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  1. Article: Vitamin D Supplementation: Effect on Cytokine Profile in Multiple Sclerosis.

    Sparaco, Maddalena / Bonavita, Simona

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Vitamin D is known for its role in modulating calcium and phosphate homeostasis and is implicated both in bone mineralization and immune system regulation. The immune-modulatory role of vitamin D and its impact on multiple sclerosis (MS) courses are ... ...

    Abstract Vitamin D is known for its role in modulating calcium and phosphate homeostasis and is implicated both in bone mineralization and immune system regulation. The immune-modulatory role of vitamin D and its impact on multiple sclerosis (MS) courses are still debated. The aim of this review was to check the effect of vitamin D supplementation on cytokine profile regulation in people with MS. A significant increase in serum concentrations of interleukin (IL)-10 and Transforming growth factor (TGF)-β1 after vitamin D supplementation was demonstrated in most studies, with some of them reporting a reduction in disability scores after vitamin D supplementation and an inverse correlation between IL-10 levels and disability. The effect of vitamin D on the serum levels of IL-17 and IL-6 was controversial; different results across studies could be explained by a variability in the treatment duration, route, and frequency of administration, as well as the dosage of vitamin D supplementation, responses to vitamin D treatment and the serum levels reached with supplementation, including the methods used for cytokine analysis and the different cell types investigated, the MS phenotype, the disease phase (active vs. non-active) and duration, and concomitant treatment with disease-modifying therapies. Nevertheless, the significant increase in the serum concentrations of IL-10 and TGF-β1, demonstrated in most studies, suggests an anti-inflammatory effect of vitamin D supplementation.
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Exercise and Parkinson's Disease.

    Bonavita, Simona

    Advances in experimental medicine and biology

    2020  Volume 1228, Page(s) 289–301

    Abstract: Parkinson's disease (PD) is an aging-related neurodegenerative disorder characterized by progressive motor impairment.The etiology of PD is poorly understood but likely involves both genetic and environmental factors; the management of the disease is ... ...

    Abstract Parkinson's disease (PD) is an aging-related neurodegenerative disorder characterized by progressive motor impairment.The etiology of PD is poorly understood but likely involves both genetic and environmental factors; the management of the disease is still with symptomatic therapy without any interference on the progression of neurodegeneration. In the past two decades, the results of a series of prospective cohort studies suggested that lifestyle factors likely modify the risk of developing PD. Among these, physical activity is known to reduce the risk of a wide range of diseases and conditions, including cardiovascular disease, stroke, and diabetes.Recently, a growing body of evidence has suggested that increased physical activity may also reduce the risk of PD and partly improve motor and non-motor symptoms during the disease course.Here we report the main findings on the effect of physical activity on both mobility and cognition either in animal models of PD or in people with PD. We also highlighted the structural and functional links between gait and cognition by reporting evidence from neuroimaging studies.
    MeSH term(s) Animals ; Exercise ; Exercise Therapy ; Humans ; Neuroimaging ; Parkinson Disease ; Prospective Studies
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-15-1792-1_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pelvic Floor Dysfunctions and Their Rehabilitation in Multiple Sclerosis.

    Sparaco, Maddalena / Bonavita, Simona

    Journal of clinical medicine

    2022  Volume 11, Issue 7

    Abstract: Urinary, bowel, and sexual dysfunctions are the most frequent and disabling pelvic floor (PF) disorders in patients with multiple sclerosis (MS). PF dysfunction negatively impacts the performance of daily living activities, walking, and the physical ... ...

    Abstract Urinary, bowel, and sexual dysfunctions are the most frequent and disabling pelvic floor (PF) disorders in patients with multiple sclerosis (MS). PF dysfunction negatively impacts the performance of daily living activities, walking, and the physical dimension of quality of life (QoL) in people with MS. Patient-reported outcomes on sphincteric functioning could be useful to detect PF disorders and their impact on patients' lives. PF rehabilitation proposed by Kegel is based on a series of regularly repeated exercises for "the functional restoration of the perineal muscles". Over time, various therapeutic modalities have been added to PF muscles exercises, through the application of physical or instrumental techniques, such as intravaginal neuromuscular electrical stimulation, electromyographic biofeedback, transcutaneous tibial nerve stimulation. PF rehabilitation has been applied in MS treatment, with improvements of lower urinary tract symptoms severity, QoL, level of anxiety and depression, and sexual dysfunction. This review aims to examine the different PF disorders in MS to evaluate the application of PF rehabilitation in MS and to highlight its advantages and limits, suggesting a multidisciplinary management of PF disorders, with a well-deserved space reserved for PF rehabilitation.
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11071941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Bridging the gap between basic neurosciences and clinical neuroimmunology.

    Abbadessa, Gianmarco / Bombaci, Alessandro / Gajofatto, Alberto / Bonavita, Simona

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1285678

    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1285678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Viral pericarditis following ocrelizumab in a multiple sclerosis patient.

    Miele, Giuseppina / Abbadessa, Gianmarco / Maida, Elisabetta / Bonavita, Simona

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2023  Volume 44, Issue 8, Page(s) 2947–2949

    Abstract: Ocrelizumab is a humanized monoclonal anti-CD20 antibody, approved for the treatment of relapsing and primary-progressive multiple sclerosis. We reported a case of pericarditis in an RRMS patient treated with ocrelizumab, who presented with chest pain, ... ...

    Abstract Ocrelizumab is a humanized monoclonal anti-CD20 antibody, approved for the treatment of relapsing and primary-progressive multiple sclerosis. We reported a case of pericarditis in an RRMS patient treated with ocrelizumab, who presented with chest pain, high body temperature and laboratory findings of systemic inflammation, with a favorable clinical outcome.
    MeSH term(s) Humans ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/complications ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Immunologic Factors/adverse effects ; Antibodies, Monoclonal, Humanized/adverse effects ; Pericarditis/chemically induced ; Pericarditis/diagnostic imaging ; Pericarditis/drug therapy
    Chemical Substances ocrelizumab (A10SJL62JY) ; Immunologic Factors ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-04-25
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-06782-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Artificial intelligence will change MS care within the next 10 years: Commentary.

    Lavorgna, Luigi / Bonavita, Simona

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2021  Volume 28, Issue 14, Page(s) 2175–2176

    MeSH term(s) Humans ; Artificial Intelligence
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585221133537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4428: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Editorial: Disease modifying therapies in multiple sclerosis.

    Bonavita, Simona / Ghajarzadeh, Mahsa / Lavorgna, Luigi

    Frontiers in neurology

    2022  Volume 13, Page(s) 927321

    Language English
    Publishing date 2022-08-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.927321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Integrated Cognitive Rehabilitation Home-Based Protocol to Improve Cognitive Functions in Multiple Sclerosis Patients: A Randomized Controlled Study.

    Sharbafshaaer, Minoo / Trojsi, Francesca / Bonavita, Simona / Azimi, Amirreza

    Journal of clinical medicine

    2022  Volume 11, Issue 12

    Abstract: Cognitive impairment (CI) occurs in about 40-65% of people with multiple sclerosis (MS) during the disease course. Cognitive rehabilitation has produced non-univocal results in MS patients.: Objective: The present study aimed to evaluate whether an ... ...

    Abstract Cognitive impairment (CI) occurs in about 40-65% of people with multiple sclerosis (MS) during the disease course. Cognitive rehabilitation has produced non-univocal results in MS patients.
    Objective: The present study aimed to evaluate whether an Integrated Cognitive Rehabilitation Program (ICRP) in MS patients might significantly improve CI.
    Methods: Forty patients with three phenotypes of MS were randomly assigned into two groups: the experimental group (EG, n = 20), which participated in the ICRP for 10 weeks of training; and the control group (CG, n = 20). All participants' cognitive functions were assessed at three timepoints (baseline, post-treatment, and 3-month follow-up) with the California Verbal Learning (CVLT), Brief Visuospatial Memory (BVMTR), Numerical Stroop, and Wisconsin tests.
    Results: When compared to CG patients, EG patients showed significant improvements in several measures of cognitive performance after ICRP, including verbal learning, visuospatial memory, attention, and executive functions.
    Conclusions: Home-based ICRP can improve cognitive functions and prevent the deterioration of patients' cognitive deficits. As an integrated cognitive rehabilitation program aimed at potentiation of restorative and compensatory mechanisms, this approach might suggest an effective role in preserving neuronal flexibility as well as limiting the progression of cognitive dysfunction in MS.
    Language English
    Publishing date 2022-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11123560
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  9. Article ; Online: Hemostasis Components as Therapeutic Targets in Autoimmune Demyelination.

    Abbadessa, Gianmarco / Mainero, Caterina / Bonavita, Simona

    Clinical pharmacology and therapeutics

    2022  Volume 111, Issue 4, Page(s) 807–816

    Abstract: Several studies in both multiple sclerosis (MS) and experimental autoimmune encephalitis (EAE) have shed light on the vascular mechanisms contributing to MS pathogenesis. The dysregulation of the hemostatic pathways revealed to play a pivotal role. Here, ...

    Abstract Several studies in both multiple sclerosis (MS) and experimental autoimmune encephalitis (EAE) have shed light on the vascular mechanisms contributing to MS pathogenesis. The dysregulation of the hemostatic pathways revealed to play a pivotal role. Here, we review the numerous findings providing evidence on the involvement of hemostasis components in MS pathogenesis to highlight why they might be considered potential therapeutic targets in the disease. A literature search for articles from January 1950 to September 2021 was conducted in PubMed and Scopus. A consistent body of evidence supports the pro-inflammatory activity of activated platelets in MS pathogenesis and the beneficial effect of aspirin administration on the EAE clinical course. Further, neuropathological findings in subjects with MS and experimental studies in EAE have revealed dysregulation of coagulation/fibrinolysis system in autoimmune demyelination. Fibrin deposition in the central nervous system and its interaction with the CD11b receptor on microglia cells seems to drive neuroinflammation and autoimmune demyelination. However, at present, few and controversial clinical data are available on the implementation of drugs targeting fibrin deposition in MS therapy. In conclusion, targeting platelet activation and receptors for fibrin(ogen) deserve further research to hopefully purpose new drugs in the pharmacologic paraphernalia of MS neurologists.
    MeSH term(s) Animals ; Central Nervous System/metabolism ; Encephalomyelitis, Autoimmune, Experimental ; Fibrin/therapeutic use ; Hemostasis ; Humans ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis/drug therapy
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.2532
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Family planning in people with multiple sclerosis: a plain language summary.

    Bonavita, Simona / Lavorgna, Luigi / Worton, Hilary / Jack, Dominic

    Neurodegenerative disease management

    2022  Volume 12, Issue 1, Page(s) 9–14

    Abstract: What is this summary about?: This is a plain language summary of an article originally published in the journal Frontiers in Neurology. People with multiple sclerosis (often shortened to MS) may have concerns about pregnancy and fertility. To understand ...

    Abstract What is this summary about?: This is a plain language summary of an article originally published in the journal Frontiers in Neurology. People with multiple sclerosis (often shortened to MS) may have concerns about pregnancy and fertility. To understand more about these concerns, 332 people with MS in the USA, UK, France, Germany, Italy, and Spain took a survey with questions about how they made family planning decisions.
    What were the results?: Most of the survey participants (around 82%) were women. The survey found that people with MS were less likely to have children than people without MS. Over half (56%) of people with MS said the disease impacted their family planning decisions in some way, almost one quarter (22%) significantly changed their plans for the timing of their pregnancy or number of children, and 14% decided against having children. For almost 4 out of 5 (81%) people with MS the main source of family planning information was healthcare professionals.
    What do the results of the study mean?: Overall, MS significantly impacted patients' decisions about family planning.
    MeSH term(s) Child ; Family Planning Services ; Female ; Germany ; Humans ; Language ; Multiple Sclerosis ; Pregnancy ; Surveys and Questionnaires
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article ; Review ; Comment
    ZDB-ID 2608846-0
    ISSN 1758-2032 ; 1758-2024
    ISSN (online) 1758-2032
    ISSN 1758-2024
    DOI 10.2217/nmt-2021-0045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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