Article ; Online: Biological evaluation of a natural steroid ester, Stigmasta-5(6), 22(23)-dien-3-beta-yl acetate isolated from the Himalayan herb Astilbe rivularis as potential antitumor agent.
Chemico-biological interactions
2022 Volume 360, Page(s) 109935
Abstract: Background: Cancer remains a major world health issue due to its high morbidity and mortality rate. Plant based natural products (NPs) have played vital role in discovery of valuable anti-cancer drugs. Darjeeling Himalayan region has a rich diversity of ...
| Abstract | Background: Cancer remains a major world health issue due to its high morbidity and mortality rate. Plant based natural products (NPs) have played vital role in discovery of valuable anti-cancer drugs. Darjeeling Himalayan region has a rich diversity of therapeutic plants that can be utilized for development of novel drugs. Aim: We previously reported cytotoxic potential of rhizome extract of A.rivularis, a Darjeeling himalayan herb. Present study reports isolation and characterization of a phytosteroid from the plant rhizome in a bioassay-guided approach and evaluation of its anti-tumorigenic potential. Results: The phytosteroid was characterized as stigmasta-5(6), 22(23)-dien-3-beta-yl acetate (A11) by various spectrometric techniques (IR, NMR, MS etc.). The catalytic inhibition and structural alteration of human dihydrofolate reductase (hDHFR) by A11 was evaluated using methotrexate (MTX), a DHFR inhibitor anticancer drug as a reference. A11 inhibited hDHFR activity with IC |
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| MeSH term(s) | Acetates/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Esters ; HEK293 Cells ; Humans ; Molecular Docking Simulation ; Phytosterols ; Saxifragaceae/metabolism ; Steroids ; Tetrahydrofolate Dehydrogenase/chemistry ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism |
| Chemical Substances | Acetates ; Antineoplastic Agents ; Esters ; Phytosterols ; Steroids ; Tetrahydrofolate Dehydrogenase (EC 1.5.1.3) |
| Language | English |
| Publishing date | 2022-04-12 |
| Publishing country | Ireland |
| Document type | Journal Article |
| ZDB-ID | 218799-1 |
| ISSN | 1872-7786 ; 0009-2797 |
| ISSN (online) | 1872-7786 |
| ISSN | 0009-2797 |
| DOI | 10.1016/j.cbi.2022.109935 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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