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Article ; Online: Sometimes it is better to just make it simple. De-escalation of oncoplastic and reconstructive procedures.

Bonci, E-A / Anacleto, J Correia / Cardoso, M-J

2023 Volume 69, Page(s) 265–273

Abstract: Simple breast conservation surgery (sBCS) has technically advanced onto oncoplastic breast procedures (OBP) to avoid mastectomy and improve breast cancer patients' psychosocial well-being and cosmetic outcome. Although OBP are time-consuming and ... ...

Abstract	Simple breast conservation surgery (sBCS) has technically advanced onto oncoplastic breast procedures (OBP) to avoid mastectomy and improve breast cancer patients' psychosocial well-being and cosmetic outcome. Although OBP are time-consuming and expensive, we are witnessing an increase in their use, even for cases that could be managed with sBCS. The choice between keeping it simple or opting for more complex oncoplastic procedures is difficult. This review proposes a pragmatic approach in assisting this decision. Medical literature suggests that OBP and sBCS might be similar regarding local recurrence and overall survival, and patients seem to have higher satisfaction levels with the aesthetic outcome of OBP when compared to sBCS. However, the lack of comprehensive high-quality research assessing their safety, efficacy, and patient-reported outcomes hinders these supposed conclusions. Postoperative complications after OBP may delay the initiation of adjuvant RT. In addition, precise displacement of the breast volume is not effectively recorded despite surgical clips placement, making accurate dose delivery tricky for radiation oncologists, and WBRT preferable to APBI in complex OBP cases. With a critical eye on financial toxicity, patient satisfaction, and oncological outcomes, OBP must be carefully integrated into clinical practice. The thoughtful provision of informed consent is essential for decision-making between sBCS and OBP. As we look into the future, machine learning and artificial intelligence can potentially help patients and doctors avoid postoperative regrets by setting realistic aesthetic expectations.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/surgery ; Mastectomy ; Mastectomy, Segmental/methods ; Artificial Intelligence ; Breast/surgery ; Mammaplasty/methods
Language	English
Publishing date	2023-03-13
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	1143210-x
ISSN	1532-3080 ; 0960-9776
ISSN (online)	1532-3080
ISSN	0960-9776
DOI	10.1016/j.breast.2023.03.006
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Zs.A 3620: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Mandatory vaccine policies associated with increased vaccination rates and decreased measles incidence.

Bozzola, Elena / Bonci, Enea

The Journal of pediatrics

2020 Volume 222, Page(s) 253–257

MeSH term(s)	Europe ; Humans ; Incidence ; Measles/epidemiology ; Measles/prevention & control ; Vaccination
Language	English
Publishing date	2020-06-25
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2020.04.024
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Article ; Online: Comment on "Solar maculopathy secondary to sunlight exposure reflected from the screen of mobile devices: two case reports".

Piccoli, Bruno / Pisaniello, Dino / Bonci, Emanuela / Orsini, Silvano / Di Censi, Roberto

Journal of medical case reports

2023 Volume 17, Issue 1, Page(s) 272

MeSH term(s)	Humans ; Sunlight/adverse effects ; Macular Degeneration/etiology
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-023-04009-6
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Article ; Online: Respiratory Syncytial Virus Bronchiolitis Before and After COVID-19 Pandemic: Has the Immunity Debt Been Paid Off?

Nenna, Raffaella / Pierangeli, Alessandra / Matera, Luigi / Petrarca, Laura / Conti, Maria Giulia / Mancino, Enrica / di Mattia, Greta / La Regina, Domenico Paolo / Virgili, Fabrizio / Papoff, Paola / Bonci, Enea / Midulla, Fabio

The Pediatric infectious disease journal

2024

Abstract: Background: Our aim was to hypothesize that the COVID-19 pandemic influenced the characteristics of viral bronchiolitis by comparing the last 3 epidemics with 3 pre-COVID-19 epidemics in infants hospitalized with bronchiolitis.: Methods: We ... ...

Abstract	Background: Our aim was to hypothesize that the COVID-19 pandemic influenced the characteristics of viral bronchiolitis by comparing the last 3 epidemics with 3 pre-COVID-19 epidemics in infants hospitalized with bronchiolitis. Methods: We prospectively enrolled 637 consecutive infants (median age 3.0 ± 2.1 months, 58.5% males), hospitalized for bronchiolitis during 6 consecutive annual epidemic seasons from 2017 to 2023. All parents of the children were given a structured anamnestic questionnaire. A nasopharyngeal aspirate was tested for 15 respiratory viruses. As measures of severity, we evaluated the O2 supplementation and the admission at the pediatric intensive care unit. Results: A total of 166 were hospitalized with bronchiolitis in 2017-2018, 97 in 2018-2019, 69 in 2019-2020, 0 in 2020-2021, 129 in 2021-2022 and 176 in 2022-2023. Taking together the 332 bronchiolitis cases hospitalized during the 3 prepandemic seasons, they peaked between December and January; after the flat curve in 2020-2021, the cases of bronchiolitis peaked in November 2021 and in December 2022. While the 2021-2022 season registered a less severe clinical presentation, O2 supplementation and pediatric intensive care unit admissions increased in 2022-2023 with respect to the prepandemic seasons (P < 0.001). Conclusions: This study represents an important scientific demonstration of the impact of primary prevention measures on the epidemiology of viral infections; their fluctuations were related to the intensity of restrictive measures and to the changing trend of respiratory viruses. It is essential to predict the real temporal trend of bronchiolitis in order not to leave high-risk children uncovered and to guide hospitals to maintain a high level of readiness.
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004314
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Article ; Online: First-Time Diagnosis After an Emergency Presentation in Children With Cancer.

Schiavetti, Amalia / Aliotti Lippolis, Maria / Gentile, Isotta / De Grazia, Alessandra / Ferrara, Eva / Bonci, Enea

Pediatric emergency care

2021 Volume 38, Issue 2, Page(s) e650–e653

Abstract: Aim: To determine the prevalence rate of cancer diagnoses by an emergency route, the related risk factors and whether the emergency diagnosis was associated with poorer outcome.: Methods: Retrospective observational study with identification of ... ...

Abstract	Aim: To determine the prevalence rate of cancer diagnoses by an emergency route, the related risk factors and whether the emergency diagnosis was associated with poorer outcome. Methods: Retrospective observational study with identification of patients diagnosed at the Pediatric Oncology Unit of "Sapienza" University between 2008 and 2018. The percentage of patients who received a first-time diagnosis after an emergency presentation was determined. Two-year survival and clinical factors, such as sex, age and histology, associated to emergency presentation were evaluated. Results: Of 207 patients (109 girls and 98 boys; median age, 120 months), with a first-time diagnosis of solid tumor, 5.8% were diagnosed during an emergency admission after a median latency time of 2.5 days. Cases with an emergency diagnosis were younger compared with those who were diagnosed electively (median age, 30 months vs 120 months, P < 0.005). Higher prevalence rate of emergency presentation was detected in patients with lymphoma compared with those with no lymphoma disease (28.6% vs 4.1%; P < 0.0001). All patients were managed to overcome their emergency presentation, 33.3% of these died later. No statistically significant difference for 2-year overall survival was found between patients with an emergency diagnosis and those with elective diagnosis (66.7% vs 81.0%; odds ratio, 2.1; confidence interval, 0.6-7.5; P = 0.22). Conclusions: A minor but not negligible number of pediatric patients come to a first-time diagnosis of cancer as result of a life-threatening event; risk factors were younger age and lymphoma disease. The emergency event can be successfully treated, and it was not related to a poorer survival.
MeSH term(s)	Child ; Child, Preschool ; Female ; Hospitalization ; Humans ; Male ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2021-03-30
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002329
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Article ; Online: Genetic association of ARHGAP21 gene variant with mandibular prognathism.

Perillo, L / Monsurrò, A / Bonci, E / Torella, A / Mutarelli, M / Nigro, V

Journal of dental research

2015 Volume 94, Issue 4, Page(s) 569–576

Abstract: Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malocclusion. MP is a complex genetic trait, although familial recurrence also suggests the contribution of single inherited variations. To date, the genetic ... ...

Abstract	Mandibular prognathism (MP) is a recognizable phenotype associated with dentoskeletal class III malocclusion. MP is a complex genetic trait, although familial recurrence also suggests the contribution of single inherited variations. To date, the genetic causes of MP have been investigated using linkage analysis or association studies in pooled families. Here for the first time, next-generation sequencing was used to study a single family with a large number of MP-affected members and to identify MP-related candidate genes. A 6-generation kindred with MP segregating as an autosomal dominant character was recruited. To identify family members affected by MP, a standard cephalometric procedure was used. In 5 MP subjects separated by the largest number of meioses, whole-exome sequencing was performed. Five promising missense gene variants (BMP3, ANXA2, FLNB, HOXA2, and ARHGAP21) associated with MP were selected and genotyped in most other family members. In this family, MP seemed to consist of 2 distinct genetic branches. Interestingly, the Gly1121Ser variant in the ARHGAP21 gene was found to be shared by all MP individuals in the larger branch of the family with nearly complete penetrance. This variant is rare in the Caucasian population (frequency 0.00034) and is predicted as damaging by all bioinformatic algorithms. ARHGAP21 protein strengthens cell-cell adhesions and may be regulated by bone morphogenetic factors, thus influencing mandibular growth. Further studies in both animal models and human patients are required to clarify the significance of this association.
MeSH term(s)	Adolescent ; Adult ; Aged ; Annexin A2/genetics ; Bone Morphogenetic Protein 3/genetics ; Child ; Exome/genetics ; Female ; Filamins/genetics ; GTPase-Activating Proteins/genetics ; Genes, Dominant/genetics ; Genetic Association Studies ; Genetic Linkage/genetics ; Genetic Variation/genetics ; Genotype ; Glycine/genetics ; Homeodomain Proteins/genetics ; Humans ; Male ; Malocclusion, Angle Class III/genetics ; Meiosis/genetics ; Middle Aged ; Mutation, Missense/genetics ; Pedigree ; Penetrance ; Prognathism/genetics ; Sequence Analysis, DNA ; Serine/genetics ; Young Adult
Chemical Substances	ANXA2 protein, human ; ARHGAP21 protein, human ; Annexin A2 ; BMP3 protein, human ; Bone Morphogenetic Protein 3 ; FLNB protein, human ; Filamins ; GTPase-Activating Proteins ; HOXA2 protein, human ; Homeodomain Proteins ; Serine (452VLY9402) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2015-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/0022034515572190
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Ul III Zs.75: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Pediatric meningococcocal meningitis in the acute phase: how much does it cost?

Bozzola, Elena / Guolo, Stefano / Bonci, Enea / Rossetti, Chiara / Bozzola, Mauro / Raponi, Massimiliano / Villani, Alberto

Italian journal of pediatrics

2019 Volume 45, Issue 1, Page(s) 25

Abstract: Background: Meningococcal meningitis (MM) is known to be responsible of high cost for the Public Health Administration. Aim of the work is to calculate the costs for the hospitalization of pediatric patients affected by MM.: Methods: We calculate the ...

Abstract	Background: Meningococcal meningitis (MM) is known to be responsible of high cost for the Public Health Administration. Aim of the work is to calculate the costs for the hospitalization of pediatric patients affected by MM. Methods: We calculate the costs for the hospitalization of pediatric patients affected by MM in the acute phase (HAP) over a nine year period. We performed a MEDLINE search to verify the cost of MM HAP reported in other studies. Results: At Bambino Gesù Children Hospital, the median cost of HAP was of 12,604 euro (range from 9203 to 35,050 euro). Comparing our data with the previous studies, we find out similar results of approximately 16,750 euro (range 12,000-20,000 euro). Discussion: Despite the relative rarety of the disease, MM is associated to direct high cost of HAP. Conclusions: Hospital costs are an important end-point in health economic evaluation of the disease and may be useful to policy makers and health economists to understand the potential benefit of improving meningococcal vaccination programmes.
MeSH term(s)	Acute Disease ; Adolescent ; Child ; Child, Preschool ; Female ; Health Care Costs ; Hospitalization/economics ; Humans ; Infant ; Italy ; Male ; Meningitis, Meningococcal/diagnosis ; Meningitis, Meningococcal/economics ; Meningitis, Meningococcal/therapy
Language	English
Publishing date	2019-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2084688-5
ISSN	1824-7288 ; 1720-8424 ; 0392-5161
ISSN (online)	1824-7288
ISSN	1720-8424 ; 0392-5161
DOI	10.1186/s13052-019-0616-z
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Article ; Online: Evaluation of Nephron-Sparing Surgery as Potential Risk Factor for Relapse in Unilateral Wilms Tumor.

Schiavetti, Amalia / Bonci, Enea / Varrasso, Giulia / De Grazia, Alessandra / Cozzi, Denis A

The Journal of surgical research

2019 Volume 247, Page(s) 21–27

Abstract: Background: The aim of the study was to assess the prognostic significance of nephron-sparing surgery (NSS) without tumor size limits as a risk factor for relapse in children with unilateral Wilms Tumor (WT).: Methods: A 28-y retrospective single- ... ...

Abstract	Background: The aim of the study was to assess the prognostic significance of nephron-sparing surgery (NSS) without tumor size limits as a risk factor for relapse in children with unilateral Wilms Tumor (WT). Methods: A 28-y retrospective single-center review was performed. Prognostic relevance of age, gender, stage, histology, nephrectomy (N), and NSS was analyzed. Results: Sixty-nine cases (42 females and 27 males) with WT, off-therapy from 21 to 325 mo after chemotherapy mainly based on the International Society of Pediatric Oncology trials, were treated at our institution. Five cases were excluded (three children with synchronous bilateral WT and two adults with unilateral WT). Of 64 children with unilateral WT, 51 underwent N and 13 NSS without tumor size limits. Indeed, two-thirds of children who underwent NSS presented with a tumor diameter >4 cm. Overall, nine patients (14%) had a relapse (male-to-female ratio = 1:8). Initial surgery was N in eight cases and NSS in another one. Relapse rates in N and NSS groups were 15.7% and 7.7% (P = nonsignificant), respectively; the relapse rates in N and NSS groups were 8.6% and 7.7% (P = nonsignificant) for stages I-II unilateral WT cohort, respectively. On univariate analysis, factors correlated with probability of relapse were unfavorable histology (P < 0.002) and stage III disease (P < 0.01). Conclusions: In unilateral WT, NSS, whenever feasible, does not seem to increase the risk of recurrence. A multicenter prospective trial is required to carefully evaluate this risk.
MeSH term(s)	Child ; Child, Preschool ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/prevention & control ; Nephrectomy/adverse effects ; Nephrectomy/methods ; Nephrons/surgery ; Organ Sparing Treatments/adverse effects ; Organ Sparing Treatments/methods ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Treatment Outcome ; Wilms Tumor/epidemiology ; Wilms Tumor/pathology ; Wilms Tumor/surgery
Language	English
Publishing date	2019-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2019.11.001
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Article ; Online: A Single Center Observational Study on Clinical Manifestations and Associated Factors of Pediatric Long COVID.

Mancino, Enrica / Nenna, Raffaella / Matera, Luigi / La Regina, Domenico Paolo / Petrarca, Laura / Iovine, Elio / Di Mattia, Greta / Frassanito, Antonella / Conti, Maria Giulia / Bonci, Enea / Spatuzzo, Mattia / Ialongo, Sara / Zicari, Anna Maria / Spalice, Alberto / Midulla, Fabio / On Behalf Of The Long Covid Research Group

International journal of environmental research and public health

2023 Volume 20, Issue 18

Abstract: Children with SARS-CoV-2 are mostly mild symptomatic, but they may develop conditions, such as persisting symptoms, that may put them at greater risk of complications. Our aim was to evaluate the frequency and the presence of risk factors for persisting ... ...

Abstract	Children with SARS-CoV-2 are mostly mild symptomatic, but they may develop conditions, such as persisting symptoms, that may put them at greater risk of complications. Our aim was to evaluate the frequency and the presence of risk factors for persisting COVID-19 symptoms in children. We carried out a prospective observational study of the clinical manifestation of Long COVID at the Department of Maternal Infantile Science of a tertiary University hospital in Rome. We included 697 children (0-18 years), with previous SARS-CoV-2 infection. Children and parents were asked questions regarding persistent symptoms of COVID-19. Children with symptoms 30 days after initial diagnosis were 185/697 (26.4%). Moreover, 81/697 (11.6%) patients presented symptoms 90 days after the diagnosis. Thirty-day-persisting symptoms were mostly present in children with anosmia, atopy, asthenia, and cough in the acute phase compared with the asymptomatic children 30 days after infection. After 90 days, symptoms described were mainly neurological (47/697 children, 6.7%), and headache (19/697; 2.7%) was the most frequent manifestation. In conclusion, a relatively large proportion of the patients reported persisting symptoms that seem to be related to the symptom burden and to the atopy. Ninety days after the infection, most of the children had recovered, showing that long-term effects are not frequent. Limitations of the study include the single-center design and the lack of a control group.
MeSH term(s)	Humans ; Child ; Post-Acute COVID-19 Syndrome ; COVID-19/epidemiology ; SARS-CoV-2 ; Family ; Anosmia ; Hypersensitivity, Immediate
Language	English
Publishing date	2023-09-21
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20186799
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Article ; Online: Investigating Biomarkers for COVID-19 Morbidity and Mortality.

Ceci, Flavio Maria / Ferraguti, Giampiero / Lucarelli, Marco / Angeloni, Antonio / Bonci, Enea / Petrella, Carla / Francati, Silvia / Barbato, Christian / Di Certo, Maria Grazia / Gabanella, Francesca / Gavaruzzi, Francesca / Mastroianni, Claudio Maria / Minni, Antonio / Greco, Antonio / Ralli, Massimo / Ceccanti, Mauro / Tarani, Luigi / Fiore, Marco

Current topics in medicinal chemistry

2023 Volume 23, Issue 13, Page(s) 1196–1210

Abstract: Background and objectives: This retrospective study aims to disclose further early parameters of COVID-19 morbidity and mortality.: Methods: Three hundred and eighty-two COVID-19 patients, recruited between March and April 2020, were divided into ... ...

Abstract	Background and objectives: This retrospective study aims to disclose further early parameters of COVID-19 morbidity and mortality. Methods: Three hundred and eighty-two COVID-19 patients, recruited between March and April 2020, were divided into three groups according to their outcome: (1) hospital ward group (patients who entered the hospital wards and survived); (2) intensive care unit (ICU) group (patients who attended the ICU and survived); (3) the deceased group (patients admitted to ICU with a fatal outcome). We investigated routine laboratory parameters such as albumin, glycemia, hemoglobin amylase, lipase, AST, ALT, GGT, LDH, CK, MGB, TnT-hs, IL-6, ferritin, CRP, PCT, WBC, RBC, PLT, PT, INR, APTT, FBG, and D-dimer. Blood withdrawal was carried out at the beginning of the hospitalization period. Results: ANOVA and ROC data evidenced that the concomitant presence of alterations in albumin, lipase, AST, ALT, LDH, MGB, CK, IL-6, ferritin in women, CRP and D-dimer is an early sign of fatal outcomes. Conclusion: The present study confirms and extends the validity of routine laboratory biomarkers (i.e., lipase, AST, ALT, LDH, CK, IL-6, ferritin in women, CRP and D-dimer) as indicators of COVID-19 morbidity and mortality. Furthermore, the investigation suggests that both gross changes in albumin and MGB, markers of liver and heart damage, may early disclose COVID-19 fatal outcomes.
MeSH term(s)	Humans ; Female ; COVID-19 ; SARS-CoV-2 ; Retrospective Studies ; Interleukin-6 ; Biomarkers ; Morbidity ; Albumins ; Ferritins
Chemical Substances	Interleukin-6 ; Biomarkers ; Albumins ; Ferritins (9007-73-2)
Language	English
Publishing date	2023-03-10
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026623666230222094517
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