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  1. Book ; Thesis: Hypoxia-inducible factors inhibit NLRP3 inflammasome by decreasing the activity of Inhibitory-κB Kinase in the THP-1 monocytic cell line

    Zhao, Shuai / Bode, Christian

    2021  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Shuai Zhao ; 1. Gutachter: PD Dr. med. Christian Bode
    Language English
    Size 85 Seiten, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
    HBZ-ID HT021079146
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 D 315 order for loan Magazin

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  2. Book ; Thesis: Zur Geschichte der gerichtlichen Medizin an der Universität Jena im Zeitraum von 1901 bis 1945

    Bode, Christian

    2007  

    Author's details von Christian Bode
    Subject code 614.1
    Language German
    Size 144, XXVI S., Ill., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 2008 (Nicht für den Austausch)
    HBZ-ID HT016106943
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 E 178 order for loan Magazin

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  3. Article ; Online: Non-occlusive mesenteric ischemia and intra-arterial vasodilatory therapy in severe shock and multi-organ failure: treating the untreatable?

    Stahl, Klaus / Bode, Christian / David, Sascha

    Intensive care medicine

    2024  

    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07403-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Thesis: Insulin-like growth factor-II zur Diagnostik und Paclitaxel in kationischen Liposomen als neuer therapeutischer Ansatz beim Prostatakarzinom

    Bode, Christian Hans

    2006  

    Author's details vorgelegt von Christian Hans Bode
    Language German
    Size 86 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2006
    HBZ-ID HT015206707
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 E 1207 order for loan Magazin

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  5. Article ; Online: EXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock-a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial.

    David, Sascha / Bode, Christian / Stahl, Klaus

    Trials

    2023  Volume 24, Issue 1, Page(s) 277

    Abstract: Background: Sepsis is as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. The mortality of sepsis and particular of septic shock is very high. Treatment mostly focuses on infection control but a specific ... ...

    Abstract Background: Sepsis is as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. The mortality of sepsis and particular of septic shock is very high. Treatment mostly focuses on infection control but a specific intervention that targets the underlying pathological host response is lacking to the present time. The investigators hypothesize that early therapeutic plasma exchange (TPE) will dampen the maladaptive host response by removing injurious mediators thereby limiting organ dysfunction and improving survival in patients with septic shock. Although small prospective studies demonstrated rapid hemodynamic stabilization under TPE, no adequately powered randomized clinical trial has investigated hard outcomes.
    Methods: This is a randomized, prospective, multicenter, open-label, controlled, parallel-group interventional trial to test the adjunctive effect of TPE in patients with early septic shock. Patients with a refractory (defined as norepinephrine (NE) ≥ 0.4 μg/kg/min ≥ 30 min OR NE 0.3 μg/kg/min + vasopressin) and early (shock onset < 24 h) septic shock will be included. The intervention is a standard TPE with donor fresh frozen plasma (1.2 × individual plasma volume) performed within 6 h after randomization and will be compared to a standard of care (SOC) control arm. The primary endpoint is 28 days mortality for which the power analysis revealed a group size of 137 / arm (n = 274) to demonstrate a benefit of 15%. The key secondary objective will be to compare the extent of organ failure indicated by mean SOFA over the first 7 days as well as organ support-free days until day 28 following randomization. Besides numerous biological secondary, safety endpoints such as incidence of bleeding, allergic reactions, transfusion associated lung injury, severe thrombocytopenia, and other severe adverse events will be assessed during the first 7 days. For exploratory scientific analyses, biomaterial will be acquired longitudinally and multiple predefined scientific subprojects are planned. This study is an investigator-initiated trial supported by the German Research Foundation (DFG, DA 1209/7-1), in which 26 different centers in Germany, Switzerland, and Austria will participate over a duration of 33 months.
    Discussion: This trial has substantial clinical relevance as it evaluates a promising adjunctive treatment option in refractory septic shock patients suffering from an extraordinary high mortality. A positive trial result could change the current standard of care for this septic subgroup. The results of this study will be disseminated through presentations at international congresses, workshops, and peer-reviewed publications.
    Trial registration: ClinicalTrials.gov NCT05726825 , Registered on 14 February 2023.
    MeSH term(s) Humans ; Shock, Septic/diagnosis ; Shock, Septic/therapy ; Plasma Exchange/adverse effects ; Prospective Studies ; Multiple Organ Failure/therapy ; Sepsis ; Norepinephrine ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
    Chemical Substances Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2023-04-15
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07300-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bridging patients with acute-on-chronic liver failure for transplantation: plasma exchange to stabilize multiorgan failure?

    Stahl, Klaus / Bode, Christian / David, Sascha

    Intensive care medicine

    2023  Volume 49, Issue 7, Page(s) 890–891

    MeSH term(s) Humans ; Plasma Exchange ; Acute-On-Chronic Liver Failure/therapy ; Multiple Organ Failure/therapy ; Plasmapheresis
    Language English
    Publishing date 2023-05-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07092-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Letter to the Editor: Innovative future concepts of extracorporeal strategies in sepsis and septic shock.

    Stahl, Klaus / Bode, Christian / David, Sascha

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 121

    MeSH term(s) Humans ; Shock, Septic/therapy ; Sepsis/therapy ; Extracorporeal Membrane Oxygenation
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04408-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Thesis: Der Maligne Müllersche Mischtumor

    Bode, Christian

    Kasuistik eines homologen und drei heterologer Karzinosarkome unter Berücksichtigung immunhistochemischer Befunde mit Literaturübersicht

    1998  

    Author's details vorgelegt von Christian Bode
    Language German
    Size 57 Bl. : Ill.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg i. Br., Univ., Diss., 1999
    HBZ-ID HT012806612
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2000 MB 282 order for loan Magazin

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  9. Article: Current clinical practice in using adjunctive extracorporeal blood purification in sepsis and septic shock: results from the ESICM "EXPLORATION" survey.

    Stahl, Klaus / Bode, Christian / Seeliger, Benjamin / Wendel-Garcia, Pedro David / David, Sascha

    Intensive care medicine experimental

    2024  Volume 12, Issue 1, Page(s) 5

    Abstract: Background: Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis and believes in both efficacy and ...

    Abstract Background: Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis and believes in both efficacy and level of evidence are very heterogeneous.
    Methods: The "EXPLORATION" (Current Clinical Practice in using adjunctive extracorporeal blood purification in septic shock), a web-based survey endorsed by the European Society of Intensive Care Medicine (ESICM), questioned both the current local clinical practices as well as future perspectives of EBP in sepsis and septic shock.
    Results: One hundred and two people participated in the survey. The majority of three quarters of participants (74.5%) use adjunctive EBP in their clinical routine with a varying frequency of description. Unselective cytokine adsorption (CA) (37.5%) and therapeutic plasma exchange (TPE) (34.1%) were by far the most commonly used modalities. While the overall theoretical rational was found to be moderate to high by the majority of the participants (74%), the effectively existing clinical evidence was acknowledged to be rather low (66%). Although CA was used most frequently in clinical practice, both the best existing clinical evidence endorsing its current use (45%) as well the highest potential to be explored in future clinical trials (51.5%) was attributed to TPE.
    Conclusions: Although the majority of participants use EBP techniques in their clinical practice and acknowledge a subjective good theoretical rationale behind it, the clinical evidence is assessed to be limited. While both CA and TPE are by far the most common used technique, both clinical evidence as well as future potential for further exploration in clinical trials was assessed to be the highest for TPE.
    Language English
    Publishing date 2024-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-023-00592-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: "Dosis sola facit venenum"-Evidence for causality in the association between ketamine and cholestatic liver injury.

    Wendel-Garcia, Pedro David / Andermatt, Rea / Bode, Christian / David, Sascha / Stahl, Klaus

    Hepatology international

    2024  

    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-024-10646-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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