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  1. Article ; Online: From immune to olfactory expression: neofunctionalization of formyl peptide receptors.

    Boillat, Madlaina / Carleton, Alan / Rodriguez, Ivan

    Cell and tissue research

    2021  Volume 383, Issue 1, Page(s) 387–393

    Abstract: Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory ... ...

    Abstract Variations in gene expression patterns represent a powerful source of evolutionary innovation. In a rodent living about 70 million years ago, a genomic accident led an immune formyl peptide receptor (FPR) gene to hijack a vomeronasal receptor regulatory sequence. This gene shuffling event forced an immune pathogen sensor to transition into an olfactory chemoreceptor, which thus moved from sensing the internal world to probing the outside world. We here discuss the evolution of the FPR gene family, the events that led to their neofunctionalization in the vomeronasal organ and the functions of immune and vomeronasal FPRs.
    MeSH term(s) Animals ; Receptors, Formyl Peptide ; Receptors, Odorant/metabolism
    Chemical Substances Receptors, Formyl Peptide ; Receptors, Odorant
    Language English
    Publishing date 2021-01-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-020-03393-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Publisher Correction: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

    Horgue, Luis Flores / Assens, Alexis / Fodoulian, Leon / Marconi, Leonardo / Tuberosa, Joël / Haider, Alexander / Boillat, Madlaina / Carleton, Alan / Rodriguez, Ivan

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1156

    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36849-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.

    Dietschi, Quentin / Tuberosa, Joël / Fodoulian, Leon / Boillat, Madlaina / Kan, Chenda / Codourey, Julien / Pauli, Véronique / Feinstein, Paul / Carleton, Alan / Rodriguez, Ivan

    Science advances

    2022  Volume 8, Issue 46, Page(s) eabn7450

    Abstract: Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered ... ...

    Abstract Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abn7450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

    Horgue, Luis Flores / Assens, Alexis / Fodoulian, Leon / Marconi, Leonardo / Tuberosa, Joël / Haider, Alexander / Boillat, Madlaina / Carleton, Alan / Rodriguez, Ivan

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2929

    Abstract: In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities ... ...

    Abstract In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding.
    MeSH term(s) Animals ; Mammals ; Mice ; Odorants ; Olfactory Receptor Neurons/physiology ; Receptors, Odorant/genetics ; Sensory Receptor Cells ; Smell
    Chemical Substances Receptors, Odorant
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30511-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii.

    Boillat, Madlaina / Hammoudi, Pierre-Mehdi / Dogga, Sunil Kumar / Pagès, Stéphane / Goubran, Maged / Rodriguez, Ivan / Soldati-Favre, Dominique

    Cell reports

    2019  Volume 30, Issue 2, Page(s) 320–334.e6

    Abstract: In rodents, the decrease of felid aversion induced by Toxoplasma gondii, a phenomenon termed fatal attraction, is interpreted as an adaptive manipulation by the neurotropic protozoan parasite. With the aim of understanding how the parasite induces such ... ...

    Abstract In rodents, the decrease of felid aversion induced by Toxoplasma gondii, a phenomenon termed fatal attraction, is interpreted as an adaptive manipulation by the neurotropic protozoan parasite. With the aim of understanding how the parasite induces such specific behavioral modifications, we performed a multiparametric analysis of T. gondii-induced changes on host behavior, physiology, and brain transcriptome as well as parasite cyst load and distribution. Using a set of complementary behavioral tests, we provide strong evidence that T. gondii lowers general anxiety in infected mice, increases explorative behaviors, and surprisingly alters predator aversion without selectivity toward felids. Furthermore, we show a positive correlation between the severity of the behavioral alterations and the cyst load, which indirectly reflects the level of inflammation during brain colonization. Taken together, these findings refute the myth of a selective loss of cat fear in T. gondii-infected mice and point toward widespread immune-related alterations of behaviors.
    MeSH term(s) Animals ; Behavior, Animal/physiology ; Brain/parasitology ; Exploratory Behavior/physiology ; Fear/psychology ; Host-Parasite Interactions/physiology ; Male ; Mice ; Toxoplasma/pathogenicity ; Toxoplasmosis/transmission
    Language English
    Publishing date 2019-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2019.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain.

    Fodoulian, Leon / Tuberosa, Joël / Rossier, Daniel / Boillat, Madlaina / Kan, Chenda / Pauli, Véronique / Egervari, Kristof / Lobrinus, Johannes A / Landis, Basile N / Carleton, Alan / Rodriguez, Ivan

    iScience

    2020  Volume 23, Issue 12, Page(s) 101839

    Abstract: Reports indicate an association between COVID-19 and anosmia, as well as the presence of SARS-CoV-2 virions in the olfactory bulb. To test whether the olfactory neuroepithelium may represent a target of the virus, we generated RNA-seq libraries from ... ...

    Abstract Reports indicate an association between COVID-19 and anosmia, as well as the presence of SARS-CoV-2 virions in the olfactory bulb. To test whether the olfactory neuroepithelium may represent a target of the virus, we generated RNA-seq libraries from human olfactory neuroepithelia, in which we found substantial expression of the genes coding for the virus receptor angiotensin-converting enzyme-2 (ACE2) and for the virus internalization enhancer TMPRSS2. We analyzed a human olfactory single-cell RNA-seq dataset and determined that sustentacular cells, which maintain the integrity of olfactory sensory neurons, express
    Language English
    Publishing date 2020-11-25
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2020.101839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The vomeronasal system mediates sick conspecific avoidance.

    Boillat, Madlaina / Challet, Ludivine / Rossier, Daniel / Kan, Chenda / Carleton, Alan / Rodriguez, Ivan

    Current biology : CB

    2015  Volume 25, Issue 2, Page(s) 251–255

    Abstract: Although sociability offers many advantages, a major drawback is the increased risk of exposure to contagious pathogens, like parasites, viruses, or bacteria. Social species have evolved various behavioral strategies reducing the probability of pathogen ... ...

    Abstract Although sociability offers many advantages, a major drawback is the increased risk of exposure to contagious pathogens, like parasites, viruses, or bacteria. Social species have evolved various behavioral strategies reducing the probability of pathogen exposure. In rodents, sick conspecific avoidance can be induced by olfactory cues emitted by parasitized or infected conspecifics. The neural circuits involved in this behavior remain largely unknown. We observed that olfactory cues present in bodily products of mice in an acute inflammatory state or infected with a viral pathogen are aversive to conspecifics. We found that these chemical signals trigger neural activity in the vomeronasal system, an olfactory subsystem controlling various innate behaviors. Supporting the functional relevance of these observations, we show that preference toward healthy individuals is abolished in mice with impaired vomeronasal function. These findings reveal a novel function played by the vomeronasal system.
    MeSH term(s) Animals ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Cues ; Inflammation/metabolism ; Lipopolysaccharides/physiology ; Male ; Mice/immunology ; Mice/physiology ; Mice/virology ; Mice, Inbred C57BL ; Murine hepatitis virus/physiology ; Odorants ; Olfactory Perception ; Rodent Diseases/metabolism ; Rodent Diseases/virology ; Social Behavior ; Urine/chemistry ; Urine/virology ; Vomeronasal Organ/physiology
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2015-01-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2014.11.061
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  8. Article ; Online: SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium

    Fodoulian, Leon / Tuberosa, Joel / Rossier, Daniel / Boillat, Madlaina / Kan, Chenda / Pauli, Véronique / Egervari, Kristof / Lobrinus, Johannes A. / Landis, Basile N. / Carleton, Alan / Rodriguez, Ivan

    bioRxiv

    Abstract: Various reports indicate an association between COVID-19 and anosmia, suggesting an infection of the olfactory sensory epithelium, and thus a possible direct virus access to the brain. To test this hypothesis, we generated RNA-seq libraries from human ... ...

    Abstract Various reports indicate an association between COVID-19 and anosmia, suggesting an infection of the olfactory sensory epithelium, and thus a possible direct virus access to the brain. To test this hypothesis, we generated RNA-seq libraries from human olfactory neuroepithelia, in which we found substantial expression of the genes coding for the virus receptor angiotensin-converting enzyme-2 (ACE2), and for the virus internalization enhancer TMPRSS2. We analyzed a human olfactory single-cell RNA-seq dataset and determined that sustentacular cells, which maintain the integrity of olfactory sensory neurons, express ACE2 and TMPRSS2. We then observed that the ACE2 protein was highly expressed in a subset of sustentacular cells in human and mouse olfactory tissues. Finally, we found ACE2 transcripts in specific brain cell types, both in mice and humans. Sustentacular cells thus represent a potential entry door for SARS-CoV-2 in a neuronal sensory system that is in direct connection with the brain.
    Keywords covid19
    Publisher BioRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.03.31.013268
    Database COVID19

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