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Article ; Online: The immune response to a Coxiella burnetii vaccine in sheep varies according to their natural pre-exposure.

Böttcher, Jens / Bauer, Benjamin U / Ambros, Christina / Alex, Michaela / Domes, Ursula / Roth, Sabine / Boll, Kerstin / Korneli, Martin / Bogner, Karl-Heinz / Randt, Andreas / Janowetz, Britta

Vaccine

2024 Volume 42, Issue 8, Page(s) 1993–2003

Abstract: Q fever in humans is caused by Coxiella (C.) burnetii. In 2008 and 2012, cases of Q fever in humans were linked to an infected flock of approximately 650 ewes. Since 2013 gimmers (G'13, G'14, G'15 etc.) were primary vaccinated (two doses) with an ... ...

Abstract	Q fever in humans is caused by Coxiella (C.) burnetii. In 2008 and 2012, cases of Q fever in humans were linked to an infected flock of approximately 650 ewes. Since 2013 gimmers (G'13, G'14, G'15 etc.) were primary vaccinated (two doses) with an inactivated C.burnetii vaccine without any revaccination. In 2013, 30 ewes were primary vaccinated (A'13). Shedding was annually monitored by qPCR-testing of vaginal and nasal swabs collected at lambing. Animals were tested for Phase I- (PhI) and PhII-antibodies (Ab) and for PhII-specific-interferon-γ (IFN-γ) before and after vaccination. The effect of a revaccination was determined in 2018 and 2023. Groups of randomly selected gimmers primary vaccinated in 2015, 2016 and 2017 and a mixed group of older animals (A'13, G'13 and G'14) were revaccinated once in 2018. The trial was repeated in 2023 on groups primary vaccinated in 2019-2023. Major shedding after the outbreak in 2012 ceased in 2014. Thereafter C.burnetii was only sporadically detected at low-level in 2018, 2021 and 2023. Sheep naturally exposed to C.burnetii during the outbreak in 2012 (A'13, G'13) mounted a strong and complete (PhI, PhII, IFN-γ) recall immune response after vaccination. A serological PhI
MeSH term(s)	Humans ; Sheep ; Animals ; Female ; Coxiella burnetii ; Q Fever/prevention & control ; Q Fever/veterinary ; Q Fever/epidemiology ; Antibodies ; Bacterial Vaccines ; Immunity
Chemical Substances	Antibodies ; Bacterial Vaccines
Language	English
Publishing date	2024-02-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.048
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Zs.MO 458: Show issues

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Article: Long-term control of Coxiellosis in sheep by annual primary vaccination of gimmers

Böttcher, Jens / Bauer, Benjamin U. / Ambros, Christina / Alex, Michaela / Domes, Ursula / Roth, Sabine / Boll, Kerstin / Korneli, Martin / Bogner, Karl-Heinz / Randt, Andreas / Janowetz, Britta

Vaccine. 2022 July 21,

2022

Abstract: Coxiella (C.) burnetii, a Gram-negative intracellular bacterium, causes Q fever in humans and Coxiellosis in animals. Ruminants are a primary source of human infection with C.burnetii. In 2013, vaccination was implemented in a sheep flock with 650 ewes ... ...

Abstract	Coxiella (C.) burnetii, a Gram-negative intracellular bacterium, causes Q fever in humans and Coxiellosis in animals. Ruminants are a primary source of human infection with C.burnetii. In 2013, vaccination was implemented in a sheep flock with 650 ewes associated with two outbreaks of Q fever in humans in 2008 and 2012. Only gimmers (yearlings) received two doses of a commercial C.burnetii phase I whole cell vaccine three weeks apart (primary vaccination) without any revaccination. Vaginal and nasal swabs collected shortly after lambing were tested by qPCR. Additionally, a group of non-vaccinated sentinels was serologically monitored for phase I (PhI), II (PhII) antibodies and for Interferon γ (IFN-γ) after stimulation of whole blood cells with PhII-antigen with and without an IL-10-neutralizing monoclonal antibody. In 2021, 679 sera collected in 2014–2021 were retested retrospectively with three commercial ELISA kits and one batch of an in-house PhI/PhII-ELISA. A low-level shedding of C.burnetii (<10³ mean C.burnetii/swab) was observed until 2014. In 2021 C.burnetii was detected in two animals (<10³.¹C.burnetii/swab), but vaginal swabs collected at two subsequent lambing seasons remained negative. Seroconversion of sentinels was detected until 2017. However, the retrospective analysis of sentinels in 2021 revealed additional single seropositive animals from 2018 to 2021. IFN-γ reactivity was observed during the whole study period; it peaked in 2014 and in 2018 and decreased thereafter. The sporadic detection of C.burnetii and the immune responses of sentinels suggested that a subliminal infection persisted despite vaccination. Nevertheless, vaccination of gimmers prevented the development of a major outbreak, it controlled the infection and reduced the risk of human infection.
Keywords	Coxiella ; Q fever ; bacteria ; flocks ; human diseases ; monoclonal antibodies ; nose ; retrospective studies ; seroconversion ; seroprevalence ; vaccination ; vaccines
Language	English
Dates of publication	2022-0721
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.07.029
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Long-term control of Coxiellosis in sheep by annual primary vaccination of gimmers.

Böttcher, Jens / Bauer, Benjamin U / Ambros, Christina / Alex, Michaela / Domes, Ursula / Roth, Sabine / Boll, Kerstin / Korneli, Martin / Bogner, Karl-Heinz / Randt, Andreas / Janowetz, Britta

Vaccine

2022 Volume 40, Issue 35, Page(s) 5197–5206

Abstract	Coxiella (C.) burnetii, a Gram-negative intracellular bacterium, causes Q fever in humans and Coxiellosis in animals. Ruminants are a primary source of human infection with C.burnetii. In 2013, vaccination was implemented in a sheep flock with 650 ewes associated with two outbreaks of Q fever in humans in 2008 and 2012. Only gimmers (yearlings) received two doses of a commercial C.burnetii phase I whole cell vaccine three weeks apart (primary vaccination) without any revaccination. Vaginal and nasal swabs collected shortly after lambing were tested by qPCR. Additionally, a group of non-vaccinated sentinels was serologically monitored for phase I (PhI), II (PhII) antibodies and for Interferon γ (IFN-γ) after stimulation of whole blood cells with PhII-antigen with and without an IL-10-neutralizing monoclonal antibody. In 2021, 679 sera collected in 2014-2021 were retested retrospectively with three commercial ELISA kits and one batch of an in-house PhI/PhII-ELISA. A low-level shedding of C.burnetii (<10
MeSH term(s)	Animals ; Coxiella burnetii ; Female ; Humans ; Q Fever/epidemiology ; Q Fever/prevention & control ; Q Fever/veterinary ; Retrospective Studies ; Sheep ; Sheep Diseases/epidemiology ; Sheep Diseases/microbiology ; Sheep Diseases/prevention & control ; Vaccination/veterinary
Language	English
Publishing date	2022-07-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.07.029
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Article: Anforderungen an den Umgang mit ELISA-Systemen bei Bekämpfungsverfahren.

Bogner, Karl-Heinz

Berliner und Munchener tierarztliche Wochenschrift

2003 Volume 116, Issue 5-6, Page(s) 259–262

Abstract: Users of ELISA test systems applied in eradication schemes must be aware of their potential and their limitations. Means to improve laboratory quality as well as strict performance of the test procedure are essential. Sensitivity and specificity of test ... ...

Title translation	Requirements for the use of ELISA systems in eradication programs.
Abstract	Users of ELISA test systems applied in eradication schemes must be aware of their potential and their limitations. Means to improve laboratory quality as well as strict performance of the test procedure are essential. Sensitivity and specificity of test systems are limited. Therefore the establishment of a cascade of methods to verify questionable and positive results is important. Thus false positive results, which may threat the general acceptance of an eradication scheme, can be avoided.
MeSH term(s)	Animals ; Cattle ; Cattle Diseases/immunology ; Cattle Diseases/prevention & control ; Cattle Diseases/virology ; Enzyme-Linked Immunosorbent Assay/standards ; Enzyme-Linked Immunosorbent Assay/veterinary ; Herpesviridae Infections/immunology ; Herpesviridae Infections/prevention & control ; Herpesviridae Infections/veterinary ; Herpesvirus 1, Bovine ; Reproducibility of Results ; Viral Vaccines
Chemical Substances	Viral Vaccines
Language	German
Publishing date	2003-05
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	5674-1
ISSN	0005-9366
ISSN	0005-9366
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Zs.A 647: Show issues

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Article: Wildvogelmonitoring zum Vorkommen von aviärem Influenza A Virus (AIV) in Bayern in den Jahren 2007 und 2008.

Rabl, Stephanie / Rinder, Monika / Neubauer-Juric, Antonie / Bogner, Karl-Heinz / Korbel, Rüdiger / Büttner, Mathias

Berliner und Munchener tierarztliche Wochenschrift

2009 Volume 122, Issue 11-12, Page(s) 486–493

Abstract: A monitoring programme has been initiated in Bavaria to continuously control wild birds for the presence of avian Influenza A virus (AIV) and to monitor the possible occurrence and accumulation of notifiable AIV subtypes as an early-warning system. In ... ...

Title translation	Surveillance of wild birds for avian influenza A virus (AIV) in Bavaria in the years 2007 and 2008.
Abstract	A monitoring programme has been initiated in Bavaria to continuously control wild birds for the presence of avian Influenza A virus (AIV) and to monitor the possible occurrence and accumulation of notifiable AIV subtypes as an early-warning system. In addition information about the regional, seasonal and species-specific distribution of AIV could be obtained. Between July 2007 and December 2008 samples from 5864 wild birds of twelve different zoological orders had been collected (cloacal- and tracheal swab samples, droppings, and organs) and analysed. AIV genomes were detected in 3.7% of the 5864 wild birds by RT real time PCR. The subtype component H5 was identified in 52 samples (0.9%) and the N1 subtype component in 13 samples (0.2%), but never in combination with each other. The hemagglutinine subtype component H7 could not be detected. Most of the positive AIV genome results originated from samples in the district Swabia, which is situated in the central area of the south-west bird migration route across southern Germany and harbours favourable resting areas for migrating birds. Mallards (Anas platyrhynchos) were the most frequently sampled bird species and had the highest AIV infection rate of 6.4%, followed by Tufted ducks (Aythya fuligula) (AIV prevalence of 5.4%), Mute Swans (Cygnus olor) (1.6%), Coots (Fulica atra) (0.3%) and Greylag Goose (Anser anser) (0.1%). The detection rate of AIV in Bavarian wild birds showed a seasonal peak in autumn/winter. Ten virus isolates could be obtained after sample inoculation in embryonated hen's eggs.
MeSH term(s)	Animals ; Animals, Wild/virology ; Birds/virology ; Cloaca/virology ; Germany/epidemiology ; Influenza A virus/genetics ; Influenza A virus/isolation & purification ; Seasons ; Trachea/virology
Language	German
Publishing date	2009-11
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	5674-1
ISSN	0005-9366
ISSN	0005-9366
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Article: Enterohemorrhagic Escherichia coll excretion by child and her cat.

Busch, Ulrich / Hörmansdorfer, Stefan / Schranner, Stephan / Huber, Ingrid / Bogner, Karl-Heinz / Sing, Andreas

Emerging infectious diseases

2007 Volume 13, Issue 2, Page(s) 348–349

MeSH term(s)	Animals ; Cats/microbiology ; Child, Preschool ; Diarrhea/microbiology ; Escherichia coli Infections/microbiology ; Escherichia coli Infections/transmission ; Escherichia coli Infections/veterinary ; Escherichia coli O157/classification ; Escherichia coli O157/isolation & purification ; Escherichia coli O157/pathogenicity ; Feces/microbiology ; Female ; Humans ; Vomiting/microbiology ; Zoonoses/microbiology ; Zoonoses/transmission
Language	English
Publishing date	2007-03-15
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1380686-5
ISSN	1080-6040
ISSN	1080-6040
DOI	10.3201/eid1302.061106
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Zs.A 4778: Show issues

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Book: Versuche zur Aktualisierung des Nachweises des allgemeinen Keimgehalts, der Salmonellen und der Clostridien im Rahmen der "Amtlichen bakteriologischen Fleischuntersuchung" (BU)

Bogner, Karl-Heinz

1985

Title variant	Berlin, Fr. Univ., Diss., 1985
Institution	Institut für Lebensmittelhygiene
Author's details	von Karl-Heinz Bogner
Keywords	Dissertation
Language	German
Size	142 S
Document type	Book
Database	Federal Institute for Risk Assessment

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Book: Versuche zur Aktualisierung des Nachweises des allgemeinen Keimgehalts, der Salmonellen der Clostridien im Rahmen der "amtlichen bakteriologischen Fleischuntersuchung" <BU>

Bogner, Karl-Heinz

1985

Author's details	Karl-Heinz Bogner
Language	Undetermined
Size	142 S, graph. Darst, 21 cm
Document type	Book
Note	Berlin, Freie Univ., Fachbereich Veterinärmedizin, Diss. 1985
Database	Special collection on veterinary medicine and general parasitology

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Article: Genetic evidence for multi-event imports of avian influenza virus A (H5N1) into Bavaria, Germany.

Rinder, Monika / Lang, Victoria / Fuchs, Cordula / Hafner-Marx, Angela / Bogner, Karl-Heinz / Neubauer, Antonie / Büttner, Mathias / Rinder, Heinz

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

2006 Volume 19, Issue 3, Page(s) 279–282

Abstract: The almost simultaneous initial detections of avian influenza A H5N1 viruses in central Europe in February 2006, at a time devoid of migratory bird activity, raised the question of the origin of these viruses. This report presents molecular data from ... ...

Abstract	The almost simultaneous initial detections of avian influenza A H5N1 viruses in central Europe in February 2006, at a time devoid of migratory bird activity, raised the question of the origin of these viruses. This report presents molecular data from Europe providing evidence for multiple and spatially overlapping H5N1 introductions into Bavaria, Germany.
MeSH term(s)	Animals ; Birds ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/veterinary ; Communicable Diseases, Emerging/virology ; DNA, Viral/chemistry ; DNA, Viral/genetics ; Disease Outbreaks/veterinary ; Genetic Variation ; Germany/epidemiology ; Hemagglutinins/chemistry ; Hemagglutinins/genetics ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza A Virus, H5N1 Subtype/isolation & purification ; Influenza in Birds/epidemiology ; Influenza in Birds/virology ; Neuraminidase/chemistry ; Neuraminidase/genetics ; Phylogeny ; Polymerase Chain Reaction/veterinary
Chemical Substances	DNA, Viral ; Hemagglutinins ; Neuraminidase (EC 3.2.1.18)
Language	English
Publishing date	2006-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/104063870701900308
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3645: Show issues

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Article: BHV-1-Bekämpfung in Bayern: Eine markerunabhängige Strategie.

Truyen, Uwe / Isa, Gisela / Gerbermann, Hermann / Bogner, Karl-Heinz / Banzhaf, Klaus / Köstler, Michael / Pauels, Franz Josef / Czerny, Claus-Peter / Wittkowski, Gerhard

Berliner und Munchener tierarztliche Wochenschrift

2003 Volume 116, Issue 5-6, Page(s) 197–202

Abstract: In Bavaria a BHV-1 eradication program was initiated in 1986 and was changed to a compulsory program in 1998. The eradication success increased progressively from < 50% in 1986 to 87% of the farms in 2002. BHV 1-free farms are controlled by bulk milk ... ...

Title translation	BHV-1 eradication program in Bavaria: a marker-independent strategy.
Abstract	In Bavaria a BHV-1 eradication program was initiated in 1986 and was changed to a compulsory program in 1998. The eradication success increased progressively from < 50% in 1986 to 87% of the farms in 2002. BHV 1-free farms are controlled by bulk milk serology twice a year along with blood serology in animals that are negative but from herds where positive field virus infected animals are present. All serological tests are performed with an indirect ELISA test, all positive results are confirmed by a gB ELISA. Currently about 100.000 virus infected cattle are in Bavarian herds, approximately 80% of these animals are in heavily infected herds (> 10 infected animals). These herds comprise about 5% of all Bavarian herds. The eradication of the virus in these heavily infected herds is the most diifficult, whereas the prevention of new infections appears controllable. In this review current problems in BHV1 eradication are named and possible improvements are discussed.
MeSH term(s)	Animals ; Antigens, Viral/blood ; Biomarkers/blood ; Cattle ; Cattle Diseases/epidemiology ; Cattle Diseases/prevention & control ; Cattle Diseases/virology ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/veterinary ; Female ; Germany/epidemiology ; Herpesviridae Infections/epidemiology ; Herpesviridae Infections/prevention & control ; Herpesviridae Infections/veterinary ; Herpesvirus 1, Bovine ; Milk/virology ; Viral Envelope Proteins/blood ; Viral Proteins
Chemical Substances	Antigens, Viral ; Biomarkers ; Viral Envelope Proteins ; Viral Proteins ; bovine herpesvirus type-1 glycoproteins
Language	German
Publishing date	2003-05
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	5674-1
ISSN	0005-9366
ISSN	0005-9366
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