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  1. Article ; Online: Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-Resistant

    Banerjee, Kasturi / Motley, Michael P / Boniche-Alfaro, Camila / Bhattacharya, Somanon / Shah, Raj / Ardizzone, Andrew / Fries, Bettina C

    Microbiology spectrum

    2022  Volume 10, Issue 4, Page(s) e0176022

    Abstract: The most pressing challenge for the development of anti-capsular antibodies is maximizing coverage against the heterogenous capsular polysaccharide (CPS) of carbapenem-resistant Klebsiella pneumoniae (CR- ...

    Abstract The most pressing challenge for the development of anti-capsular antibodies is maximizing coverage against the heterogenous capsular polysaccharide (CPS) of carbapenem-resistant Klebsiella pneumoniae (CR-
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Klebsiella Infections/drug therapy ; Klebsiella Infections/prevention & control ; Klebsiella pneumoniae ; Macrophages ; Mice
    Chemical Substances Anti-Bacterial Agents ; Antibodies, Monoclonal ; Carbapenems
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01760-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antibody- Based Immunotherapy Combined With Antimycotic Drug TMP- SMX to Treat Infection With

    Boniche-Alfaro, Camila / Kischkel, Brenda / Thomaz, Luciana / Carvalho-Gomes, Monique Maria / Lopes-Bezerra, Leila M / Nosanchuk, Joshua Daniel / Taborda, Carlos Pelleschi

    Frontiers in immunology

    2021  Volume 12, Page(s) 725882

    Abstract: Monoclonal antibodies (mAbs) are promising alternatives to treat infectious diseases, especially given their potential for applications in combination therapies with antimicrobial drugs to enhance the antifungal efficacy. Protection mediated by mAbs used ...

    Abstract Monoclonal antibodies (mAbs) are promising alternatives to treat infectious diseases, especially given their potential for applications in combination therapies with antimicrobial drugs to enhance the antifungal efficacy. Protection mediated by mAbs used to treat experimental paracoccidioidomycosis (PCM) has been demonstrated previously. Our aim in the present work was to characterize a monoclonal antibody (mAbF1.4) raised against a cell wall glycoconjugate fraction of
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Antifungal Agents/pharmacology ; Antigens, Fungal/immunology ; Cytokines/immunology ; Disease Models, Animal ; Female ; Immunotherapy/methods ; Lung/microbiology ; Lung/pathology ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Paracoccidioides/immunology ; Paracoccidioidomycosis/drug therapy ; Paracoccidioidomycosis/immunology ; Paracoccidioidomycosis/microbiology ; Trimethoprim, Sulfamethoxazole Drug Combination/pharmacology
    Chemical Substances Antibodies, Monoclonal ; Antifungal Agents ; Antigens, Fungal ; Cytokines ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
    Language English
    Publishing date 2021-10-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.725882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immunoproteomic and Immunopeptidomic Analyses of

    Kischkel, Brenda / Boniche-Alfaro, Camila / Menezes, Isabela de Godoy / Rossi, Suelen Andreia / Angeli, Claudia Blanes / de Almeida, Sandro Rogério / Palmisano, Giuseppe / Lopes-Bezerra, Leila / Nosanchuk, Joshua D / Taborda, Carlos Pelleschi

    Frontiers in immunology

    2021  Volume 12, Page(s) 764501

    Abstract: As there are more than 6 million human deaths due to mycoses each year, there is an urgent need to develop fungal vaccines. Moreover, given the similarities among pathogenic fungi, it may be possible to create a multi-fungi vaccine. In this study, we ... ...

    Abstract As there are more than 6 million human deaths due to mycoses each year, there is an urgent need to develop fungal vaccines. Moreover, given the similarities among pathogenic fungi, it may be possible to create a multi-fungi vaccine. In this study, we combined immunoproteomic and immunopeptidomic methods, for which we have adapted a technique based on co-immunoprecipitation (Co-IP) that made it possible to map
    MeSH term(s) Animals ; Epitope Mapping ; Fungal Vaccines/immunology ; Histoplasma/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Peptidomimetics ; Proteomics
    Chemical Substances Fungal Vaccines ; Peptidomimetics
    Language English
    Publishing date 2021-11-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.764501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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