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  1. Article: R&D and productivity

    Bond, Stephen R / Guceri, Irem

    Economics of innovation and new technology Vol. 26, No. 1/2 , p. 108-120

    evidence from large UK establishments with substantial R&D activities

    2017  Volume 26, Issue 1, Page(s) 108–120

    Author's details Stephen R. Bond and Irem Guceri
    Keywords R&D ; productivity
    Language English
    Dates of publication 2017-9999
    Publisher Routledge, Taylor & Francis Group
    Publishing place Abingdon
    Document type Article
    ZDB-ID 1067565-6 ; 2069648-6
    ISSN 1476-8364 ; 1043-8599
    ISSN (online) 1476-8364
    ISSN 1043-8599
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  2. Article: The pannexins: past and present.

    Bond, Stephen R / Naus, Christian C

    Frontiers in physiology

    2014  Volume 5, Page(s) 58

    Abstract: The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to ... ...

    Abstract The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to have suppressed (or even lost) their ability to directly couple adjacent cells. Connecting the intracellular and extracellular compartments is now widely accepted as Panx's primary function, facilitating the passive movement of ions and small molecules along electrochemical gradients. The tissue distribution of the Panxs ranges from pervasive to very restricted, depending on the paralog, and are often cell type-specific and/or developmentally regulated within any given tissue. In recent years, Panxs have been implicated in an assortment of physiological and pathophysiological processes, particularly with respect to ATP signaling and inflammation, and they are now considered to be a major player in extracellular purinergic communication. The following is a comprehensive review of the Panx literature, exploring the historical events leading up to their discovery, outlining our current understanding of their biochemistry, and describing the importance of these proteins in health and disease.
    Language English
    Publishing date 2014-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2014.00058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Conditional investment-cash flow sensitivities and financing constraints

    Bond, Stephen R / Söderbom, Måns

    Journal of the European Economic Association Vol. 11, No. 1 , p. 112-136

    2013  Volume 11, Issue 1, Page(s) 112–136

    Author's details Stephen R. Bond; Måns Söderbom
    Keywords Investition ; Cash Flow ; Liquiditätsbeschränkung ; Anpassungskosten ; Simulation ; Theorie
    Language English
    Size graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford ; Malden, Mass
    Document type Article
    ZDB-ID 2114709-7 ; 2118178-0
    ISSN 1542-4774 ; 1542-4766
    ISSN (online) 1542-4774
    ISSN 1542-4766
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  4. Article ; Online: RF-Cloning.org: an online tool for the design of restriction-free cloning projects.

    Bond, Stephen R / Naus, Christian C

    Nucleic acids research

    2012  Volume 40, Issue Web Server issue, Page(s) W209–13

    Abstract: Restriction-free cloning (RF-cloning) is a PCR-based technology that expands on the QuikChange™ mutagenesis process originally popularized by Stratagene in the mid-1990s, and allows the insertion of essentially any sequence into any plasmid at any ... ...

    Abstract Restriction-free cloning (RF-cloning) is a PCR-based technology that expands on the QuikChange™ mutagenesis process originally popularized by Stratagene in the mid-1990s, and allows the insertion of essentially any sequence into any plasmid at any location. While RF-cloning is a powerful tool for the design of custom plasmids when restriction sites are not conveniently situated, manually designing the requisite primers can be tedious and error prone. We present here a web-service that automates the primer design process, along with a user interface that includes a number of useful tools for managing both the input sequences and the resulting outputs. RF-Cloning is free and open to all users, and can be accessed at http://www.rf-cloning.org.
    MeSH term(s) Algorithms ; Cloning, Molecular/methods ; DNA Primers/chemistry ; Internet ; Plasmids/genetics ; Polymerase Chain Reaction ; Sequence Analysis, DNA ; Software
    Chemical Substances DNA Primers
    Language English
    Publishing date 2012-05-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gks396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: BuddySuite: Command-Line Toolkits for Manipulating Sequences, Alignments, and Phylogenetic Trees.

    Bond, Stephen R / Keat, Karl E / Barreira, Sofia N / Baxevanis, Andreas D

    Molecular biology and evolution

    2017  Volume 34, Issue 6, Page(s) 1543–1546

    Abstract: The ability to manipulate sequence, alignment, and phylogenetic tree files has become an increasingly important skill in the life sciences, whether to generate summary information or to prepare data for further downstream analysis. The command line can ... ...

    Abstract The ability to manipulate sequence, alignment, and phylogenetic tree files has become an increasingly important skill in the life sciences, whether to generate summary information or to prepare data for further downstream analysis. The command line can be an extremely powerful environment for interacting with these resources, but only if the user has the appropriate general-purpose tools on hand. BuddySuite is a collection of four independent yet interrelated command-line toolkits that facilitate each step in the workflow of sequence discovery, curation, alignment, and phylogenetic reconstruction. Most common sequence, alignment, and tree file formats are automatically detected and parsed, and over 100 tools have been implemented for manipulating these data. The project has been engineered to easily accommodate the addition of new tools, is written in the popular programming language Python, and is hosted on the Python Package Index and GitHub to maximize accessibility. Documentation for each BuddySuite tool, including usage examples, is available at http://tiny.cc/buddysuite_wiki. All software is open source and freely available through http://research.nhgri.nih.gov/software/BuddySuite.
    MeSH term(s) Computational Biology ; Phylogeny ; Sequence Alignment/methods ; Sequence Analysis, DNA/methods ; Software
    Language English
    Publishing date 2017-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msx089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2137: Show issues Location:
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  6. Book ; Online: Trends in UK BERD after the introduction of R&D tax credits

    Bond, Stephen R / Guceri, Irem

    (Working paper / Oxford University Centre for Business Taxation ; 12,01)

    2012  

    Author's details Stephen R. Bond and Irem Guceri
    Series title Working paper / Oxford University Centre for Business Taxation ; 12,01
    Keywords R&D ; tax credits
    Language English
    Size Online-Ressource (PDF-Datei: 21 S.), graph. Darst.
    Publisher Oxford University Centre for Business Taxation
    Publishing place Oxford
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  7. Article: Natural resources, export structure, and investment

    Bond, Stephen R / Malik, Adeel

    Oxford economic papers Vol. 61, No. 4 , p. 675-702

    2009  Volume 61, Issue 4, Page(s) 675–702

    Author's details by Stephen R. Bond and Adeel Malik
    Keywords Natürliche Ressourcen ; Erdölvorkommen ; Investition ; Außenhandelsstruktur ; Entwicklungsländer
    Language English
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    Publisher Oxford Univ. Press
    Publishing place Oxford
    Document type Article
    ZDB-ID 207599-4
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  8. Book ; Online: Dynamic panel data models

    Bond, Stephen R

    a guide to micro data methods and practice

    (Working papers / Centre for Microdata Methods and Practice ; 09/02)

    2002  

    Institution Centre for Microdata Methods and Practice
    Author's details Stephen Bond
    Series title Working papers / Centre for Microdata Methods and Practice ; 09/02
    Keywords Panel ; Dynamische Wirtschaftstheorie ; Momentenmethode
    Language English
    Size Online-Ressource, 34 p., text
    Edition [Elektronische Ressource]
    Publisher Centre for Microdata Methods and Practice
    Publishing place London
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
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  9. Book ; Online: Natural resources, export structure and investment

    Bond, Stephen R / Malik, Adeel

    (Working paper series / Centre for the Study of African Economies ; 2008,20)

    2008  

    Author's details Stephen R. Bond; Adeel Malik
    Series title Working paper series / Centre for the Study of African Economies ; 2008,20
    Keywords Natürliche Ressourcen ; Erdölvorkommen ; Investition ; Außenhandelsstruktur ; Entwicklungsländer
    Language English
    Size Online-Ressource (PDF-Datei: 39 S., 181 Kb), graph. Darst.
    Publisher Centre for the Study of African Economies
    Publishing place Oxford
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  10. Article ; Online: Pannexin 3 is required for late stage bone growth but not for initiation of ossification in avian embryos.

    Bond, Stephen R / Abramyan, John / Fu, Kathy / Naus, Christian C / Richman, Joy M

    Developmental dynamics : an official publication of the American Association of Anatomists

    2016  Volume 245, Issue 9, Page(s) 913–924

    Abstract: Background: Pannexin 3 (PANX3) is a channel-forming protein capable of stimulating osteogenesis in vitro. Here, we studied the in vivo roles of PANX3 in the chicken embryo using the RCAS retroviral system to over-express and knockdown expression during ... ...

    Abstract Background: Pannexin 3 (PANX3) is a channel-forming protein capable of stimulating osteogenesis in vitro. Here, we studied the in vivo roles of PANX3 in the chicken embryo using the RCAS retroviral system to over-express and knockdown expression during endochondral bone formation.
    Results: In the limbs, PANX3 RNA was first detected in the cartilage condensations and became restricted to the prehypertrophic cartilage of the epiphyses, diaphysis, and perichondrium. The increase in PANX3 was not sufficient to alter osteogenesis; however, knockdown with a virus containing an interference RNA construct caused a 20% reduction in bone volume. The control virus containing an shEGFP cassette did not affect development. Interestingly, the phenotype was restricted to later stages rather than to proliferation of the skeletogenic mesenchyme, formation of the cartilage condensation, or creation of the hypertrophic zones. In addition, there was also no change in readouts of Hedgehog, WNT, fibroblast growth factor, or bone morphogenetic protein signaling using either quantitative real-time polymerase chain reaction or radioactive in situ hybridization.
    Conclusions: Based on the normal expression domains of PANX3 and the relatively late manifestation of the phenotype, it is possible that PANX3 hemichannels may be required to facilitate the transition of hypertrophic chondrocytes to osteoblasts, thereby achieving final bone size. Developmental Dynamics 245:913-924, 2016. © 2016 Wiley Periodicals, Inc.
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1102541-4
    ISSN 1097-0177 ; 1058-8388
    ISSN (online) 1097-0177
    ISSN 1058-8388
    DOI 10.1002/dvdy.24425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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