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  1. Book ; Thesis: Experimentelle Untersuchungen zur Pathophysiologie des neuronalen Schadens in Tiermodellen der Streptococcus pneumoniae-Meningitis

    Böttcher, Tobias

    2008  

    Author's details vorgelegt von Tobias Böttcher
    Language German
    Size 160 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Rostock, Univ., Habil.-schrift, 2010
    HBZ-ID HT016642311
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 E 3389 order for loan Magazin

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  2. Article ; Online: Unveiling the Hidden Theatre of Microbes.

    Böttcher, Thomas

    Chembiochem : a European journal of chemical biology

    2020  Volume 21, Issue 20, Page(s) 2869

    Abstract: The chemical interactions of microbes shape and structure their communities and have important effects on the health and diseases of multicellular hosts. This special collection on Microbial Biosynthesis and Interactions sheds light on some of these ... ...

    Abstract The chemical interactions of microbes shape and structure their communities and have important effects on the health and diseases of multicellular hosts. This special collection on Microbial Biosynthesis and Interactions sheds light on some of these interactions and takes a closer look at the molecules involved in them.
    MeSH term(s) Biological Products/chemistry ; Biological Products/metabolism ; Macromolecular Substances/chemistry ; Macromolecular Substances/metabolism ; Microbiota
    Chemical Substances Biological Products ; Macromolecular Substances
    Language English
    Publishing date 2020-09-01
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202000554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Beyond iron: metal-binding activity of the

    Szamosvári, Dávid / Savchenko, Viktoriia / Badouin, Natalie / Böttcher, Thomas

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 25, Page(s) 5158–5163

    Abstract: ... ...

    Abstract The
    MeSH term(s) Humans ; Iron/metabolism ; Quinolones/metabolism ; Quorum Sensing ; Virulence ; Pseudomonas aeruginosa/metabolism ; Bacterial Proteins/metabolism
    Chemical Substances 2-heptyl-3-hydroxy-4-quinolone ; Iron (E1UOL152H7) ; Quinolones ; Bacterial Proteins
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00710c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: From Molecules to Life: Quantifying the Complexity of Chemical and Biological Systems in the Universe.

    Böttcher, Thomas

    Journal of molecular evolution

    2017  Volume 86, Issue 1, Page(s) 1–10

    Abstract: Life is a complex phenomenon and much research has been devoted to both understanding its origins from prebiotic chemistry and discovering life beyond Earth. Yet, it has remained elusive how to quantify this complexity and how to compare chemical and ... ...

    Abstract Life is a complex phenomenon and much research has been devoted to both understanding its origins from prebiotic chemistry and discovering life beyond Earth. Yet, it has remained elusive how to quantify this complexity and how to compare chemical and biological units on one common scale. Here, a mathematical description of molecular complexity was applied allowing to quantitatively assess complexity of chemical structures. This in combination with the orthogonal measure of information complexity resulted in a two-dimensional complexity space ranging over the entire spectrum from molecules to organisms. Entities with a certain level of information complexity directly require a functionally complex mechanism for their production or replication and are hence indicative for life-like systems. In order to describe entities combining molecular and information complexity, the term biogenic unit was introduced. Exemplified biogenic unit complexities were calculated for ribozymes, protein enzymes, multimeric protein complexes, and even an entire virus particle. Complexities of prokaryotic and eukaryotic cells, as well as multicellular organisms, were estimated. Thereby distinct evolutionary stages in complexity space were identified. The here developed approach to compare the complexity of biogenic units allows for the first time to address the gradual characteristics of prebiotic and life-like systems without the need for a definition of life. This operational concept may guide our search for life in the Universe, and it may direct the investigations of prebiotic trajectories that lead towards the evolution of complexity at the origins of life.
    MeSH term(s) Biological Evolution ; Earth (Planet) ; Eukaryotic Cells ; Evolution, Chemical ; Evolution, Molecular ; Life ; Models, Biological ; Models, Statistical ; Origin of Life ; Prokaryotic Cells
    Language English
    Publishing date 2017-12-19
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120148-7
    ISSN 1432-1432 ; 0022-2844
    ISSN (online) 1432-1432
    ISSN 0022-2844
    DOI 10.1007/s00239-017-9824-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1129: Show issues Location:
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  5. Article ; Online: The Impact of Invasive Buckthorn on Ecosystem Services and its Potential for Bioenergy Production: A review

    Boettcher, T.J. / Gautam, Shuva / Cook, James

    Journal of Sustainable Forestry. 2023 Feb. 07, v. 42, no. 2 p.218-240

    2023  

    Abstract: Two species of invasive shrubs are causing extensive environmental harm across North America. Common buckthorn (Rhamnus cathartica L.) and glossy buckthorn (Frangula alnus P. Mill.), originally imported from Europe, have become naturalized in many ... ...

    Abstract Two species of invasive shrubs are causing extensive environmental harm across North America. Common buckthorn (Rhamnus cathartica L.) and glossy buckthorn (Frangula alnus P. Mill.), originally imported from Europe, have become naturalized in many different ecosystems and are causing negative effects on associated ecosystem services. These invasive plants often create dense, monotypic stands that out-compete native plant species for nutrients and light. Current control methods, including manual or mechanical removal, are expensive and are mainly limited to destroying the buckthorn on site. The high cost of removal may be a barrier for restoration. Economic valuation should be carried out in terms of ecosystems services to better understand the cost-benefit of removing buckthorn. A cost-effective solution for removing buckthorn should also be explored. In this review, the state of the knowledge on the effects of buckthorn and its cost associated with major ecosystem services were synthesized. Existing methods to harvest and transport buckthorn and potential new methods were compiled. Finally, a policy review of buckthorn was completed for states where buckthorn is most prevalent. Findings from this review will be important for applying an economic cost to buckthorn and revealing where more work can be done.
    Keywords Frangula alnus ; Rhamnus cathartica ; bioenergy ; cost effectiveness ; economic costs ; economic valuation ; ecosystems ; indigenous species ; issues and policy ; sustainable forestry ; Europe ; North America ; Invasive species ; buckthorn ; supply chain ; woody biomass ; ecosystem services
    Language English
    Dates of publication 2023-0207
    Size p. 218-240.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2094282-5
    ISSN 1540-756X ; 1054-9811
    ISSN (online) 1540-756X
    ISSN 1054-9811
    DOI 10.1080/10549811.2021.1992637
    Database NAL-Catalogue (AGRICOLA)

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  6. Book ; Thesis: Untersuchungen an spontan hypertensiven Ratten zum Einfluß der arteriellen Katheterisierung auf die Funktion der peripheren arteriellen Chemorezeptoren im Glomus caroticum

    Böttcher, Tobias

    1998  

    Author's details vorgelegt von Tobias Böttcher
    Language German
    Size 79 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Rostock, Univ., Diss., 1998
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT009819130
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 MB 337 order for loan Magazin

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  7. Article: Seltene Erkrankungen. Diagnostische Herausforderung - Neurologische Symptomatik bei Morbus Fabry: Ein Fall aus der Praxis

    Böttcher, Tobias

    Kompendium ... ZNS

    2019  Volume 1, Issue 1, Page(s) 63

    Language German
    Document type Article
    ZDB-ID 2966536-X
    ISSN 2628-3573
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7191: Show issues Location:
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  8. Article ; Online: A Metabolite of

    Jancheva, Magdalena / Böttcher, Thomas

    Journal of the American Chemical Society

    2021  Volume 143, Issue 22, Page(s) 8344–8351

    Abstract: Bacteriophages have major impact on their microbial hosts and shape entire microbial communities. The majority of these phages are latent and reside as prophages integrated in the genomes of their microbial hosts. A variety of intricate regulatory ... ...

    Abstract Bacteriophages have major impact on their microbial hosts and shape entire microbial communities. The majority of these phages are latent and reside as prophages integrated in the genomes of their microbial hosts. A variety of intricate regulatory systems determine the switch from a lysogenic to lytic life style, but so far strategies are lacking to selectively control prophage induction by small molecules. Here we show that
    MeSH term(s) Lysogeny/drug effects ; Molecular Structure ; Prophages/drug effects ; Prophages/metabolism ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/metabolism ; Pyocyanine/pharmacology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/metabolism
    Chemical Substances Pyocyanine (9OQM399341)
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.1c01275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  9. Article ; Online: An Additive Definition of Molecular Complexity.

    Böttcher, Thomas

    Journal of chemical information and modeling

    2016  Volume 56, Issue 3, Page(s) 462–470

    Abstract: A framework for molecular complexity is established that is based on information theory and consistent with chemical knowledge. The resulting complexity index Cm is derived from abstracting the information content of a molecule by the degrees of freedom ... ...

    Abstract A framework for molecular complexity is established that is based on information theory and consistent with chemical knowledge. The resulting complexity index Cm is derived from abstracting the information content of a molecule by the degrees of freedom in the microenvironments on a per-atom basis, allowing the molecular complexity to be calculated in a simple and additive way. This index allows the complexity of any molecule to be universally assessed and is sensitive to stereochemistry, heteroatoms, and symmetry. The performance of this complexity index is evaluated and compared against the current state of the art. Its additive character gives consistent values also for very large molecules and supports direct comparisons of chemical reactions. Finally, this approach may provide a useful tool for medicinal chemistry in drug design and lead selection, as demonstrated by correlating molecular complexities of antibiotics with compound-specific parameters.
    MeSH term(s) Drug Design ; Models, Chemical
    Language English
    Publishing date 2016-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.5b00723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1230: Show issues Location:
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  10. Article ; Online: Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated 2-alkylquinolones with proinflammatory host response.

    Savchenko, Viktoriia / Szamosvári, Dávid / Bao, Yifan / Pignitter, Marc / Böttcher, Thomas

    Communications chemistry

    2023  Volume 6, Issue 1, Page(s) 138

    Abstract: The human pathogen Pseudomonas aeruginosa produces various 4(1H)-quinolones with diverse functions. Among these, 2-nonyl-4(1H)-quinolone (NQ) and its N-oxide (NQNO) belong to the main metabolites. Their biosynthesis involves substrates from the fatty ... ...

    Abstract The human pathogen Pseudomonas aeruginosa produces various 4(1H)-quinolones with diverse functions. Among these, 2-nonyl-4(1H)-quinolone (NQ) and its N-oxide (NQNO) belong to the main metabolites. Their biosynthesis involves substrates from the fatty acid metabolism and we hypothesized that oxidized fatty acids could be responsible for a so far undetected class of metabolites. We developed a divergent synthesis strategy for 2'-hydroxy (2'-OH) and 2'-oxo- substituted quinolones and N-oxides and demonstrated for the first time that 2'-OH-NQ and 2'-OH-NQNO but not the corresponding 2'-oxo compounds are naturally produced by PAO1 and PA14 strains of P. aeruginosa. The main metabolite 2'-OH-NQ is produced even in concentrations comparable to NQ. Exogenous availability of β-hydroxydecanoic acid can further increase the production of 2'-OH-NQ. In contrast to NQ, 2'-OH-NQ potently induced the cytokine IL-8 in a human cell line at 100 nм, suggesting a potential role in host immune modulation.
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929562-2
    ISSN 2399-3669 ; 2399-3669
    ISSN (online) 2399-3669
    ISSN 2399-3669
    DOI 10.1038/s42004-023-00937-y
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