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  1. Article ; Online: Guidelines: the same evidence but different conclusions - relaxation of indications for irradiation of cellular blood components?

    Bolton-Maggs, Paula H B

    British journal of haematology

    2021  Volume 195, Issue 5, Page(s) 657–659

    MeSH term(s) Blood Component Transfusion ; Humans
    Language English
    Publishing date 2021-09-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17845
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  2. Article ; Online: A Novel Assay for Determining Bleeding Risk in Factor XI Deficiency.

    Bolton-Maggs, Paula H B

    Thrombosis and haemostasis

    2020  Volume 121, Issue 2, Page(s) 121

    MeSH term(s) Factor XI ; Factor XI Deficiency/diagnosis ; Hemorrhage/diagnosis ; Humans
    Chemical Substances Factor XI (9013-55-2)
    Language English
    Publishing date 2020-10-29
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0040-1718731
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  3. Article ; Online: Pulmonary complications of transfusion: Changes, challenges, and future directions.

    Grey, Sharran / Bolton-Maggs, Paula

    Transfusion medicine (Oxford, England)

    2020  Volume 30, Issue 6, Page(s) 442–449

    Abstract: The pulmonary complications of transfusion (TACO, TRALI and TAD) are the leading cause of transfusion-related mortality and major morbidity. Advance in this area is essential in improving transfusion safety. This review describes the drivers for change ... ...

    Abstract The pulmonary complications of transfusion (TACO, TRALI and TAD) are the leading cause of transfusion-related mortality and major morbidity. Advance in this area is essential in improving transfusion safety. This review describes the drivers for change in haemovigilance practice, the influence of recent key publications and future directions.
    MeSH term(s) Blood Safety ; Blood Transfusion ; Humans ; Transfusion-Related Acute Lung Injury/blood ; Transfusion-Related Acute Lung Injury/prevention & control
    Language English
    Publishing date 2020-09-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12709
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  4. Article ; Online: Prevention and treatment of infection in patients with an absent or hypofunctional spleen: A British Society for Haematology guideline.

    Ladhani, Shamez N / Fernandes, Savio / Garg, Mamta / Borrow, Ray / de Lusignan, Simon / Bolton-Maggs, Paula H B

    British journal of haematology

    2024  

    Abstract: Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen were published by the British Committee for Standards in Haematology in 1996 and updated in 2002 and 2011. With advances in vaccinations and ... ...

    Abstract Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen were published by the British Committee for Standards in Haematology in 1996 and updated in 2002 and 2011. With advances in vaccinations and changes in patterns of infection, the guidelines required updating. Key aspects included in this guideline are the identification of patients at risk of infection, patient education and information and immunisation schedules. This guideline does not address the non-infective complications of splenectomy or functional hyposplenism (FH). This replaces previous guidelines and significantly revises the recommendations related to immunisation. Patients at risk include those who have undergone surgical removal of the spleen, including partial splenectomy and splenic embolisation, and those with medical conditions that predispose to FH. Immunisations should include those against Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus) and influenza. Haemophilus influenzae type b (Hib) is part of the infant immunisation schedule and is no longer required for older hyposplenic patients. Treatment of suspected or proven infections should be based on local protocols and consider relevant anti-microbial resistance patterns. The education of patients and their medical practitioners is essential, particularly in relation to the risk of serious infection and its prevention. Further research is required to establish the effectiveness of vaccinations in hyposplenic patients; infective episodes should be regularly audited. There is no single group ideally placed to conduct audits into complications arising from hyposplenism, highlighting a need for a national registry, as has proved very successful in Australia or alternatively, the establishment of appropriate multidisciplinary networks.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19361
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  5. Article ; Online: Immune Thrombocytopenia Treatment.

    Bolton-Maggs, Paula H B / George, James N

    The New England journal of medicine

    2021  Volume 385, Issue 10, Page(s) 948–950

    MeSH term(s) Autoimmunity ; Humans ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Thrombocytopenia
    Language English
    Publishing date 2021-09-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2110953
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  6. Article ; Online: Guideline on the use of predeposit autologous donation prepared by the BSH Blood Transfusion Task Force.

    McSporran, Wendy / Anand, Rekha / Bolton-Maggs, Paula / Madgwick, Karen / McLintock, Lorna / Nwankiti, Kelly

    British journal of haematology

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19374
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  7. Article: A Novel Assay for Determining Bleeding Risk in Factor XI Deficiency

    Bolton-Maggs, Paula H.B.

    Thrombosis and Haemostasis

    2020  Volume 121, Issue 02, Page(s) 121–121

    Language English
    Publishing date 2020-10-29
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0040-1718731
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  8. Article ; Online: Transfusion errors - can they be eliminated?

    Bolton-Maggs, Paula H B / Watt, Alison

    British journal of haematology

    2019  Volume 189, Issue 1, Page(s) 9–20

    Abstract: The Serious Hazards of Transfusion haemovigilance scheme has documented adverse transfusion incidents for 22 years. Transmission of infection (three in 2018), transfusion-related lung injury (one in 2018) and transfusion-associated graft-versus-host ... ...

    Abstract The Serious Hazards of Transfusion haemovigilance scheme has documented adverse transfusion incidents for 22 years. Transmission of infection (three in 2018), transfusion-related lung injury (one in 2018) and transfusion-associated graft-versus-host disease (none since 2012) are rare. Despite national recommendations, guidelines and protocols, most incidents more than 85% of incidents are still due to errors in the transfusion process. European regulation and mandatory competency assessments have been associated with a reduction in ABO-incompatible transfusion, but errors continue to put patients at risk. What can be done? Errors are reduced by the use of electronic identification systems. Exploration of human factors and ergonomics (HFE) results in amended approaches away from blaming individuals to a full review of the systems and environment. Research examining how transfusion is performed (work-as-done) compared to work-as-imagined (set out in protocols and guidelines) discovers where variability results in either resilience or error. All staff require HFE training, but this should be alongside employment of suitably qualified and experienced HFE professionals. Good teamwork is key and is undermined by insufficient staffing and poor morale. The five choosing wisely recommendations for transfusion (to ensure appropriate use) need to be widely disseminated to medical staff in all specialties to ensure patients participate in the decision-making.
    MeSH term(s) Blood Group Incompatibility ; Blood Safety ; Humans ; Transfusion Reaction/prevention & control
    Language English
    Publishing date 2019-12-02
    Publishing country England
    Document type Editorial
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16256
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  9. Article ; Online: Diagnosis and management of thrombotic microangiopathy: the role of registries.

    Bolton-Maggs, Paula

    Pediatric blood & cancer

    2013  Volume 60, Issue 10, Page(s) 1561–1562

    MeSH term(s) Female ; Humans ; Male ; Registries ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/therapy
    Language English
    Publishing date 2013-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.24650
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  10. Article ; Online: Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021).

    Toy, Pearl / Looney, Mark R / Popovsky, Mark / Palfi, Miodrag / Berlin, Gösta / Chapman, Catherine E / Bolton-Maggs, Paula / Matthay, Michael A

    Annals of the American Thoracic Society

    2022  Volume 19, Issue 5, Page(s) 705–712

    Abstract: The term transfusion-related acute lung injury (TRALI) was coined in 1985 to describe acute respiratory distress syndrome (ARDS) after transfusion, when another ARDS risk factor was absent; TRALI cases were mostly associated with donor leukocyte antibody. ...

    Abstract The term transfusion-related acute lung injury (TRALI) was coined in 1985 to describe acute respiratory distress syndrome (ARDS) after transfusion, when another ARDS risk factor was absent; TRALI cases were mostly associated with donor leukocyte antibody. In 2001, plasma from multiparous donors was implicated in TRALI in a randomized controlled trial in Sweden. In 2003 and in many years thereafter, the U.S. Food and Drug Administration reported that TRALI was the leading cause of death from transfusion in the United States. In 2003, the United Kingdom was the first among many countries to successfully reduce TRALI using male-predominant plasma. These successes are to be celebrated. Nevertheless, questions remain about the mechanisms of non-antibody TRALI, the role of blood products in the development of ARDS in patients receiving massive transfusion, the causes of unusual TRALI cases, and how to reduce inaccurate diagnoses of TRALI in clinical practice. Regarding the latter, a study in 2013-2015 at 169 U.S. hospitals found that many TRALI diagnoses did not meet clinical definitions. In 2019, a consensus panel established a more precise terminology for clinical diagnosis: TRALI type I and TRALI type II are cases where transfusion is the likely cause, and ARDS are cases where transfusion is not the likely cause. For accurate diagnosis using these clinical definitions, critical care or pulmonary expertise is needed to distinguish between permeability versus hydrostatic pulmonary edema, to determine whether an ARDS risk factor is present, and, if so, to determine whether respiratory function was stable within the 12 hours before transfusion.
    MeSH term(s) Blood Transfusion ; Humans ; Male ; Pulmonary Edema/etiology ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Transfusion Reaction/complications ; Transfusion-Related Acute Lung Injury/complications ; Transfusion-Related Acute Lung Injury/diagnosis
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202108-963CME
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