Artikel ; Online: IL-33-ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways.
2023 Band 16, Heft 800, Seite(n) eadd7705
Abstract: Cell stemness is characterized by quiescence, pluripotency, and long-term self-renewal capacity. Therapy-resistant leukemic stem cells (LSCs) are the primary cause of relapse in patients with chronic and acute myeloid leukemia (CML and AML). However, the ...
| Abstract | Cell stemness is characterized by quiescence, pluripotency, and long-term self-renewal capacity. Therapy-resistant leukemic stem cells (LSCs) are the primary cause of relapse in patients with chronic and acute myeloid leukemia (CML and AML). However, the same signaling pathways frequently support stemness in both LSCs and normal hematopoietic stem cells (HSCs), making LSCs difficult to therapeutically target. In cell lines and patient samples, we found that interleukin-33 (IL-33) signaling promoted stemness only in leukemia cells in a subtype-specific manner. The IL-33 receptor ST2 was abundant on the surfaces of CD34 |
|---|---|
| Mesh-Begriff(e) | Animals ; Mice ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33/genetics ; Leukemia, Myeloid ; NF-kappa B ; Wnt Signaling Pathway |
| Chemische Substanzen | Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33 ; NF-kappa B ; IL1RL1 protein, human ; IL33 protein, human |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-08-29 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2417226-1 |
| ISSN | 1937-9145 ; 1945-0877 |
| ISSN (online) | 1937-9145 |
| ISSN | 1945-0877 |
| DOI | 10.1126/scisignal.add7705 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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