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  1. Article: Seroprevalence of

    Macías Luaces, Laura / Boll, Kerstin / Klose, Corinna / Domogalla-Urbansky, Janina / Müller, Matthias / Eisenberger, David / Riehm, Julia M

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: ... ...

    Abstract Brucella
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The immune response to a Coxiella burnetii vaccine in sheep varies according to their natural pre-exposure.

    Böttcher, Jens / Bauer, Benjamin U / Ambros, Christina / Alex, Michaela / Domes, Ursula / Roth, Sabine / Boll, Kerstin / Korneli, Martin / Bogner, Karl-Heinz / Randt, Andreas / Janowetz, Britta

    Vaccine

    2024  Volume 42, Issue 8, Page(s) 1993–2003

    Abstract: Q fever in humans is caused by Coxiella (C.) burnetii. In 2008 and 2012, cases of Q fever in humans were linked to an infected flock of approximately 650 ewes. Since 2013 gimmers (G'13, G'14, G'15 etc.) were primary vaccinated (two doses) with an ... ...

    Abstract Q fever in humans is caused by Coxiella (C.) burnetii. In 2008 and 2012, cases of Q fever in humans were linked to an infected flock of approximately 650 ewes. Since 2013 gimmers (G'13, G'14, G'15 etc.) were primary vaccinated (two doses) with an inactivated C.burnetii vaccine without any revaccination. In 2013, 30 ewes were primary vaccinated (A'13). Shedding was annually monitored by qPCR-testing of vaginal and nasal swabs collected at lambing. Animals were tested for Phase I- (PhI) and PhII-antibodies (Ab) and for PhII-specific-interferon-γ (IFN-γ) before and after vaccination. The effect of a revaccination was determined in 2018 and 2023. Groups of randomly selected gimmers primary vaccinated in 2015, 2016 and 2017 and a mixed group of older animals (A'13, G'13 and G'14) were revaccinated once in 2018. The trial was repeated in 2023 on groups primary vaccinated in 2019-2023. Major shedding after the outbreak in 2012 ceased in 2014. Thereafter C.burnetii was only sporadically detected at low-level in 2018, 2021 and 2023. Sheep naturally exposed to C.burnetii during the outbreak in 2012 (A'13, G'13) mounted a strong and complete (PhI, PhII, IFN-γ) recall immune response after vaccination. A serological PhI
    MeSH term(s) Humans ; Sheep ; Animals ; Female ; Coxiella burnetii ; Q Fever/prevention & control ; Q Fever/veterinary ; Q Fever/epidemiology ; Antibodies ; Bacterial Vaccines ; Immunity
    Chemical Substances Antibodies ; Bacterial Vaccines
    Language English
    Publishing date 2024-02-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.02.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 458: Show issues

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  3. Book ; Thesis: Klonierung und Charakterisierung eines Phagenlysins und sein Einsatz zur diagnostischen Erkennung von Bacillus anthracis

    Boll, Kerstin

    (édition scientifique)

    2013  

    Title variant Herstellung von rPLyG und Diagnostik von Milzbrand ; rekombinantes Phagenlysin-gamma
    Author's details Kerstin Boll
    Series title édition scientifique
    Keywords Bacillus anthracis ; Milzbrand ; Bakteriophagen ; Diagnose
    Language German
    Size 198 S., 210 mm x 146 mm, 395 g
    Edition 1. Aufl.
    Publisher VVB Laufersweiler
    Publishing place Gießen, Lahn
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Facher. Veterinärmed., Diss.--Gießen, 2013
    ISBN 9783835960251 ; 3835960253
    Database Special collection on veterinary medicine and general parasitology

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  4. Book ; Online ; Thesis: Klonierung und Charakterisierung eines Phagenlysins und sein Einsatz zur diagnostischen Erkennung von Bacillus anthracis

    Boll, Kerstin

    (Edition scientifique)

    2013  

    Author's details Kerstin Boll
    Series title Edition scientifique
    Language German
    Size Online-Ressource
    Publisher Universitätsbibliothek
    Publishing place Gießen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Gießen, Justus-Liebig-Universität, Diss., 2013
    Note In: Giessen : VVB Laufersweiler
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book ; Online ; Thesis: Klonierung und Charakterisierung eines Phagenlysins und sein Einsatz zur diagnostischen Erkennung von Bacillus anthracis

    Boll, Kerstin

    (Edition scientifique)

    2013  

    Author's details Kerstin Boll
    Series title Edition scientifique
    Language German
    Size Online-Ressource
    Publisher Universitätsbibliothek
    Publishing place Gießen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Gießen, Justus-Liebig-Universität, Diss., 2013
    Note In: Giessen : VVB Laufersweiler
    Database Special collection on veterinary medicine and general parasitology

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  6. Book ; Online ; Thesis: Klonierung und Charakterisierung eines Phagenlysins und sein Einsatz zur diagnostischen Erkennung von Bacillus anthracis

    Boll, Kerstin [Verfasser]

    2013  

    Author's details Kerstin Boll
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Language German
    Publisher Universitätsbibliothek
    Publishing place Gießen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article: Long-term control of Coxiellosis in sheep by annual primary vaccination of gimmers

    Böttcher, Jens / Bauer, Benjamin U. / Ambros, Christina / Alex, Michaela / Domes, Ursula / Roth, Sabine / Boll, Kerstin / Korneli, Martin / Bogner, Karl-Heinz / Randt, Andreas / Janowetz, Britta

    Vaccine. 2022 July 21,

    2022  

    Abstract: Coxiella (C.) burnetii, a Gram-negative intracellular bacterium, causes Q fever in humans and Coxiellosis in animals. Ruminants are a primary source of human infection with C.burnetii. In 2013, vaccination was implemented in a sheep flock with 650 ewes ... ...

    Abstract Coxiella (C.) burnetii, a Gram-negative intracellular bacterium, causes Q fever in humans and Coxiellosis in animals. Ruminants are a primary source of human infection with C.burnetii. In 2013, vaccination was implemented in a sheep flock with 650 ewes associated with two outbreaks of Q fever in humans in 2008 and 2012. Only gimmers (yearlings) received two doses of a commercial C.burnetii phase I whole cell vaccine three weeks apart (primary vaccination) without any revaccination. Vaginal and nasal swabs collected shortly after lambing were tested by qPCR. Additionally, a group of non-vaccinated sentinels was serologically monitored for phase I (PhI), II (PhII) antibodies and for Interferon γ (IFN-γ) after stimulation of whole blood cells with PhII-antigen with and without an IL-10-neutralizing monoclonal antibody. In 2021, 679 sera collected in 2014–2021 were retested retrospectively with three commercial ELISA kits and one batch of an in-house PhI/PhII-ELISA. A low-level shedding of C.burnetii (<10³ mean C.burnetii/swab) was observed until 2014. In 2021 C.burnetii was detected in two animals (<10³.¹C.burnetii/swab), but vaginal swabs collected at two subsequent lambing seasons remained negative. Seroconversion of sentinels was detected until 2017. However, the retrospective analysis of sentinels in 2021 revealed additional single seropositive animals from 2018 to 2021. IFN-γ reactivity was observed during the whole study period; it peaked in 2014 and in 2018 and decreased thereafter. The sporadic detection of C.burnetii and the immune responses of sentinels suggested that a subliminal infection persisted despite vaccination. Nevertheless, vaccination of gimmers prevented the development of a major outbreak, it controlled the infection and reduced the risk of human infection.
    Keywords Coxiella ; Q fever ; bacteria ; flocks ; human diseases ; monoclonal antibodies ; nose ; retrospective studies ; seroconversion ; seroprevalence ; vaccination ; vaccines
    Language English
    Dates of publication 2022-0721
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.07.029
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  8. Thesis ; Online: Three microRNAs synergistically repress androgen receptor signaling and are downregulated in prostate carcinoma

    Boll, Kerstin

    2010  

    Abstract: Prostate cancer (PCa) as the second leading cause of cancer death in men in the Western world is of great interest for the clinic and for scientific research. An effective treatment and molecular markers for the agressive, hormone-refractory form of the ... ...

    Abstract Prostate cancer (PCa) as the second leading cause of cancer death in men in the Western world is of great interest for the clinic and for scientific research. An effective treatment and molecular markers for the agressive, hormone-refractory form of the cancer are still missing. During the last years, microRNAs, small regulatory non-coding RNAs (\'1822nt), involved in post-transcriptional regulation of mRNAs, have become an important study field of molecular biology and there are many microRNAs known to be associated with different cancers. However, only few microRNAs are reported for PCa. In this study global microRNA profiling of different prostate cancer cell lines and a nonmalignant prostate epithelial cell line was used to identify microRNAs that are deregulated in PCa. In a subsequent analysis in non-malignant prostate tissue and tumor samples of different progression stages, we found miR-130a, miR-203, and miR-205 to be most significantly downregulated in PCa. Reconstitution of these microRNAs induced cell growth arrest caused by apoptosis (miR-130a, miR-203) or cell cycle arrest (miR-203, miR-205), which was even stronger, if the microRNAs were concomitantly reconstituted. Using four different target identification approaches, most targets were found to be associated with the androgen receptor (AR) signaling pathway, the central pathway for PCa initiation and growth. These included AR coregulators, as well as members of the MAPK pathway, a known ligand-independent activator pathway of the AR. We conclude from this study that the microRNAs -130a, -203, and -205 act as tumor suppressors in PCa cells, by negatively regulating AR coactivators. This may have therapeutic implications in particular for castration resistant PCa.
    Keywords 610 ; 620
    Subject code 571
    Language English
    Publishing country de
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Long-term control of Coxiellosis in sheep by annual primary vaccination of gimmers.

    Böttcher, Jens / Bauer, Benjamin U / Ambros, Christina / Alex, Michaela / Domes, Ursula / Roth, Sabine / Boll, Kerstin / Korneli, Martin / Bogner, Karl-Heinz / Randt, Andreas / Janowetz, Britta

    Vaccine

    2022  Volume 40, Issue 35, Page(s) 5197–5206

    Abstract: Coxiella (C.) burnetii, a Gram-negative intracellular bacterium, causes Q fever in humans and Coxiellosis in animals. Ruminants are a primary source of human infection with C.burnetii. In 2013, vaccination was implemented in a sheep flock with 650 ewes ... ...

    Abstract Coxiella (C.) burnetii, a Gram-negative intracellular bacterium, causes Q fever in humans and Coxiellosis in animals. Ruminants are a primary source of human infection with C.burnetii. In 2013, vaccination was implemented in a sheep flock with 650 ewes associated with two outbreaks of Q fever in humans in 2008 and 2012. Only gimmers (yearlings) received two doses of a commercial C.burnetii phase I whole cell vaccine three weeks apart (primary vaccination) without any revaccination. Vaginal and nasal swabs collected shortly after lambing were tested by qPCR. Additionally, a group of non-vaccinated sentinels was serologically monitored for phase I (PhI), II (PhII) antibodies and for Interferon γ (IFN-γ) after stimulation of whole blood cells with PhII-antigen with and without an IL-10-neutralizing monoclonal antibody. In 2021, 679 sera collected in 2014-2021 were retested retrospectively with three commercial ELISA kits and one batch of an in-house PhI/PhII-ELISA. A low-level shedding of C.burnetii (<10
    MeSH term(s) Animals ; Coxiella burnetii ; Female ; Humans ; Q Fever/epidemiology ; Q Fever/prevention & control ; Q Fever/veterinary ; Retrospective Studies ; Sheep ; Sheep Diseases/epidemiology ; Sheep Diseases/microbiology ; Sheep Diseases/prevention & control ; Vaccination/veterinary
    Language English
    Publishing date 2022-07-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.07.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Antimicrobial Resistance, Serologic and Molecular Characterization of

    Feuerstein, Andrea / Scuda, Nelly / Klose, Corinna / Hoffmann, Angelika / Melchner, Alexander / Boll, Kerstin / Rettinger, Anna / Fell, Shari / Straubinger, Reinhard K / Riehm, Julia M

    Antibiotics (Basel, Switzerland)

    2021  Volume 11, Issue 1

    Abstract: Worldwide, ... ...

    Abstract Worldwide, enterotoxigenic
    Language English
    Publishing date 2021-12-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11010023
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