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  1. Article ; Online: Pulmonary complications of transfusion: Changes, challenges, and future directions.

    Grey, Sharran / Bolton-Maggs, Paula

    Transfusion medicine (Oxford, England)

    2020  Volume 30, Issue 6, Page(s) 442–449

    Abstract: The pulmonary complications of transfusion (TACO, TRALI and TAD) are the leading cause of transfusion-related mortality and major morbidity. Advance in this area is essential in improving transfusion safety. This review describes the drivers for change ... ...

    Abstract The pulmonary complications of transfusion (TACO, TRALI and TAD) are the leading cause of transfusion-related mortality and major morbidity. Advance in this area is essential in improving transfusion safety. This review describes the drivers for change in haemovigilance practice, the influence of recent key publications and future directions.
    MeSH term(s) Blood Safety ; Blood Transfusion ; Humans ; Transfusion-Related Acute Lung Injury/blood ; Transfusion-Related Acute Lung Injury/prevention & control
    Language English
    Publishing date 2020-09-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Guideline on the use of predeposit autologous donation prepared by the BSH Blood Transfusion Task Force.

    McSporran, Wendy / Anand, Rekha / Bolton-Maggs, Paula / Madgwick, Karen / McLintock, Lorna / Nwankiti, Kelly

    British journal of haematology

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Staffing in hospital transfusion laboratories: UKTLC surveys show cause for concern.

    Bolton-Maggs, P / Mistry, H / Glencross, H / Rook, R

    Transfusion medicine (Oxford, England)

    2019  Volume 29, Issue 2, Page(s) 95–102

    Abstract: Objectives: To monitor minimum standards in hospital transfusion laboratories in relation to qualifications, training, competency and the use of information technology over time against published recommendations.: Background: The United Kingdom ... ...

    Abstract Objectives: To monitor minimum standards in hospital transfusion laboratories in relation to qualifications, training, competency and the use of information technology over time against published recommendations.
    Background: The United Kingdom Transfusion Laboratory Collaborative was formed in 2006 with representatives from relevant organisations and has published standards for transfusion laboratory practice. The standards are set to ensure safe transfusion laboratory practice. Regular surveys are performed to see the extent to which laboratories are able to meet these standards and where any problems lie.
    Methods: An electronic survey is sent to hospital transfusion laboratories on a single mid-week day in the spring and is repeated every 2 years from 2011, to be completed by the lead in transfusion for the day. The questions cover staffing, training, funding and workload.
    Results: Transfusion laboratories are having difficulty with staffing, particularly recruitment of suitably trained biomedical scientists, and with funding and time for training and education. Laboratory errors reported to the Serious Hazards of Transfusion haemovigilance scheme (SHOT) have not decreased with time, related to the under-resourced workforce.
    Conclusion: Problems in laboratory staffing and expertise in hospital transfusion laboratories need to be urgently addressed. The transfusion laboratory provides a key service to hospitals. The Blood Services in England and Wales are developing supportive strategies.
    MeSH term(s) Blood Safety ; Blood Transfusion ; Humans ; Laboratories, Hospital ; United Kingdom ; Workforce
    Language English
    Publishing date 2019-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Conference report: International Haemovigilance Seminar and the SHOT Annual Symposium, 10-12 July 2018.

    Bolton-Maggs, P H B

    Transfusion medicine (Oxford, England)

    2018  Volume 29, Issue 4, Page(s) 247–252

    Abstract: The Annual SHOT Report was published on July 12 at the Annual Symposium. This was preceded by a 2-day meeting of the International Haemovigilance Network (IHN). The IHN meeting provides an opportunity for haemovigilance experts to network with one ... ...

    Abstract The Annual SHOT Report was published on July 12 at the Annual Symposium. This was preceded by a 2-day meeting of the International Haemovigilance Network (IHN). The IHN meeting provides an opportunity for haemovigilance experts to network with one another and share presentations, which this year included those from China and Taiwan. Reviews of pulmonary complications were highlighted since the definitions of both transfusion-related acute lung injury and transfusion-associated circulatory overload are undergoing revision. The seminar provided an opportunity to present some UK data to an international group (the INTERVAL donor study, the value of big data and work on genomics and human factors). SHOT reports for incidents reported in 2017 demonstrate that, overall, 85·5% are caused by errors. Key recommendations from SHOT are: (i) All staff involved in transfusion must be trained in and know ABO group compatibility. Clinical staff must not just rely on the laboratory staff to get this right. (ii) IT systems have the potential to increase transfusion safety by minimising human factors and should be considered for all transfusion steps. (iii) A formal risk assessment for transfusion-associated circulatory overload should be undertaken wherever possible.
    MeSH term(s) Acute Lung Injury/epidemiology ; Acute Lung Injury/genetics ; Acute Lung Injury/prevention & control ; Big Data ; Blood Safety ; Congresses as Topic ; Genome, Human ; Humans ; Transfusion Reaction/epidemiology ; Transfusion Reaction/genetics ; Transfusion Reaction/prevention & control
    Language English
    Publishing date 2018-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Acute immune thrombocytopenic purpura. To treat or not to treat?

    Bolton-Maggs, P

    Hamostaseologie

    2009  Volume 29, Issue 1, Page(s) 74–75

    Abstract: Immune thrombocytopenia in children is usually a self-limiting illness, but in adults the disease is likely to be chronic, and may be associated with other pathology which predisposes to bleeding. Despite very low platelet counts serious bleeding is rare ...

    Abstract Immune thrombocytopenia in children is usually a self-limiting illness, but in adults the disease is likely to be chronic, and may be associated with other pathology which predisposes to bleeding. Despite very low platelet counts serious bleeding is rare in both adults and children. More than 80% of children have mild clinical manifestations. Intracranial haemorrhage is rare at all ages, is unpredictable and can occur at any time when the count is very low. Currently recommended therapies for both adults and children are associated with significant side effects and occasional deaths. Treatment may interfere with quality of life more than the illness itself. Drugs can be withheld in the majority of children with appropriate advice to child and family. Treatment can be individualised, taking into account the person's needs and lifestyle as well as bleeding. In chronic ITP many need no active therapy. The situation with adults is more complex but those with a platelet count above 30 x 10(9)/l usually need no treatment as bleeding is rare, and those adults with refractory ITP unresponsive to treatment live with very low counts for years without significant bleeding suggesting the need to re-evaluate the balance of risks of treatment versus bleeding. It is notable that adults with ITP may die from infection, probably related to therapy.
    MeSH term(s) Acute Disease ; Child ; Emergencies ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Platelet Count ; Prednisolone/therapeutic use ; Purpura, Thrombocytopenic, Idiopathic/blood ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Splenectomy ; Treatment Outcome
    Chemical Substances Immunoglobulins, Intravenous ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2009-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801512-0
    ISSN 0720-9355
    ISSN 0720-9355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Serious hazards of transfusion - conference report: celebration of 20 years of UK haemovigilance.

    Bolton-Maggs, P H B

    Transfusion medicine (Oxford, England)

    2017  Volume 27, Issue 6, Page(s) 393–400

    Abstract: The Annual SHOT Report for incidents in 2016 was published on July 12 and celebrated of 20 years of UK haemovigilance. Components are very safe, related in part to risk-reduction measures triggered by SHOT reporting. Transfusion-related acute lung injury ...

    Abstract The Annual SHOT Report for incidents in 2016 was published on July 12 and celebrated of 20 years of UK haemovigilance. Components are very safe, related in part to risk-reduction measures triggered by SHOT reporting. Transfusion-related acute lung injury is now very rare (all plasma components are provided from male donors), and infection transmission is also uncommon - a single transmission of hepatitis E in 2016 and no bacterial transmissions. Human factors (errors) account for 87% of all reports. Deaths and major morbidity most often result from transfusion-associated circulatory overload. Wrong transfusions and deaths from ABO-incompatible transfusion can be reduced by correct bedside checks. It is notable that information technology systems may not be safe. Standardisation is required for flags and alerts. SHOT key recommendations include: assess patients for transfusion-associated circulatory overload prior to transfusion. Be like a pilot - use a bedside checklist when setting up the transfusion.
    MeSH term(s) Blood Safety/history ; Blood Safety/methods ; Blood Safety/standards ; Congresses as Topic ; History, 20th Century ; History, 21st Century ; Humans ; Transfusion Reaction/epidemiology ; Transfusion Reaction/history ; Transfusion Reaction/prevention & control ; United Kingdom
    Language English
    Publishing date 2017-12-27
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SHOT conference report 2016: serious hazards of transfusion - human factors continue to cause most transfusion-related incidents.

    Bolton-Maggs, P H B

    Transfusion medicine (Oxford, England)

    2016  Volume 26, Issue 6, Page(s) 401–405

    Abstract: The Annual SHOT Report for incidents reported in 2015 was published on 7 July at the SHOT symposium. Once again, the majority of reports (77·7%) were associated with mistakes ('human factors'). Pressures and stress in the hospital environment contributed ...

    Abstract The Annual SHOT Report for incidents reported in 2015 was published on 7 July at the SHOT symposium. Once again, the majority of reports (77·7%) were associated with mistakes ('human factors'). Pressures and stress in the hospital environment contributed to several error reports. There were 26 deaths where transfusion played a part, one due to haemolysis from anti-Wr
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Diagnosis and management of thrombotic microangiopathy: the role of registries.

    Bolton-Maggs, Paula

    Pediatric blood & cancer

    2013  Volume 60, Issue 10, Page(s) 1561–1562

    MeSH term(s) Female ; Humans ; Male ; Registries ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/therapy
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.24650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021).

    Toy, Pearl / Looney, Mark R / Popovsky, Mark / Palfi, Miodrag / Berlin, Gösta / Chapman, Catherine E / Bolton-Maggs, Paula / Matthay, Michael A

    Annals of the American Thoracic Society

    2022  Volume 19, Issue 5, Page(s) 705–712

    Abstract: The term transfusion-related acute lung injury (TRALI) was coined in 1985 to describe acute respiratory distress syndrome (ARDS) after transfusion, when another ARDS risk factor was absent; TRALI cases were mostly associated with donor leukocyte antibody. ...

    Abstract The term transfusion-related acute lung injury (TRALI) was coined in 1985 to describe acute respiratory distress syndrome (ARDS) after transfusion, when another ARDS risk factor was absent; TRALI cases were mostly associated with donor leukocyte antibody. In 2001, plasma from multiparous donors was implicated in TRALI in a randomized controlled trial in Sweden. In 2003 and in many years thereafter, the U.S. Food and Drug Administration reported that TRALI was the leading cause of death from transfusion in the United States. In 2003, the United Kingdom was the first among many countries to successfully reduce TRALI using male-predominant plasma. These successes are to be celebrated. Nevertheless, questions remain about the mechanisms of non-antibody TRALI, the role of blood products in the development of ARDS in patients receiving massive transfusion, the causes of unusual TRALI cases, and how to reduce inaccurate diagnoses of TRALI in clinical practice. Regarding the latter, a study in 2013-2015 at 169 U.S. hospitals found that many TRALI diagnoses did not meet clinical definitions. In 2019, a consensus panel established a more precise terminology for clinical diagnosis: TRALI type I and TRALI type II are cases where transfusion is the likely cause, and ARDS are cases where transfusion is not the likely cause. For accurate diagnosis using these clinical definitions, critical care or pulmonary expertise is needed to distinguish between permeability versus hydrostatic pulmonary edema, to determine whether an ARDS risk factor is present, and, if so, to determine whether respiratory function was stable within the 12 hours before transfusion.
    MeSH term(s) Blood Transfusion ; Humans ; Male ; Pulmonary Edema/etiology ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Transfusion Reaction/complications ; Transfusion-Related Acute Lung Injury/complications ; Transfusion-Related Acute Lung Injury/diagnosis
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202108-963CME
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Conference report: the 2015 SHOT symposium and report--what's new?

    Bolton-Maggs, P H B

    Transfusion medicine (Oxford, England)

    2015  Volume 25, Issue 5, Page(s) 295–298

    MeSH term(s) Blood Component Transfusion/adverse effects ; Blood Component Transfusion/methods ; Blood Safety ; Congresses as Topic ; Female ; Humans ; Male ; United Kingdom
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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