LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 58

Search options

  1. Article ; Online: Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis.

    Humeau, Mélanie / Boniface, Katia / Bodet, Charles

    Frontiers in immunology

    2022  Volume 13, Page(s) 801579

    Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction, dysregulated immune response, and dysbiosis with ... ...

    Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction, dysregulated immune response, and dysbiosis with increased
    MeSH term(s) Cytokines ; Dermatitis, Atopic ; Humans ; Keratinocytes ; Staphylococcal Infections/pathology ; Staphylococcus aureus
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.801579
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The Antiviral Activities of Poly-ADP-Ribose Polymerases.

    Malgras, Mathilde / Garcia, Magali / Jousselin, Clément / Bodet, Charles / Lévêque, Nicolas

    Viruses

    2021  Volume 13, Issue 4

    Abstract: The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of ... ...

    Abstract The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of translation and cell death. In addition to these physiological functions, recent studies have highlighted the role of PARPs in host defenses against viruses, either by direct antiviral activity, targeting certain steps of virus replication cycle, or indirect antiviral activity, via modulation of the innate immune response. This review focuses on the antiviral activity of PARPs, as well as strategies developed by viruses to escape their action.
    MeSH term(s) ADP-Ribosylation/genetics ; ADP-Ribosylation/physiology ; Cell Death ; Host Microbial Interactions/genetics ; Host Microbial Interactions/immunology ; Humans ; Immunity, Innate ; Immunomodulation ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/immunology ; Protein Processing, Post-Translational ; Viruses/genetics ; Viruses/immunology
    Chemical Substances Poly(ADP-ribose) Polymerases (EC 2.4.2.30)
    Language English
    Publishing date 2021-03-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13040582
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Skin tropism during Usutu virus and West Nile virus infection: an amplifying and immunological role.

    Vouillon, Axelle / Barthelemy, Jonathan / Lebeau, Lucie / Nisole, Sébastien / Savini, Giovanni / Lévêque, Nicolas / Simonin, Yannick / Garcia, Magali / Bodet, Charles

    Journal of virology

    2023  Volume 98, Issue 1, Page(s) e0183023

    Abstract: Usutu virus (USUV) and West Nile virus (WNV) are closely related emerging arboviruses belonging to ... ...

    Abstract Usutu virus (USUV) and West Nile virus (WNV) are closely related emerging arboviruses belonging to the
    MeSH term(s) Animals ; Humans ; Mice ; Antiviral Agents ; Culicidae ; Flavivirus ; Flavivirus Infections/virology ; Interferons ; West Nile Fever/virology ; West Nile virus ; Skin/immunology ; Skin/pathology ; Skin/virology ; Viral Tropism ; In Vitro Techniques
    Chemical Substances Antiviral Agents ; Interferons (9008-11-1)
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01830-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Anti-SARS-CoV-2 Activity of Polysaccharides Extracted from

    Jousselin, Clément / Pliego-Cortés, Hugo / Damour, Alexia / Garcia, Magali / Bodet, Charles / Robledo, Daniel / Bourgougnon, Nathalie / Lévêque, Nicolas

    Marine drugs

    2023  Volume 21, Issue 6

    Abstract: Even after hundreds of clinical trials, the search for new antivirals to treat COVID-19 is still relevant. Carrageenans are seaweed sulfated polysaccharides displaying antiviral activity against a wide range of respiratory viruses. The objective of this ... ...

    Abstract Even after hundreds of clinical trials, the search for new antivirals to treat COVID-19 is still relevant. Carrageenans are seaweed sulfated polysaccharides displaying antiviral activity against a wide range of respiratory viruses. The objective of this work was to study the antiviral properties of
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Rhodophyta ; Polysaccharides/pharmacology ; Carrageenan/pharmacology ; Antiviral Agents/pharmacology
    Chemical Substances Polysaccharides ; Carrageenan (9000-07-1) ; Antiviral Agents
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21060348
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Antibiofilm Activity of Invasive Plants against Candida albicans: Focus on Baccharis halimifolia Essential Oil and Its Compounds.

    Desrini, Sufi / Ducloux, Julien / Hamion, Guillaume / Bodet, Charles / Labanowski, Jérome / Mustofa, Mustofa / Nuryastuti, Titik / Imbert, Christine / Girardot, Marion

    Chemistry & biodiversity

    2023  Volume 20, Issue 8, Page(s) e202300130

    Abstract: The extracts of five invasive plants were investigated for antifungal and antibiofilm activities against Candida albicans, C. glabrata, C. krusei, and C. parapsilosis. The antifungal activity was evaluated using the microdilution assay and the ... ...

    Abstract The extracts of five invasive plants were investigated for antifungal and antibiofilm activities against Candida albicans, C. glabrata, C. krusei, and C. parapsilosis. The antifungal activity was evaluated using the microdilution assay and the antibiofilm effect by measurement of the metabolic activity. Ethanol and ethanol-water extracts of Reynoutria japonica leaves inhibited 50 % of planktonic cells at 250 μg mL
    MeSH term(s) Candida albicans ; Antifungal Agents/pharmacology ; Oils, Volatile/pharmacology ; Baccharis ; Ethanol/pharmacology ; Biofilms ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Oils, Volatile ; caryophyllene oxide (S2XU9K448U) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202300130
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: The Antiviral Activities of Poly-ADP-Ribose Polymerases

    Malgras, Mathilde / Garcia, Magali / Jousselin, Clément / Bodet, Charles / Lévêque, Nicolas

    Viruses. 2021 Mar. 30, v. 13, no. 4

    2021  

    Abstract: The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of ... ...

    Abstract The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of translation and cell death. In addition to these physiological functions, recent studies have highlighted the role of PARPs in host defenses against viruses, either by direct antiviral activity, targeting certain steps of virus replication cycle, or indirect antiviral activity, via modulation of the innate immune response. This review focuses on the antiviral activity of PARPs, as well as strategies developed by viruses to escape their action.
    Keywords DNA repair ; antiviral properties ; cell death ; chromatin ; innate immunity ; post-translational modification ; virus replication
    Language English
    Dates of publication 2021-0330
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13040582
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Antiviral Effect of hBD-3 and LL-37 during Human Primary Keratinocyte Infection with West Nile Virus

    Chessa, Céline / Bodet, Charles / Jousselin, Clément / Larivière, Andy / Damour, Alexia / Garnier, Julien / Lévêque, Nicolas / Garcia, Magali

    Viruses. 2022 July 15, v. 14, no. 7

    2022  

    Abstract: West Nile virus (WNV) is an emerging flavivirus transmitted through mosquito bites and responsible for a wide range of clinical manifestations. Following their inoculation within the skin, flaviviruses replicate in keratinocytes of the epidermis, ... ...

    Abstract West Nile virus (WNV) is an emerging flavivirus transmitted through mosquito bites and responsible for a wide range of clinical manifestations. Following their inoculation within the skin, flaviviruses replicate in keratinocytes of the epidermis, inducing an innate immune response including the production of antimicrobial peptides (AMPs). Among them, the cathelicidin LL-37 and the human beta-defensin (hBD)-3 are known for their antimicrobial and immunomodulatory properties. We assessed their role during WNV infection of human primary keratinocytes. LL-37 reduced the viral load in the supernatant of infected keratinocytes and of the titer of a viral inoculum incubated in the presence of the peptide, suggesting a direct antiviral effect of this AMP. Conversely, WNV replication was not inhibited by hBD-3. The two peptides then demonstrated immunomodulatory properties whether in the context of keratinocyte stimulation by poly(I:C) or infection by WNV, but not alone. This study demonstrates the immunostimulatory properties of these two skin AMPs at the initial site of WNV replication and the ability of LL-37 to directly inactivate West Nile viral infectious particles. The results provide new information on the multiple functions of these two peptides and underline the potential of AMPs as new antiviral strategies in the fight against flaviviral infections.
    Keywords Culicidae ; West Nile virus ; antiviral properties ; cathelicidins ; humans ; immunostimulants ; innate immunity ; inoculum ; keratinocytes ; viral load
    Language English
    Dates of publication 2022-0715
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14071552
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Eczema Herpeticum: Clinical and Pathophysiological Aspects.

    Damour, Alexia / Garcia, Magali / Seneschal, Julien / Lévêque, Nicolas / Bodet, Charles

    Clinical reviews in allergy & immunology

    2020  Volume 59, Issue 1, Page(s) 1–18

    Abstract: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the world. AD is a complex pathology mainly characterized by an impaired skin barrier, immune response dysfunction, and unbalanced skin microbiota. Moreover, AD patients ... ...

    Abstract Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the world. AD is a complex pathology mainly characterized by an impaired skin barrier, immune response dysfunction, and unbalanced skin microbiota. Moreover, AD patients exhibit an increased risk of developing bacterial and viral infections. One of the most current, and potentially life-threatening, viral infection is caused by herpes simplex virus (HSV), which occurs in about 3% of AD patients under the name of eczema herpeticum (EH). Following a first part dedicated to the clinical features, virological diagnosis, and current treatments of EH, this review will focus on the description of the pathophysiology and, more particularly, the presently known predisposing factors to herpetic complications in AD patients. These factors include those related to impairment of the skin barrier such as deficit in filaggrin and anomalies in tight and adherens junctions. In addition, low production of the antimicrobial peptides cathelicidin LL-37 and human β-defensins; overexpression of cytokines such as interleukin (IL)-4, IL-13, IL-25, IL-33, and thymic stromal lymphopoietin (TSLP); or downregulation of type I to III interferons as well as defect in functions of immune cells such as dendritic, natural killer, and regulatory T cells have been involved. Otherwise, genetic polymorphisms and AD topical calcineurin inhibitor treatments have been associated with an increased risk of EH. Finally, dysbiosis of skin microbiota characterized in AD patients by Staphylococcus aureus colonization and toxin secretion, such as α-toxin, has been described as promoting HSV replication and could therefore contribute to EH.
    MeSH term(s) Dermatitis, Atopic/immunology ; Disease Susceptibility ; Dysbiosis/immunology ; Herpesviridae Infections/immunology ; Humans ; Kaposi Varicelliform Eruption/immunology ; Microbiota/immunology ; Simplexvirus/physiology ; Skin/pathology
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1239045-8
    ISSN 1559-0267 ; 1080-0549
    ISSN (online) 1559-0267
    ISSN 1080-0549
    DOI 10.1007/s12016-019-08768-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1844: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Antiviral Effect of hBD-3 and LL-37 during Human Primary Keratinocyte Infection with West Nile Virus.

    Chessa, Céline / Bodet, Charles / Jousselin, Clément / Larivière, Andy / Damour, Alexia / Garnier, Julien / Lévêque, Nicolas / Garcia, Magali

    Viruses

    2022  Volume 14, Issue 7

    Abstract: West Nile virus (WNV) is an emerging flavivirus transmitted through mosquito bites and responsible for a wide range of clinical manifestations. Following their inoculation within the skin, flaviviruses replicate in keratinocytes of the epidermis, ... ...

    Abstract West Nile virus (WNV) is an emerging flavivirus transmitted through mosquito bites and responsible for a wide range of clinical manifestations. Following their inoculation within the skin, flaviviruses replicate in keratinocytes of the epidermis, inducing an innate immune response including the production of antimicrobial peptides (AMPs). Among them, the cathelicidin LL-37 and the human beta-defensin (hBD)-3 are known for their antimicrobial and immunomodulatory properties. We assessed their role during WNV infection of human primary keratinocytes. LL-37 reduced the viral load in the supernatant of infected keratinocytes and of the titer of a viral inoculum incubated in the presence of the peptide, suggesting a direct antiviral effect of this AMP. Conversely, WNV replication was not inhibited by hBD-3. The two peptides then demonstrated immunomodulatory properties whether in the context of keratinocyte stimulation by poly(I:C) or infection by WNV, but not alone. This study demonstrates the immunostimulatory properties of these two skin AMPs at the initial site of WNV replication and the ability of LL-37 to directly inactivate West Nile viral infectious particles. The results provide new information on the multiple functions of these two peptides and underline the potential of AMPs as new antiviral strategies in the fight against flaviviral infections.
    MeSH term(s) Antiviral Restriction Factors/immunology ; Cathelicidins/immunology ; Humans ; Keratinocytes/virology ; West Nile Fever/immunology ; West Nile virus ; beta-Defensins/immunology
    Chemical Substances Antiviral Restriction Factors ; CAMP protein, human ; Cathelicidins ; beta-Defensins
    Language English
    Publishing date 2022-07-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14071552
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes.

    Chessa, Céline / Bodet, Charles / Jousselin, Clément / Wehbe, Michel / Lévêque, Nicolas / Garcia, Magali

    Frontiers in microbiology

    2020  Volume 11, Page(s) 1155

    Abstract: Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the first line of defense against many viruses such as arboviruses, enteroviruses, herpes viruses, human papillomaviruses, or vaccinia virus. During viral ... ...

    Abstract Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the first line of defense against many viruses such as arboviruses, enteroviruses, herpes viruses, human papillomaviruses, or vaccinia virus. During viral replication, these cells can sense virus associated molecular patterns leading to the initiation of an innate immune response composed of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. Human keratinocytes produce and secrete at least nine antimicrobial peptides: human cathelicidin LL-37, types 1-4 human β-defensins, S100 peptides such as psoriasin (S100A7), calprotectin (S100A8/9) and koebnerisin (S100A15), and RNase 7. These peptides can exert direct antiviral effects on the viral particle or its replication cycle, and indirect antiviral activity, by modulating the host immune response. The purpose of this review is to summarize current knowledge of antiviral and immunomodulatory properties of human keratinocyte antimicrobial peptides.
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.01155
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top