Article ; Online: Non-protective immunity after standard pneumococcal vaccination series identified as a potential contributing risk factor for refractory otolaryngologic conditions in children.
The Annals of otology, rhinology, and laryngology
2023 Volume 133, Issue 1, Page(s) 37–42
Abstract: Objective: To examine the relationship between conferred immunity after standard pneumococcal series and refractory otolaryngologic infections in pediatric patients using post-vaccination antibody titers, and to identify contributory underlying ... ...
Abstract | Objective: To examine the relationship between conferred immunity after standard pneumococcal series and refractory otolaryngologic infections in pediatric patients using post-vaccination antibody titers, and to identify contributory underlying conditions revealed when vaccination/re-vaccination fails to confer protective immunity. Study design: IRB-reviewed and "exempt" retrospective case series with chart review using the Epic Setting: Dedicated tertiary referral children's hospital. Methods: Pneumococcal antibody titer results were assessed for children ages 0 to 21 years and: (1) at least 1 of 7 otolaryngologic disease diagnoses and (2) having received the 4-dose schedule of pneumococcal conjugate vaccine (PCV 7 or 13). Results: A total of 241 subjects met inclusion criteria with 356 laboratory tests. Recurrent acute otitis media, chronic rhinitis, and chronic otitis media with effusion were the 3 most frequent diagnoses. At presentation, only 27.0% of subjects had titers conferring immunity from their prior vaccinations with PCV. About 85 subjects had been subsequently revaccinated with Pneumococcal Polysaccharide Vaccine (PPSV), and antibody responses conferring immunity reached 91.8%. Seven subjects never developed adequate responses; 5 of these had recurrent acute otitis media as the primary otolaryngologic diagnosis. Secondary "revealed" diagnoses included Juvenile Rheumatoid Arthritis (n = 1), unresolved specific antibody deficiency (n = 2), and Hypogammaglobulinemia (n = 1). Conclusion: In pediatric patients with recurrent infectious otolaryngologic disease refractory to traditional medical and surgical therapy, inadequate responses to pneumococcal vaccination may be revealed. This correlation represents a potential pathway for diagnosis and therapy. |
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MeSH term(s) | Child ; Humans ; Otitis Media/drug therapy ; Pneumococcal Infections/prevention & control ; Pneumococcal Infections/drug therapy ; Pneumococcal Vaccines/adverse effects ; Retrospective Studies ; Risk Factors ; Streptococcus pneumoniae ; Vaccination |
Chemical Substances | Pneumococcal Vaccines |
Language | English |
Publishing date | 2023-06-29 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 120642-4 |
ISSN | 1943-572X ; 0003-4894 |
ISSN (online) | 1943-572X |
ISSN | 0003-4894 |
DOI | 10.1177/00034894231182745 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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