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  1. Article ; Online: Self-rated health and C-reactive protein in young adults.

    Shanahan, Lilly / Bauldry, Shawn / Freeman, Jason / Bondy, Carmen L

    Brain, behavior, and immunity

    2014  Volume 36, Page(s) 139–146

    Abstract: Background: Poor self-rated health (SRH) and elevated inflammation and morbidity and mortality are robustly associated in middle- and older-aged adults. Less is known about SRH-elevated inflammation associations during young adulthood and whether these ... ...

    Abstract Background: Poor self-rated health (SRH) and elevated inflammation and morbidity and mortality are robustly associated in middle- and older-aged adults. Less is known about SRH-elevated inflammation associations during young adulthood and whether these linkages differ by sex.
    Methods: Data came from the National Longitudinal Study of Adolescent Health. At Wave IV, young adults aged 24–34 reported their SRH, acute and chronic illnesses, and sociodemographic and psychological characteristics relevant to health. Trained fieldworkers assessed medication use, BMI, waist circumference, and also collected bloodspots from which high-sensitivity CRP (hs-CRP) was assayed. The sample size for the present analyses was N = 13,236.
    Results: Descriptive and bivariate analyses revealed a graded association between SRH and hs-CRP: Lower ratings of SRH were associated with a higher proportion of participants with hs-CRP >3 mg/L and higher mean levels of hs-CRP. Associations between SRH and hs-CRP remained significant when acute and chronic illnesses, medication use, and health behaviors were taken into account. When BMI was taken into account, the association between SRH and hs-CRP association fully attenuated in females; a small, but significant association between SRH and hs-CRP remained in males.
    Conclusion: Poor SRH and elevated hs-CRP are associated in young adults, adjusting for other health status measures, medication use, and health behavior. In males, SRH provided information about elevated hs-CRP that was independent of BMI. In females, BMI may be a better surrogate indicator of global health and pro-inflammatory influences compared to SRH.
    MeSH term(s) Adult ; C-Reactive Protein/metabolism ; Diagnostic Self Evaluation ; Female ; Humans ; Inflammation/metabolism ; Male ; Sex Factors ; Young Adult
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2014-02-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2013.10.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder.

    Shanahan, Lilly / Copeland, William E / Angold, Adrian / Bondy, Carmen L / Costello, E Jane

    Journal of the American Academy of Child and Adolescent Psychiatry

    2014  Volume 53, Issue 5, Page(s) 550–558

    Abstract: Objective: We tested whether sleep problems co-occur with, precede, and/or follow common psychiatric disorders during childhood and adolescence. We also clarified the role of comorbidity and tested for specificity of associations among sleep problems ... ...

    Abstract Objective: We tested whether sleep problems co-occur with, precede, and/or follow common psychiatric disorders during childhood and adolescence. We also clarified the role of comorbidity and tested for specificity of associations among sleep problems and psychiatric disorders.
    Method: Data came from the Great Smoky Mountains Study, a representative population sample of 1,420 children, assessed 4 to 7 times per person between ages 9 and 16 years for major Diagnostic and Statistical Manual-Fourth Edition (DSM-IV) disorders and sleep problems. Sleep-related symptoms were removed from diagnostic criteria when applicable.
    Results: Sleep problems during childhood and adolescence were common, with restless sleep and difficulty falling asleep being the most common symptoms. Cross-sectional analyses showed that sleep problems co-occurred with many psychiatric disorders. Longitudinal analyses revealed that sleep problems predicted increases in the prevalence of later generalized anxiety disorder (GAD) and high GAD/depression symptoms, and oppositional defiant disorder (ODD). In turn, GAD and/or depression and ODD predicted increases in sleep problems over time.
    Conclusions: Sleep problems both predict and are predicted by a diagnostic cluster that includes ODD, GAD, and depression. Screening children for sleep problems could offer promising opportunities for reducing the burden of mental illness during the early life course.
    MeSH term(s) Adolescent ; Anxiety Disorders/diagnosis ; Anxiety Disorders/epidemiology ; Anxiety Disorders/psychology ; Attention Deficit and Disruptive Behavior Disorders/diagnosis ; Attention Deficit and Disruptive Behavior Disorders/epidemiology ; Attention Deficit and Disruptive Behavior Disorders/psychology ; Checklist/statistics & numerical data ; Child ; Comorbidity ; Depressive Disorder/diagnosis ; Depressive Disorder/epidemiology ; Depressive Disorder/psychology ; Female ; Health Surveys ; Humans ; Longitudinal Studies ; Male ; Psychometrics ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/psychology ; Statistics as Topic ; United States
    Language English
    Publishing date 2014-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2013.12.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anxiety sensitivity and risk-taking behavior.

    Broman-Fulks, Joshua J / Urbaniak, Anna / Bondy, Carmen L / Toomey, Kelsey J

    Anxiety, stress, and coping

    2014  Volume 27, Issue 6, Page(s) 619–632

    Abstract: High trait anxiety has been linked with risk-avoidant decision-making, though little is known regarding the specific facets of anxiety contributing to this negative association. Anxiety sensitivity (AS), a transdiagnostic vulnerability factor for anxiety- ...

    Abstract High trait anxiety has been linked with risk-avoidant decision-making, though little is known regarding the specific facets of anxiety contributing to this negative association. Anxiety sensitivity (AS), a transdiagnostic vulnerability factor for anxiety-related pathology, may be particularly relevant to risk decision-making given that risk-taking behaviors generate heightened somatic arousal and produce many of the sensations feared by individuals with high AS. Two studies were conducted to investigate the relation between AS and risk decision-making. In the first study, 268 undergraduate students completed a series of questionnaires that included measures of AS and gambling behaviors. Significant negative correlations were observed between AS and several gambling-related risk-taking activities, and hierarchical multiple regression analyses indicated that AS scores added significant incremental validity in predicting risk-taking over and above demographic variables, negative affect, and trait anxiety. In the second study, 43 participants who had screened for high (n=20) or low (n=23) AS completed the Iowa gambling task, a behavioral measure of risk-taking. Results indicated that, when placed under conditions of risk, individuals with high AS engaged in significantly less risk-taking than their low AS counterparts. The implications of these findings and potential directions for future research are discussed.
    MeSH term(s) Adolescent ; Adult ; Anxiety Disorders/psychology ; Decision Making ; Female ; Gambling/psychology ; Humans ; Male ; Risk-Taking ; Students/psychology ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2014
    Publishing country England
    Document type Journal Article
    ZDB-ID 1115932-7
    ISSN 1477-2205 ; 1061-5806
    ISSN (online) 1477-2205
    ISSN 1061-5806
    DOI 10.1080/10615806.2014.896906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Categorical or dimensional: a reanalysis of the anxiety sensitivity construct.

    Broman-Fulks, Joshua J / Deacon, Brett J / Olatunji, Bunmi O / Bondy, Carmen L / Abramowitz, Jonathan S / Tolin, David F

    Behavior therapy

    2010  Volume 41, Issue 2, Page(s) 154–171

    Abstract: Anxiety sensitivity, or the fear of anxiety sensations, has been implicated in the etiology of anxiety disorders, particularly panic disorder. Recently, inconsistent findings have been reported regarding the latent structure of anxiety sensitivity. ... ...

    Abstract Anxiety sensitivity, or the fear of anxiety sensations, has been implicated in the etiology of anxiety disorders, particularly panic disorder. Recently, inconsistent findings have been reported regarding the latent structure of anxiety sensitivity. Whereas some taxometric studies of anxiety sensitivity have reported evidence of categorical latent structure, others have found evidence of a latent dimension. The purpose of the present research was to further examine the latent structure of anxiety sensitivity using taxometric procedures and commonly utilized measures of anxiety sensitivity. To this end, three mathematically independent taxometric procedures (MAXEIG, MAMBAC, and L-Mode) were applied to data collected from two large nonclinical samples (n's=1,171 and 2,173) that completed the Anxiety Sensitivity Index and the Anxiety Sensitivity Index-Revised. Results from both studies converged in support of a dimensional conceptualization of anxiety sensitivity. A third study was conducted using indicators derived from the newly revised Anxiety Sensitivity Index-3 in a separate sample of 1,462 nonclinical participants. Results of these analyses provided further support for a dimensional anxiety sensitivity solution. The implications of these results for anxiety sensitivity research are discussed, and several potential directions for future research are considered.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anxiety ; Anxiety Disorders/diagnosis ; Anxiety Disorders/psychology ; Computer Simulation ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Middle Aged ; Models, Psychological ; Psychiatric Status Rating Scales ; Young Adult
    Language English
    Publishing date 2010-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 211996-1
    ISSN 1878-1888 ; 0005-7894
    ISSN (online) 1878-1888
    ISSN 0005-7894
    DOI 10.1016/j.beth.2009.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Incremental specificity of disgust sensitivity in the prediction of obsessive-compulsive disorder symptoms: Cross-sectional and prospective approaches.

    David, Bieke / Olatunji, Bunmi O / Armstrong, Thomas / Ciesielski, Bethany G / Bondy, Carmen L / Broman-Fulks, Joshua

    Journal of behavior therapy and experimental psychiatry

    2009  Volume 40, Issue 4, Page(s) 533–543

    Abstract: The present study examines the association between disgust sensitivity (DS) and obsessive-compulsive disorder (OCD) symptoms in two non-clinical samples. Findings from Study 1 (n=270) revealed a significant association between DS and OCD symptoms even ... ...

    Abstract The present study examines the association between disgust sensitivity (DS) and obsessive-compulsive disorder (OCD) symptoms in two non-clinical samples. Findings from Study 1 (n=270) revealed a significant association between DS and OCD symptoms even after controlling for negative affect and anxiety sensitivity. Subsequent analysis also revealed a specific association between DS and the washing subtype of OCD symptoms when controlling for other OCD symptom dimensions. DS did not significantly predict residual change in total symptoms of OCD over a 12-week period (n=300) when controlling for risk factors for anxiety disorder symptoms in general (e.g., negative affect, anxiety sensitivity) and OCD specifically (e.g., obsessive beliefs) in Study 2. However, exploratory analyses suggest that DS may be predictive of residual change in some OCD symptom subtypes but not others. Implications of these findings for future research on the role of disgust in OCD are discussed.
    MeSH term(s) Adolescent ; Adult ; Association ; Cross-Sectional Studies ; Emotions/physiology ; Female ; Humans ; Male ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/physiopathology ; Predictive Value of Tests ; Prospective Studies ; Psychiatric Status Rating Scales ; Psychometrics ; Sensitivity and Specificity ; Statistics as Topic ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2009-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 280250-8
    ISSN 1873-7943 ; 0005-7916
    ISSN (online) 1873-7943
    ISSN 0005-7916
    DOI 10.1016/j.jbtep.2009.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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