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  1. AU="Boehler, Michael"
  2. AU="Mirfakhraei, Mahdi"
  3. AU="de Jongste, Johan C"
  4. AU="Holmgren, A Jay"
  5. AU="Mićanović, S"
  6. AU="Chiu, Joanne S"
  7. AU=D'Amora Paulo
  8. AU="Jansen, Hans"
  9. AU=Beukes Eldre W
  10. AU="Francis, Sarah"
  11. AU="Camara, Amadou K.S."
  12. AU="Chaudhari, Sachin R."
  13. AU="Ovchinnikova, Tatiana V"
  14. AU="Aït Ali, F"
  15. AU="Jeong, Jae Cheon"
  16. AU="Luca Baldassari"
  17. AU="Wakfie-Corieh, C G"
  18. AU="Desouza, Cyrus V"
  19. AU="Esaka, Naoki"
  20. AU="Haruka Wada"
  21. AU="Klouda, Timothy"
  22. AU="Olsson-Brown, Anna C."
  23. AU="Schmauß, Max"
  24. AU="Raza, Syed Tasleem"
  25. AU="Humphreys, H"
  26. AU="Robert A Casero Jr"
  27. AU="Marinec, Paul S"
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  1. Article ; Online: Towards the rational design of the Py5-ligand framework for ruthenium-based water oxidation catalysts.

    Schilling, Mauro / Böhler, Michael / Luber, Sandra

    Dalton transactions (Cambridge, England : 2003)

    2018  Volume 47, Issue 31, Page(s) 10480–10490

    Abstract: In order to rationally design water oxidation catalysts (WOCs), an in-depth understanding of the reaction mechanism is essential. In this study we showcase the complexity of catalytic water oxidation, by elucidating how modifications of the pentapyridyl ( ...

    Abstract In order to rationally design water oxidation catalysts (WOCs), an in-depth understanding of the reaction mechanism is essential. In this study we showcase the complexity of catalytic water oxidation, by elucidating how modifications of the pentapyridyl (Py5) ligand-framework influence the thermodynamics and kinetics of the process. In the reaction mechanism the pyridine-water exchange was identified as a key reaction which appears to determine the reactivity of the Py5-WOCs. Exploring the capabilities of in silico design we show which modifications of the ligand framework appear promising when attempting to improve the catalytic performance of WOCs derived from Py5.
    Language English
    Publishing date 2018-08-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c8dt01209a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Reconstruction of photon conversions in [tau] lepton decays in the ATLAS experiment

    Böhler, Michael

    (DESY-Thesis ; 2009,13)

    2009  

    Author's details by M. Böhler
    Series title DESY-Thesis ; 2009,13
    Language English ; German
    Size V, 125 S., graph. Darst., 30 cm
    Publisher Dt. Elektronen-Synchrotron
    Publishing place Hamburg
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diplomarbeit--Hamburg, 2008
    Note Zsfassungen in dt. und engl. Sprache
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Book: Kulturtopographie deutschsprachiger Literaturen

    Böhler, Michael

    Perspektivierungen im Spannungsfeld von Integration und Differenz

    2002  

    Author's details hrsg. von Michael Böhler
    Keywords Nationalbewusstsein ; Deutsch ; Literatur ; Kulturelle Identität
    Language German
    Size VI, 273 S, 23 cm
    Publisher Niemeyer
    Publishing place Tübingen
    Document type Book
    ISBN 3484108444 ; 9783484108448
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book ; Conference proceedings: Republikanische Tugend

    Böhler, Michael

    Ausbildung eines Schweizer Nationalbewusstseins und Erziehung eines neuen Bürgers ; contribution à une nouvelle approche des Lumières helvétiques ; actes du 16e [vielm.: 17e] colloque de l'Académie Suisse des Sciences Humaines et Sociales (Ascona, Monte Verità, Centro Stefano Franscini) 7 - 11 septembre 1998

    (Travaux sur la Suisse des Lumières ; 2)

    2000  

    Institution Schweizerische Akademie der Geistes- und Sozialwissenschaften
    Event/congress Colloque de l'Académie Suisse des Sciences Humaines et Sociales (17, 1998.09.07-11, Ascona) ; Internationale Tagung über die Schweizer Aufklärung (1998.09.07-11, Ascona)
    Author's details éd. par Michael Böhler
    Series title Travaux sur la Suisse des Lumières ; 2
    Language German ; French ; English
    Size 623 S, Ill
    Publisher Slatkine
    Publishing place Genève u.a.
    Document type Book ; Conference proceedings
    Note Beitr. teilw. dt., teilw. franz., teilw. engl.
    ISBN 2051018286 ; 9782051018289
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: Preparing Distributed Computing Operations for the HL-LHC Era With Operational Intelligence.

    Di Girolamo, Alessandro / Legger, Federica / Paparrigopoulos, Panos / Schovancová, Jaroslava / Beermann, Thomas / Boehler, Michael / Bonacorsi, Daniele / Clissa, Luca / Decker de Sousa, Leticia / Diotalevi, Tommaso / Giommi, Luca / Grigorieva, Maria / Giordano, Domenico / Hohn, David / Javůrek, Tomáš / Jezequel, Stephane / Kuznetsov, Valentin / Lassnig, Mario / Mageirakos, Vasilis /
    Olocco, Micol / Padolski, Siarhei / Paltenghi, Matteo / Rinaldi, Lorenzo / Sharma, Mayank / Tisbeni, Simone Rossi / Tuckus, Nikodemas

    Frontiers in big data

    2022  Volume 4, Page(s) 753409

    Abstract: As a joint effort from various communities involved in the Worldwide LHC Computing Grid, the Operational Intelligence project aims at increasing the level of automation in computing operations and reducing human interventions. The distributed computing ... ...

    Abstract As a joint effort from various communities involved in the Worldwide LHC Computing Grid, the Operational Intelligence project aims at increasing the level of automation in computing operations and reducing human interventions. The distributed computing systems currently deployed by the LHC experiments have proven to be mature and capable of meeting the experimental goals, by allowing timely delivery of scientific results. However, a substantial number of interventions from software developers, shifters, and operational teams is needed to efficiently manage such heterogenous infrastructures. Under the scope of the Operational Intelligence project, experts from several areas have gathered to propose and work on "smart" solutions. Machine learning, data mining, log analysis, and anomaly detection are only some of the tools we have evaluated for our use cases. In this community study contribution, we report on the development of a suite of operational intelligence services to cover various use cases: workload management, data management, and site operations.
    Language English
    Publishing date 2022-01-07
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2624-909X
    ISSN (online) 2624-909X
    DOI 10.3389/fdata.2021.753409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies.

    Leondopulos, Stathis S / Boehler, Michael D / Wheeler, Bruce C / Brewer, Gregory J

    Journal of neural engineering

    2012  Volume 9, Issue 2, Page(s) 26015

    Abstract: Slow wave oscillations in the brain are essential for coordinated network activity but have not been shown to self-organize in vitro. Here, the development of dissociated hippocampal neurons into an active network with oscillations on multi-electrode ... ...

    Abstract Slow wave oscillations in the brain are essential for coordinated network activity but have not been shown to self-organize in vitro. Here, the development of dissociated hippocampal neurons into an active network with oscillations on multi-electrode arrays was evaluated in the absence and presence of chronic external stimulation. Significant changes in signal power were observed in the range of 1-400 Hz with an increase in amplitude during bursts. Stimulation increased oscillatory activity primarily in the theta (4-11 Hz) and slow gamma (30-55 Hz) bands. Spikes were most prominently phase-locked to the slow gamma waves. Notably, the dissociated network self-organized to exhibit sustained delta, theta, beta and gamma oscillations without input from cortex, thalamus or organized pyramidal cell layers.
    MeSH term(s) Action Potentials/physiology ; Analysis of Variance ; Animals ; Cells, Cultured ; Data Interpretation, Statistical ; Delta Rhythm/physiology ; Electric Stimulation ; Electroencephalography ; Electrophysiology ; Fourier Analysis ; Glutamate Decarboxylase/metabolism ; Glutamic Acid/metabolism ; Hippocampus/cytology ; Hippocampus/physiology ; Immunohistochemistry ; Nerve Net/cytology ; Nerve Net/physiology ; Neurons/physiology ; Rats ; Rats, Sprague-Dawley ; Signal Processing, Computer-Assisted ; Theta Rhythm/physiology
    Chemical Substances Glutamic Acid (3KX376GY7L) ; Glutamate Decarboxylase (EC 4.1.1.15)
    Language English
    Publishing date 2012-02-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2560/9/2/026015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6071: Show issues Location:
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  7. Article ; Online: Hippocampal networks on reliable patterned substrates.

    Boehler, Michael D / Leondopulos, Stathis S / Wheeler, Bruce C / Brewer, Gregory J

    Journal of neuroscience methods

    2011  Volume 203, Issue 2, Page(s) 344–353

    Abstract: Toward the goal of reproducible live neuronal networks, we investigated the influence of substrate patterns on neuron compliance and network activity. We optimized process parameters of micro-contact printing for reproducible geometric patterns of 10 μm ... ...

    Abstract Toward the goal of reproducible live neuronal networks, we investigated the influence of substrate patterns on neuron compliance and network activity. We optimized process parameters of micro-contact printing for reproducible geometric patterns of 10 μm wide lines of polylysine with 4, 6, or 8 connections at a constant square array of nodes overlying the recording electrodes of a multielectrode array (MEA). We hypothesized that an increase in node connections would give the network more inputs resulting in higher neuronal outputs as network spike rates. We also chronically stimulated these networks during development and added astroglia to enhance network activity. Our results show that despite frequent localization of neuron somata over the electrodes, the number of spontaneously active electrodes was reduced 3-fold compared to random networks, independent of pattern complexity. Of the electrodes active, the overall spike rate was independent of pattern complexity, consistent with homeostasis of activity. Lower mean burst rates were seen with higher levels of pattern complexity; however, burst durations increased 1.6-fold with pattern complexity (n=6027 bursts, p<0.001). Inter-burst interval and percentage of active electrodes displaying bursts also increased with pattern complexity. The extra-burst (non-burst or isolated) spike rate increased 4-fold with pattern complexity, but this relationship was reversed with either chronic stimulation or astroglia addition. These studies suggest for the first time that patterns which limit the distribution of branches and inputs are deleterious to activity in a hippocampal network, but that higher levels of pattern complexity promote non-burst activity and favor longer lasting, but fewer bursts.
    MeSH term(s) Animals ; Cell Culture Techniques/instrumentation ; Cell Culture Techniques/methods ; Diffusion Chambers, Culture/standards ; Electrophysiology/instrumentation ; Electrophysiology/methods ; Hippocampus/cytology ; Hippocampus/physiology ; Nerve Net/cytology ; Nerve Net/physiology ; Primary Cell Culture/instrumentation ; Primary Cell Culture/methods ; Rats ; Substrate Specificity
    Language English
    Publishing date 2011-10-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Validation Study
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2011.09.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1486: Show issues Location:
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  8. Article ; Online: Added astroglia promote greater synapse density and higher activity in neuronal networks.

    Boehler, Michael D / Wheeler, Bruce C / Brewer, Gregory J

    Neuron glia biology

    2008  Volume 3, Issue 2, Page(s) 127–140

    Abstract: Astroglia are known to potentiate individual synapses, but their contribution to networks is unclear. Here we examined the effect of adding either astroglia or media conditioned by astroglia on entire networks of rat hippocampal neurons cultured on ... ...

    Abstract Astroglia are known to potentiate individual synapses, but their contribution to networks is unclear. Here we examined the effect of adding either astroglia or media conditioned by astroglia on entire networks of rat hippocampal neurons cultured on microelectrode arrays. Added astroglia increased spontaneous spike rates nearly two-fold and glutamate-stimulated spiking by six-fold, with desensitization eliminated for bath addition of 25 microM glutamate. Astrocyte-conditioned medium partly mimicked the effects of added astroglia. Bursting behavior was largely unaffected by added astroglia except with added glutamate. Addition of the GABA(A) receptor antagonist bicuculline also increased spike rates but with more subtle differences between networks without or with added astroglia. This indicates that networks without added astroglia were inhibited greatly. In all conditions, the log-log distribution of spike rates fit well to linear distributions over three orders of magnitude. Networks with added astroglia shifted consistently toward higher spike rates. Immunostaining for GFAP revealed a linear increase with added astroglia, which also increased neuronal survival. The increased spike rates with added astroglia correlated with a 1.7-fold increase in immunoreactive synaptophysin puncta, and increases of six-fold for GABA(Abeta), two-fold for NMDA-R1 and two-fold for Glu-R1 puncta, with receptor clustering that indicated synaptic scaling. Together, these results indicate that added astroglia increase the density of synapses and receptors, and facilitate higher spike rates for many elements in the network. These effects are reproduced by glia-conditioned media, with the exception of glutamate-mediated transmission.
    Language English
    Publishing date 2008-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2143089-5
    ISSN 1741-0533 ; 1740-925X ; 1741-0533
    ISSN (online) 1741-0533
    ISSN 1740-925X ; 1741-0533
    DOI 10.1017/S1740925X07000440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6470: Show issues Location:
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  9. Article ; Online: The Mini Report: a Practical Tool to Address Lung Cancer Disparities in Rural Communities.

    Mueller-Luckey, Georgia S / Zahnd, Whitney E / Garner, Kyle / Heitkamp, Ruth / Jenkins, Wiley D / Boehler, Michael D / Steward, David E

    Journal of cancer education : the official journal of the American Association for Cancer Education

    2015  Volume 32, Issue 2, Page(s) 293–300

    Abstract: Community-based participatory research (CBPR) is an effective way to address cancer disparities in medically underserved populations. Our research demonstrates how CBPR principles were used to develop lung cancer and risk factor mini reports for a ... ...

    Abstract Community-based participatory research (CBPR) is an effective way to address cancer disparities in medically underserved populations. Our research demonstrates how CBPR principles were used to develop lung cancer and risk factor mini reports for a network of community coalitions in the Illinois Delta Region, a predominately rural region with high lung cancer disparities in southern Illinois. An academic-community partnership, including a community-based medical school, state public health department, and a healthcare system, used CBPR principles to translate epidemiological, behavioral, and demographic data into understandable, comprehensive, yet concise mini reports for each coalition. A cyclical and iterative process was used to draft, revise, and optimize these mini reports to raise awareness about lung cancer disparities in the community and to provide information to help guide the development of interventions that address these disparities. The use of CBPR principles was a successful way to create mini reports about local lung cancer disparities and risk factors that were usable in individual communities. Local coalitions used the mini reports to educate community members at local meetings, to guide strategic planning, and to disseminate information through their respective websites. Additionally, the process of creating these reports built trust among academic-community partners and provided additional avenues of engagement, such as the involvement of an academic partner in the strategic planning process of a local coalition. Using CBPR processes is an effective way to translate epidemiological data into a community-friendly format to address cancer disparities.
    MeSH term(s) Community-Based Participatory Research ; Health Status Disparities ; Humans ; Illinois ; Lung Neoplasms ; Public Health ; Research Report ; Rural Population ; Vulnerable Populations
    Language English
    Publishing date 2015-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 632898-2
    ISSN 1543-0154 ; 0885-8195 ; 1543-1154
    ISSN (online) 1543-0154
    ISSN 0885-8195 ; 1543-1154
    DOI 10.1007/s13187-015-0921-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2185: Show issues Location:
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  10. Article ; Online: Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates.

    Brewer, Gregory J / Boehler, Michael D / Ide, Alessandro N / Wheeler, Bruce C

    Journal of neuroscience methods

    2009  Volume 184, Issue 1, Page(s) 104–109

    Abstract: We chronically stimulated hippocampal networks in culture for either 0, 1 or 3h/day between 7 and 22 days in culture in an effort to increase spontaneous spike rates and to give these networks some portion of external stimuli that brain networks receive ... ...

    Abstract We chronically stimulated hippocampal networks in culture for either 0, 1 or 3h/day between 7 and 22 days in culture in an effort to increase spontaneous spike rates and to give these networks some portion of external stimuli that brain networks receive during their formation. Chronic electrical stimulation of hippocampal networks on multi-electrode arrays (MEAs) increased spike rates 2-fold after 3 weeks of culture compared to cultures that received no external stimulation prior to recording. More than 90% of the spikes for all experimental conditions occurred within bursts. The frequency of spikes within a burst increased with time of stimulation during culture up to 2-fold higher (90Hz) compared to networks without chronic stimulation. However, spontaneous overall spike rates did not correlate well with the amount of stimulation either as h/day or proximity to the limited number of stimulation sites due to shorter burst duration with 3h/day stimulation. The results suggest that chronic stimulation applied during network development recruits activity at 50% more electrodes and enables higher rates of spontaneous activity within bursts in cultured hippocampal networks.
    MeSH term(s) Action Potentials/physiology ; Animals ; Cells, Cultured ; Electric Stimulation/methods ; Hippocampus/physiology ; Microelectrodes ; Neurons/physiology ; Rats ; Time Factors
    Language English
    Publishing date 2009-08-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2009.07.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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