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  1. Article ; Online: Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19.

    Owens, Cameron D / Bonin Pinto, Camila / Detwiler, Sam / Olay, Lauren / Pinaffi-Langley, Ana Clara da C / Mukli, Peter / Peterfi, Anna / Szarvas, Zsofia / James, Judith A / Galvan, Veronica / Tarantini, Stefano / Csiszar, Anna / Ungvari, Zoltan / Kirkpatrick, Angelia C / Prodan, Calin I / Yabluchanskiy, Andriy

    Brain communications

    2024  Volume 6, Issue 2, Page(s) fcae080

    Abstract: Components that comprise our brain parenchymal and cerebrovascular structures provide a homeostatic environment for proper neuronal function to ensure normal cognition. Cerebral insults (e.g. ischaemia, microbleeds and infection) alter cellular ... ...

    Abstract Components that comprise our brain parenchymal and cerebrovascular structures provide a homeostatic environment for proper neuronal function to ensure normal cognition. Cerebral insults (e.g. ischaemia, microbleeds and infection) alter cellular structures and physiologic processes within the neurovascular unit and contribute to cognitive dysfunction. COVID-19 has posed significant complications during acute and convalescent stages in multiple organ systems, including the brain. Cognitive impairment is a prevalent complication in COVID-19 patients, irrespective of severity of acute SARS-CoV-2 infection. Moreover, overwhelming evidence from in vitro, preclinical and clinical studies has reported SARS-CoV-2-induced pathologies in components of the neurovascular unit that are associated with cognitive impairment. Neurovascular unit disruption alters the neurovascular coupling response, a critical mechanism that regulates cerebromicrovascular blood flow to meet the energetic demands of locally active neurons. Normal cognitive processing is achieved through the neurovascular coupling response and involves the coordinated action of brain parenchymal cells (i.e. neurons and glia) and cerebrovascular cell types (i.e. endothelia, smooth muscle cells and pericytes). However, current work on COVID-19-induced cognitive impairment has yet to investigate disruption of neurovascular coupling as a causal factor. Hence, in this review, we aim to describe SARS-CoV-2's effects on the neurovascular unit and how they can impact neurovascular coupling and contribute to cognitive decline in acute and convalescent stages of the disease. Additionally, we explore potential therapeutic interventions to mitigate COVID-19-induced cognitive impairment. Given the great impact of cognitive impairment associated with COVID-19 on both individuals and public health, the necessity for a coordinated effort from fundamental scientific research to clinical application becomes imperative. This integrated endeavour is crucial for mitigating the cognitive deficits induced by COVID-19 and its subsequent burden in this especially vulnerable population.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcae080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Top 100 cited noninvasive neuromodulation clinical trials.

    Lucena, Mariana F G / Teixeira, Paulo E P / Bonin Pinto, Camila / Fregni, Felipe

    Expert review of medical devices

    2019  Volume 16, Issue 6, Page(s) 451–466

    Abstract: Introduction: Introduction: Areas covered: A de-novo keyword search strategy identified and characterized the 100 most-cited trials. Total citation count for the most cited trials was 13,204. Articles were published between 2008 and 2014 in 50 ... ...

    Abstract Introduction: Introduction
    Areas covered: A de-novo keyword search strategy identified and characterized the 100 most-cited trials. Total citation count for the most cited trials was 13,204. Articles were published between 2008 and 2014 in 50 different journals with a median impact factor of 6.52 (IQR 3.37). Almost half of the top cited papers were investigating mechanisms of action in healthy subjects. Most studies were feasibility trials and only five were pivotal trials, including the ones used for recent FDA approval. Seven articles were interlinked with another article by at least 25 citations and eight authors had collaborated with at least one other author.
    Expert opinion: Although there has been a significant increase in interest for rTMS and tDCS, most of the cited clinical trials are still small feasibility studies, what reinforced the need for more robust clinical trials (larger samples sizes and effects sizes) to better define clinical effectiveness.
    MeSH term(s) Authorship ; Clinical Trials as Topic ; Humans ; Periodicals as Topic ; Publications ; Transcranial Direct Current Stimulation ; Transcranial Magnetic Stimulation
    Language English
    Publishing date 2019-05-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2019.1615440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study.

    Owens, Cameron D / Bonin Pinto, Camila / Mukli, Peter / Szarvas, Zsofia / Peterfi, Anna / Detwiler, Sam / Olay, Lauren / Olson, Ann L / Li, Guangpu / Galvan, Veronica / Kirkpatrick, Angelia C / Balasubramanian, Priya / Tarantini, Stefano / Csiszar, Anna / Ungvari, Zoltan / Prodan, Calin I / Yabluchanskiy, Andriy

    PloS one

    2023  Volume 18, Issue 8, Page(s) e0289508

    Abstract: Introduction: Mild cognitive impairment (MCI) is a prodromal stage to dementia, affecting up to 20% of the aging population worldwide. Patients with MCI have an annual conversion rate to dementia of 15-20%. Thus, conditions that increase the conversion ... ...

    Abstract Introduction: Mild cognitive impairment (MCI) is a prodromal stage to dementia, affecting up to 20% of the aging population worldwide. Patients with MCI have an annual conversion rate to dementia of 15-20%. Thus, conditions that increase the conversion from MCI to dementia are of the utmost public health concern. The COVID-19 pandemic poses a significant impact on our aging population with cognitive decline as one of the leading complications following recovery from acute infection. Recent findings suggest that COVID-19 increases the conversion rate from MCI to dementia in older adults. Hence, we aim to uncover a mechanism for COVID-19 induced cognitive impairment and progression to dementia to pave the way for future therapeutic targets that may mitigate COVID-19 induced cognitive decline.
    Methodology: A prospective longitudinal study is conducted at the University of Oklahoma Health Sciences Center. Patients are screened in the Department of Neurology and must have a formal diagnosis of MCI, and MRI imaging prior to study enrollment. Patients who meet the inclusion criteria are enrolled and followed-up at 18-months after their first visit. Visit one and 18-month follow-up will include an integrated and cohesive battery of vascular and cognitive measurements, including peripheral endothelial function (flow-mediated dilation, laser speckle contrast imaging), retinal and cerebrovascular hemodynamics (dynamic vessel retinal analysis, functional near-infrared spectroscopy), and fluid and crystalized intelligence (NIH-Toolbox, n-back). Multiple logistic regression will be used for primary longitudinal data analysis to determine whether COVID-19 related impairment in neurovascular coupling and increases in white matter hyperintensity burden contribute to progression to dementia.
    MeSH term(s) Humans ; Aged ; Brain ; Prospective Studies ; Longitudinal Studies ; Pandemics ; Disease Progression ; COVID-19/epidemiology ; Cognitive Dysfunction/epidemiology ; Dementia/epidemiology ; Neuropsychological Tests ; Observational Studies as Topic
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0289508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of Combined and Alone Transcranial Motor Cortex Stimulation and Mirror Therapy in Phantom Limb Pain: A Randomized Factorial Trial.

    Gunduz, Muhammed Enes / Pacheco-Barrios, Kevin / Bonin Pinto, Camila / Duarte, Dante / Vélez, Faddi Ghassan Saleh / Gianlorenco, Anna Carolyna Lepesteur / Teixeira, Paulo Eduardo Portes / Giannoni-Luza, Stefano / Crandell, David / Battistella, Linamara Rizzo / Simis, Marcel / Fregni, Felipe

    Neurorehabilitation and neural repair

    2021  Volume 35, Issue 8, Page(s) 704–716

    Abstract: Phantom limb pain (PLP) is a frequent complication in amputees, which is often refractory to treatments. We aim to assess in a factorial trial the effects of transcranial direct current stimulation (tDCS) and mirror therapy (MT) in patients with ... ...

    Abstract Phantom limb pain (PLP) is a frequent complication in amputees, which is often refractory to treatments. We aim to assess in a factorial trial the effects of transcranial direct current stimulation (tDCS) and mirror therapy (MT) in patients with traumatic lower limb amputation; and whether the motor cortex plasticity changes drive these results. In this large randomized, blinded, 2-site, sham-controlled, 2 × 2 factorial trial, 112 participants with traumatic lower limb amputation were randomized into treatment groups. The interventions were active or covered MT for 4 weeks (20 sessions, 15 minutes each) combined with 2 weeks of either active or sham tDCS (10 sessions, 20 minutes each) applied to the contralateral primary motor cortex. The primary outcome was PLP changes on the visual analogue scale at the end of interventions (4 weeks). Motor cortex excitability and cortical mapping were assessed by transcranial magnetic stimulation (TMS). We found no interaction between tDCS and MT groups (
    MeSH term(s) Adult ; Combined Modality Therapy ; Double-Blind Method ; Evoked Potentials, Motor/physiology ; Female ; Humans ; Male ; Middle Aged ; Mirror Movement Therapy/methods ; Motor Cortex/physiopathology ; Phantom Limb/physiopathology ; Phantom Limb/therapy ; Transcranial Magnetic Stimulation/methods ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1491637-x
    ISSN 1552-6844 ; 1545-9683 ; 0888-4390
    ISSN (online) 1552-6844
    ISSN 1545-9683 ; 0888-4390
    DOI 10.1177/15459683211017509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3096: Show issues Location:
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  5. Article ; Online: Optimised transcranial direct current stimulation (tDCS) for fibromyalgia-targeting the endogenous pain control system: a randomised, double-blind, factorial clinical trial protocol.

    Castelo-Branco, Luis / Uygur Kucukseymen, Elif / Duarte, Dante / El-Hagrassy, Mirret M / Bonin Pinto, Camila / Gunduz, Muhammed Enes / Cardenas-Rojas, Alejandra / Pacheco-Barrios, Kevin / Yang, Yiling / Gonzalez-Mego, Paola / Estudillo-Guerra, Anayali / Candido-Santos, Ludmilla / Mesia-Toledo, Ines / Rafferty, Haley / Caumo, Wolnei / Fregni, Felipe

    BMJ open

    2019  Volume 9, Issue 10, Page(s) e032710

    Abstract: Introduction: Fibromyalgia (FM) is a common debilitating condition with limited therapeutic options. Medications have low efficacy and are often associated with adverse effects. Given that FM is associated with a defective endogenous pain control system ...

    Abstract Introduction: Fibromyalgia (FM) is a common debilitating condition with limited therapeutic options. Medications have low efficacy and are often associated with adverse effects. Given that FM is associated with a defective endogenous pain control system and central sensitisation, combining interventions such as transcranial direct current stimulation (tDCS) and aerobic exercise (AE) to modulate pain-processing circuits may enhance pain control.
    Methods and analysis: A prospective, randomised (1:1:1:1), placebo-controlled, double-blind, factorial clinical trial will test the hypothesis that optimised tDCS (16 anodal tDCS sessions combined with AE) can restore of the pain endogenous control system. Participants with FM (n=148) will undergo a conditioning exercise period and be randomly allocated to one of four groups: (1) active tDCS and AE, (2) sham tDCS and AE, (3) active tDCS and non-aerobic exercise (nAE) or (4) sham tDCS and nAE. Pain inhibitory activity will be assessed using conditioned pain modulation (CPM) and temporal slow pain summation (TSPS)-primary outcomes. Secondary outcomes will include the following assessments: Transcranial magnetic stimulation and electroencephalography as cortical markers of pain inhibitory control and thalamocortical circuits; secondary clinical outcomes on pain, FM, quality of life, sleep and depression. Finally, the relationship between the two main mechanistic targets in this study-CPM and TSPS-and changes in secondary clinical outcomes will be tested. The change in the primary efficacy endpoint, CPM and TSPS, from baseline to week 4 of stimulation will be tested with a mixed linear model and adjusted for important demographic variables.
    Ethics and dissemination: This study obeys the Declaration of Helsinki and was approved by the Institutional Review Board (IRB) of Partners Healthcare under the protocol number 2017P002524. Informed consent will be obtained from participants. Study findings will be reported in conferences and peer-reviewed journal publications.
    Trial registration number: NCT03371225.
    MeSH term(s) Adult ; Double-Blind Method ; Exercise Therapy/methods ; Female ; Fibromyalgia/therapy ; Humans ; Male ; Middle Aged ; Pain Management/methods ; Prospective Studies ; Randomized Controlled Trials as Topic ; Transcranial Direct Current Stimulation/methods ; Young Adult
    Language English
    Publishing date 2019-10-30
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2019-032710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Combining Fluoxetine and rTMS in Poststroke Motor Recovery: A Placebo-Controlled Double-Blind Randomized Phase 2 Clinical Trial.

    Bonin Pinto, Camila / Morales-Quezada, Leon / de Toledo Piza, Polyana Vulcano / Zeng, Dian / Saleh Vélez, Faddi Ghassan / Ferreira, Isadora Santos / Lucena, Pedro Henrique / Duarte, Dante / Lopes, Fernanda / El-Hagrassy, Mirret M / Rizzo, Luiz Vicente / Camargo, Erica C / Lin, David J / Mazwi, Nicole / Wang, Qing Mei / Black-Schaffer, Randie / Fregni, Felipe

    Neurorehabilitation and neural repair

    2019  Volume 33, Issue 8, Page(s) 643–655

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Combined Modality Therapy ; Double-Blind Method ; Female ; Fluoxetine/therapeutic use ; Humans ; Male ; Middle Aged ; Motor Activity/drug effects ; Motor Activity/physiology ; Paresis/etiology ; Paresis/physiopathology ; Paresis/therapy ; Pyramidal Tracts/drug effects ; Pyramidal Tracts/physiopathology ; Recovery of Function ; Serotonin Uptake Inhibitors/therapeutic use ; Stroke/complications ; Stroke/physiopathology ; Stroke/therapy ; Transcranial Magnetic Stimulation/methods ; Treatment Outcome ; Upper Extremity
    Chemical Substances Serotonin Uptake Inhibitors ; Fluoxetine (01K63SUP8D)
    Language English
    Publishing date 2019-07-09
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 1491637-x
    ISSN 1552-6844 ; 1545-9683 ; 0888-4390
    ISSN (online) 1552-6844
    ISSN 1545-9683 ; 0888-4390
    DOI 10.1177/1545968319860483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3096: Show issues Location:
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