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Article ; Online: Management of coronavirus disease-2019 (COVID-19) in patients with diabetes

Bodhini, Dhanasekaran / Mohan, Viswanathan

2020 Volume 11, Issue 3, Page(s) 125

Keywords	covid19
Language	English
Publisher	Medknow
Publishing country	in
Document type	Article ; Online
ZDB-ID	2573347-3
ISSN	2078-7685
ISSN	2078-7685
DOI	10.4103/jod.jod_67_20
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mediators of insulin resistance & cardiometabolic risk: Newer insights.

Bodhini, Dhanasekaran / Mohan, Viswanathan

The Indian journal of medical research

2018 Volume 148, Issue 2, Page(s) 127–129

MeSH term(s)	Blood Glucose ; Cardiovascular Diseases ; Humans ; Insulin Resistance ; Metabolic Syndrome ; Obesity ; Risk Factors
Chemical Substances	Blood Glucose
Language	English
Publishing date	2018-10-31
Publishing country	India
Document type	Journal Article ; Comment
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/ijmr.IJMR_969_18
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes: a systematic review.

Bodhini, Dhanasekaran / Morton, Robert W / Santhakumar, Vanessa / Nakabuye, Mariam / Pomares-Millan, Hugo / Clemmensen, Christoffer / Fitzpatrick, Stephanie L / Guasch-Ferre, Marta / Pankow, James S / Ried-Larsen, Mathias / Franks, Paul W / Tobias, Deirdre K / Merino, Jordi / Mohan, Viswanathan / Loos, Ruth J F

medRxiv : the preprint server for health sciences

2023

Abstract: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a ... ...

Abstract	The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular characteristics modify the efficacy of dietary or lifestyle interventions to prevent T2D. Among the 80 publications that met our criteria for inclusion, the evidence was low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. We found evidence, albeit low certainty, to support conclusions that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
Language	English
Publishing date	2023-05-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.03.23289433
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review.

Communications medicine

2023 Volume 3, Issue 1, Page(s) 133

Abstract: Background: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We ... ...

Abstract	Background: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. Methods: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. We extracted relevant statistical findings and qualitatively synthesized the evidence for each modifier based on the direction of findings reported in available studies. We used the Diabetes Canada Clinical Practice Scale to assess the certainty of the evidence for a given effect modifier. Results: The 81 publications that met our criteria for inclusion are from 33 unique trials. The evidence is low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. Conclusions: We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ISSN	2730-664X
ISSN (online)	2730-664X
DOI	10.1038/s43856-023-00363-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Association study of the ABCC8 gene variants with type 2 diabetes in south Indians.

Venkatesan, Radha / Bodhini, Dhanasekaran / Narayani, Nagarajan / Mohan, Viswanathan

Indian journal of human genetics

2014 Volume 20, Issue 1, Page(s) 37–42

Abstract: Background: The ABCC8 gene which encodes the sulfonylurea receptor plays a major role in insulin secretion and is a potential candidate for type 2 diabetes. The -3c → t (rs1799854) and Thr759Thr (C → T, rs1801261) single nucleotide polymorphisms (SNPs) ... ...

Abstract	Background: The ABCC8 gene which encodes the sulfonylurea receptor plays a major role in insulin secretion and is a potential candidate for type 2 diabetes. The -3c → t (rs1799854) and Thr759Thr (C → T, rs1801261) single nucleotide polymorphisms (SNPs) of the ABCC8 gene have been associated with type 2 diabetes in many populations. The present study was designed to investigate the association of these two SNPs in an Asian Indian population from south India. Materials and methods: A total of 1,300 subjects, 663 normal glucose tolerant (NGT) and 637 type 2 diabetic subjects were randomly selected from the Chennai Urban Rural Epidemiology Study (CURES). The -3c → t and Thr759Thr were genotyped in these subjects using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and a few variants were confirmed by direct sequencing. Results: The frequency of the 't' allele of the -3c → t SNP was found to be 0.27 in NGT and 0.29 in type 2 diabetic subjects (P = 0.44). There was no significant difference in the genotypic frequency between the NGT and type 2 diabetic group (P = 0.18). Neither the genotypic frequency nor the allele frequency of the Thr759Thr polymorphism was found to differ significantly between the NGT and type 2 diabetic groups. Conclusion: The -3c → t and the Thr759Thr polymorphisms of the ABCC8 gene were not associated with type 2 diabetes in this study. However, an effect of these genetic variants on specific unidentified sub groups of type 2 diabetes cannot be excluded.
Language	English
Publishing date	2014-05-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2109167-5
ISSN	1998-362X ; 0971-6866
ISSN (online)	1998-362X
ISSN	0971-6866
DOI	10.4103/0971-6866.132752
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lower Dietary Intake of Plant Protein Is Associated with Genetic Risk of Diabetes-Related Traits in Urban Asian Indian Adults

Alsulami, Sooad / Bodhini, Dhanasekaran / Sudha, Vasudevan / Shanthi Rani, Coimbatore Subramanian / Pradeepa, Rajendra / Anjana, Ranjit Mohan / Radha, Venkatesan / Lovegrove, Julie A. / Gayathri, Rajagopal / Mohan, Viswanathan / Vimaleswaran, Karani Santhanakrishnan

Nutrients. 2021 Aug. 31, v. 13, no. 9

2021

Abstract: The increasing prevalence of type 2 diabetes among South Asians is caused by a complex interplay between environmental and genetic factors. We aimed to examine the impact of dietary and genetic factors on metabolic traits in 1062 Asian Indians. Dietary ... ...

Abstract	The increasing prevalence of type 2 diabetes among South Asians is caused by a complex interplay between environmental and genetic factors. We aimed to examine the impact of dietary and genetic factors on metabolic traits in 1062 Asian Indians. Dietary assessment was performed using a validated semi-quantitative food frequency questionnaire. Seven single nucleotide polymorphisms (SNPs) from the Transcription factor 7-like 2 and fat mass and obesity-associated genes were used to construct two metabolic genetic risk scores (GRS): 7-SNP and 3-SNP GRSs. Both 7-SNP GRS and 3-SNP GRS were associated with a higher risk of T2D (p = 0.0000134 and 0.008, respectively). The 3-SNP GRS was associated with higher waist circumference (p = 0.010), fasting plasma glucose (FPG) (p = 0.002) and glycated haemoglobin (HbA1c) (p = 0.000066). There were significant interactions between 3-SNP GRS and protein intake (% of total energy intake) on FPG (Pᵢₙₜₑᵣₐcₜᵢₒₙ = 0.011) and HbA1c (Pᵢₙₜₑᵣₐcₜᵢₒₙ = 0.007), where among individuals with lower plant protein intake (<39 g/day) and those with >1 risk allele had higher FPG (p = 0.001) and HbA1c (p = 0.00006) than individuals with ≤1 risk allele. Our findings suggest that lower plant protein intake may be a contributor to the increased ethnic susceptibility to diabetes described in Asian Indians. Randomised clinical trials with increased plant protein in the diets of this population are needed to see whether the reduction of diabetes risk occurs in individuals with prediabetes.
Keywords	alleles ; blood glucose ; energy intake ; food frequency questionnaires ; food intake ; hemoglobin ; noninsulin-dependent diabetes mellitus ; nutrition assessment ; plant proteins ; protein intake ; risk ; transcription factors ; waist circumference
Language	English
Dates of publication	2021-0831
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13093064
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Circulating adiponectin mediates the association between omentin gene polymorphism and cardiometabolic health in Asian Indians.

Vimaleswaran, Karani Santhanakrishnan / Bodhini, Dhanasekaran / Jiang, Juanjie / Ramya, Kandaswamy / Mohan, Deepa / Shanthi Rani, Coimbatore Subramanian / Lakshmipriya, Nagarajan / Sudha, Vasudevan / Pradeepa, Rajendra / Anjana, Ranjit Mohan / Mohan, Viswanathan / Radha, Venkatesan

PloS one

2021 Volume 16, Issue 5, Page(s) e0238555

Abstract: Background: Plasma omentin levels have been shown to be associated with circulating adiponectin concentrations and cardiometabolic disease-related outcomes. In this study, we aim to examine the association of omentin gene polymorphism with serum ... ...

Abstract	Background: Plasma omentin levels have been shown to be associated with circulating adiponectin concentrations and cardiometabolic disease-related outcomes. In this study, we aim to examine the association of omentin gene polymorphism with serum adiponectin levels and cardiometabolic health status using a genetic approach, and investigate whether these associations are modified by lifestyle factors. Methods: The study included 945 normal glucose tolerant and 941 unrelated individuals with type 2 diabetes randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), in southern India. Study participants were classified into cardiometabolically healthy and unhealthy, where cardiometabolically healthy were those without hypertension, diabetes, and dyslipidemia. Fasting serum adiponectin levels were measured by radioimmunoassay. The omentin A326T (rs2274907) single nucleotide polymorphism (SNP) was screened by polymerase chain reaction-restriction fragment length polymorphism and direct sequencing. Results: The 'A' allele of the omentin SNP was significantly associated with lower adiponectin concentrations after adjusting for age, sex, body mass index (BMI), waist circumference (WC) and cardiometabolic health status (p = 1.90 x 10-47). There was also a significant association between circulating adiponectin concentrations and cardiometabolic health status after adjusting for age, sex, BMI, WC and Omentin SNP (p = 7.47x10-10). However, after adjusting for age, sex, BMI, WC and adiponectin levels, the association of 'A' allele with cardiometabolic health status disappeared (p = 0.79) suggesting that adiponectin serves as a mediator of the association between omentin SNP and cardiometabolic health status. There were no significant interactions between the SNP and dietary factors on adiponectin levels and cardiometabolic health status (p>0.25, for all comparisons). Conclusions: Our findings show that adiponectin might function as a mechanistic link between omentin SNP and increased risk of cardiometabolic diseases independent of common and central obesity in Asian Indians. Before strategies to promote adiponectin modulation could be implemented, further studies are required to confirm the molecular mechanisms involved in this triangular relationship between omentin gene, adiponectin and cardiometabolic diseases.
MeSH term(s)	Adiponectin/blood ; Adult ; Blood Glucose/metabolism ; Body Mass Index ; Cytokines/blood ; Cytokines/genetics ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/genetics ; Female ; GPI-Linked Proteins/blood ; GPI-Linked Proteins/genetics ; Genotyping Techniques ; Humans ; Lectins/blood ; Lectins/genetics ; Male ; Middle Aged ; Polymorphism, Restriction Fragment Length/genetics ; Polymorphism, Single Nucleotide/genetics ; Young Adult
Chemical Substances	Adiponectin ; Blood Glucose ; Cytokines ; GPI-Linked Proteins ; ITLN1 protein, human ; Lectins
Language	English
Publishing date	2021-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0238555
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lower Dietary Intake of Plant Protein Is Associated with Genetic Risk of Diabetes-Related Traits in Urban Asian Indian Adults.

Alsulami, Sooad / Bodhini, Dhanasekaran / Sudha, Vasudevan / Shanthi Rani, Coimbatore Subramanian / Pradeepa, Rajendra / Anjana, Ranjit Mohan / Radha, Venkatesan / Lovegrove, Julie A / Gayathri, Rajagopal / Mohan, Viswanathan / Vimaleswaran, Karani Santhanakrishnan

Nutrients

2021 Volume 13, Issue 9

Abstract	The increasing prevalence of type 2 diabetes among South Asians is caused by a complex interplay between environmental and genetic factors. We aimed to examine the impact of dietary and genetic factors on metabolic traits in 1062 Asian Indians. Dietary assessment was performed using a validated semi-quantitative food frequency questionnaire. Seven single nucleotide polymorphisms (SNPs) from the Transcription factor 7-like 2 and fat mass and obesity-associated genes were used to construct two metabolic genetic risk scores (GRS): 7-SNP and 3-SNP GRSs. Both 7-SNP GRS and 3-SNP GRS were associated with a higher risk of T2D (
MeSH term(s)	Adult ; Asian People/statistics & numerical data ; Diabetes Mellitus, Type 2/epidemiology ; Diet/methods ; Female ; Genetic Predisposition to Disease/epidemiology ; Humans ; India/epidemiology ; Male ; Middle Aged ; Plant Proteins/administration & dosage ; Polymorphism, Single Nucleotide/genetics ; Risk ; Urban Population/statistics & numerical data
Chemical Substances	Plant Proteins
Language	English
Publishing date	2021-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13093064
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Nutrigenetic Approach to Investigate the Relationship between Metabolic Traits and Vitamin D Status in an Asian Indian Population

Alathari, Buthaina E / Bodhini, Dhanasekaran / Jayashri, Ramamoorthy / Lakshmipriya, Nagarajan / Shanthi Rani, Coimbatore Subramanian / Sudha, Vasudevan / Lovegrove, Julie A / Anjana, Ranjit Mohan / Mohan, Viswanathan / Radha, Venkatesan / Pradeepa, Rajendra / Vimaleswaran, Karani S

Nutrients. 2020 May 09, v. 12, no. 5

2020

Abstract: Studies in Asian Indians have examined the association of metabolic traits with vitamin D status. However, findings have been quite inconsistent. Hence, we aimed to explore the relationship between metabolic traits and 25-hydroxyvitamin D [25(OH)D] ... ...

Abstract	Studies in Asian Indians have examined the association of metabolic traits with vitamin D status. However, findings have been quite inconsistent. Hence, we aimed to explore the relationship between metabolic traits and 25-hydroxyvitamin D [25(OH)D] concentrations. We investigate whether this relationship was modified by lifestyle factors using a nutrigenetic approach in 545 Asian Indians randomly selected from the Chennai Urban Rural Epidemiology Study (219 normal glucose tolerant individuals, 151 with pre-diabetes and 175 individuals with type 2 diabetes). A metabolic genetic risk score (GRS) was developed using five common metabolic disease-related genetic variants. There was a significant interaction between metabolic GRS and carbohydrate intake (energy%) on 25(OH)D (Pᵢₙₜₑᵣₐcₜᵢₒₙ = 0.047). Individuals consuming a low carbohydrate diet (≤62%) and those having lesser number of metabolic risk alleles (GRS ≤ 1) had significantly higher levels of 25(OH)D (p = 0.033). Conversely, individuals consuming a high carbohydrate diet despite having lesser number of risk alleles did not show a significant increase in 25(OH)D (p = 0.662). In summary, our findings show that individuals carrying a smaller number of metabolic risk alleles are likely to have higher 25(OH)D levels if they consume a low carbohydrate diet. These data support the current dietary carbohydrate recommendations of 50%–60% energy suggesting that reduced metabolic genetic risk increases 25(OH)D.
Keywords	Asian Indians ; alleles ; carbohydrate intake ; dietary carbohydrate ; energy ; epidemiology ; genetic variation ; glucose ; high carbohydrate diet ; lifestyle ; low carbohydrate diet ; noninsulin-dependent diabetes mellitus ; nutrients ; population ; risk ; vitamin status ; India
Language	English
Dates of publication	2020-0509
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12051357
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Nutrigenetic Approach to Investigate the Relationship between Metabolic Traits and Vitamin D Status in an Asian Indian Population.

Nutrients

2020 Volume 12, Issue 5

Abstract	Studies in Asian Indians have examined the association of metabolic traits with vitamin D status. However, findings have been quite inconsistent. Hence, we aimed to explore the relationship between metabolic traits and 25-hydroxyvitamin D [25(OH)D] concentrations. We investigate whether this relationship was modified by lifestyle factors using a nutrigenetic approach in 545 Asian Indians randomly selected from the Chennai Urban Rural Epidemiology Study (219 normal glucose tolerant individuals, 151 with pre-diabetes and 175 individuals with type 2 diabetes). A metabolic genetic risk score (GRS) was developed using five common metabolic disease-related genetic variants. There was a significant interaction between metabolic GRS and carbohydrate intake (energy%) on 25(OH)D (P
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Alleles ; Asian People ; Body Composition ; Body Constitution ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Diet, Carbohydrate-Restricted ; Dietary Carbohydrates/administration & dosage ; Eating/physiology ; Exercise ; Female ; Genetic Variation ; Humans ; India ; Life Style ; Male ; Middle Aged ; Nutrigenomics ; Prediabetic State/genetics ; Prediabetic State/metabolism ; Risk Factors ; Vitamin D/analogs & derivatives ; Vitamin D/metabolism
Chemical Substances	Dietary Carbohydrates ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2020-05-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12051357
Database	MEDical Literature Analysis and Retrieval System OnLINE

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