Article ; Online: Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms.
Drug development and industrial pharmacy
2017 Volume 43, Issue 7, Page(s) 1126–1133
Abstract: The bioavailability of the anthelminthic flubendazole was remarkably enhanced in comparison with the pure crystalline drug by developing completely amorphous electrospun nanofibres with a matrix consisting of hydroxypropyl-β-cyclodextrin and ... ...
| Abstract | The bioavailability of the anthelminthic flubendazole was remarkably enhanced in comparison with the pure crystalline drug by developing completely amorphous electrospun nanofibres with a matrix consisting of hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone. The thus produced formulations can potentially be active against macrofilariae parasites causing tropical diseases, for example, river blindness and elephantiasis, which affect altogether more than a hundred million people worldwide. The bioavailability enhancement was based on the considerably improved dissolution. The release of a dose of 40 mg could be achieved within 15 min. Accordingly, administration of the nanofibrous system ensured an increased plasma concentration profile in rats in contrast to the practically non-absorbable crystalline flubendazole. Furthermore, easy-to-grind fibers could be developed, which enabled compression of easily administrable immediate release tablets. |
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| MeSH term(s) | 2-Hydroxypropyl-beta-cyclodextrin ; Administration, Oral ; Animals ; Biological Availability ; Chemistry, Pharmaceutical ; Crystallization ; Mebendazole/administration & dosage ; Mebendazole/analogs & derivatives ; Mebendazole/chemistry ; Nanofibers/chemistry ; Povidone/chemistry ; Rats ; Tablets/chemistry ; beta-Cyclodextrins/chemistry |
| Chemical Substances | Tablets ; beta-Cyclodextrins ; 2-Hydroxypropyl-beta-cyclodextrin (1I96OHX6EK) ; Mebendazole (81G6I5V05I) ; Povidone (FZ989GH94E) ; flubendazole (R8M46911LR) |
| Language | English |
| Publishing date | 2017-07 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 751874-2 |
| ISSN | 1520-5762 ; 0363-9045 |
| ISSN (online) | 1520-5762 |
| ISSN | 0363-9045 |
| DOI | 10.1080/03639045.2017.1298121 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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