabolism that can be restored in presence of exogenous IL-2. Collectively, we demonstrate the crucial role of endogenous NOS2 in promoting optimal IL-2 production, proliferation and glycolysis of γδ T cells that may contribute to their regulation at steady state.
MeSH term(s)	Animals ; Cell Proliferation/genetics ; Cell Proliferation/physiology ; Cells, Cultured ; Glycolysis/genetics ; Glycolysis/physiology ; Interleukin-2/biosynthesis ; Lymph Nodes/cytology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide Synthase Type II/antagonists & inhibitors ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; T-Lymphocyte Subsets/metabolism
Chemical Substances	Interleukin-2 ; Receptors, Antigen, T-Cell, gamma-delta ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, mouse (EC 1.14.13.39)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0165639
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Inflammation drives nitric oxide synthase 2 expression by γδ T cells and affects the balance between melanoma and vitiligo associated melanoma.

Douguet, Laetitia / Bod, Lloyd / Labarthe, Laura / Lengagne, Renée / Kato, Masashi / Couillin, Isabelle / Prévost-Blondel, Armelle

Oncoimmunology

2018 Volume 7, Issue 9, Page(s) e1484979

Abstract: The high expression of inducible nitric oxide synthase (NOS2) by myeloid-derived suppressor cells (MDSCs) is a key mechanism of immune evasion in cancer. Recently we reported that NOS2 is also expressed by γδ T cells in melanoma, contributing to their ... ...

Abstract	The high expression of inducible nitric oxide synthase (NOS2) by myeloid-derived suppressor cells (MDSCs) is a key mechanism of immune evasion in cancer. Recently we reported that NOS2 is also expressed by γδ T cells in melanoma, contributing to their polarization towards a pro-tumor phenotype. The molecular mechanisms underlying regulation of NOS2 expression in tumor-induced γδ T cells remain unexplored. By using the model of mice transgenic for the ret oncogene (Ret mice) that develops a spontaneous metastatic melanoma, we evidence that interleukin (IL)-1β and IL-6 drive NOS2 expression in γδ T cells. Indeed, their
Language	English
Publishing date	2018-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2645309-5
ISSN	2162-402X ; 2162-4011
ISSN (online)	2162-402X
ISSN	2162-4011
DOI	10.1080/2162402X.2018.1484979
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: B-cell-specific checkpoint molecules that regulate anti-tumour immunity.

Bod, Lloyd / Kye, Yoon-Chul / Shi, Jingwen / Torlai Triglia, Elena / Schnell, Alexandra / Fessler, Johannes / Ostrowski, Stephen M / Von-Franque, Max Y / Kuchroo, Juhi R / Barilla, Rocky M / Zaghouani, Sarah / Christian, Elena / Delorey, Toni Marie / Mohib, Kanishka / Xiao, Sheng / Slingerland, Nadine / Giuliano, Christopher J / Ashenberg, Orr / Li, Zhaorong /

Rothstein, David M / Fisher, David E / Rozenblatt-Rosen, Orit / Sharpe, Arlene H / Quintana, Francisco J / Apetoh, Lionel / Regev, Aviv / Kuchroo, Vijay K

Nature

2023 Volume 619, Issue 7969, Page(s) 348–356

Abstract: The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour ... ...

Abstract	The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth
MeSH term(s)	Animals ; Mice ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Lymphocyte Activation ; Melanoma/immunology ; Melanoma/pathology ; Melanoma/prevention & control ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; Flow Cytometry ; Melanoma, Experimental/immunology ; Melanoma, Experimental/pathology ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Antigen Presentation ; Receptors, Antigen, B-Cell/genetics ; Single-Cell Gene Expression Analysis ; Tumor Burden ; Interferon Type I
Chemical Substances	Havcr1 protein, mouse ; Lag3 protein, mouse ; T cell Ig and ITIM domain protein, mouse ; Receptors, Antigen, B-Cell ; Interferon Type I
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06231-0
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy.

Revach, Or-Yam / Cicerchia, Angelina M / Shorer, Ofir / Petrova, Boryana / Anderson, Seth / Park, Joshua / Chen, Lee / Mehta, Arnav / Wright, Samuel J / McNamee, Niamh / Tal-Mason, Aya / Cattaneo, Giulia / Tiwari, Payal / Xie, Hongyan / Sweere, Johanna M / Cheng, Li-Chun / Sigal, Natalia / Enrico, Elizabeth / Miljkovic, Marisa /

Evans, Shane A / Nguyen, Ngan / Whidden, Mark E / Srinivasan, Ramji / Spitzer, Matthew H / Sun, Yi / Sharova, Tatyana / Lawless, Aleigha R / Michaud, William A / Rasmussen, Martin Q / Fang, Jacy / Palin, Claire A / Chen, Feng / Wang, Xinhui / Ferrone, Cristina R / Lawrence, Donald P / Sullivan, Ryan J / Liu, David / Sachdeva, Uma M / Sen, Debattama R / Flaherty, Keith T / Manguso, Robert T / Bod, Lloyd / Kellis, Manolis / Boland, Genevieve M / Yizhak, Keren / Yang, Jiekun / Kanarek, Naama / Sade-Feldman, Moshe / Hacohen, Nir / Jenkins, Russell W

bioRxiv : the preprint server for biology

2024

Abstract: A central problem in cancer immunotherapy with immune checkpoint blockade (ICB) is the development of resistance, which affects 50% of patients with metastatic ... ...

Abstract	A central problem in cancer immunotherapy with immune checkpoint blockade (ICB) is the development of resistance, which affects 50% of patients with metastatic melanoma
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.12.579184
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

Wagner, Allon / Wang, Chao / Fessler, Johannes / DeTomaso, David / Avila-Pacheco, Julian / Kaminski, James / Zaghouani, Sarah / Christian, Elena / Thakore, Pratiksha / Schellhaass, Brandon / Akama-Garren, Elliot / Pierce, Kerry / Singh, Vasundhara / Ron-Harel, Noga / Douglas, Vivian Paraskevi / Bod, Lloyd / Schnell, Alexandra / Puleston, Daniel / Sobel, Raymond A. /

Haigis, Marcia / Pearce, Erika L. / Soleimani, Manoocher / Clish, Clary / Regev, Aviv / Kuchroo, Vijay K. / Yosef, Nir

Cell. 2021 Aug. 05, v. 184, no. 16

2021

Abstract: Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA sequencing and ... ...

Abstract	Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA sequencing and flux balance analysis. We applied Compass to associate metabolic states with T helper 17 (Th17) functional variability (pathogenic potential) and recovered a metabolic switch between glycolysis and fatty acid oxidation, akin to known Th17/regulatory T cell (Treg) differences, which we validated by metabolic assays. Compass also predicted that Th17 pathogenicity was associated with arginine and downstream polyamine metabolism. Indeed, polyamine-related enzyme expression was enhanced in pathogenic Th17 and suppressed in Treg cells. Chemical and genetic perturbation of polyamine metabolism inhibited Th17 cytokines, promoted Foxp3 expression, and remodeled the transcriptome and epigenome of Th17 cells toward a Treg-like state. In vivo perturbations of the polyamine pathway altered the phenotype of encephalitogenic T cells and attenuated tissue inflammation in CNS autoimmunity.
Keywords	CD4-positive T-lymphocytes ; RNA ; algorithms ; arginine ; autoimmunity ; beta oxidation ; cytokines ; enzymes ; epigenome ; glycolysis ; inflammation ; pathogenicity ; phenotype ; polyamines ; transcriptome
Language	English
Dates of publication	2021-0805
Size	p. 4168-4185.e21.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.05.045
Database	NAL-Catalogue (AGRICOLA)

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