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  1. Article ; Online: Viremia and HIV Drug Resistance Among People Receiving Dolutegravir Versus Efavirenz-Based First-Line Antiretroviral Therapy.

    Dorward, Jienchi / Sookrajh, Yukteshwar / Lessells, Richard / Bulo, Elliot / Bodley, Nicola / Singh, Lavanya / Moodley, Pravikrishnen / Samsunder, Natasha / Drain, Paul K / Hayward, Gail / Butler, Christopher C / Garrett, Nigel

    Journal of acquired immune deficiency syndromes (1999)

    2024  Volume 95, Issue 5, Page(s) e8–e11

    MeSH term(s) Humans ; Viremia/drug therapy ; HIV Infections/drug therapy ; Oxazines/therapeutic use ; Benzoxazines/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Pyridones/therapeutic use ; Anti-HIV Agents/therapeutic use ; Alkynes ; Cyclopropanes ; Piperazines
    Chemical Substances dolutegravir (DKO1W9H7M1) ; efavirenz (JE6H2O27P8) ; Oxazines ; Benzoxazines ; Anti-Retroviral Agents ; Heterocyclic Compounds, 3-Ring ; Pyridones ; Anti-HIV Agents ; Alkynes ; Cyclopropanes ; Piperazines
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Diagnostic Accuracy of the Alere Afinion AS100 Point-of-Care Assay to Screen for Noncommunicable Diseases Among People Living With HIV.

    Bodley, Nicola / Dorward, Jienchi / Naidoo, Jessica / Letsoalo, Marothi / Ramsaroop, Kaminee / Sayed, Fathima / Sookrajh, Yukteshwar / Drain, Paul K / Garrett, Nigel

    Journal of acquired immune deficiency syndromes (1999)

    2022  Volume 92, Issue 1, Page(s) e1–e3

    MeSH term(s) Humans ; Point-of-Care Systems ; Noncommunicable Diseases/epidemiology ; HIV Infections/complications ; HIV Infections/diagnosis ; HIV Infections/epidemiology
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003098
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Point-of-Care Viral Load Testing to Manage HIV Viremia During the Rollout of Dolutegravir-Based ART in South Africa: A Randomized Feasibility Study (POwER).

    Dorward, Jienchi / Sookrajh, Yukteshwar / Lessells, Richard / Bulo, Elliot / Naidoo, Jessica / Naidoo, Keshani / Bodley, Nicola / Khanyile, Mlungisi / Van Vuuren, Claudia Jansen / Moodley, Pravikrishnen / Samsunder, Natasha / Lewis, Lara / Drain, Paul K / Hayward, Gail / Butler, Christopher C / Garrett, Nigel

    Journal of acquired immune deficiency syndromes (1999)

    2023  Volume 93, Issue 5, Page(s) 403–412

    Abstract: Background: Data are required regarding the feasibility of conducting a randomized trial of point-of-care viral load (VL) testing to guide management of HIV viremia and to provide estimates of effect to guide potential future trial design.: Setting: ... ...

    Abstract Background: Data are required regarding the feasibility of conducting a randomized trial of point-of-care viral load (VL) testing to guide management of HIV viremia and to provide estimates of effect to guide potential future trial design.
    Setting: Two public South African clinics during the dolutegravir-based antiretroviral therapy (ART) rollout.
    Methods: We randomized adults receiving first-line ART, with recent VL ≥1000 copies/mL, in a 1:1 ratio to receive point-of-care Xpert HIV-1 VL versus standard-of-care laboratory VL testing after 12 weeks. Feasibility outcomes included proportions of eligible patients enrolled and completing follow-up and VL process outcomes. Estimates of effect were assessed using the trial primary outcome of VL <50 copies/mL after 24 weeks.
    Results: From August 2020 to March 2022, we enrolled 80 eligible participants, an estimated 24% of those eligible. 47 of 80 (58.8%) were women, and the median age was 38.5 years (interquartile range [IQR], 33-45). 44 of 80 (55.0%) were receiving dolutegravir, and 36 of 80 (465.0%) were receiving efavirenz. After 12 weeks, point-of-care participants received VL results after median 3.1 hours (IQR 2.6-3.8), versus 7 days (IQR 6-8, P < 0.001) in standard of care. Twelve-week follow-up VL was ≥1000 copies/mL in 13 of 39 (33.3%) point-of-care participants and in 16 of 41 (39.0%) standard-of-care participants; 11 of 13 (84.6%) and 12 of 16 (75.0%) switched to second-line ART. After 24 weeks, 76 of 80 (95.0%) completed follow-up. 27 of 39 (69.2% [95% CI: 53.4 to 81.4]) point-of-care participants achieved VL <50 copies/mL versus 29 of 40 (72.5% [57.0 to 83.9]) standard-of-care participants. Point-of-care participants had median 3 (IQR, 3-4) clinical visits versus 4 (IQR, 4-5) in standard-of-care participants ( P < 0.001).
    Conclusions: It was feasible to conduct a trial of point-of-care VL testing to manage viremia. Point-of-care VL lead to quicker results and fewer clinical visits, but estimates of 24-week VL suppression were similar between arms.
    Trial registration: Pan African Clinical Trials Registry: PACTR202001785886049.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Anti-HIV Agents/therapeutic use ; Feasibility Studies ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; Point-of-Care Systems ; South Africa ; Viral Load/methods ; Viremia/drug therapy ; Middle Aged
    Chemical Substances Anti-HIV Agents ; dolutegravir (DKO1W9H7M1)
    Language English
    Publishing date 2023-04-30
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003212
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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