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Article ; Online: Comparative Studies of Bone Graft and Orthobiologics for Foot Ankle Arthrodesis: A Critical Review.

Bolia, Ioanna K / Covell, Donal J / Tan, Eric W

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

2024 Volume 8, Issue 5

Abstract: Graft materials available to supplement hindfoot and ankle arthrodesis procedures include autologous (autograft) or allogeneic bone graft (allograft) but also bone graft substitutes such as demineralized bone matrix, calcium sulfate, calcium phosphate, ... ...

Abstract	Graft materials available to supplement hindfoot and ankle arthrodesis procedures include autologous (autograft) or allogeneic bone graft (allograft) but also bone graft substitutes such as demineralized bone matrix, calcium sulfate, calcium phosphate, and tricalcium phosphate/hydroxyapatite. In addition, biologic agents, such as recombinant human bone morphogenetic protein-2 or recombinant human platelet derived growth factor-BB (rhPDGF-BB), and preparations, including platelet-rich plasma or concentrated bone marrow aspirate, have been used to facilitate bone healing in ankle or hindfoot arthrodesis. The purpose of this review was to summarize the available clinical evidence surrounding the utilization and efficacy of the above materials and biological agents in ankle or hindfoot arthrodesis procedures, with emphasis on the quality of the existing evidence to facilitate clinical decision making.
MeSH term(s)	Humans ; Arthrodesis/methods ; Bone Transplantation/methods ; Bone Substitutes/therapeutic use ; Ankle Joint/surgery ; Calcium Phosphates/therapeutic use
Chemical Substances	Bone Substitutes ; Calcium Phosphates
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article ; Review ; Comparative Study
ZDB-ID	2898328-2
ISSN	2474-7661 ; 1067-151X
ISSN (online)	2474-7661
ISSN	1067-151X
DOI	e23.00216
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Article ; Online: Editorial Commentary: Evidence-Based Guidelines for Management of the Hip Capsule During Arthroscopy: Has It Become Personal?

Bolia, Ioanna K

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

2020 Volume 37, Issue 1, Page(s) 95–97

Abstract: The management of the capsule during hip arthroscopy for femoroacetabular impingement syndrome has been in the spotlight during the last decade. Although there is robust biomechanical evidence that preserving the anatomic integrity of the iliofemoral ... ...

Abstract	The management of the capsule during hip arthroscopy for femoroacetabular impingement syndrome has been in the spotlight during the last decade. Although there is robust biomechanical evidence that preserving the anatomic integrity of the iliofemoral ligament is important for the stability of the hip joint, the effect of capsular management on patient outcomes is often debated in clinical studies. Mid-term and long-term follow-up studies have shown that capsular closure is associated with decreased risk of hip arthroscopy failure, but no difference in patient outcomes based on capsular management has been found by some case series studies. What is driving the controversy in the literature? It seems to stem from the variation in surgical techniques used to perform hip capsulotomy or capsular repair, worldwide. Given that improvement in patient outcomes must be prioritized, it is time to use the existing knowledge appropriately to establish evidence-based guidelines for the management of hip capsule during hip arthroscopy.
MeSH term(s)	Arthroscopy ; Femoracetabular Impingement/surgery ; Hip Joint/surgery ; Humans ; Joint Capsule/surgery ; Research Design
Language	English
Publishing date	2020-12-31
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	632528-2
ISSN	1526-3231 ; 0749-8063
ISSN (online)	1526-3231
ISSN	0749-8063
DOI	10.1016/j.arthro.2020.09.045
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Article: Dilemmas for the Team Physician: Return to Play and the Management of In-Season Injuries.

Weber, Alexander E / Bolia, Ioanna K

Instructional course lectures

2020 Volume 70, Page(s) 259–272

Abstract: Given that sports medicine covers a broad spectrum of orthopaedic injuries, the team physician is often required to face challenging decisions when treating injured athletes. Injuries of the upper and lower extremities can lead to clinical dilemmas for ... ...

Abstract	Given that sports medicine covers a broad spectrum of orthopaedic injuries, the team physician is often required to face challenging decisions when treating injured athletes. Injuries of the upper and lower extremities can lead to clinical dilemmas for the team physician, who needs to ensure appropriate treatment and interventions to prevent subsequent injuries. The athlete's personal goals and athletic career must also be respected throughout this process. It is important to discuss the most common athletic injuries that pose clinical dilemmas for the sports physician and useful tips to address them based on the existing evidence.
MeSH term(s)	Athletic Injuries/diagnosis ; Athletic Injuries/therapy ; Humans ; Physicians ; Return to Sport ; Seasons ; Sports
Language	English
Publishing date	2020-11-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	802490-x
ISSN	0065-6895
ISSN	0065-6895
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Article ; Online: Platelet-rich Plasma in the Management of Shoulder Disorders: Basic Science and Implications Beyond the Rotator Cuff.

Omid, Reza / Lalezari, Ramin / Bolia, Ioanna K / Weber, Alexander E

The Journal of the American Academy of Orthopaedic Surgeons

2022 Volume 30, Issue 19, Page(s) e1217–e1226

Abstract: Platelet-rich plasma (PRP) is an autologous mixture produced by centrifugal separation of whole blood. Understanding the clinical efficacy of PRP remains a challenge in the field of sports medicine, including the treatment of various shoulder conditions. ...

Abstract	Platelet-rich plasma (PRP) is an autologous mixture produced by centrifugal separation of whole blood. Understanding the clinical efficacy of PRP remains a challenge in the field of sports medicine, including the treatment of various shoulder conditions. Animal studies have examined the biologic actions of PRP on the rotator cuff tendon and shoulder capsule. Human studies have reported the outcomes of PRP in the management of subacromial impingement syndrome, rotator cuff tears, frozen shoulder, and glenohumeral osteoarthritis. These studies highlight the role of PRP in the nonsurgical management of these conditions and its utilization in the perioperative setting to augment tissue healing and optimize the surgical outcomes. The role of PRP as an adjunct therapy in patients undergoing rotator cuff repair has been in the spotlight during the last decade; however, a limited number of studies have examined the role of PRP in the management of non-rotator cuff shoulder conditions. This article aims to provide an overview of the biologic actions of PRP on shoulder tissues and to summarize the outcomes of PRP injection in patients with rotator cuff and non-rotator cuff disease of the shoulder. We sought to organize the existing literature and to provide recommendations on the use of PRP in various shoulder conditions, based on the existing evidence.
MeSH term(s)	Animals ; Arthroscopy ; Biological Products ; Humans ; Platelet-Rich Plasma ; Rotator Cuff/surgery ; Rotator Cuff Injuries/surgery ; Shoulder/surgery ; Treatment Outcome
Chemical Substances	Biological Products
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-22-00066
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Article ; Online: Clinical Efficacy of Bone Marrow Aspirate Concentrate Versus Stromal Vascular Fraction Injection in Patients With Knee Osteoarthritis: Response.

Bolia, Ioanna K / Petrigliano, Frank A / Lieberman, Jay R / Weber, Alexander E

The American journal of sports medicine

2022 Volume 50, Issue 2, Page(s) NP13

MeSH term(s)	Bone Marrow ; Humans ; Knee Joint ; Osteoarthritis, Knee/drug therapy ; Stromal Vascular Fraction ; Treatment Outcome
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197482-8
ISSN	1552-3365 ; 0363-5465
ISSN (online)	1552-3365
ISSN	0363-5465
DOI	10.1177/03635465211055453
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Article ; Online: Patient Reported Clinical Outcomes Following PCL Suture Augmentation in Patients with Multiligamentous Knee Injury: A Retrospective Observational Study.

Fathi, Amir / Thompson, Ashley A / Bolia, Ioanna K / Mayfield, Cory K / Korber, Shane S / Iyer, Avinash / Hatch Iii, George F

Orthopedic research and reviews

2024 Volume 16, Page(s) 67–74

Abstract: Purpose: To compare the patient-reported outcomes between patients with posterior cruciate ligament (PCL) reconstruction or repair alone versus PCL reconstruction or repair with internal bracing (IB) in the context of multi-ligament knee injuries (MLKI). ...

Abstract	Purpose: To compare the patient-reported outcomes between patients with posterior cruciate ligament (PCL) reconstruction or repair alone versus PCL reconstruction or repair with internal bracing (IB) in the context of multi-ligament knee injuries (MLKI). Methods: All patients who underwent surgical management of MLKI at two institutions between 2006 and 2020 were retrospectively identified and offered participation in the study. Patient reported outcomes were measured via three instruments: Lysholm Knee score, Multiligament Quality of Life (ML-QOL), and the Patient-Reported Outcomes Measurement Information System (PROMIS) computer adaptive testing (CAT). The postoperative outcomes and reoperation rates were compared between the internal bracing and non-internal bracing groups. Results: Fifty-two patients were analyzed; 34 were included in the IB group (17.6% female; age 33.1 ±1.60 years), and 18 were included in the non-IB group (11.1% female; age 34.1 ±3.72 years). Mean follow-up time of the entire cohort was 1.44 ± 0.22 years (IB: 1.21 ± 0.18; non-IB: 2.1 ±0.65). There were no significant differences between PROMIS CAT [PROMIS Pain (54.4 ±1.78 vs 51.7 ±1.70, p=0.319), Physical Function (44.3 ±2.27 vs 47.9 ±1.52, p=0.294), Mobility (44.0 ±1.71 vs 46.1 ±2.10, p=0.463)], ML-QOL [ML-QOL Physical Impairment (40.7 ±4.21 vs 41.7±5.10, p=0.884), Emotional Impairment (49.2 ±4.88 vs 44.7±5.87, p=0.579), Activity Limitation (43.5 ±4.56 vs 31.5±3.62, p=0.087), Societal Involvement (44.9 ±4.96 vs 37.5 ±5.30, p=0.345)] and Lysholm knee score (61.8 ±4.55 vs 61.0 ±4.95, p=0.916) postoperatively compared to the non-IB group. Conclusion: In this group of patients, function and patient-reported outcomes between patients treated with PCL reconstruction and repair without internal brace versus those with additional internal brace augmentation were not significantly different. Further research encompassing a larger patient sample is necessary to investigate the efficacy of the internal brace for PCL injury in the context of MLKI injuries.
Language	English
Publishing date	2024-02-16
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520718-0
ISSN	1179-1462 ; 1179-1462
ISSN (online)	1179-1462
ISSN	1179-1462
DOI	10.2147/ORR.S425781
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Article ; Online: Hip Abductor and Peritrochanteric Space Conditions.

Weber, Alexander E / Bell, Jennifer A / Bolia, Ioanna K

Clinics in sports medicine

2021 Volume 40, Issue 2, Page(s) 311–322

Abstract: The hip trochanteric bursa, tendinous insertions of the gluteal muscles, and the origin vastus lateralis make up the main structures of the peritrochanteric space. Greater trochanteric pain syndrome (GTPS) refers to pain generated by one or multiple ... ...

Abstract	The hip trochanteric bursa, tendinous insertions of the gluteal muscles, and the origin vastus lateralis make up the main structures of the peritrochanteric space. Greater trochanteric pain syndrome (GTPS) refers to pain generated by one or multiple disorders of the peritrochanteric space, such as trochanteric bursitis, gluteus medius and minimus tendinopathy or tear, and disorders of the proximal iliotibial band. Patients with GTPS might present with associated intra-articular hip pathology, which requires further investigation and appropriate management. Successful midterm outcomes have been reported in patients undergoing surgical treatment of GTPS using an open or endoscopic approach.
MeSH term(s)	Bursitis/surgery ; Hip/physiology ; Hip Joint/physiology ; Hip Joint/surgery ; Humans ; Lacerations ; Muscle, Skeletal/injuries ; Pain ; Tendinopathy/complications ; Tendons/surgery
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	779944-5
ISSN	1556-228X ; 0278-5919
ISSN (online)	1556-228X
ISSN	0278-5919
DOI	10.1016/j.csm.2021.01.001
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Article ; Online: Hip arthroscopy: an evidence-based approach.

Briggs, Karen K / Bolia, Ioanna K

Lancet (London, England)

2018 Volume 391, Issue 10136, Page(s) 2189–2190

MeSH term(s)	Arthroscopy ; Femoracetabular Impingement ; Humans ; Radiography
Language	English
Publishing date	2018-06-01
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(18)31218-2
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Article ; Online: Biological strategies for osteoarthritis: from early diagnosis to treatment.

Weber, Alexander E / Bolia, Ioanna K / Trasolini, Nicholas A

International orthopaedics

2020 Volume 45, Issue 2, Page(s) 335–344

Abstract: Purpose: To provide an updated review of the literature on the use of orthobiologics as a potential treatment option to alleviate symptoms associated with osteoarthritis (OA), slow the progression of the disease, and aid in cartilage regeneration.: ... ...

Abstract	Purpose: To provide an updated review of the literature on the use of orthobiologics as a potential treatment option to alleviate symptoms associated with osteoarthritis (OA), slow the progression of the disease, and aid in cartilage regeneration. Methods: A comprehensive review of the literature was performed to identify basic science and clinical studies examining the role of orthobiologics in the diagnosis and management of osteoarthritis. Results: Certain molecules (such as interleukin-6 (IL-6), interleukin-8 (IL-8), matrix metalloproteinase (MMPs), cartilage oligomeric matrix protein (COMP), and tumor necrosis factor (TNF), microRNAs, growth differentiation factor 11 (GDF-11)) have been recognized as biomarkers that are implicated in the pathogenesis and progression of degenerative joint disease (DJD). These biomarkers have been used to develop newer diagnostic applications and targeted biologic therapies for DJD. Local injection therapy with biologic agents such as platelet-rich plasma or stem cell-based preparations has been associated with significant improvement in joint pain and function in patients with OA and has increased in popularity during the last decade. The combination of PRP with kartogenin or TGF-b3 may also enhance its biologic effect. The mesenchymal stem cell secretome has been recognized as a potential target for the development of OA therapies due to its role in mediating the chondroprotective effects of these cells. Recent experiments have also suggested the modification of gut microbiome as a newer method to prevent OA or alter the progression of the disease. Conclusions: The application of orthobiologics for the diagnosis and treatment of DJD is a rapidly evolving field that will continue to expand. The identification of OA-specific and joint-specific biomarker molecules for early diagnosis of OA would be extremely useful for the development of preventive and therapeutic protocols. Local injection therapies with HA, PRP, BMAC, and other stem cell-based preparations are currently being used to improve pain and function in patients with early OA or those with progressed disease who are not surgical candidates. Although the clinical outcomes of these therapies seem to be promising in clinical studies, future research will determine the true role of orthobiologic applications in the field of DJS.
MeSH term(s)	Cartilage ; Early Diagnosis ; Humans ; Osteoarthritis/diagnosis ; Osteoarthritis/therapy ; Platelet-Rich Plasma ; Tumor Necrosis Factor-alpha
Chemical Substances	Tumor Necrosis Factor-alpha
Language	English
Publishing date	2020-10-19
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-020-04838-w
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Article ; Online: Vitamin C in orthopedic practices: Current concepts, novel ideas, and future perspectives.

Oakes, Bennett / Bolia, Ioanna K / Weber, Alexander E / Petrigliano, Frank A

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

2021 Volume 39, Issue 4, Page(s) 698–706

Abstract: Vitamin C (ascorbic acid), is an important antioxidant that has been applied broadly in the field of orthopaedics. Current research on vitamin C examines the molecule's role in bone and tendon physiology, as well as joint replacement and Postoperative ... ...

Abstract	Vitamin C (ascorbic acid), is an important antioxidant that has been applied broadly in the field of orthopaedics. Current research on vitamin C examines the molecule's role in bone and tendon physiology, as well as joint replacement and Postoperative pain. Most laboratory and human studies associate the use of vitamin C with improved bone health and tendon healing. Recent literature moderately supports the use of vitamin C to improve functional outcomes, decreased postoperative pain, and prevent complex regional pain syndrome following orthopaedic procedures. The perioperative use of vitamin C in patients undergoing joint replacement surgery and anterior cruciate ligament reconstruction is still under investigation. Overall, there is need for high-quality human trials to confirm whether vitamin C can potentiate the outcomes of orthopaedic procedures and to determine optimal dosage and means of administration to maximize its proposed benefits. The purpose of this review was to summarize the application of vitamin C in orthopaedic practices and to identify potential areas for future study.
MeSH term(s)	Animals ; Anterior Cruciate Ligament/surgery ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction ; Antioxidants/therapeutic use ; Arthroplasty, Replacement ; Ascorbic Acid/therapeutic use ; Bone and Bones/drug effects ; Bone and Bones/surgery ; Clinical Trials as Topic ; Humans ; Orthopedics/trends ; Osteoporosis/therapy ; Pain, Postoperative/prevention & control ; Perioperative Period ; Randomized Controlled Trials as Topic ; Tendons/drug effects ; Tendons/surgery ; Treatment Outcome
Chemical Substances	Antioxidants ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605542-4
ISSN	1554-527X ; 0736-0266
ISSN (online)	1554-527X
ISSN	0736-0266
DOI	10.1002/jor.24947
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