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Article: Involvement of Peripheral Opioid Receptors in the Realization of Food Motivation Into Eating Behavior.

Sudakov, Sergey / Bogdanova, Natalia

2021 Volume 14, Page(s) 600920

Abstract: The involvement of peripheral opioid receptors in the mechanisms of eating behavior is still unclear. The aim of this work was to study the role of peripheral, predominantly gastric mu and delta opioid receptors in the realization of food motivation in ... ...

Abstract	The involvement of peripheral opioid receptors in the mechanisms of eating behavior is still unclear. The aim of this work was to study the role of peripheral, predominantly gastric mu and delta opioid receptors in the realization of food motivation in conditions of different energy costs for eating behavior. Experiments were performed under a between-sessions progressive ratio schedule of reinforcement in food-deprived rats. The level of food motivation was calculated using a self-developed method. Food intake, motor activity, and metabolic rate were recorded in fed and hungry animals. Results showed that intragastric administration of the mu opioid receptor agonist DAMGO led to an increase in the level of food motivation in the light variant of operant feeding behaviors. Food consumption did not change. At high costs for feeding behavior, the administration of DAMGO did not alter food motivation; however, food consumption and motor activity were reduced. Intragastric administration of the delta opioid receptor agonist DADLE did not lead to changes in the level of food motivation and physical activity, but inhibition of feeding behavior was observed in all reinforcement schedules. Three regulatory pathways of eating behavior in difficult food conditions by peripheral, predominantly gastric opioid receptors are hypothesized: environmental-inhibitory afferentations and suppression of the realization of food motivation into behavior; homeostatic-inhibitory action on food motivation; and rewarding-suppression of the anticipatory reinforcement.
Language	English
Publishing date	2021-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452960-6
ISSN	1662-5153
ISSN	1662-5153
DOI	10.3389/fnbeh.2020.600920
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cross-Generational Impact of Epigenetic Male Influence on Physical Activity in Rat.

Sudakov, Sergey K / Bogdanova, Natalia G / Nazarova, Galina A

Biology

2022 Volume 11, Issue 11

Abstract: The aim of this work was to study whether epigenetic events at conception influence the formation of behavioral features found in adult rats. First generational inheritance of activity level, anxiety like behavior, and learning ability was studied. To ... ...

Abstract	The aim of this work was to study whether epigenetic events at conception influence the formation of behavioral features found in adult rats. First generational inheritance of activity level, anxiety like behavior, and learning ability was studied. To separate genetic and non-genetic inheritance, mating of males and females with average motor activity was carried out in the presence anesthetized or conscious males with high or low activity. Our results show that offspring of parents who mated in the presence of males with a high motor activity were significantly more active than offspring of parents that were paired in the presence of males with low activity. Anxiety like behavior and learning ability were not inherited in this way. It is possible that the phenomenon we discovered is important for maintaining a certain level of activity of specific populations of animals. It counteracts natural selection, which should lead to a constant increase in the activity of animals.
Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11111606
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Article: Efficiency of moderately hypofractionated radiotherapy in NSCLC cell model.

Lüdeking, Marcus / Stemwedel, Katharina / Ramachandran, Dhanya / Grosche, Sinja / Christiansen, Hans / Merten, Roland / Henkenberens, Christoph / Bogdanova, Natalia V

Frontiers in oncology

2024 Volume 14, Page(s) 1293745

Abstract: Background: The current standard of radiotherapy for inoperable locally advanced NSCLCs with single fraction doses of 2.0 Gy, results in poor outcomes. Several fractionation schedules have been explored that developed over the past decades to ... ...

Abstract	Background: The current standard of radiotherapy for inoperable locally advanced NSCLCs with single fraction doses of 2.0 Gy, results in poor outcomes. Several fractionation schedules have been explored that developed over the past decades to increasingly more hypofractionated treatments. Moderate hypofractionated radiotherapy, as an alternative treatment, has gained clinical importance due to shorter duration and higher patient convenience. However, clinical trials show controversial results, adding to the need for pre-clinical radiobiological studies of this schedule. Methods: We examined in comparative analysis the efficiency of moderate hypofractionation and normofractionation in four different NSCLC cell lines and fibroblasts using several molecular-biological approaches. Cells were daily irradiated with 24x2.75 Gy (moderate hypofractionation) or with 30x2 Gy (normofractionation), imitating the clinical situation. Proliferation and growth rate via direct counting of cell numbers, MTT assay and measurements of DNA-synthesizing cells (EdU assay), DNA repair efficiency via immunocytochemical staining of residual γH2AX/53BP1 foci and cell surviving via clonogenic assay (CSA) were experimentally evaluated. Results: Overall, the four tumor cell lines and fibroblasts showed different sensitivity to both radiation regimes, indicating cell specificity of the effect. The absolute cell numbers and the CSA revealed significant differences between schedules (P < 0.0001 for all employed cell lines and both assays) with a stronger effect of moderate hypofractionation. Conclusion: Our results provide evidence for the similar effectiveness and toxicity of both regimes, with some favorable evidence towards a moderate hypofractionation. This indicates that increasing the dose per fraction may improve patient survival and therapy outcomes.
Language	English
Publishing date	2024-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1293745
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Article ; Online: Impact of filtration artifacts on the seasonality of river waters chemical composition

Shulkin Vladimir / Bogdanova Natalia / Lutsenko Tatyana / Yurchenko Svetlana

E3S Web of Conferences, Vol 98, p

2019 Volume 06013

Abstract: The difference in concentration of filterable trace metals, macro ions, nitrate and dissolved organic carbon (DOC) after capsule and membrane 0.45 µm filters was studied at the seasonal sampling of the typical medium size boreal Razdolnaya River, Far ... ...

Abstract	The difference in concentration of filterable trace metals, macro ions, nitrate and dissolved organic carbon (DOC) after capsule and membrane 0.45 µm filters was studied at the seasonal sampling of the typical medium size boreal Razdolnaya River, Far East of Russia. Trace metals showed notable decrease after membrane filtration compared with capsules, though concentrations of macro ions, nitrates and DOC were equal. Clogging of membranes with subsequent retention of coarse colloids was suggested as a reason for this difference. In summer the dissimilarity in concentration grew in order Cu < Zn < Ni, Cd < Mn < Fe reflecting a significant role of coarse colloids in the pool of filterable forms for Fe and Mn. In winter, retention of Mn was declined due to input of ionic forms from redox cycle. Floods are the periods with the most notable increase of coarse colloids content and maximum bias in the determination of filterable trace metals if frontal membrane filtration is being used.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Assessment of the role of translationally controlled tumor protein 1 (TPT1/TCTP) in breast cancer susceptibility and ATM signaling.

Neuhäuser, Katharina / Küper, Leonie / Christiansen, Hans / Bogdanova, Natalia

Clinical and translational radiation oncology

2019 Volume 15, Page(s) 99–107

Abstract: Background and purpose: The translationally controlled tumor protein 1 (TPT1/TCTP) has been implicated in the intracellular DNA damage response. We tested the role of TPT1 in breast cancer (BC) predisposition and re-evaluated its function in Ataxia- ... ...

Abstract	Background and purpose: The translationally controlled tumor protein 1 (TPT1/TCTP) has been implicated in the intracellular DNA damage response. We tested the role of TPT1 in breast cancer (BC) predisposition and re-evaluated its function in Ataxia-Telangiectasia mutated (ATM)-mediated damage recognition and DNA repair. Material and methods: The Results: The sequencing study identified a novel, potentially damaging missense mutation in a single patient. Silencing of Conclusions: TPT1
Language	English
Publishing date	2019-01-24
Publishing country	Ireland
Document type	Journal Article
ISSN	2405-6308
ISSN (online)	2405-6308
DOI	10.1016/j.ctro.2019.01.006
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Article: Effectiveness of hypofractionated and normofractionated radiotherapy in a triple-negative breast cancer model.

Grosche, Sinja / Bogdanova, Natalia V / Ramachandran, Dhanya / Lüdeking, Marcus / Stemwedel, Katharina / Christiansen, Hans / Henkenberens, Christoph / Merten, Roland

Frontiers in oncology

2022 Volume 12, Page(s) 852694

Abstract: Breast cancer (BC) is one of the most diagnosed malignant carcinomas in women with a triple-negative breast cancer (TNBC) phenotype being correlated with poorer prognosis. Fractionated radiotherapy (RT) is a central component of breast cancer management, ...

Abstract	Breast cancer (BC) is one of the most diagnosed malignant carcinomas in women with a triple-negative breast cancer (TNBC) phenotype being correlated with poorer prognosis. Fractionated radiotherapy (RT) is a central component of breast cancer management, especially after breast conserving surgery and is increasingly important for TNBC subtype prognosis. In recent years, moderately hypofractionated radiation schedules are established as a standard of care, but many professionals remain skeptical and are concerned about their efficiency and side effects. In the present study, two different triple-negative breast cancer cell lines, a non-malignant breast epithelial cell line and fibroblasts, were irradiated daily under normofractionated and hypofractionated schedules to evaluate the impact of different irradiation regimens on radiation-induced cell-biological effects. During the series of radiotherapy, proliferation, growth rate, double-strand DNA break-repair (DDR), cellular senescence, and cell survival were measured. Investigated normal and cancer cells differed in their responses and receptivity to different irradiation regimens, indicating cell line/cell type specificity of the effect. At the end of both therapy concepts, normal and malignant cells reach almost the same endpoint of cell count and proliferation inhibition, confirming the clinical observations in the follow-up at the cellular level. These result in cell lines closely replicating the irradiation schedules in clinical practice and, to some extent, contributing to the understanding of growth rate or remission of tumors and the development of fibrosis.
Language	English
Publishing date	2022-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.852694
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Article ; Online: Individual radiosensitivity reflected by γ-H2AX and 53BP1 foci predicts outcome in PSMA-targeted radioligand therapy.

Widjaja, Liam / Werner, Rudolf A / Krischke, Elke / Christiansen, Hans / Bengel, Frank M / Bogdanova, Natalia / Derlin, Thorsten

European journal of nuclear medicine and molecular imaging

2022 Volume 50, Issue 2, Page(s) 602–612

Abstract: Purpose: γ-H2AX and 53BP1 are fundamental for cellular DNA damage response (DDR) after radiation exposure and are linked to cell repair, arrest, or apoptosis. We aimed to evaluate whether DDR-markers in peripheral blood lymphocytes (PBLs) may have ... ...

Abstract	Purpose: γ-H2AX and 53BP1 are fundamental for cellular DNA damage response (DDR) after radiation exposure and are linked to cell repair, arrest, or apoptosis. We aimed to evaluate whether DDR-markers in peripheral blood lymphocytes (PBLs) may have predictive potential for outcome in metastatic castration-resistant prostate cancer (mCRPC) patients receiving [ Methods: We prospectively enrolled 20 men with advanced mCRPC scheduled for PSMA-targeted RLT. Prior to the first cycle of [ Results: Low baseline 53BP1 and γ-H2AX foci (P = 0.17) tended to predict early PSA-PD, whereas low SUV Conclusion: In this prospective study investigating mCRPC patients undergoing [
MeSH term(s)	Male ; Humans ; Prostate-Specific Antigen ; Prostatic Neoplasms, Castration-Resistant/diagnostic imaging ; Prostatic Neoplasms, Castration-Resistant/radiotherapy ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prospective Studies ; Radiopharmaceuticals/therapeutic use ; Dipeptides/therapeutic use ; Treatment Outcome ; Heterocyclic Compounds, 1-Ring/therapeutic use ; Lutetium/therapeutic use ; Retrospective Studies
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77) ; Radiopharmaceuticals ; Dipeptides ; Heterocyclic Compounds, 1-Ring ; Lutetium (5H0DOZ21UJ)
Language	English
Publishing date	2022-09-22
Publishing country	Germany
Document type	Journal Article ; Comment
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-022-05974-8
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Article: Innovative food ingredients based on the milk protein–chitosan complex particles for the fortification of food with essential lipids

Chebotarev, Sergey / Antipova, Anna / Martirosova, Elena / Palmina, Nadezhda / Zelikina, Daria / Anokhina, Maria / Bogdanova, Natalia / Kasparov, Valery / Balakina, Ekaterina / Komarova, Anastasia / Semenova, Maria

International dairy journal. 2022 Sept., v. 132

2022

Abstract: The aim of this work was to elucidate the influence of both the structural features of milk proteins [whey proteins (WPI) and sodium caseinate (SC)] and the character of their electrostatic associative interactions with chitosan (CHIT) on the structure, ... ...

Abstract	The aim of this work was to elucidate the influence of both the structural features of milk proteins [whey proteins (WPI) and sodium caseinate (SC)] and the character of their electrostatic associative interactions with chitosan (CHIT) on the structure, thermodynamic parameters and functionality of their complexes with essential lipids. These lipids included soybean phosphatidylcholine liposomes (PC), rich in omega-6 linoleic (LA) polyunsaturated fatty acid (PUFA), and long chain omega-3 PUFAs (eicosapentaenoic and docosahexaenoic acids) from fish oil (FO) to their equal weight ratio with LA. A laser light scattering method was used in static, dynamic and electrophoretic modes to characterise the structure and thermodynamic parameters of the supramolecular complexes in an aqueous medium. The functionality of the supramolecular complexes (WPI−CHIT−PC−FO and SC−CHIT−PC−FO) was considered from the point of view of their solubility in an aqueous medium and protective abilities against oxidation of the essential lipids encapsulated in them.
Keywords	chitosan ; docosahexaenoic acid ; eicosapentaenoic acid ; electrophoresis ; fish oils ; food fortification ; milk ; omega-3 fatty acids ; oxidation ; phosphatidylcholines ; sodium caseinate ; solubility ; soybeans ; thermodynamics ; whey
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1076400-8
ISSN	0958-6946
ISSN	0958-6946
DOI	10.1016/j.idairyj.2022.105402
Database	NAL-Catalogue (AGRICOLA)

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Article: Efficiency of an oral delivery system based on a liposomal form of a combination of curcumin with a balanced amount of n-3 and n-6 PUFAs encapsulated in an electrostatic complex of WPI with chitosan

Zelikina, Daria / Chebotarev, Sergey / Komarova, Anastasia / Balakina, Ekaterina / Antipova, Anna / Martirosova, Elena / Anokhina, Maria / Palmina, Nadezhda / Bogdanova, Natalia / Lysakova, Elena / Borisova, Maria / Semenova, Maria

Colloids and surfaces. 2022 Oct. 20, v. 651

2022

Abstract: A water-soluble liposomal form was successfully developed based on phosphatidylcholine liposomes (PC) loaded by a combination of curcumin (CUR) with a balanced amount of n-3 and n-6 polyunsaturated fatty acids (PUFAs), which were encapsulated in an ... ...

Abstract	A water-soluble liposomal form was successfully developed based on phosphatidylcholine liposomes (PC) loaded by a combination of curcumin (CUR) with a balanced amount of n-3 and n-6 polyunsaturated fatty acids (PUFAs), which were encapsulated in an electrostatic complex of whey protein isolate (WPI) with chitosan [WPI− (PC−FO−CUR)]−CHIT. The encapsulation of (PC−FO−CUR) liposomes first by WPI (with the efficiency of encapsulation (EE) = 61 ± 7%), and then by CHIT (EE = 83.5 ± 6.6%), also made it possible to obtain nanosized particles with 100% solubility in an aqueous medium. To take full advantage of these supramolecular systems, we set out to achieve a deep understanding of the relationships between their structure and functionality immediately after their formation, during storage under adverse environmental conditions, as well as during digestion in the gastrointestinal tract (GIT) in vitro according to INFOGEST research protocol. A deep understanding of these relationships could show promise for their use as functional ingredients for new formulations of excipient, functional or therapeutic foods. The studied functional properties included an encapsulating ability, water solubility, protective ability, as well as release of bioactive substances in the GIT in vitro. To achieve the goal of the study, we used a number of physicochemical methods (electron paramagnetic resonance spectroscopy (EPRS); laser light scattering in static, dynamic and electrophoretic modes; transmission electron microscopy; spectrophotometry; and tensiometry).
Keywords	chitosan ; curcumin ; digestion ; digestive tract ; electron paramagnetic resonance spectroscopy ; electrophoresis ; encapsulation ; omega-6 fatty acids ; phosphatidylcholines ; therapeutics ; transmission electron microscopy ; water solubility ; whey protein isolate
Language	English
Dates of publication	2022-1020
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2022.129630
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Article: Endogenous opioid dependence after intermittent use of glucose, sodium chloride, and monosodium glutamate solutions.

Sudakov, Sergey K / Bogdanova, Natalia G / Alekseeva, Elena V / Nazarova, Galina A

Food science & nutrition

2019 Volume 7, Issue 9, Page(s) 2842–2846

Abstract: In 2002, Colantuoni et al described the possibility of dependency in rats after intermittent, excessive consumption of a 25% glucose solution over a one-week period. We hypothesized that the intermittent consumption of any tasty solution can lead to ... ...

Abstract	In 2002, Colantuoni et al described the possibility of dependency in rats after intermittent, excessive consumption of a 25% glucose solution over a one-week period. We hypothesized that the intermittent consumption of any tasty solution can lead to endogenous opioid dependency. Another aim was to determine whether dependency is connected to the taste of the consumed substance or with its physiological significance. Rats were maintained on chow and cyclic glucose, NaCl, or monosodium glutamate (MSG) solution for 8 days. On day 9, after a 12-hr deprivation period and administration of intraperitoneally (IP) naloxone, the general withdrawal index was calculated as the sum of teeth chattering, head shaking, forepaw tremors, and wet dog shakes. Motor activity was also documented. After the intermittent consumption of any tasty solution, rats were found to demonstrate signs of endogenous opioid dependence. The development of dependence was not related to taste preferences or the amount of solution consumed. Intermittent use of essential substance with a pleasant taste, as glucose and sodium chloride, leads to the rapid development of endogenous opioid dependence. Withdrawal syndrome following the consumption of MSG solution is associated with the presence of sodium ions in the MSG molecule.
Language	English
Publishing date	2019-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.1120
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