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Article ; Online: Bragg gratings with novel waveguide models fabricated in bulk glass via fs-laser writing and their slow-light effects.

Chen, Qingtao / Boisvert, Jean-Sébastien / Sharawi, Mohammad S / Kashyap, Raman

2024 Volume 32, Issue 1, Page(s) 188–204

Abstract: We present the experimental realization of an innovative parallel partially overlapping waveguides (PO-WGs) model grounded in the thermal accumulated regime and fabricated using femtosecond (fs) laser direct-writing within low-iron bulk glass. The 75mm ... ...

Abstract	We present the experimental realization of an innovative parallel partially overlapping waveguides (PO-WGs) model grounded in the thermal accumulated regime and fabricated using femtosecond (fs) laser direct-writing within low-iron bulk glass. The 75mm long novel PO-WGs model was made by partially overlapping the shell parts of two core-shell types of waveguides via a back-and-forth single pass fs-laser inscription. The detailed evolution of the PO-WGs model from inception to completion was offered, accompanying by a thorough characterization, which unveils a substantial refractive index (RI) change, on the order of 10
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.509482
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fs laser written volume Raman-Nath grating for integrated spectrometer on smartphone.

Boisvert, Jean-Sébastien / Loranger, Sébastien / Kashyap, Raman

Scientific reports

2023 Volume 13, Issue 1, Page(s) 13717

Abstract: In this work we demonstrate the integration of a spectrometer directly into smartphone screen by femtosecond laser inscription of a weak Raman-Nath volume grating either into the Corning Gorilla glass screen layer or in the tempered aluminosilicate glass ...

Abstract	In this work we demonstrate the integration of a spectrometer directly into smartphone screen by femtosecond laser inscription of a weak Raman-Nath volume grating either into the Corning Gorilla glass screen layer or in the tempered aluminosilicate glass protector screen placed in front of the phone camera. Outside the thermal accumulation regime, a new writing regime yielding positive refractive index change was found for both glasses which is fluence dependent. The upper-bound threshold for this thermal-accumulation-less writing regime was found for both glasses and were, respectively at a repetition rate less than 150 kHz and 101 kHz for fluence of 8.7 × 10
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-40909-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A simple high-speed random number generator with minimal post-processing using a random Raman fiber laser.

Monet, Frédéric / Boisvert, Jean-Sébastien / Kashyap, Raman

Scientific reports

2021 Volume 11, Issue 1, Page(s) 13182

Abstract: A simple novel method for random number generation is presented, based on a random Raman fiber laser. This laser is built in a half-open cavity scheme, closed on one side by a narrow-linewidth 100 mm fiber Bragg grating. The interaction between the ... ...

Abstract	A simple novel method for random number generation is presented, based on a random Raman fiber laser. This laser is built in a half-open cavity scheme, closed on one side by a narrow-linewidth 100 mm fiber Bragg grating. The interaction between the randomly excited lasing modes of this laser, in addition to nonlinear effects such as modulation instability, allow the generation of random bits at rates of up to 540 Gbps with minimal post processing. Evaluation of the resulting bit streams' randomness by the NIST statistical test suite highlights the importance of evaluating the physical entropy content, as bit sequences generated by this random laser pass all the statistical tests with a significance level of 0.01, despite being generated at more than twice the theoretical entropy generation speed.
Language	English
Publishing date	2021-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-92668-0
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Article ; Online: Femtosecond laser direct-writing of high quality first-order Bragg gratings with arbitrary complex apodization by phase modulation.

Roberge, Anthony / Loranger, Sébastien / Boisvert, Jean-Sébastien / Monet, Frédéric / Kashyap, Raman

Optics express

2022 Volume 30, Issue 17, Page(s) 30405–30419

Abstract: Femtosecond laser direct-writing is an attractive technique to fabricate fiber Bragg gratings and to achieve through-the-coating inscription. In this article, we report the direct inscription of high-quality first-order gratings in optical fiber, without ...

Abstract	Femtosecond laser direct-writing is an attractive technique to fabricate fiber Bragg gratings and to achieve through-the-coating inscription. In this article, we report the direct inscription of high-quality first-order gratings in optical fiber, without the use of an index-matching medium. A new alignment technique based on the inscription of weak probe gratings is used to track the relative position between the focal spot and fiber core. A simple and flexible method to precisely control the position of each grating plane is also presented. With this method, periodic phase modulation of grating structures is achieved and used to inscribe arbitrary apodization and phase profiles. It is shown that a burst of multiple laser pulses used to inscribe each grating plane leads to a significant increase in the grating strength, while maintaining low insertion loss, critical for many applications.
Language	English
Publishing date	2022-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.465331
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells.

Lafontaine, Julie / Cardin, Guillaume B / Malaquin, Nicolas / Boisvert, Jean-Sébastien / Rodier, Francis / Wong, Philip

Cancers

2021 Volume 13, Issue 3

Abstract: Radiotherapy (RT) is a key component of cancer treatment. Most of the time, radiation is given after surgery but for soft-tissue sarcomas (STS), pre-surgical radiation is commonly utilized. However, despite improvements in RT accuracy, the rate of local ... ...

Abstract	Radiotherapy (RT) is a key component of cancer treatment. Most of the time, radiation is given after surgery but for soft-tissue sarcomas (STS), pre-surgical radiation is commonly utilized. However, despite improvements in RT accuracy, the rate of local recurrence remains high and is the major cause of death for patients with STS. A better understanding of cell fates in response to RT could provide new therapeutic options to enhance tumour cell killing by RT and facilitate surgical resection. Here, we showed that irradiated STS cell cultures do not die but instead undergo therapy-induced senescence (TIS), which is characterized by proliferation arrest, senescence-associated β-galactosidase activity, secretion of inflammatory cytokines and persistent DNA damage. STS-TIS was also associated with increased levels of the anti-apoptotic Bcl-2 family of proteins which rendered cells targetable using senolytic Bcl-2 inhibitors. As oppose to radiation alone, the addition of senolytic agents Venetoclax (ABT-199) or Navitoclax (ABT-263) after irradiation induced a rapid apoptotic cell death in STS monolayer cultures and in a more complex three-dimensional culture model. Together, these data suggest a new promising therapeutic approach for sarcoma patients who receive neoadjuvant RT. The addition of senolytic agents to radiation treatments may significantly reduce tumour volume prior to surgery and thereby improve the clinical outcome of patients.
Language	English
Publishing date	2021-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13030386
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Article ; Online: Photosensitization agents for fs laser writing in PDMS.

Boisvert, Jean-Sebastien / Hlil, Antsar / Loranger, Sebastien / Riaz, Ali / Ledemi, Yannick / Messaddeq, Younes / Kashyap, Raman

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1623

Abstract: This study aims at identifying compounds incorporated into Polydimethylsiloxane (PDMS) which produce large refractive index change under fs laser exposition, potentially leading to optimal writing of waveguides or photonic devices in such a soft host. ... ...

Abstract	This study aims at identifying compounds incorporated into Polydimethylsiloxane (PDMS) which produce large refractive index change under fs laser exposition, potentially leading to optimal writing of waveguides or photonic devices in such a soft host. Germanium derivative, titania and zirconite derivatives, benzophenone (Bp), irgacure-184/500/1173 and 2959 are investigated. We show a mapping of the RI index change relative to the writing speed (1 to 40 mm/s), the repetition rate (606 to 101 kHz) and the number of passes (1 to 8) from which we establish quantitative parameters to allow the comparison between samples. We show that the organic materials, especially irgacure-184 and benzophenone yield a significantly higher maximum refractive index change in the order of 10
Language	English
Publishing date	2022-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05366-w
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Article: Synergy between Non-Thermal Plasma with Radiation Therapy and Olaparib in a Panel of Breast Cancer Cell Lines.

Lafontaine, Julie / Boisvert, Jean-Sébastien / Glory, Audrey / Coulombe, Sylvain / Wong, Philip

Cancers

2020 Volume 12, Issue 2

Abstract: Cancer therapy has evolved to a more targeted approach and often involves drug combinations to achieve better response rates. Non-thermal plasma (NTP), a technology rapidly expanding its application in the medical field, is a near room temperature ... ...

Abstract	Cancer therapy has evolved to a more targeted approach and often involves drug combinations to achieve better response rates. Non-thermal plasma (NTP), a technology rapidly expanding its application in the medical field, is a near room temperature ionized gas capable of producing reactive species, and can induce cancer cell death both in vitro and in vivo. Here, we used proliferation assay to characterize the plasma sensitivity of fourteen breast cancer cell lines. These assays showed that all tested cell lines were sensitive to NTP. In addition, a good correlation was found comparing cell sensitivity to NTP and radiation therapy (RT), where cells that were sensitive to RT were also sensitive to plasma. Moreover, in some breast cancer cell lines, NTP and RT have a synergistic effect. Adding a dose of PARP-inhibitor olaparib to NTP treatment always increases the efficacy of the treatment. Olaparib also exhibits a synergistic effect with NTP, especially in triple negative breast cancer cells. Results presented here help elucidate the position of plasma use as a potential breast cancer treatment.
Language	English
Publishing date	2020-02-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12020348
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Article ; Online: Effect of Photoinitiators Doped in PDMS for Femtosecond-Laser Writing: Characterization and Outcomes.

Hlil, Antsar R / Boisvert, Jean-Sebastien / Titi, Hatem M / Garcia-Puente, Yalina / Correr, Wagner / Loranger, Sebastien / Thomas, Jyothis / Riaz, Ali / Messaddeq, Younès / Kashyap, Raman

ACS omega

2023 Volume 8, Issue 36, Page(s) 32340–32351

Abstract: Herein, we have characterized in depth the effect of femtosecond (fs)-laser writing on various polydimethylsiloxane (PDMS)-based composites. The study combines systematic and nanoscale characterizations for the PDMS blends that include various ... ...

Abstract	Herein, we have characterized in depth the effect of femtosecond (fs)-laser writing on various polydimethylsiloxane (PDMS)-based composites. The study combines systematic and nanoscale characterizations for the PDMS blends that include various photoinitiators (organic and inorganic agents) before and after fs-laser writing. The results exhibit that the photoinitiators can dictate the mechanical properties of the PDMS, in which Young's modulus of PDMS composites has higher elasticity. The study illustrates a major improvement in refractive index change by 15 times higher in the case of PDMS/BP-Ge [benzophenone (BP) allytriethylgermane] and Irgacure 184. Additional enhancement was achieved in the optical performance levels of the PDMS composites (the PDMS composites of Irgacure 184/500, BP-Ge, and Ge-ATEG have a relative difference of less than 5% in comparison with pristine PDMS), which are on par with glasses. This insightful study can guide future investigators in choosing photoinitiators for particular applications in photonics and polymer chemistry.
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c01202
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Spatially resolved cross-sectional refractive index profile of fs laser-written waveguides using a genetic algorithm.

Drouin, Antoine / Lorre, Pierre / Boisvert, Jean-Sébastien / Loranger, Sébastien / Iezzi, Victor Lambin / Kashyap, Raman

Optics express

2019 Volume 27, Issue 3, Page(s) 2488–2498

Abstract: Laser-written waveguides in glass have many potential applications as photonic devices. However, there is little knowledge of the actual profile of the usually asymmetric refractive index (RI) change across the femtosecond (fs) laser-written waveguides. ... ...

Abstract	Laser-written waveguides in glass have many potential applications as photonic devices. However, there is little knowledge of the actual profile of the usually asymmetric refractive index (RI) change across the femtosecond (fs) laser-written waveguides. We show, here, a new nondestructive method to measure any symmetric or asymmetric two-dimensional RI profile of fs laser-written waveguides in transparent materials. The method is also suitable for the measurement of the RI profile of any other type of waveguide. A Mach-Zehnder interferometer is used to obtain the phase shift of light propagating transversely through the RI-modified region. A genetic algorithm is then used to determine the matching cross-sectional RI profile based on the known waveguide shape and dimensions. A validation of the method with the comparison to a RNF measurement of the industry-standard SMF-28 is presented, as well as a demonstration of its versatility with measurements on fs laser-written waveguides.
Language	English
Publishing date	2019-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.27.002488
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 3D printed long period gratings for optical fibers.

Iezzi, Victor Lambin / Boisvert, Jean-Sébastien / Loranger, Sébastien / Kashyap, Raman

Optics letters

2016 Volume 41, Issue 8, Page(s) 1865–1868

Abstract: We demonstrate a simple technique for implementing long period grating (LPG) structures by the use of a 3D printer. This Letter shows a way of manipulating the mode coupling within an optical fiber by applying stress through an external 3D printed ... ...

Abstract	We demonstrate a simple technique for implementing long period grating (LPG) structures by the use of a 3D printer. This Letter shows a way of manipulating the mode coupling within an optical fiber by applying stress through an external 3D printed periodic structure. Different LPG lengths and periods have been studied, as well as the effect of the applied stress on the coupling efficiency from the fundamental mode to cladding modes. The technique is very simple, highly flexible, affordable, and easy to implement without the need of altering the optical fiber. This Letter is part of a growing line of interest in the use of 3D printers for optical applications.
Language	English
Publishing date	2016-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.41.001865
Database	MEDical Literature Analysis and Retrieval System OnLINE

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