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  1. AU="Bojinca, Violeta"
  2. AU="Dung, Bui The"
  3. AU="Shen Jianghua"
  4. AU="Storey J."
  5. AU="Ruby Espejo-Fonseca"
  6. AU="Gupta, Abha A"
  7. AU="Mei, Yingbing"
  8. AU="Han, Chenguang"
  9. AU="Ayoub, Isabelle"
  10. AU="Spencer, Sean P"
  11. AU="Papathemelis, Thomas"
  12. AU="Tzerefos, Christos"
  13. AU="Eefje Belt-van Zoen"
  14. AU="Rahmanian, Vahid"
  15. AU="Øyen, Martin Øhlund"
  16. AU="Xinyun Xuan"
  17. AU="Dana L. M. Campbell"
  18. AU="Mukta Roy"
  19. AU="Martha Funabashi"
  20. AU="Vasina, Svetlana"
  21. AU=Reber Stephan A.
  22. AU="Kenan Onel"
  23. AU="Lawrence, Marc R"
  24. AU="Zeiler, Frederick A"
  25. AU="de la Cueva, Pablo"
  26. AU="Fuh, Jerry Ying Hsi"
  27. AU="Park, Adrian J"
  28. AU="Joshi, K D"

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  1. Artikel ; Online: Balancing Benefits and Risks: A Literature Review on Hypersensitivity Reactions to Human G-CSF (Granulocyte Colony-Stimulating Factor).

    Bumbăcea, Roxana Silvia / Udrea, Mihaela Ruxandra / Ali, Selda / Bojincă, Violeta Claudia

    International journal of molecular sciences

    2024  Band 25, Heft 9

    Abstract: Human granulocyte colony-stimulating factor (G-CSF) is a granulopoietic growth factor used in the treatment of neutropenia following chemotherapy, myeloablative treatment, or healthy donors preparing for allogeneic transplantation. Few hypersensitivity ... ...

    Abstract Human granulocyte colony-stimulating factor (G-CSF) is a granulopoietic growth factor used in the treatment of neutropenia following chemotherapy, myeloablative treatment, or healthy donors preparing for allogeneic transplantation. Few hypersensitivity reactions (HRs) have been reported, and its true prevalence is unknown. We aimed to systematically characterize G-CSF-induced HRs while including a comprehensive list of adverse reactions. We reviewed articles published before January 2024 by searching in the PubMed, Embase, Cochrane Library, and Web of Science databases using a combination of the keywords listed, selected the ones needed, and extracted relevant data. The search resulted in 68 entries, 17 relevant to our study and 7 others found from manually searching bibliographic sources. A total of 40 cases of G-CSF-induced HR were described and classified as immediate (29) or delayed (11). Immediate ones were mostly caused by filgrastim (13 minimum), with at least 9 being grade 5 on the WAO anaphylaxis scale. Delayed reactions were mostly maculopapular exanthemas and allowed for the continuation of G-CSF. Reactions after first exposure frequently appeared and were present in at least 11 of the 40 cases. Only five desensitization protocols have been found concerning the topic at hand in the analyzed data. We believe this study brings to light the research interest in this topic that could benefit from further exploration, and propose regular updating to include the most recently published evidence.
    Mesh-Begriff(e) Humans ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Granulocyte Colony-Stimulating Factor/adverse effects ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/epidemiology
    Chemische Substanzen Granulocyte Colony-Stimulating Factor (143011-72-7)
    Sprache Englisch
    Erscheinungsdatum 2024-04-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25094807
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  2. Artikel: Correlation between Trabecular Bone Score and Homocysteine Level in Rheumatoid Arthritis Patients on Anti-TNF Inhibitors.

    Ioniță-Radu, Florentina / Nicolau, Iulia-Nadine / Petrache, Oana-Georgiana / Groșeanu, Maria-Laura / Bojincă, Violeta-Claudia / Negru, Maria-Magdalena / Bucurică, Sandica / Anghel, Daniela

    Life (Basel, Switzerland)

    2024  Band 14, Heft 4

    Abstract: Rheumatoid arthritis (RA) is an independent osteoporosis risk factor. Biologic and immunosuppressive treatment, and levels of homocysteine and 25-OH vitamin D may influence the trabecular bone score (TBS) in RA patients. We aimed to compare the effects ... ...

    Abstract Rheumatoid arthritis (RA) is an independent osteoporosis risk factor. Biologic and immunosuppressive treatment, and levels of homocysteine and 25-OH vitamin D may influence the trabecular bone score (TBS) in RA patients. We aimed to compare the effects of biological (b) and conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs) on TBS in patients with RA and hyperhomocysteinemia (HHcy) or 25-OH vitamin D deficiency. Patients who had tests conducted for trabecular bone score, bone mineral density (BMD), homocysteine (Hcy) and 25-OH vitamin D at an interval of one year and met the inclusion criteria were enrolled in this retrospective study. Sixty-four patients with RA were enrolled and were divided into the following two groups: the first group (34 patients) had received treatment with bDMARDs and the second group (30 patients) had received csDMARDs. BDMARDs and csDMARDs had a positive influence on TBS and BMD. The best results were observed in the Adalimumab group (
    Sprache Englisch
    Erscheinungsdatum 2024-04-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14040463
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  3. Artikel ; Online: Paget's disease of bone and megaloblastic anemia in a 72-year-old patient: A case report and systematic literature review.

    Oprea, Violeta Diana / Bojincă, Violeta Claudia / Bălănescu, Andra-Rodica / Tatu, Alin Laurențiu / Bojincă, Mihai / Romila, Aurelia

    Experimental and therapeutic medicine

    2022  Band 23, Heft 4, Seite(n) 269

    Abstract: Paget's disease of bone (PDB) is characterized by abnormal osteoclastic bone resorption with disorganized bone neo-formation, primarily affecting elderly (>55 years) patients. Although the majority of patients are asymptomatic, some patients may ... ...

    Abstract Paget's disease of bone (PDB) is characterized by abnormal osteoclastic bone resorption with disorganized bone neo-formation, primarily affecting elderly (>55 years) patients. Although the majority of patients are asymptomatic, some patients may experience bone pain due to local periosteal involvement or osteoarthritic lesions in the spine; in addition, limb deformities may lead to secondary gait problems or degenerative joint changes. Anemia has an overall prevalence of 12-17% in elderly adults (>65 years old), with macrocytic anemia being the less common type. Megaloblastic anemia is a macrocytic anemia characterized by the presence of large, immature, nucleated cells (megaloblasts) in the blood, with the most common cause being a deficiency of folate and/or vitamin B12. We herein report the rare case of a 72-year-old male patient exhibiting both these conditions, with the aim of discussing the possible association between the two and, most importantly, the clinical management of the patient in a real-life setting over a period of 10 years. The patient was diagnosed based on clinical symptoms (bone pain), radiological imaging and specific laboratory tests, and received discontinuous courses of bisphosphonates and cyanocobalamin supplementation therapy, based mainly on aggravated symptomatology. A systematic literature review was also performed and revealed not only the scarcity of reports on similar cases, but also the mechanisms that may underlie the possible association of PDB with macrocytic anemia due to vitamin B12 deficiency in elderly patients.
    Sprache Englisch
    Erscheinungsdatum 2022-02-08
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2022.11195
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  4. Artikel: The Translation, Validation and Cultural Adaptation of Questionnaires Assessing the Quality of Life and Fatigue among Patients with Sjogren's Syndrome for the Romanian Context.

    Mardale, Denise-Ani / Opriș-Belinski, Daniela / Bojincă, Violeta / Bojincă, Mihai / Păsăran, Emilia / Săulescu, Ioana / Berghea, Florian / Bălănescu, Andra

    Clinics and practice

    2023  Band 13, Heft 6, Seite(n) 1561–1576

    Abstract: About 70% of patients with Sjogren's syndrome suffer from fatigue, and for a large proportion of patients, it is one of the most noticeable manifestations leading to disability. To date, no study has been conducted in Romania to determine the quality of ... ...

    Abstract About 70% of patients with Sjogren's syndrome suffer from fatigue, and for a large proportion of patients, it is one of the most noticeable manifestations leading to disability. To date, no study has been conducted in Romania to determine the quality of life of patients and the impact of fatigue in patients with Sjogren's syndrome. The present work proposes the translation, cultural adaptation, and validation of two questionnaires for the Romanian context, namely the 'Profile of Fatigue and Discomfort-Sicca Symptoms Inventory' (PROFAD-SSI-SF) and 'Primary Sjogren's Syndrome-Quality of Life' (PSS-QoL), whose purpose is to assess quality of life and fatigue in patients with Sjogren's syndrome. These two questionnaires were administered to 52 patients with Sjogren's syndrome diagnosed according to the 2016 ACR-EULAR criteria. Subsequently, the conceptual, semantic, and operational analyses of the data were performed with the aim of cultural adaptation. The data obtained were statistically analyzed using indices of measurement accuracy such as internal consistency. Based on statistical analyses, this pilot study shows that the Romanian versions of the PROFAD-SSI and PSS-QoL questionnaires are as reliable as their English counterparts.
    Sprache Englisch
    Erscheinungsdatum 2023-12-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2605724-4
    ISSN 2039-7283 ; 2039-7275
    ISSN (online) 2039-7283
    ISSN 2039-7275
    DOI 10.3390/clinpract13060137
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  5. Artikel ; Online: An insight into the fecal microbiota composition in Romanian patients with ankylosing spondylitis using high-throughput 16S rRNA gene amplicon sequencing

    Oprea Mihaela / Cristea Daniela / Dinu Sorin / Ciontea Simona Adriana / Bojinca Violeta Claudia / Predeteanu Denisa / Balanescu Andra Rodica / Usein Codruta Romanita

    Romanian Journal of Laboratory Medicine, Vol 30, Iss 1, Pp 49-

    2022  Band 61

    Abstract: Introduction. Application of next-generation sequencing technology generated a massive amount of information on the gut microbiome composition used to understand its role in the healthy state and in various diseases. We aimed to provide information on ... ...

    Abstract Introduction. Application of next-generation sequencing technology generated a massive amount of information on the gut microbiome composition used to understand its role in the healthy state and in various diseases. We aimed to provide information on the gut microbiota composition of Romanian subjects diagnosed with ankylosing spondylitis, an immune-mediated arthropathy linked to a genetic predisposition and gut dysbiosis.
    Schlagwörter ankylosing spondylitis ; next generation sequencing ; gut microbiome ; 16s rrna amplicon sequencing ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Sciendo
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: The Physical and Psychosocial Impact of Fatigue among Patients with Sjogren's Syndrome: A Systematic Review.

    Mardale, Denise-Ani / Opriș-Belinski, Daniela / Bojincă, Violeta / Bojincă, Mihai / Mazilu, Diana / Păsăran, Emilia / Nițăa, Cristina / Groșeanu, Laura / Berghea, Florian / Bălănescu, Andra-Rodica

    Journal of clinical medicine

    2024  Band 13, Heft 6

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061537
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  7. Artikel: Hereditary Hemorrhagic Telangiectasia Associating Neuropsychiatric Manifestations with a Significant Impact on Disease Management-Case Report and Literature Review.

    Sârbu, Fabiola / Oprea, Violeta Diana / Tatu, Alin Laurențiu / Polea Drima, Eduard / Bojincă, Violeta Claudia / Romila, Aurelia

    Life (Basel, Switzerland)

    2022  Band 12, Heft 7

    Abstract: 1) Background: Genetic hereditary hemorrhagic telangiectasia (HHT) is clinically diagnosed. The clinical manifestations and lack of curative therapeutic interventions may lead to mental illnesses, mainly from the depression-anxiety spectrum. (2) Methods: ...

    Abstract (1) Background: Genetic hereditary hemorrhagic telangiectasia (HHT) is clinically diagnosed. The clinical manifestations and lack of curative therapeutic interventions may lead to mental illnesses, mainly from the depression-anxiety spectrum. (2) Methods: We report the case of a 69-year-old patient diagnosed with HHT and associated psychiatric disorders; a comprehensive literature review was performed based on relevant keywords. (3) Results: Curaçao diagnostic criteria based the HHT diagnosis in our patient case at 63 years old around the surgical interventions for a basal cell carcinoma, after multiple episodes of epistaxis beginning in childhood, but with a long symptom-free period between 20 and 45 years of age. The anxiety-depressive disorder associated with nosocomephobia resulted in a delayed diagnosis and low adherence to medical monitoring. A comprehensive literature review revealed the scarcity of publications analyzing the impact of psychiatric disorders linked to this rare condition, frequently associating behavioral disengagement as a coping strategy, psychological distress, anxiety, depression, and hopelessness. (4) Conclusions: As patients with HHT face traumatic experiences from disease-related causes as well as recurring emergency hospital visits, active monitoring for mental illnesses and psychological support should be considered as part of the initial medical approach and throughout the continuum of care.
    Sprache Englisch
    Erscheinungsdatum 2022-07-15
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12071059
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  8. Artikel: Calcinosis in Rheumatic Disease Is Still an Unmet Need: A Retrospective Single-Center Study.

    Nita, Cristina / Groseanu, Laura / Opris, Daniela / Predeteanu, Denisa / Bojinca, Violeta / Berghea, Florian / Vlad, Violeta / Abobului, Mihai / Constantinescu, Cosmin / Negru, Magdalena / Saulescu, Ioana / Daia, Sanziana / Mazilu, Diana / Borangiu, Andreea / Cobilinschi, Claudia / Mardale, Denisse / Rosu, Madalina / Balanescu, Andra

    Diagnostics (Basel, Switzerland)

    2024  Band 14, Heft 6

    Abstract: Patients with immune-mediated rheumatic disease-related calcinosis comprise a subgroup at risk of encountering a more severe clinical outcome. Early assessment is pivotal for preventing overall disease progression, as calcinosis is commonly overlooked ... ...

    Abstract Patients with immune-mediated rheumatic disease-related calcinosis comprise a subgroup at risk of encountering a more severe clinical outcome. Early assessment is pivotal for preventing overall disease progression, as calcinosis is commonly overlooked until several years into the disease and is considered as a 'non-lethal' manifestation. This single-center retrospective study explored the prevalence, clinical associations, and impact on survival of subcutaneous calcinosis in 86 patients with immune-mediated rheumatic diseases (IMRD). Calcinosis predominantly appeared in individuals with longstanding disease, particularly systemic sclerosis (SSc), constituting 74% of cases. Smaller calcinosis lesions (≤1 cm) were associated with interstitial lung disease, musculoskeletal involvement, and digital ulcerations, while larger lesions (≥4 cm) were associated with malignancy, severe peripheral artery disease, and systemic arterial hypertension. The SSc calcinosis subgroup exhibited a higher mean adjusted European Scleroderma Study Group Activity Index score than those without. However, survival rates did not significantly differ between the two groups. Diltiazem was the most commonly used treatment, and while bisphosphonates reduced complications related to calcinosis, complete resolution was not achieved. The findings underscore current limitations in diagnosing, monitoring, and treating calcinosis, emphasizing the need for further research and improved therapeutic strategies to improve patient care and outcomes.
    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14060637
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  9. Artikel: Nailfold Videocapillaroscopy in Patients with Rheumatoid Arthritis and Psoriatic Arthropathy on ANTI-TNF-ALPHA Therapy.

    Anghel, Daniela / Sîrbu, Carmen Adella / Petrache, Oana-Georgiana / Opriș-Belinski, Daniela / Negru, Maria Magdalena / Bojincă, Violeta-Claudia / Pleșa, Cristina Florentina / Ioniță Radu, Florentina

    Diagnostics (Basel, Switzerland)

    2023  Band 13, Heft 12

    Abstract: Videocapillaroscopy is a simple, non-invasive investigation that allows the "in vivo" study of the nailfold capillaries. This method is inexpensive, easily accepted by patients and the results can be easily interpreted. It is mainly used in patients with ...

    Abstract Videocapillaroscopy is a simple, non-invasive investigation that allows the "in vivo" study of the nailfold capillaries. This method is inexpensive, easily accepted by patients and the results can be easily interpreted. It is mainly used in patients with Raynaud's phenomenon and systemic sclerosis, but this examination can also be performed on patients who are suspected of having microcirculation alterations, such as rheumatoid arthritis and psoriatic arthritis. It may aid in the diagnosis, evaluation and prognosis of other rheumatic diseases, besides systemic sclerosis. The aim of this study is to identify the nailfold videocapillaroscopic abnormalities in rheumatoid arthritis and psoriatic arthritis patients and analyze the correlation between their evolution and 12 months of anti-TNF-α therapy. The abnormal capillaroscopic findings comprised widened, dilated or giant capillaries and the distortion of the normal nailfold architecture, avascular areas, hemorrhages and neoangiogenesis. Overall, capillary density, dilated capillaries, giant capillaries, elongated capillaries and angiogenesis significantly improved after 12 months. Moreover, no avascular areas were found after 12 months of anti-TNF treatment.
    Sprache Englisch
    Erscheinungsdatum 2023-06-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13122079
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  10. Artikel: Rheumatic diseases and malignancies.

    Bojinca, Violeta / Janta, Iustina

    Maedica

    2013  Band 7, Heft 4, Seite(n) 364–371

    Abstract: There are many studies which demonstrate a higher risk for malignancy in patients with rheumatic diseases. There have been a number of possible explanations for the differences in the risk of certain malignancies in patients with rheumatic disease, ... ...

    Abstract There are many studies which demonstrate a higher risk for malignancy in patients with rheumatic diseases. There have been a number of possible explanations for the differences in the risk of certain malignancies in patients with rheumatic disease, compared with general population, but a clear mechanism is difficult to identify.Rheumatoid syndromes may be associated with malignancy as paraneoplastic conditions, which can antedate the neoplasm diagnosis.On the other hand, autoimmune rheumatic diseases have a higher risk of malignancy by themselves or because of the immunosuppressant treatments.
    Sprache Englisch
    Erscheinungsdatum 2013-03-12
    Erscheinungsland Romania
    Dokumenttyp Journal Article
    ZDB-ID 2399972-X
    ISSN 2069-6116 ; 1841-9038
    ISSN (online) 2069-6116
    ISSN 1841-9038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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