Article ; Online: 11C-methionine PET/MRI in postoperative patients after craniotomy: zero echo time and head atlas versus CT-based attenuation correction.
2022 Volume 67, Issue 3, Page(s) 215–222
Abstract: Background: Attenuation correction (AC) is an important topic in PET/MRI and particularly challenging after brain tumor surgery, near metal implants, adjacent bone and burr holes. In this study, we evaluated the performance of two MR-driven AC methods, ... ...
| Abstract | Background: Attenuation correction (AC) is an important topic in PET/MRI and particularly challenging after brain tumor surgery, near metal implants, adjacent bone and burr holes. In this study, we evaluated the performance of two MR-driven AC methods, zero-echo-time AC (ZTE-AC) and atlas-AC, in comparison to reference standard CT-AC in patients with surgically treated brain tumors at Methods: This retrospective study investigated seven postoperative patients with neuropathologically confirmed brain tumor at Results: Smaller mean percent bias range (Bland-Altman) was found for ZTE-AC than atlas-AC in all analyses (metal ZTE -0.46 to -0.02, metal atlas -3.57 to -3.26; bone ZTE -4.60 to -2.16, bone atlas -5.25 to -3.81; burr hole ZTE -0.95 to -0.52, burr hole atlas 7.86 to 8.87). Percent SD range (Bland-Altman) was large for both methods in all analyses, with lower absolute values for ZTE-AC (ZTE 7.02-8.49; atlas 11.47-14.83). A very strong correlation (Pearson correlation) was demonstrated for both methods compared to CT-AC (ZTE ρ 0.97-0.99, P<0.001; atlas ρ 0.88-0.91, P≤0.009) with higher absolute values for ZTE. An excellent intraclass correlation coefficient was found across all analyses for ZTE, atlas and CT maps (ICC ≥0.88). Conclusions: ZTE for MR-driven PET attenuation correction presented a more comparable performance to reference standard CT-AC at the postoperative site. ZTE-AC may serve as a useful diagnostic tool for MR-driven AC in patients with surgically treated brain tumors. |
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| MeSH term(s) | Humans ; Carbon Radioisotopes ; Multimodal Imaging/methods ; Retrospective Studies ; Reproducibility of Results ; Brain/diagnostic imaging ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography/methods ; Magnetic Resonance Imaging/methods ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Brain Neoplasms/pathology ; Methionine ; Craniotomy ; Racemethionine ; Tomography, X-Ray Computed/methods ; Image Processing, Computer-Assisted/methods |
| Chemical Substances | Carbon-11 ; Carbon Radioisotopes ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; carbon-11 methionine (58576-49-1) ; Methionine (AE28F7PNPL) ; Racemethionine (73JWT2K6T3) |
| Language | English |
| Publishing date | 2022-02-04 |
| Publishing country | Italy |
| Document type | Journal Article |
| ZDB-ID | 1281687-5 |
| ISSN | 1827-1936 ; 0392-0208 ; 1125-0135 ; 1824-4661 ; 1824-4785 |
| ISSN (online) | 1827-1936 |
| ISSN | 0392-0208 ; 1125-0135 ; 1824-4661 ; 1824-4785 |
| DOI | 10.23736/S1824-4785.22.03389-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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