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Article: Retinal neovascularization in Susac's syndrome: A rare imaging finding.

Adeghate, Jennifer O / Bonhomme, Gabrielle R / Indermill, Chad / Taylor, Steven L / Rocha, Marcelo / Moghadam-Kia, Siamak / Errera, Marie-Hélène

Oman journal of ophthalmology

2023 Volume 16, Issue 3, Page(s) 570–572

Language	English
Publishing date	2023-10-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2484272-2
ISSN	0974-7842 ; 0974-620X
ISSN (online)	0974-7842
ISSN	0974-620X
DOI	10.4103/ojo.ojo_330_22
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Article ; Conference proceedings: Minimally Invasive Lateral Orbitotomy Approach for Middle Fossa and Orbital Lesions

Patel, Bhuvic / Cabral, David Fernandes / Terrarosa, Anna K. / Bonhomme, Gabrielle R. / Stefko, Susan / Gardner, Paul A / Zenonos, Georgios A.

Journal of Neurological Surgery Part B: Skull Base

2024 Volume 85, Issue S 01

Event/congress	33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0044-1779880
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Article ; Online: Anterolateral keyhole transorbital routes to the skull base: a comparative anatomical study.

Karampouga, Maria / Terrarosa, Anna K / Patel, Bhuvic / Affolter, Kyle / Wang, Eric W / Choby, Garret W / Fu, Roxana / Bonhomme, Gabrielle R / Stefko, S Tonya / McDowell, Michael M / Snyderman, Carl H / Gardner, Paul A / Zenonos, Georgios A

Neurosurgical focus

2024 Volume 56, Issue 4, Page(s) E3

Abstract: Objective: Although keyhole transorbital approaches are gaining traction, their indications have not been adequately studied comparatively. In this study the authors have defined them also as transwing approaches-meaning that they use the different ... ...

Abstract	Objective: Although keyhole transorbital approaches are gaining traction, their indications have not been adequately studied comparatively. In this study the authors have defined them also as transwing approaches-meaning that they use the different facies of the sphenoid wing for cranial entry-and sought to compare the four major ones: 1) lateral orbitocraniotomy through a lateral canthal incision (LatOrb); 2) modified orbitozygomatic approach through a palpebral incision (ModOzPalp); 3) modified orbitozygomatic approach through an eyebrow incision (ModOzEyB); and 4) supraorbital craniotomy through an eyebrow incision (SupraOrb), coupled with its expanded version (SupraTransOrb). Methods: Cadaveric dissections were performed at the neuroanatomy lab. To delineate the skull base exposure, four formalin-fixed heads were used, with two sides dedicated to each approach. The outer limits were assessed via image guidance and were mapped and illustrated accordingly. A fifth head was dissected purely endoscopically, just to facilitate an overview of the transwing concept. Qualitative features were also rigorously examined. Results: The LatOrb proves to be more versatile in the middle cranial fossa (MCF), whereas the anterior cranial fossa (ACF) exposure is limited to a small area above the sphenoid ridge. An anterior clinoidectomy is possible; however, the exposure of the roof of the optic canal is suboptimal. The ModOzPalp adequately exposes both the ACF and MCF. Its lateral trajectory allows the inferior to superior view, yet there is restricted access to the medial anterior skull base (olfactory groove). The ModOzEyB also provides extensive exposure of the ACF and MCF, but has a more superior to inferior trajectory compared to the ModOzPalp, making it more appropriate for pathology reaching the medial anterior skull base or even the contralateral side. The anterior clinoidectomy is performed with improved visualization of the optic canal. The SupraOrb provides mainly anterior cranial base exposure, with minimal middle fossa. An anterior clinoidectomy can be performed, but without any direct observation of the superior orbital fissure. Some MCF access can be accomplished if the lateral sphenoid wing is drilled inferiorly, leading to its highly versatile variant, the SupraTransOrb. Conclusions: All the aforementioned approaches use the sphenoid wing as skull base corridor from a specific orientation point; hence these are designated as transwing approaches. Their peculiarities mandate careful case selection for the effective and safe completion of the surgical goals.
MeSH term(s)	Humans ; Skull Base/surgery ; Skull Base/anatomy & histology ; Craniotomy/methods ; Cranial Fossa, Middle/surgery ; Cranial Fossa, Anterior/surgery ; Orbit/surgery ; Cadaver
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2024.2.FOCUS23877
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Article ; Online: A Man With Bilateral Peripheral Visual Field Loss.

Shazly, Tarek A / Conner, Ian P / Bonhomme, Gabrielle R

JAMA ophthalmology

2017 Volume 135, Issue 11, Page(s) 1274–1275

MeSH term(s)	Eye Abnormalities/diagnosis ; Humans ; Male ; Middle Aged ; Optic Atrophy/diagnosis ; Optic Nerve/abnormalities ; Tomography, Optical Coherence ; Vision Disorders/diagnosis ; Visual Field Tests ; Visual Fields
Language	English
Publishing date	2017-08-24
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2701705-9
ISSN	2168-6173 ; 2168-6165
ISSN (online)	2168-6173
ISSN	2168-6165
DOI	10.1001/jamaophthalmol.2017.2308
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Article ; Online: Treatment of pediatric optic neuritis.

Bonhomme, Gabrielle R / Mitchell, Ellen B

Current treatment options in neurology

2011 Volume 14, Issue 1, Page(s) 93–102

Abstract: Opinion statement: Pediatric optic neuritis is a rare disorder causing a subacute loss of vision (often bilateral) in children, often of a severe degree. Common clinical findings include dense visual field loss, afferent pupillary defect (APD) in ... ...

Abstract	Opinion statement: Pediatric optic neuritis is a rare disorder causing a subacute loss of vision (often bilateral) in children, often of a severe degree. Common clinical findings include dense visual field loss, afferent pupillary defect (APD) in unilateral cases, and papillitis that is often bilateral. Contrary to optic neuritis in the adult population, the differential diagnosis for this disorder in pediatric patients is quite extensive, so neuroimaging and serologic evaluation are necessary to exclude an infectious or neoplastic process. Pediatric optic neuritis may occur as a clinically isolated syndrome, or in association with diffuse neurologic dysfunction, such as acute disseminated encephalomyelitis (ADEM). Optic neuritis may also be the first episode heralding the onset of pediatric multiple sclerosis or neuromyelitis optica (NMO or Devic's disease). Therefore, formal neurologic evaluation and follow-up are indicated. Although the management of this disorder in adults is well described, there is a paucity of evidence-based, prospective clinical data on its management and treatment in a pediatric population. The current treatment of pediatric optic neuritis consists of 3 to 5 days of intravenous methylprednisolone (4-30 mg/kg per day), followed by a prolonged oral corticosteroid taper. A prolonged course of oral steroid (2-4 weeks) is recommended to avoid recurrence, which is common in this age group. Some controversy persists concerning the exposure of children to high-dose parenteral corticosteroids to treat an entity that is usually self-limited, but given the severity of vision loss in one or both eyes in this population, this intervention is standard in neuro-ophthalmologic practice.
Language	English
Publishing date	2011-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2057342-X
ISSN	1534-3138 ; 1092-8480
ISSN (online)	1534-3138
ISSN	1092-8480
DOI	10.1007/s11940-011-0159-0
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Article ; Online: Lymphoma of the orbit masquerading as Tolosa-Hunt syndrome.

Shazly, Tarek A / Mitchell, Ellen B / Bonhomme, Gabrielle R / Schuman, Joel S

BMC ophthalmology

2015 Volume 15, Page(s) 51

Abstract: Background: Tolosa-Hunt syndrome is a rare clinical syndrome characterized by painful ophthalmoplegia and ipsilateral cranial neuropathies. It is caused by an inflammatory process of unknown etiology.: Case presentation: We present a case of a 77- ... ...

Abstract	Background: Tolosa-Hunt syndrome is a rare clinical syndrome characterized by painful ophthalmoplegia and ipsilateral cranial neuropathies. It is caused by an inflammatory process of unknown etiology. Case presentation: We present a case of a 77-year-old white man with history of Waldenstrom's macroglobulinemia transforming to large B-cell lymphoma who presented to a community physician complaining of 4 months of isolated right retro-orbital pain and later with diplopia, ptosis, 6th nerve and pupil-sparing partial 3rd nerve palsies as well as progressive neurological findings. His clinical course was complicated by debilitating neurological symptoms and multiple hospitalizations leading to a delay in diagnosis caused by incomplete initial workup. Conclusion: This case is a reminder that lymphoproliferative disorders often mimic other neurologic disorders and that Tolosa-Hunt is a rare diagnosis that must be considered a diagnosis of exclusion.
MeSH term(s)	Aged ; Biopsy, Fine-Needle ; Chemoradiotherapy ; Diagnosis, Differential ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/therapy ; Magnetic Resonance Imaging ; Male ; Orbital Neoplasms/diagnosis ; Orbital Neoplasms/therapy ; Positron-Emission Tomography ; Tolosa-Hunt Syndrome/diagnosis ; Tomography, X-Ray Computed
Language	English
Publishing date	2015-05-15
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-015-0037-8
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Article ; Online: Clinical Features and Multimodal Imaging in Atypical Posterior Uveitis Secondary to

Koretz, Zachary A / Apostolopoulou, Anna / Chen, Edwin / Beale, Oliver / Veldkamp, Peter / Viehman, John Alex / Sahel, José-Alain / Chhablani, Jay / Dansingani, Kunal K / Errera, Marie-Hélène / Bonhomme, Gabrielle R

Ocular immunology and inflammation

2021 Volume 30, Issue 7-8, Page(s) 2047–2054

Abstract: Purpose: To characterize an unusual presentation of infectious posterior uveitis using multimodal imaging, and discuss the clinical decision-making involved in diagnosis and treatment.: Methods: Wide-field fundus photography, swept-source optical ... ...

Abstract	Purpose: To characterize an unusual presentation of infectious posterior uveitis using multimodal imaging, and discuss the clinical decision-making involved in diagnosis and treatment. Methods: Wide-field fundus photography, swept-source optical coherence tomography (OCT), swept-source OCT angiography, fluorescein angiography, and indocyanine green angiography. Results: This patient presented with cyclical fevers and blurry vision. Fundus examination revealed bilateral optic disc edema, macular intraretinal white spots and many scattered yellow-white chorioretinal lesions. Multimodal imaging characteristics suggested that many of these lesions represent choroidal granulomas. Extensive systemic workup was only notable for borderline elevated Bartonella henselae IgG titers (1:128), however convalescent IgG titers were elevated at 38 days (1:512) supporting the diagnosis of Bartonella chorioretinitis. Conclusion: Ocular manifestations of Bartonella henselae infection are varied and may include choroidal granulomas. Multimodal imaging characteristics may help identify etiologies of infectious uveitis. Convalescent titers are important when evaluating patients with suspected Bartonellosis, especially patients with atypical presentations.
MeSH term(s)	Humans ; Cat-Scratch Disease/complications ; Cat-Scratch Disease/diagnosis ; Uveitis, Posterior/diagnosis ; Uveitis, Posterior/etiology ; Multimodal Imaging
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2021.1961812
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Article ; Conference proceedings: Outcomes of Redo Endoscopic Endonasal Skull Base Surgery for Recurrent or Residual Nonfunctioning Pituitary Adenomas: An Analysis of 93 Consecutive Patients at the University of Pittsburgh Medical Center

Abdallah, Hussein M. / Gersey, Zachary C. / Gray, Zane N. / Fogg, David N. / Duehr, James E. / Abou-Al-Shaar, Hussam / Arani, Keerthi / Stefko, Tonya / Bonhomme, Gabrielle R. / Fazeli, Pouneh / Mahmud, Hussain / Wang, Eric W. / Snyderman, Carl H. / Gardner, Paul A. / Zenonos, Georgios A.

Journal of Neurological Surgery Part B: Skull Base

2023 Volume 84, Issue S 01

Event/congress	32nd Annual Meeting North American Skull Base Society, JW Marriott Tampa Water Street, Tampa, Florida, United States, 2023-02-17
Language	English
Publishing date	2023-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0043-1762402
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Article ; Conference proceedings: Endoscopic Endonasal Resection of Nonfunctional Pituitary Adenomas: Comprehensive Clinical Outcomes and the Radiographic Findings Associated with Gross Total Resection

Abdallah, Hussein M. / Gersey, Zachary C. / Gray, Zane / Le, Laura / Meyers, Sarah / Arani, Keerthi N. / Bonhomme, Gabrielle R. / Stefko, Sonya T. / Fazeli, Pouneh K. / Mahmud, Hussain / Snyderman, Carl / Wang, Eric / Gardner, Paul A. / Zenonos, Georgios A.

Journal of Neurological Surgery Part B: Skull Base

2022 Volume 83, Issue S 01

Event/congress	31st Annual Meeting North American Skull Base Society, Online, 2022-02-18
Language	English
Publishing date	2022-02-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/s-0042-1743949
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Article ; Online: Venous sinus stenting shortens the duration of medical therapy for increased intracranial pressure secondary to venous sinus stenosis.

Shazly, Tarek A / Jadhav, Ashutosh P / Aghaebrahim, Amin / Ducruet, Andrew F / Jankowitz, Brian T / Jovin, Tudor G / Bonhomme, Gabrielle R

Journal of neurointerventional surgery

2018 Volume 10, Issue 3, Page(s) 310–314

Abstract: Introduction: Medical treatment, cerebrospinal fluid (CSF) shunting, and optic nerve sheath fenestration are standard treatments for increased intracranial pressure (ICP) in patients with idiopathic intracranial hypertension (IIH). Venous sinus stenting ...

Abstract	Introduction: Medical treatment, cerebrospinal fluid (CSF) shunting, and optic nerve sheath fenestration are standard treatments for increased intracranial pressure (ICP) in patients with idiopathic intracranial hypertension (IIH). Venous sinus stenting provides a novel alternative surgical treatment in cases of venous sinus stenosis with elevated ICP. Methods: 12 consecutive subjects with papilledema, increased ICP, and radiological signs of dural sinus stenosis underwent cerebral venography and manometry. All subjects had papilledema and demonstrated radiological evidence of dural venous sinus stenosis. Results: Six subjects chose venous stenting (Group A) and six declined and were managed conservatively with oral acetazolamide (Group B). The relative pressure gradient across the venous narrowing was 29±16.3 mm Hg in Group A and 17.6±9.3 mm Hg in Group B (p=0.09). The mean lumbar puncture opening pressure was 40.4±7.6 cm H Conclusions: In subjects with venous sinuses stenosis, endovascular stenting offers an effective treatment option for intracranial hypertension which may shorten the duration of medical therapy.
MeSH term(s)	Adolescent ; Adult ; Cranial Sinuses/diagnostic imaging ; Cranial Sinuses/surgery ; Female ; Follow-Up Studies ; Humans ; Intracranial Hypertension/diagnostic imaging ; Intracranial Hypertension/physiopathology ; Intracranial Hypertension/surgery ; Intracranial Pressure/physiology ; Middle Aged ; Phlebography/methods ; Retrospective Studies ; Stents ; Tomography, Optical Coherence/methods ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2018-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2017-013103
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