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  1. Article ; Online: Tensor product P-splines using a sparse mixed model formulation

    Boer, Martin

    Statistical Modelling

    2023  Volume 23, Issue 5-6

    Abstract: A new approach to represent P-splines as a mixed model is presented. The corresponding matrices are sparse allowing the new approach can find the optimal values of the penalty parameters in a computationally efficient manner. Whereas the new mixed model ... ...

    Abstract A new approach to represent P-splines as a mixed model is presented. The corresponding matrices are sparse allowing the new approach can find the optimal values of the penalty parameters in a computationally efficient manner. Whereas the new mixed model P-splines formulation is similar to the original P-splines, a key difference is that the fixed effects are modelled explicitly, and extra constraints are added to the random part of the model. An important feature ensuring that the entire computation is fast is a sparse implementation of the Automated Differentiation of the Cholesky algorithm. It is shown by means of two examples that the new approach is fast compared to existing methods. The methodology has been implemented in the R-package LMMsolver available on CRAN (https://CRAN.R-project.org/package=LMMsolver).
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2053876-5
    ISSN 1477-0342 ; 1471-082X
    ISSN (online) 1477-0342
    ISSN 1471-082X
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Effect of hay nets on horse bodyweight, body condition score, hay usage, and dental health in mature adult horses.

    DeBoer, M / Keener, L / Layeux-Parks, J / Schueller, O / Johnson, L / Martinson, K

    Journal of equine veterinary science

    2024  Volume 136, Page(s) 105051

    Abstract: Hay nets are a commonly used management practice to increase intake time and reduce hay waste but may impact horse health. The objectives were to compare hay usage, dental wear, and dental conditions between horses fed with (NET) or without (CON) hay ... ...

    Abstract Hay nets are a commonly used management practice to increase intake time and reduce hay waste but may impact horse health. The objectives were to compare hay usage, dental wear, and dental conditions between horses fed with (NET) or without (CON) hay nets during a 2-year cross-over study. In September 2021, 13 mature adult horses were blocked by bodyweight (BW) and randomly assigned to the NET or CON treatments for one year. After one year (September 2022), horses switched treatments and the trial concluded in September 2023. Horses were housed in adjacent dry lots with shelter, ad libitum water, and free choice access to round bales with or without hay nets (4.45 cm openings). Blinded dental work, including incisor length measurements and recording of dental abnormalities and conditions, and recording of horse BW and body condition score (BCS) were completed in September 2021, 2022, and 2023. Digital images were taken monthly to determine rostral oral cavity scores (ROCS). Round bales were weighed prior to being placed in the dry lot and the date fed was recorded to calculate hay usage. Significance was set at P≤0.05. Horse BW, BCS, and hay usage were greater in horses consuming hay without hay nets (P<0.05). No differences were observed in incisor length, presence of incisor bevels, ROCS, or dental abnormalities and conditions (P>0.05). These data suggest that hay nets do not result in negative impacts on dental health but can reduce hay usage and help to control horse BW and BCS.
    Language English
    Publishing date 2024-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102631-2
    ISSN 1542-7412 ; 0737-0806
    ISSN (online) 1542-7412
    ISSN 0737-0806
    DOI 10.1016/j.jevs.2024.105051
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  3. Book ; Online: Cetacean sigthings in North Sea

    De Boer, Marijke

    2023  

    Abstract: Original provider: Marijke N. de Boer Dataset credits: Marijke N. de Boer Abstract: Minke whales and other marine mammals were recorded in the central North Sea in an area characterised by frontal features and high productivity northeast of the Dogger ... ...

    Abstract Original provider: Marijke N. de Boer Dataset credits: Marijke N. de Boer Abstract: Minke whales and other marine mammals were recorded in the central North Sea in an area characterised by frontal features and high productivity northeast of the Dogger Bank (4677 km2). Survey efforts were carried out from 28 March to 2 July 2007, at a finer scale than in earlier studies in the region, using 2 vessels as platforms of opportunity and a dedicated line- transect survey vessel following distance sampling methods. The high density of whales indicated that this offshore bank slope is an important spring habitat for minke whales in the North Sea. In total, 77 sightings of minke whales comprising 130 individuals were recorded. The peak density of minke whales was estimated to be 0.029 whales km–2 (minimum estimate, 95% CI: 0.012 to 0.070) in May. During peak abundance, the minke whales temporarily congregated in the area, suggesting that the whales were taking advantage of the local spring abundance of sandeels. The density found was higher than previous studies have suggested for the central North Sea. The results correspond to recent observations of minke whale redistribution within the North Sea, and these may be related to a decline in sandeel availability elsewhere in the North Sea. Offshore banks that aggregate prey may therefore become increasingly important feeding habitats for minke whales and other top predators in the North Sea. The observed habitat preference of minke whales along this offshore bank appeared to be similar to that observed in coastal areas, and this suggests some degree of generality regarding the preference for this type of habitat. Purpose: As part of a geophysical seismic survey, marine mammals observations were carried out from three vessels: one seismic vessel, one supply vessel operating well ahead from the seismic vessel. The third vessel, MV ‘Andfjord’, carried out a dedicated Line Transect (LT) survey (23 April to 17 May). The LT vessel was surveying at distances of ≥20 km away from ...
    Keywords Life Science
    Subject code 333
    Publisher OBIS-SEAMAP
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Hybrid Repair of Large Radial Artery Pseudo-Aneurysm.

    de Boer, Madeleine / Shiraev, Timothy

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2022  Volume 63, Issue 4, Page(s) 545

    MeSH term(s) Aneurysm/diagnostic imaging ; Aneurysm/surgery ; Humans ; Radial Artery/diagnostic imaging ; Radial Artery/surgery
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2022.02.009
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Minimal important change and difference in health outcome: An overview of approaches, concepts, and methods.

    Dekker, Joost / de Boer, Michiel / Ostelo, Raymond

    Osteoarthritis and cartilage

    2023  Volume 32, Issue 1, Page(s) 8–17

    Abstract: Objective: To provide an overview of approaches, concepts, and methods used to define and assess minimal important change and difference in health outcome.: Method: A narrative review of the literature, guided by a conceptual framework.: Results: ... ...

    Abstract Objective: To provide an overview of approaches, concepts, and methods used to define and assess minimal important change and difference in health outcome.
    Method: A narrative review of the literature, guided by a conceptual framework.
    Results: We distinguish between (i) interpretation of health outcome in individuals versus groups, (ii) change within individuals or groups versus difference between change within individuals or groups; and (iii) the responder approach (based on the proportion of patients that obtain a defined response) versus the group average approach (based on the average amount of change in a group). We review approaches, concepts, and methods.
    Conclusion: By bringing together and juxtaposing various approaches, concepts, and methods, we set a precursory step in the direction of consensus building in the field concerned with defining and assessing minimal important change and difference in health outcome. We emphasize the need for conceptual clarification and terminological standardization. We argue that assessing minimal importance of change and difference in health outcome is essentially a value judgment involving a range of considerations and perspectives.
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1167809-4
    ISSN 1522-9653 ; 1063-4584
    ISSN (online) 1522-9653
    ISSN 1063-4584
    DOI 10.1016/j.joca.2023.09.002
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Contesting misrecognition online: Experiences of epistemic in/justice by vloggers with contested illnesses.

    Groenevelt, I P Irene / de Boer, M L Marjolein

    Social science & medicine (1982)

    2023  Volume 327, Page(s) 115951

    Abstract: Contested illnesses, such as fibromyalgia, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and chronic Lyme disease (CLD), are surrounded by polemic debates regarding their etiology, symptomology, treatment, and even their existence. People ... ...

    Abstract Contested illnesses, such as fibromyalgia, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and chronic Lyme disease (CLD), are surrounded by polemic debates regarding their etiology, symptomology, treatment, and even their existence. People who suffer from these contested illnesses arguably also suffer from "epistemic injustice." This concept, coined by the philosopher Miranda Fricker, captures how people's knowledge may be discredited because of identity prejudices. In our paper, this concept is used to understand how seven Dutch women with contested illnesses experience the emancipatory potential of their vlogging practices. Our findings show how these women understood their vlogging as a means to break with epistemic smothering, understood as the propensity to cater ones testimony to one's audience (Dotson, 2011), and as a means to attain and enhance epistemic justice. However, our findings also show how vlogging about contested illnesses did not seem to allow these women to fully break with their epistemic smothering practices, and that the ableist design and gendered norms of YouTube were experienced as obstacles to attaining epistemic justice. We conclude that, even though social media do seem to hold emancipatory potential for these women, the experiences of individual users are diverse and ambiguous.
    MeSH term(s) Humans ; Female ; Social Justice ; Fatigue Syndrome, Chronic/therapy ; Fibromyalgia/therapy ; Prejudice
    Language English
    Publishing date 2023-05-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2023.115951
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 625: Show issues Location:
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  7. Article ; Online: 92 Seasonal variation in plasma vitamin A and E concentrations in horses with or without pasture access

    Tuszka, A. / Erb, E. / DeBoer, M.

    Journal of Equine Veterinary Science. 2023 May, v. 124 p.104394-

    2023  

    Abstract: Vitamins A and E are essential nutrients for horses and often provided in the diet by fresh forage but become depleted when forage is cut and dried for hay and can lead to potentially fatal health problems in horses. This study evaluated seasonal changes ...

    Abstract Vitamins A and E are essential nutrients for horses and often provided in the diet by fresh forage but become depleted when forage is cut and dried for hay and can lead to potentially fatal health problems in horses. This study evaluated seasonal changes in plasma vitamin A and E for a mature horse herd in the Upper Midwest to determine the impact of pasture access on the prevalence of vitamin deficiency. Researchers hypothesized horses on dry lot would be deficient all year while horses with pasture access would have increased vitamin A and E concentrations during the grazing season. The study took place between February and November 2022 in River Falls, Wisconsin. Twenty-seven mature horses were divided into 2 treatments based on management practices including 1) horses consuming a hay-only diet in a dry lot (n = 13) and 2) horses with pasture access in the summer (n = 14). All horses had ad libitum access to water and a vitamin and mineral mix (200 IU/kg Vitamin E; 176,320 IU/kg Vitamin A) for the duration of the study and received ad libitum cool-season grass hay round bales from September through May. Hay-only horses continued this diet from June through August while pastured horses continuously grazed cool-season grass pasture. Jugular venous blood samples were taken in February (winter), May (spring), August (summer), and November (fall) and plasma samples were sent theMichigan State Veterinary Diagnostic Lab for analysis of plasma vitamin A and E concentrations. Data were analyzed using PROC MIXED in SAS with significance set at P ≤ 0.05. Adequate vitamin A was classified as 175 to 300 ng/ml, and adequate vitamin E was classified as 2.0 to 4.0 µg/ml. Vitamin A deficiency was observed in 81% and 85% of horses in winter and spring, respectively, with an average concentration of 145 ng/ml. Pastured horses exhibited an increase in plasma vitamin A in the summer compared with dry lot horses (P ≤ 0.05), however 64% of pastured horses remained deficient. In the fall, vitamin A deficiency increased to 97% for all horses and plasma vitamin A averaged 139 ng/ml. When evaluating vitamin E, 70 to 74% of horses were deficient in the winter and spring, respectively, with an average concentration of 1.83 µg/ml. Plasma vitamin E concentrations did not change over time for dry lot horses and remained inadequate in the summer at 1.43 µg/ml (P > 0.05) while concentrations in pastured horses rose to 2.4 µg/ml (P ≤ 0.05). These results confirm recommendations to provide additional vitamin A and E to horses on a hay-only diet and demonstrates the short-lived increases in vitamin A and E for horses provided limited pasture access.
    Keywords blood ; cool season grasses ; diet ; forage ; grass hay ; herds ; horses ; pastures ; rivers ; seasonal variation ; spring ; summer ; veterinary medicine ; vitamin A ; vitamin A deficiency ; vitamin E ; winter ; Wisconsin
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 2102631-2
    ISSN 1542-7412 ; 0737-0806
    ISSN (online) 1542-7412
    ISSN 0737-0806
    DOI 10.1016/j.jevs.2023.104394
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Mutations in cis that affect mRNA synthesis, processing and translation.

    Roos, Dirk / de Boer, Martin

    Biochimica et biophysica acta. Molecular basis of disease

    2021  Volume 1867, Issue 9, Page(s) 166166

    Abstract: Genetic mutations that cause hereditary diseases usually affect the composition of the transcribed mRNA and its encoded protein, leading to instability of the mRNA and/or the protein. Sometimes, however, such mutations affect the synthesis, the ... ...

    Abstract Genetic mutations that cause hereditary diseases usually affect the composition of the transcribed mRNA and its encoded protein, leading to instability of the mRNA and/or the protein. Sometimes, however, such mutations affect the synthesis, the processing or the translation of the mRNA, with similar disastrous effects. We here present an overview of mRNA synthesis, its posttranscriptional modification and its translation into protein. We then indicate which elements in these processes are known to be affected by pathogenic mutations, but we restrict our review to mutations in cis, in the DNA of the gene that encodes the affected protein. These mutations can be in enhancer or promoter regions of the gene, which act as binding sites for transcription factors involved in pre-mRNA synthesis. We also describe mutations in polyadenylation sequences and in splice site regions, exonic and intronic, involved in intron removal. Finally, we include mutations in the Kozak sequence in mRNA, which is involved in protein synthesis. We provide examples of genetic diseases caused by mutations in these DNA regions and refer to databases to help identify these regions. The over-all knowledge of mRNA synthesis, processing and translation is essential for improvement of the diagnosis of patients with genetic diseases.
    MeSH term(s) Animals ; Humans ; Mutation/genetics ; Protein Biosynthesis/genetics ; Protein Processing, Post-Translational/genetics ; RNA, Messenger/genetics
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2021-05-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2021.166166
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    Uc I Zs.247: Show issues Location:
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  9. Article ; Online: Is the use of diagnostic imaging and the self-reported clinical management of low back pain patients influenced by the attitudes and beliefs of chiropractors? A survey of chiropractors in the Netherlands and Belgium.

    van der Vossen, Brenda / de Zoete, Annemarie / Rubinstein, Sidney / Ostelo, Raymond / de Boer, Michiel

    Chiropractic & manual therapies

    2024  Volume 32, Issue 1, Page(s) 1

    Abstract: Background: No previous studies have examined the association between attitudes and beliefs of chiropractors and their adherence to low back pain (LBP) guidelines. The aim of this study is: (1) to assess the attitudes and beliefs towards the management ... ...

    Abstract Background: No previous studies have examined the association between attitudes and beliefs of chiropractors and their adherence to low back pain (LBP) guidelines. The aim of this study is: (1) to assess the attitudes and beliefs towards the management of LBP of Dutch and Belgian chiropractors; and (2) to investigate the association of these attitudes and beliefs on the use of diagnostic imaging and on the adherence to diagnostic guidelines and guidelines in the management of patients with LBP.
    Methods: STUDY DESIGN: Cross-sectional study using a web-based questionnaire in chiropractic private practices in the Netherlands and Belgium. The survey included sociodemographic characteristics, use of diagnostic imaging, the Pain Attitude and Beliefs Scale-Physiotherapists (PABS.PT) and 6 vignettes (3 acute and 3 chronic LBP patients). We used Latent Profile Analysis (LPA) to categorise the chiropractors into clusters depending on their PABS.PT outcome, whereby the classes differed primarily on the biomedical score. We used linear, logistic, and mixed models to examine the associations between these clusters, and adherence to the recommendations of guidelines on: (1) diagnostic imaging use, and (2) management of LBP (i.e. advice on activity, treatment, return-to-work, and bedrest).
    Results: The response rate of the Dutch and Belgian chiropractors was 61% (n = 149/245) and 57% (n = 54/95), respectively. The majority of chiropractors scored midrange of the biomedical scale of the PABS.PT. Three clusters were identified using LPA: (1) high biomedical class (n = 18), (2) mid biomedical class (n = 117) and (3) low biomedical class (n = 23). Results from the vignettes suggest that chiropractors in the high biomedical class better adhere to diagnostic imaging guidelines and to LBP guidelines when it concerns advice on return-to-work and activity compared to the other two classes. However, no differences were identified between the classes for treatment of LBP. All chiropractors adhered to the guidelines' recommendation on bedrest.
    Conclusion: The high biomedical class demonstrated better overall adherence to the practice guidelines for the management of LBP and diagnostic imaging than the other classes. Due to the small numbers for the high and low biomedical classes, these results should be interpreted with caution.
    MeSH term(s) Humans ; Self Report ; Belgium ; Low Back Pain/diagnostic imaging ; Low Back Pain/therapy ; Netherlands ; Chiropractic ; Cross-Sectional Studies ; Physical Therapists
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2590836-4
    ISSN 2045-709X ; 2045-709X
    ISSN (online) 2045-709X
    ISSN 2045-709X
    DOI 10.1186/s12998-023-00523-y
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  10. Article ; Online: National-Level Schoolwork Pressure, Family Structure, Internet Use, and Obesity as Drivers of Time Trends in Adolescent Psychological Complaints Between 2002 and 2018.

    Boer, M / Cosma, A / Twenge, J M / Inchley, J / Jeriček Klanšček, H / Stevens, G W J M

    Journal of youth and adolescence

    2023  Volume 52, Issue 10, Page(s) 2061–2077

    Abstract: Little is known about societal processes that contribute to changes in adolescent mental health problems. This study aims to fill this gap using data from the Health Behavior in School-aged Children study between 2002 and 2018 ( ... ...

    Abstract Little is known about societal processes that contribute to changes in adolescent mental health problems. This study aims to fill this gap using data from the Health Behavior in School-aged Children study between 2002 and 2018 (n
    MeSH term(s) Male ; Child ; Humans ; Female ; Adolescent ; Internet Use ; Family Structure ; Obesity/epidemiology ; Schools ; Adolescent Behavior
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 186743-x
    ISSN 1573-6601 ; 0047-2891
    ISSN (online) 1573-6601
    ISSN 0047-2891
    DOI 10.1007/s10964-023-01800-y
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