Article ; Online: A Lab-On-chip Tool for Rapid, Quantitative, and Stage-selective Diagnosis of Malaria.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2021 Volume 8, Issue 14, Page(s) 2004101
Abstract: Malaria remains the most important mosquito-borne infectious disease worldwide, with 229 million new cases and 409.000 deaths in 2019. The infection is caused by a protozoan parasite which attacks red blood cells by feeding on hemoglobin and transforming ...
| Abstract | Malaria remains the most important mosquito-borne infectious disease worldwide, with 229 million new cases and 409.000 deaths in 2019. The infection is caused by a protozoan parasite which attacks red blood cells by feeding on hemoglobin and transforming it into hemozoin. Despite the WHO recommendation of prompt malaria diagnosis, the quality of microscopy-based diagnosis is frequently inadequate while rapid diagnostic tests based on antigens are not quantitative and still affected by non-negligible false negative/positive results. PCR-based methods are highly performant but still not widely used in endemic areas. Here, a diagnostic tool (TMek), based on the paramagnetic properties of hemozoin nanocrystals in infected red blood cells (i-RBCs), is reported on. Exploiting the competition between gravity and magnetic forces, i-RBCs in a whole blood specimen are sorted and electrically detected in a microchip. The amplitude and time evolution of the electrical signal allow for the quantification of i-RBCs (in the range 10-10 |
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| MeSH term(s) | Erythrocytes/parasitology ; Evaluation Studies as Topic ; Humans ; Lab-On-A-Chip Devices ; Malaria/diagnosis ; Reproducibility of Results ; Sensitivity and Specificity |
| Language | English |
| Publishing date | 2021-05-13 |
| Publishing country | Germany |
| Document type | Evaluation Study ; Journal Article |
| ZDB-ID | 2808093-2 |
| ISSN | 2198-3844 ; 2198-3844 |
| ISSN (online) | 2198-3844 |
| ISSN | 2198-3844 |
| DOI | 10.1002/advs.202004101 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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