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  1. Book ; Online: Neurocardiovascular Diseases: New Aspects of the Old Issues

    Bojić, Tijana / Bojić, Tijana / Esquinas, Antonio M. / Francis Antonios, Tarek

    2019  

    Keywords Science: general issues ; Neurosciences ; neurocardiovascular ; Autonomic Nervous System ; stress ; Atrial Fibrillation ; Obesity ; Heart Failure ; information spectrum method ; Generalized Poincare Plot ; multiple trigonometric regressive spectral analysis ; Cerebral Blood Flow
    Size 1 electronic resource (155 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229866
    ISBN 9782889457755 ; 2889457753
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial: Neurocardiovascular Diseases: New Aspects of the Old Issues.

    Bojić, Tijana

    Frontiers in neuroscience

    2019  Volume 12, Page(s) 1032

    Language English
    Publishing date 2019-01-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2018.01032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Acupuncture, autonomic nervous system and biophysical origin of acupuncture system

    Matić Zoran / Bojić Tijana

    Vojnosanitetski Pregled, Vol 77, Iss 1, Pp 79-

    2020  Volume 86

    Abstract: ... ...

    Abstract nema
    Keywords acupuncture therapy ; acupuncture points ; biophysics ; autonomic nervous system ; fascia ; cardiovascular system ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Military Health Department, Ministry of Defance, Serbia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article: Two Operational Modes of Cardio-Respiratory Coupling Revealed by Pulse-Respiration Quotient.

    Kalauzi, Aleksandar / Matić, Zoran / Platiša, Mirjana M / Bojić, Tijana

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 2

    Abstract: Due to the fact that respiratory breath-to-breath and cardiac intervals between two successive R peaks ( ...

    Abstract Due to the fact that respiratory breath-to-breath and cardiac intervals between two successive R peaks (
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10020180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In Silico Screening of Natural Compounds for Candidates 5HT6 Receptor Antagonists against Alzheimer's Disease.

    Bojić, Tijana / Sencanski, Milan / Perovic, Vladimir / Milicevic, Jelena / Glisic, Sanja

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 9

    Abstract: Alzheimer's disease (AD), a devastating neurodegenerative disease, is the focus of pharmacological research. One of the targets that attract the most attention for the potential therapy of AD is the serotonin 5HT6 receptor, which is the receptor situated ...

    Abstract Alzheimer's disease (AD), a devastating neurodegenerative disease, is the focus of pharmacological research. One of the targets that attract the most attention for the potential therapy of AD is the serotonin 5HT6 receptor, which is the receptor situated exclusively in CNS on glutamatergic and GABAergic neurons. The neurochemical impact of this receptor supports the hypothesis about its role in cognitive, learning, and memory systems, which are of critical importance for AD. Natural products are a promising source of novel bioactive compounds with potential therapeutic potential as a 5HT6 receptor antagonist in the treatment of AD dementia. The ZINC-natural product database was in silico screened in order to find the candidate antagonists of 5-HT6 receptor against AD. A virtual screening protocol that includes both short-and long-range interactions between interacting molecules was employed. First, the EIIP/AQVN filter was applied for in silico screening of the ZINC database followed by 3D QSAR and molecular docking. Ten best candidate compounds were selected from the ZINC Natural Product database as potential 5HT6 Receptor antagonists and were proposed for further evaluation. The best candidate was evaluated by molecular dynamics simulations and free energy calculations.
    MeSH term(s) Alzheimer Disease/drug therapy ; Biological Products/chemistry ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Neurodegenerative Diseases ; Receptors, Serotonin ; Zinc/therapeutic use
    Chemical Substances Biological Products ; Receptors, Serotonin ; serotonin 6 receptor ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27092626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article: Editorial: Cardiorespiratory Coupling-Novel Insights for Integrative Biomedicine.

    Acampa, Maurizio / Voss, Andreas / Bojić, Tijana

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 671900

    Language English
    Publishing date 2021-04-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.671900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling.

    Matić, Zoran / Platiša, Mirjana M / Kalauzi, Aleksandar / Bojić, Tijana

    Frontiers in physiology

    2020  Volume 11, Page(s) 24

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2020-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.00024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Generalized Poincaré plots analysis of heart period dynamics in different physiological conditions: Trained vs. untrained men.

    Platiša, Mirjana M / Bojić, Tijana / Mazić, Sanja / Kalauzi, Aleksandar

    PloS one

    2019  Volume 14, Issue 7, Page(s) e0219281

    Abstract: Background: Recently we proposed a new method called generalized Poincaré plot (gPp) analysis which gave a new insight into the pattern of neurocaridac control. In this study we examined potential of gPp method to reveal changes in cardiac neural ... ...

    Abstract Background: Recently we proposed a new method called generalized Poincaré plot (gPp) analysis which gave a new insight into the pattern of neurocaridac control. In this study we examined potential of gPp method to reveal changes in cardiac neural control in young athletes during three conditions: supine rest, running and relaxation, with respect to untrained subjects.
    Methods: This method is based on the quantification of Pearson's correlation coefficients r(j, k), between symmetrical (j = k) and asymmetrical summed j previous and k following RR intervals up to the 100th order (j,k≤100).
    Results: Differences between groups were obtained at all levels of this analysis. The main result is the significant difference of NAI, normalized index of asymmetry, between groups in running, which was originated in different positions of local maxima of r(j, k). Compared with untrained subjects, these findings indicate modified neural control and altered intrinsic heart rate behavior in athletes which are related to some kind of memory mechanism between RR intervals.
    Conclusion: Obtained results provide great potential of gPp method analysis in the recognition of changes in neurocardiac control in healthy subjects. Further studies are needed for identification of altered cardiac regulatory mechanisms whose background may be useful in the evaluation of genesis of athletes neurocardiovascular pathology.
    MeSH term(s) Adult ; Athletes ; Biometry/methods ; Data Analysis ; Heart/physiology ; Heart Rate/physiology ; Humans ; Male ; Rest/physiology ; Running/physiology ; Young Adult
    Language English
    Publishing date 2019-07-05
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0219281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: New complexity measures reveal that topographic loops of human alpha phase potentials are more complex in drowsy than in wake.

    Kalauzi, Aleksandar / Vuckovic, Aleksandra / Bojić, Tijana

    Medical & biological engineering & computing

    2017  Volume 56, Issue 6, Page(s) 967–978

    Abstract: A number of measures, stemming from nonlinear dynamics, exist to estimate complexity of biomedical objects. In most cases they are appropriate, but sometimes unconventional measures, more suited for specific objects, are needed to perform the task. In ... ...

    Abstract A number of measures, stemming from nonlinear dynamics, exist to estimate complexity of biomedical objects. In most cases they are appropriate, but sometimes unconventional measures, more suited for specific objects, are needed to perform the task. In our present work, we propose three new complexity measures to quantify complexity of topographic closed loops of alpha carrier frequency phase potentials (CFPP) of healthy humans in wake and drowsy states. EEG of ten adult individuals was recorded in both states, using a 14-channel montage. For each subject and each state, a topographic loop (circular directed graph) was constructed according to CFPP values. Circular complexity measure was obtained by summing angles which directed graph edges (arrows) form with the topographic center. Longitudinal complexity was defined as the sum of all arrow lengths, while intersecting complexity was introduced by counting the number of intersections of graph edges. Wilcoxon's signed-ranks test was used on the sets of these three measures, as well as on fractal dimension values of some loop properties, to test differences between loops obtained in wake vs. drowsy. While fractal dimension values were not significantly different, longitudinal and intersecting complexities, as well as anticlockwise circularity, were significantly increased in drowsy. Graphical abstract An example of closed topographic carrier frequency phase potential (CFPP) loops, recorded in one of the subjects in the wake (A) and drowsy (C) states. Lengths of loop graph edges, r(c
    MeSH term(s) Adult ; Alpha Rhythm/physiology ; Electroencephalography ; Female ; Fractals ; Humans ; Male ; Signal Processing, Computer-Assisted ; Sleep Stages/physiology ; Wakefulness/physiology
    Language English
    Publishing date 2017-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 282327-5
    ISSN 1741-0444 ; 0025-696X ; 0140-0118
    ISSN (online) 1741-0444
    ISSN 0025-696X ; 0140-0118
    DOI 10.1007/s11517-017-1746-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope.

    Bojić, Tijana / Perović, Vladimir R / Glišić, Sanja

    Frontiers in neuroscience

    2016  Volume 9, Page(s) 520

    Abstract: Neurocardiovascular diseases (NCVD) are the leading cause of death in the developed world and will remain so till 2020. In these diseases the pathologically changed nervous control of cardiovascular system has the central role. The actual NCV syndromes ... ...

    Abstract Neurocardiovascular diseases (NCVD) are the leading cause of death in the developed world and will remain so till 2020. In these diseases the pathologically changed nervous control of cardiovascular system has the central role. The actual NCV syndromes are neurogenic hypertension, representing the sympathetically mediated disorder, and vasovagal syncope, which is the vagally mediated disorders. Vasovagal syncope, the disease far from its etiological treatment, could benefit from recruiting and application of antimuscarinic drugs used in other parasympathetic disorders. The informational spectrum method (ISM), a method widely applied for the characterization of protein-protein interactions in the field of immunology, endocrinology and anti HIV drug discovery, was applied for the first time in the analysis of neurogenic hypertension and vasovagal syncope therapeutic targets. In silico analysis revealed the potential involvement of apelin in neurogenic hypertension. Applying the EIIP/ISM bioinformatics concept in investigation of drugs for treatment of vasovagal syncope suggests that 78% of tested antimuscarinic drugs could have anti vasovagal syncope effect. The presented results confirm that ISM is a promissing method for investigation of molecular mechanisms underlying pathophysiological proceses of NCV syndromes and discovery of therapeutics targets for their treatment.
    Language English
    Publishing date 2016-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2015.00520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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