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  1. Article ; Online: Discussions on VT4COVID.

    Boncyk, Christina / Kotfis, Katarzyna / Ely, E Wesley

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 11, Page(s) e89

    Language English
    Publishing date 2023-05-14
    Publishing country England
    Document type Letter
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00343-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ear Plugs, Eye Masks, and Risk of Bias.

    Lopez, Marcos G / Boncyk, Christina

    Critical care medicine

    2021  Volume 49, Issue 11, Page(s) e1180

    MeSH term(s) Ear Protective Devices
    Language English
    Publishing date 2021-10-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Elderly Patients and Management in Intensive Care Units (ICU): Clinical Challenges.

    Brunker, Lucille B / Boncyk, Christina S / Rengel, Kimberly F / Hughes, Christopher G

    Clinical interventions in aging

    2023  Volume 18, Page(s) 93–112

    Abstract: There is a growing population of older adults requiring admission to the intensive care unit (ICU). This population outpaces the ability of clinicians with geriatric training to assist in their management. Specific training and education for intensivists ...

    Abstract There is a growing population of older adults requiring admission to the intensive care unit (ICU). This population outpaces the ability of clinicians with geriatric training to assist in their management. Specific training and education for intensivists in the care of older patients is valuable to help understand and inform clinical care, as physiologic changes of aging affect each organ system. This review highlights some of these aging processes and discusses clinical implications in the vulnerable older population. Other considerations when caring for these older patients in the ICU include functional outcomes and morbidity, as opposed to merely a focus on mortality. An overall holistic approach incorporating physiology of aging, applying current evidence, and including the patient and their family in care should be used when caring for older adults in the ICU.
    MeSH term(s) Humans ; Aged ; Intensive Care Units ; Aging/physiology
    Language English
    Publishing date 2023-01-22
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2364924-0
    ISSN 1178-1998 ; 1176-9092
    ISSN (online) 1178-1998
    ISSN 1176-9092
    DOI 10.2147/CIA.S365968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Validation of an Intensive Care Unit Data Mart for Research and Quality Improvement.

    Boncyk, Christina / Butler, Pamela / McCarthy, Karen / Freundlich, Robert E

    Journal of medical systems

    2022  Volume 46, Issue 11, Page(s) 81

    Abstract: Data derived from the electronic health record (EHR) is frequently extracted using undefined approaches that may affect the accuracy of collected variables. Further, efforts to assess data accuracy often suffer from limited collaboration between ... ...

    Abstract Data derived from the electronic health record (EHR) is frequently extracted using undefined approaches that may affect the accuracy of collected variables. Further, efforts to assess data accuracy often suffer from limited collaboration between clinicians and data analysts who perform the extraction. In this manuscript, we describe the methodology behind creation of a structured, rigorously derived intensive care unit (ICU) data mart based on data automatically and routinely derived from the EHR. This ICU data mart includes high-quality data elements commonly used for quality improvement and research purposes. These data elements were identified by physicians working closely with data analysts to iteratively develop and refine algorithmic definitions for complex outcomes and risk factors. We contend that this methodology can be reproduced and applied across other institution or to other clinical domains to create high quality data marts, inclusive of complex outcomes data.
    MeSH term(s) Data Accuracy ; Data Warehousing ; Electronic Health Records ; Humans ; Intensive Care Units ; Quality Improvement
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-022-01873-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Delirium after Cardiac Surgery and Cognitive Change: Comment.

    Boncyk, Christina / Hughes, Christopher G

    Anesthesiology

    2019  Volume 130, Issue 5, Page(s) 857–859

    MeSH term(s) Cardiac Surgical Procedures ; Cognition ; Cognitive Dysfunction ; Delirium ; Humans
    Keywords covid19
    Language English
    Publishing date 2019-04-17
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000002698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Blessing and the Curse of the Administrative Database.

    Boncyk, Christina S / Jelly, Christina A / Freundlich, Robert E

    Annals of the American Thoracic Society

    2020  Volume 17, Issue 2, Page(s) 174–175

    MeSH term(s) Canada ; Data Collection ; Data Management ; Hospitals
    Language English
    Publishing date 2020-01-31
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201906-430ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Perioperative Neurocognitive Disorders in Adults Requiring Cardiac Surgery: Screening, Prevention, and Management.

    Rengel, Kimberly F / Boncyk, Christina S / DiNizo, Daniella / Hughes, Christopher G

    Seminars in cardiothoracic and vascular anesthesia

    2022  Volume 27, Issue 1, Page(s) 25–41

    Abstract: Neurocognitive changes are the most common complication after cardiac surgery, ranging from acute postoperative delirium to prolonged postoperative neurocognitive disorder. Changes in cognition are distressing to patients and families and associated with ...

    Abstract Neurocognitive changes are the most common complication after cardiac surgery, ranging from acute postoperative delirium to prolonged postoperative neurocognitive disorder. Changes in cognition are distressing to patients and families and associated with worse outcomes overall. This review outlines definitions and diagnostic criteria, risk factors for, and mechanisms of Perioperative Neurocognitive Disorders and offers strategies for preoperative screening and perioperative prevention and management of neurocognitive complications.
    MeSH term(s) Humans ; Adult ; Delirium/prevention & control ; Postoperative Complications/etiology ; Anesthesia ; Emergence Delirium ; Cardiac Surgical Procedures/adverse effects
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2012371-1
    ISSN 1940-5596 ; 1089-2532
    ISSN (online) 1940-5596
    ISSN 1089-2532
    DOI 10.1177/10892532221127812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Association of Nonmodifiable Patient Factors on Antipsychotic Medication use in the Intensive Care Unit.

    Connell, Jennifer / McCann, Brittany / Feng, Xiaoke / Shotwell, Matthew S / Hughes, Christopher G / Boncyk, Christina S

    Journal of intensive care medicine

    2023  Volume 39, Issue 2, Page(s) 176–182

    Abstract: Purpose: We investigated the association of age, sex, race, and insurance status on antipsychotic medication use among intensive care unit (ICU) patients.: Materials and methods: Retrospective study of adults admitted to ICUs at a tertiary academic ... ...

    Abstract Purpose: We investigated the association of age, sex, race, and insurance status on antipsychotic medication use among intensive care unit (ICU) patients.
    Materials and methods: Retrospective study of adults admitted to ICUs at a tertiary academic center. Patient characteristics, hospital course, and medication (olanzapine, quetiapine, and haloperidol) data were collected. Logistic regression models evaluated the independent association of age, sex, race, and insurance status on the use of each antipsychotic, adjusting for prespecified covariates.
    Results: Of 27,137 encounters identified, 6191 (22.8%) received antipsychotics. Age was significantly associated with the odds of receiving olanzapine (
    Conclusions: Age, sex, race, and insurance status were associated with the use of all antipsychotic medications investigated, highlighting the importance of investigating the potential impact of these prescribing decisions on patient outcomes across diverse populations. Recognizing how nonmodifiable patient factors have the potential to influence prescribing practices may be considered an important factor toward optimizing medication regimens.
    MeSH term(s) Adult ; Humans ; Male ; Female ; Antipsychotic Agents/therapeutic use ; Olanzapine ; Haloperidol/therapeutic use ; Quetiapine Fumarate/therapeutic use ; Retrospective Studies ; Intensive Care Units ; Benzodiazepines/therapeutic use
    Chemical Substances Antipsychotic Agents ; Olanzapine (N7U69T4SZR) ; Haloperidol (J6292F8L3D) ; Quetiapine Fumarate (2S3PL1B6UJ) ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/08850666231198030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Recurrent delirium episodes within the intensive care unit: Incidence and associated factors.

    Boncyk, Christina / Rengel, Kimberly / Stollings, Joanna / Marshall, Matt / Feng, Xiaoke / Shotwell, Matthew / Pandharipande, Pratik P / Hughes, Christopher G

    Journal of critical care

    2023  Volume 79, Page(s) 154490

    Abstract: Purpose: Describe the incidence and factors associated with recurrent delirium in the intensive care unit (ICU).: Materials and methods: Retrospective study of ICU patients diagnosed with delirium. Delirium clearance defined as 48 h of negative ... ...

    Abstract Purpose: Describe the incidence and factors associated with recurrent delirium in the intensive care unit (ICU).
    Materials and methods: Retrospective study of ICU patients diagnosed with delirium. Delirium clearance defined as 48 h of negative delirium assessments following initial episode and recurrent delirium as any positive delirium assessment following clearance. Multivariable logistic regression model assessed independent association of patient and hospital factors on development of recurrent delirium, adjusting for pre-defined covariates.
    Results: Among 8591 ICU admissions identified with delirium, 1067 (12.4%) had recurrent symptoms. Factors associated with increased odds of recurrent delirium were age (nonlinear; p = 0.02), shock (OR 1.45, 95% CI [1.20, 1.75]), admission to medical (OR 3.25, 95% CI [2.42, 4.37]), surgical (OR 3.00, 95% CI [2.21, 4.06]), or trauma (OR 2.17, 95% CI [1.58, 3.00]) ICU vs. cardiovascular ICU, increased duration of mechanical ventilation (OR 2.43, 95% CI [2.22, 2.65]), propofol use (OR 1.35, 95% CI [1.02, 1.80]), and antipsychotic medications (haloperidol OR 1.53, 95% CI [1.26, 1.86]; quetiapine OR 2.45, 95% CI [1.98, 3.02]; and olanzapine OR 1.54, 95% CI [1.25, 1.88]).
    Conclusions: Over 10% of delirious ICU patients had recurrent symptoms. Factors associated with recurrence included age, duration of mechanical ventilation and medication exposure.
    Clinical trial number: Not applicable.
    MeSH term(s) Humans ; Retrospective Studies ; Incidence ; Delirium/diagnosis ; Intensive Care Units ; Haloperidol/therapeutic use
    Chemical Substances Haloperidol (J6292F8L3D)
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2023.154490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Continuous Intrathecal Morphine Infusion for Pain Management in a Polytrauma Patient: A Case Report.

    Boncyk, Christina S / Brennan, Kaitlyn A / Guillamondegui, Oscar / Benson, Clayne

    A&A practice

    2020  Volume 14, Issue 13, Page(s) e01338

    Abstract: Polytrauma patients are at high risk for neurologic complications as a result of the primary mechanism of their trauma and/or delirium caused by subsequent pain, sedatives and analgesic exposure, sleep disturbances, infections, metabolic derangements, ... ...

    Abstract Polytrauma patients are at high risk for neurologic complications as a result of the primary mechanism of their trauma and/or delirium caused by subsequent pain, sedatives and analgesic exposure, sleep disturbances, infections, metabolic derangements, organ dysfunctions, withdrawal syndromes, or other factors. The high prevalence of delirium within trauma intensive care units increases risks for both patients and providers and is associated with worsened patient outcomes. This case report explains the rationale and utilization of continuous intrathecal morphine administration to improve pain control while reducing and eliminating intravenous (IV) analgesics and sedatives to enable wakefulness in a polytrauma patient with refractory agitated delirium.
    MeSH term(s) Humans ; Injections, Spinal ; Morphine/therapeutic use ; Multiple Trauma/complications ; Pain/drug therapy ; Pain Management
    Chemical Substances Morphine (76I7G6D29C)
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2575-3126
    ISSN (online) 2575-3126
    DOI 10.1213/XAA.0000000000001338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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